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Expert Opinion on Drug Delivery Volume 6, 2009 - Issue 1
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Review

Targeting drugs to the airways: the role of spacer devices

Federico Lavorini Università degli Studi di Firenze, Dipartimento di Area Critica Medico Chirurgica, Unità Funzionale di Medicina Respiratoria, Viale G. B. Morgagni 85 – 50134, Firenze, Italy +39 055 413183; +39 055 4223202; [email protected]
, MD PhD &
Giovanni A Fontana Università degli Studi di Firenze, Dipartimento di Area Critica Medico Chirurgica, Unità Funzionale di Medicina Respiratoria, Viale G. B. Morgagni 85 – 50134, Firenze, Italy +39 055 413183; +39 055 4223202; [email protected]
Pages 91-102 | Published online: 09 Jan 2009

Bibliography

  • Pauwels R, Newman S, Borgström L. Airway deposition and airway effects of antiasthma drugs delivered from metered-dose inhalers. Eur Respir J 1997;10:2127-38
  • Dolovich MB, Arhens RC, Hess DR, et al. Device selection and outcomes of aerosol therapy: evidence-based guidelines. Chest 2005;127:335-71
  • McFadden ER Jr. Improper patient techniques with metered dose inhalers: clinical consequences and solutions to misuse. J Allergy Clin Immunol 1995;96:278-83
  • Crompton GK. Problems patients have using pressurised aerosol inhalers. Eur J Respir Dis 1982;63(Suppl 119):101-4
  • Newman S, Newhouse M. Effect of add-on devices for aerosol drug delivery: deposition studies and clinical aspects. J Aerosol Med 1996;9:55-70
  • Newman SP. Spacer devices for metered dose inhalers. Clin Pharmacokinet 2004;43:349-60
  • Terzano C. Pressurized metered dose inhalers and add-on devices. Pulm Pharmacol Ther 2001;14:351-66
  • Rau JL. Practical problems with aerosol therapy in COPD. Respir Care 2006;51:158-72
  • Barry PW, Robertson C, O'Callaghan C. Optimal use of a spacer device. Arch Dis Child 1993;69:693-4
  • Barry PW, O'Callaghan C. The effect of delay, multiple actuations and spacer charge on the in vitro delivery of budesonide from the Nebuhaler. Br J Clin Pharmacol 1995;40:76-8
  • Mitchell JP, Nagel MW. Valved-holding chamber (VHCs) for use with pressurised metered-dose inhalers (pMDIs). A review of causes of inconsistent medication delivery. Prim Care Respir J 2007;16:207-14
  • Pierart F, Wildhaber JH, Vrancken I, et al. Washing plastic spacers in household detergent reduces electrostatic charge and greatly improves delivery. Eur Respir J 1999;13:673-8
  • Wildhaber JH, Waterer GW, Hall GL, et al. Reducing electrostatic charge on spacer devices and bronchodilator response. Br J Clin Pharmacol 2000;50:277-80
  • Bisgaard H, Anhøj J, Klug B, et al. A non-electrostatic spacer for aerosol delivery. Arch Dis Child 1995;73:226-30
  • Ahrens RA, Lux C, Bahl T, et al. Choosing the metered-dose inhaler spacer or holding chamber that matches the patient's need: evidence that specific drug being delivered is an important consideration. J Allergy Clin Immunol 1995;96:288-94
  • Thorsson L, Edsbacker S. Lung deposition of budesonide from pressurised metered-dose inhaler attached to a spacer. Eur Respir J 1998;12:1340-5
  • Derom E, Pauwels R. Pharmacokinetic and pharmacodynamic properties of inhaled beclomethasone dipropionate delivered via hydrofluoroalkane-containing devices. Clin Pharmacokinet 2005;44:815-36
  • Everard ML, Clarke AR, Milner AD. Drug delivery from holding chambers with attached facemask. Arch Dis Child 1992;67:580-5
  • O'Callaghan C, Lynch J, Cant M, et al. Improvement in sodium cromoglycate delivery from a spacer device by use of an antistatic lining, immediate inhalation and avoiding multiple actuations of drug. Thorax 1993;48:603-6
  • Bisgaard H, Anhøj J, Wildhaber JH. Spacer devices. In: Bisgaard H, O'Callaghan C, Smaldone GC, editors, Drug delivery to the lung. New York: Marcel Dekker; 2002; p. 389-420
  • Green CP, Price JF. Bronchodilator effect of salbutamol via the volumatic in children. Respir Med 1991;85:325-6
  • Zak M, Madsen J, Berg E, et al. A mathematical model of aerosol holding chambers. J Aerosol Med 1999;12:187-96
  • Leach CL. Improved delivery of inhaled steroids to the large and small airways. Respir Med 1998;92(Suppl A):3-8
  • Barry PW, O'Callaghan C. In vitro comparison of the amount of salbutamol available for inhalation from different formulations used with different spacer devices. Eur Respir J 1997;10:1345-8
  • Gabrio BJ, Stein SW, Velasquez DJ. A new method to evaluate plume characteristics of hydrofluoroalkane and chlorofluorocarbon metered dose inhalers. Int J Pharm 1999;186:3-12
  • Lipworth BJ, Clark DJ. Early lung absorption profile of non-CFC salbutamol via small and large volume plastic spacer devices. Br J Clin Pharmacol 1998;46:45-8
  • Joguparthi V, Breen P, Compadre C, et al. Effect of propellant on the pharmacokinetics and pharmacodynamics of inhaled albuterol in asthmatic subjects. J Aerosol Med 2003;16:47-53
  • Roller CM, Zhang G, Troedson RG, et al. Spacer inhalation technique and deposition of extrafine aerosol in asthmatic children. Eur Respir J 2007;29:299-306
  • Nair A, Menzies D, Barnes M, et al. Respirable dose delivery of fluticasone propionate from a small valved holding chamber, a compact breath actuated integrated vortex device and a metered dose inhaler. Br J Clin Pharmacol 2008;66:20-6
  • Dewsbury NJ, Kenyon CJ, Newman SP. The effect of handling techniques on electrostatic charge on spacer devices: A correlation with in vitro particle size analysis. Int J Pharm 1996;137:261-4
  • Jansenns HM, Devadason SG, Hop WCJ, et al. Variability of aerosol delivery via spacer devices in young asthmatic children in daily life. Eur Respir J 1999;13:787-91
  • Anhøj J, Bisgaard H, Lipworth BJ. Effect of electrostatic charge in plastic spacers on the lung delivery of HFA-salbutamol in children. Br J Clin Pharmacol 1999;47:333-6
  • Wildhaber JH, Waterer GW, Hall GL, Sumers QA. Reducing electrostatic charge on spacer devices and bronchodilator response. Br J Clin Pharmacol 2000;50:277-80
  • Chuffart AA, Sennhauser FH, Wildhaber JH. Factors affecting the efficiency of aerosol therapy with pressurised metered-dose inhalers through plastic spacers. Swiss Med Wkly 2001;131:14-18
  • Dompeling E, Oudesluys-Murphy AM, Janssens HM, et al. Randomised controlled study of clinical efficacy of spacer therapy in asthma with regard to electrostatic charge. Arch Dis Child 2001;84:178-82
  • Dubus JC, Guillot C, Badier M. Electrostatic charge on spacer devices and salbutamol response in young children. Int J Pharm 2003;261:159-64
  • Le Souëf PN. Drug delivery. Med J Aust 2002;177(Suppl):S69-71
  • Bisgaard H. Delivery of inhaled medication to children. J Asthma 1997;34:443-67
  • Matthys H. Inhalation delivery of asthma drug. Lung 1990;168(Suppl):645-52
  • Ernst P. Inhaled drug delivery: a practical guide to prescribing inhaler devices. Can Respir J 1998;5:180-3
  • Laube BL, Norman PS, Adamns GK. The effect of aerosol distribution on airway responsiveness to inhaled methacholine in patients with asthma. J Allergy Clin Immunol 1992;89:510-8
  • Global Initiative for Asthma. Global strategy for asthma management and prevention. Available from: http://www.ginaasthma.com. Updated December 2007
  • König P. Spacer devices used with metered-dose inhalers. Breakthrough or gimmick? Chest 1985;88:276-84
  • Morgan MDL, Singh BV, Frame MH, Williams SJ. Terbutaline aerosol given through pear spacer in acute severe asthma. Br Med J 1982;285:849-50
  • Barry PW, O'Callaghan C. The influence of inhaler selection on efficacy of asthma therapies. Adv Drug Deliv Rev 2003;55:879-923
  • Cates CJ, Adams N, Bestall J. Holding chambers versus nebulisers for inhaled steroids in chronic asthma. Cochrane Database Syst Rev 2006;(1):CD001491
  • Benton GM, Thomas RC, Nickerson BG, et al. Experience with metered-dose inhaler with spacer in the paediatric emergency department. Am J Dis Child 1989;143:678-81
  • Chou KJ, Cunningham SJ, Crain EF. Metered-dose inhalers with spacers vs nebulizers for paediatric asthma. Arch Pediatr Adolesc Med 1995;149:201-5
  • Dolovich M, Ruffin R, Newhouse MT. Clinical evaluation of a simple demand inhalation MDI aerosol delivery device. Chest 1983;84:37-41
  • Lee H, Evans HE. Evaluation of inhalation aids of metered dose inhalers in asthmatic children. Chest 1987;91:366-9
  • Tobin MJ, Jenouri G, Danta I, et al. Response to bronchodilator drug administration by a new reservoir aerosol delivery system and a review of other auxiliary delivery systems. Am Rev Respir Dis 1982;126:670-5
  • Pedersen S. Aerosol treatment of bronchocostriction in children with or without a tube spacer. N Engl J Med 1983;308:1328-30
  • Fontana GA, Lavorini F, Chiostri M, et al. Large and small airway responses to procaterol hydrochloride administered through different extension devices in asthmatic patients. J Aerosol Med 1999;12:177-85
  • Salzman GA, Pyszczynski DR. Oropharyngeal candidiasis in patients treated with beclomethasone dipropionate delivered by metered-dose inhaler alone and with Aerochamber. J Allergy Clin Immunol 1988;81:424-8
  • British Asthma Guidelines Coordinating Committee. British Guidelines on asthma management: 1995 review and position statement. Thorax 1997;45:S1-24
  • Bröeders ME, Molema J, Hop WC, et al. Does the inhalation device affect the bronchodilatory dose–response curve of salbutamol in asthma and chronic obstructive pulmonary disease patients? Eur J Clin Pharmacol 2003;59:449-55
  • Ahlstrom H, Svenonius E, Svensson M. Treatment of asthma in pre-school children with inhalation of terbutaline in Turbuhaler compared with Nebuhaler. Allergy 1989;44:515-8
  • Laberge S, Spier S, Drblik SP, et al. Comparison of inhaled terbutaline administered by either the Turbuhaler dry powder inhaler or a metered-dose inhaler with spacer in preschool children with asthma. J Pediatr 1994;124:815-7
  • Engen T, Heining JH, Malling HJ, et al. Clinical comparison of inhaled budesonide delivered either via a pressurized metered-dose inhaler or Turbuhaler. Allergy 1989;44:220-5
  • Nieminen MM, Lahdensuo A. Inhalation treatment with budesonide in asthma. A comparison of Turbuhaler and metered dose inhalation with Nebuhaler. Acta Ther 1995;21:179-92
  • Lavorini F, Geri P, Luperini M, et al. Clinical and functional responses to salbutamol inhaled via different devices in asthmatic patients with induced bronchoconstriction. Br J Clin Pharmacol 2004;58:512-20
  • Lavorini F, Geri P, Mariani L, et al. Speed of onset of bronchodilator response to salbutamol inhaled via different devices in asthmatics. A bioassay based on functional antagonism. Br J Clin Pharmacol 2006;62:403-11
  • Lavorini F, Geri P, Camiciottoli G, et al. Agreement between two methods for assessing bioequivalence Pulm Pharmacol Ther 2008;21:380-4
  • Agertoft L, Pedersen S. Importance of the inhalation device on the effect of budesonide. Arch Dis Child 1993;69:130-3
  • Agertoft L, Pedersen S. Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children. Respir Med 1994;88:373-81
  • Summer W, Elston R, Tharpe L, et al. Aerosol bronchodilator delivery methods. Relative impact on pulmonary function and cost of respiratory care. Arch Intern Med 1989;149:618-23
  • Bowton DL, Goldsmith WM, Haponik EF. Substitution of metered-dose inhalers for hand-held nebulizers – success and cost savings in a large, acute-care hospital. Chest 1992;101:305-8
  • Turner MO, Peal A, Ginsburg S, Fitzgerald JM. Bronchodilator delivery in acute airflow obstruction. A meta-analysis. Arch Intern Med 1997;157:1736-44
  • Mason N, Roberts N, Yard N, Partridge MR. Nebulisers or spacers for the administration of bronchodilators to those with asthma attending emergency departments? Respir Med 2008;102:993-8
  • Rabe K, Vermeire P, Soriano J, Maier W. Clinical management of asthma in 1999: the Asthma Insights and Reality in Europe (AIRE) study. Eur Respir J 2000;16:802-7
  • Virchow JC, Crompton GK, Dal Negro R, et al. Importance of inhaler device in the management of airway disease. Respir Med 2008;102:10-19
  • Lavorini F, Magnan A, Dubus JC, et al. Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD. Respir Med 2008;102:593-604
  • O'Callaghan C, Barry PW. How to choose delivery devices for asthma. Arch Dis Child 2000;82:185-7
  • Barry PW, O'Callaghan C. Inhalational drug delivery from seven different spacer devices. Thorax 1996;51:835-40

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