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Review

Leukotriene receptor antagonists – risks and benefits for use in paediatric asthma

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Pages 173-185 | Published online: 03 Mar 2005

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  • ••One of few randomised, multi-centre trialsin children evaluating the effects of montelukast for mild, persistent asthma.
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  • ••Important study that looked at children aged6–14 years with EIB. Evaluated the efficacy and safety of zafirlukast for inhibiting EIB.
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  • ••Studied the effects of montelukast inpreventing EIB in children.
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  • •Adult trial that studied the effects of montelukast in controlling mild asthma and EIB.
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  • ••Important consensus statement regardingthe diagnosis and treatment of asthma with recommendations for childhood asthma.
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  • ••Important consensus statement regardingthe diagnosis and treatment of asthma with recommendations for childhood asthma.
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  • ••Important consensus statement regardingthe diagnosis and treatment of asthma with recommendations for childhood asthma.
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  • •Studied the safety and efficacy of montelukast for children aged 2–5 years with persistent asthma.
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  • ••Large, multi-centre trial evlauating the efficacy and safety of zafirlukast in children with mild persistent asthma.
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  • ••Large, multi-centre trial comparing ICSto LTRA in patients with moderate, persistent asthma.
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  • ••One of few studies to evaluate theinflammatory process that occurs in children with wheezing.
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  • •Small trial that evaluated the effect of montelukast on post-viral wheeze.
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  • •Important trial looking at whether montelukast could benefit patients by allowing ICS doses to be tapered.
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  • •Evaluated the benefits of adding montelukast to ICS for control of moderate, persistent asthma.
  • VIRCHOW JC, PRASSE A, NAYA I et al.: Zafirlukast improves asthma control in patients receiving high-dose inhaled corticosteroids. Am. Respir. Crit. Care Med (2000) 162(2):578–585.
  • •Evaluated the benefits of adding zafilukast to ICS for moderate-to-severe, persistent asthma.
  • BUSSE WW, NELSON H, WOLFE J et al: Comparison of inhaled salmeterol and oral zafirlukast in patients with asthma. Allergy Clin. Immunol (1999) 103:1075–1080.
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  • SIMONS FE, VILLA JR, LEE BW et al:Montelukast added to budesonide in children with persistent asthma: a randomized, double-blind, crossover study. Pediatr. (2001) 138(5):694–698.
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  • •Important study in children that demonstrated a decrease in inflammation in the respiratory tract after treatment with montelukast.
  • MASPERO JF, DUENAS-MEZA E, VOLOVITZ B et al.: Oral montelukast versus beclomethasone in 6–11 year old children with asthma: results of an open-label extension study evaluating long-term safety, satisfaction and adherence with therapy. Carr: Med. Res. Opin. (2001) 17:96–104.
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  • DUCHARME FM: Inhaled glucocorticoidsversus leukotriene receptor antagonists as single agent asthma treatment: systematic review of current evidence. Br. Med. (2003) 326:621.
  • •Review of current literature citing 1 paediatric and 12 adult trials that have looked at ICS versus LTRAs for control of asthma.
  • BUKSTEIN DA, LUSKIN AT, BERNSTEIN A: 'Real-world' effectiveness of daily controller medicine in children with mild persistent asthma. Ann. Allergy Asthma Innnunol. (2003) 90(5):543–549.
  • ARMSTRONG EP, MALONE DC: Fluticasone is associated with lower asthma-related costs than leukotriene modifiers in a real world analysis. Phapnacotherapy (2002) 22:1117–1123.
  • KATIAL RK, STELZLE RC, BONNER MW, MARINO M, CANTILENA LR, SMITH LJ: A drug-interaction between zafirlukast and theophylline. Arch. Intern. Med. (1998) 158:1713–1715.
  • GREEN RL, VAYONIS AG: Churg-Strauss syndrome after zafirlukast in two patients not receiving steroid treatment. Lancet (1999) 353:725–726.
  • KINOSHITA M, SHIRAISHI T, KOGA Tet al.: Churg-Strauss syndrome after corticosteroid withdrawal in an asthmatic patient treated with pranlukast. Allergy Olin. bronunol (1999) 103(3 Pt 1):534–535.
  • WECHSLER ME, GARPESTAD E, FLIER SR et al: Pulmonary infiltrates, eosinophilia, and cardiomyopathy following corticosteroid withdrawal in patients with asthma receiving zafirlukast. JAMA (1998) 279(6):455–457.
  • WECHSLER ME, FINN D, GUNAWARDENA D et al: Churg-Strauss syndrome in patients receiving montelukast as treatment for asthma. Chest (2000) 117:708–713.
  • MARTIN RM, WILTON LV, MANN RD: Prevalence of Churg-Strauss syndrome, vasculitis, eosinophilia and associated condition: retrospective analysis of 58 prescription-event monitoring cohort studies. Phannacoepidennol Drug Sal: (1999) 8:179.
  • TUGGEY JM, HOSKER HS: Churg-Strauss syndrome associated with montelukast therapy. Thorax (2000) 55:805–806.
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  • SCHURMAN SJ, ALDERMAN JM, MASSANARI M et al.: Tubulointerstitial nephritis induced by the leukotriene receptor antagonist pranlukast. Chest (1998) 114:1220–1223.

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