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Review

Safety of verteporfin for treatment of subfoveal choroidal neovascular membranes associated with age-related macular degeneration

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Pages 345-361 | Published online: 23 Feb 2005

Bibliographys

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  • •A well written review of the principals of PDT for disease treatment.
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  • •A concise and well organised paper, discussing the principles of PDT, as applied to retinal disease, and reviews the chemistry of various photosensitive entities and their potential use in ophthalmic practice with an emphasis on verteporfin.
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  • •A comprehensive review of AMD.
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  • NO AUTHORS LISTED: Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: One-year results of 2 randomized clinical trials-tap report 1. Arch. Ophthalmol (1999) 117:1329–1345.
  • •The first of a series of clinical reports summarising details of therapeutic results and safety of verteportin for AMD.
  • NO AUTHORS LISTED: Subfoveal neovascular lesions in age-related macular degeneration. Guidelines for evaluation and treatment in the macular photocogaulation study. The Macular Photocoagulation Study Group. Arch. Ophthalmol (1991) 109:1242–1257.
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  • NO AUTHORS LISTED: Macular Photocoagulation Study Group. Laser photocoagulation of subfoveal neovascular lesions of age-related macular degeneration: results of a randomized clinical trial. Arch. OphthahnoL (1993) 111:1200–1209.
  • MILLER G, MILLER B: Photodynamic therapy of subretinal neovascularization in the monkey eye. Arch. Ophthalmol (1993) 111:855–860.
  • MILLER JW, WALSH AW, KRAMER M et al.: Photodynamic therapy of experimental neovascularization using lipoprotein-delivered benzoporphyrin. Arch. Ophthalmol (1995) 113:810–818.
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  • COHEN SY, BULIK A, DUBOIS L, QUENTEL G: Photodynamic therapy for juxtafoveal choroidal neovascularization in myopic eyes. Am. Ophthalmol (2003) 136:371–374.
  • BUSQUETS MA, SHAH GK, WICKENS J et al.: Ocular photodynamic therapy with verteporfin for choroidal neovascularization secondary to ocular histoplasmosis syndrome. Retina (2003) 23(3):299–306.
  • BLINDER KJ, BRADLEY S, BRESSLER NM et al.: Effect of lesion size, visual acuity and lesion composition on visual acuity change with and without verteporfin therapy for choroidal neovascularization secondary to age-related macular degeneration: TAP and VIP report no. 1. Am. J. Ophthalrnol (2003) 136:407–418.
  • •• Pivotal study discussing enhanced optionsfor verteporfin in AMD, in terms of lesion size and classification, and safety.
  • MILLER JW, WALSH AW, KRAMER M: Photodynamic therapy of experimental choroidal neovascularization using a lipoprotein delivered benzoporphyrin. Arch. Ophthalmol (1995) 113:810–818.
  • REINKE MH, CANAKIS C, HUSAIN D: Verteporfin photodynamic therapy retreatment of the normal retina and choroid in the cynomoglus monkey. Ophthalmology (1999) 106:1915–1923.
  • MILLER JW, SCHMIDT-ERFURTH U, SICKENBERG M et al: Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration. Results of a single treatment in a Phase I and 2 study. Arch. Ophthalmol (1999) 117:1161–1173.
  • SCHMIDT-ERFURTH U, MILLER JVV, SICKENBERG M et al: Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration. Results of retreatments in a Phase I and II study. Arch. Ophthalmol (1999) 117:1177–1187.
  • •• This important clinical trial demonstratedthe visual benefits and safety of serial verteporfin treatment for AMD.
  • BRESSLER NM: Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin. Two-year results of 2 randomized clinical trials - TAP report 2. Arch. Ophthalmol (2001) 119:198–207.
  • BLUMENKRANZ MS, BRESSLER NM, BRESSLER SB et al: Verteporfin therapy for subfoveal choroidal neovascularization in age-related macular degeneration. Three-year results of an open label extension of 2 randomized clinical trials - TAP report No. 5. Arch. Ophthalmol (2002) 120:1307–1314.
  • ••Discusses long-term vision outcomes andsafety of verteporfin use in AMD.
  • NO AUTHORS LISTED: Verteporfin in Photodynamic therapy study group. Subfoveal neovascular lesions in age-related macular degeneration: two-year results of a randomized clinical trial including lesions with occult and non-classic chorodial neovascularization. Verteporfin in Photodynamic therapy report 2. Am. J. Ophthalmol (2001) 131:541–560.
  • ••Summarises the influence of lesion size and initial visual acuity on the result of verteporfin treatment for AMD.
  • BRESSLER NM, ARNOLD J, BENCHABOUNE M et al: Verteporfin therapy of subfoveal choroidal neovascularization in patients with age related macular degeneration. Additional information regarding baseline lesion composition's impact on vision outcomes - TAP Report No. 3. Arch. Ophthalmol (2002) 120:1443–1454.
  • ••Demonstrates that use of nutritionalanti-oxidant supplements or laser photocoagulation does not affect the visual outcome of verteporfin therapy for AMD.
  • HOSKIN A, BIRD AC, SEHMI K: Tears of the detached retinal pigmented epithelium. Br. J. Ophthalmol (1981) 65:417–422.
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  • GELISKEN F, INHOFFEN W, PARTSCH M, SCHNEIDER U, KREISSIG I: Retinal pigment epithelial tear after photodynamic therapy for choroidal neovascularizatoin. Am. J. Ophthalmol (2001) 131:518–520.
  • PECE A, INTROINI U, BOTTONI F, BRANCATO R: Acute retinal pigment epithelial tear after photodynamic therapy. Retina (2001) 21:361–363.
  • WACHTLIN J, BEHME T, HEIMANN H, KELLNER U, FOERSTER MH: Concentric retinal pigment epithelium atrophy after a single photodynamic therapy. Graefes Arch. Clin. Exp. Ophthalmol (2003) 241:518–521.
  • MANSOUR AM, HUSSEINI AM, SCHAKAL AR: Macular hole following photodynamic therapy. Ophthalmic Surg. Lasers (2002) 33:511–513.
  • THEODOSSIADIS GP, PANAGIOTIDIS D, GEORGALAS IG, MOSCHOS M: Retinal hemorrhage after photodynamic therapy in patients with subfoveal choroidal neovascularization caused by age-related macular degeneration. Graefes Arch. Clin. Exp. Ophthalmol (2003) 241:8–13.
  • HOULE JM, STRONG HA: Duration of skin photosensitivity and incidence of photosensitivity reactions after administration of verteporfin. Retina (2002) 22:691-697. 359
  • •Describes the kinetics and incidence of photosensitivity and photosensitvity reactions associated with verteporfin use.
  • ITAGAKI T, MATSUYUKI D, SHIGEHITO S, SHIGERU K: Skin burn caused by operating light during a long operation after photodynamic therapy. Anesthesiology(2003) 98:1011–1013.
  • PACKAGE LABELING; VisudyneTm (verteporfin for injection), Novartis Ophthalmics Inc., Duluth, Georgia, USA. May 2002.
  • BICKERS DR: Photosensitivity and other reactions to light. In: Harrison's Principles of Internal Medicine (13th edni. Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci A, Kasper DL (Eds), McGraw-Hill, Inc., New York, USA (1994):307–312.
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  • ••A comprehensive, widely utilised, referencetext, describing drugs currently approved for use within the US. Updated yearly.
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  • TORNAMBE PE: Using intravenous diphenhydramine to minimize back pain associated with photodynamic therapy with Verteporfin. Arch. Ophthalinol (2002) 120:872–873.
  • •An informative study describing the outcome of prophylaxis for verteporfin-associated pain.
  • BORODOKER N, SPAIDE RF, MARANAN L et al.: Verteporfin infusion-associated pain. Ain. J. Ophthalinol (2002) 133:211–214.
  • •Discusses the role of oral hydration in the prevention of verteporfin-associated pain.
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  • BROWN GC, MURPHY RP: Visual symptoms associated with choroidal neovascularization. Photopsia and the Charles Bonnet syndrome. Arch. Ophthalinol (1992) 110:1251–1256.
  • •An interesting discussion of various photopsia and visual hallucinations observed in retinal disease.
  • COHEN SY, SAFRAN AB, TADAYONI R et al.: Visual hallucinations immediately after macular photocoagulaion. Am. J. Ophthalinol (2000) 129:815–816.
  • AU EONG K, FUJII GY, NG EW et al: Transient formed hallucinations following macular translocation for subfoveal choroidal neovascularization secondary to age-related macular degeneration. Am. J. Ophthalinol (2001) 131:664–666.
  • KANG SW, KANG SJ, KIM OH, NAM ES, LEE JH, KOH HJ: Photodynamic therapy using verteporfin-induced minimal change nephrotic syndrome. Ain. .1. Ophthalinol (2002) 134:907–908.
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  • FINKELSTEIN A, FRALEY DS, STACHURA I, FELDMAN HA, GANDY DR, BOURKE E: Fenoprofen nephropathy: lipoid nephrosis and interstitial nephritis. A possible T-lymphocyte disorder. Am. .1. Med. (1982) 72:81–87.
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  • ••A description of the immunomodulatoryaction of verteporfin in terms of the antigenic potential on circulating T cells.
  • NOFFKE AS, JAMPOL LM, WEINBERG DV, MUNANA A: A potentially life-threatening adverse event reaction to verteporfin. Arch. Ophthalmol (2001) 119:143.
  • •A case report of an apparently isolated, yet potentially serious event related to verteporfin use.
  • CAHILL MT, SMITH BT, FEKRAT S: Adverse reaction characterized by chest pain, shortness of breath, and syncope associated with verteporfin (Visudyne). Am. J. Ophthalmol (2002) 134:281–282.
  • •A case scenario that all health care workers should be familiar with.
  • MIMOUNI KF, BRESSLER SB, BRESSLER NM: Photodynamic therapy with verteporfin for subfoveal choroidal neovascularization in children. Am. J. Ophthalmol (2003) 135:900–902.
  • •The typical exclusion of children in both pre- and post-marketing clinical drug studies in the US, makes this article of particular interest.
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