486
Views
87
CrossRef citations to date
0
Altmetric
Review

Emerging strategies for the transdermal delivery of peptide and protein drugs

, , &
Pages 533-548 | Published online: 10 May 2005

Bibliography

  • CEVC G: Drug delivery across the skin. Expert Opin. Investig. Drugs (1997) 6(12):1887–1937.
  • NAIK A. KALIA YN, GUY RH: Transdermal drug delivery: overcoming the skin's barrier function. Pharm. Sci. TechnoL Today (2000) 3(9):318–326.
  • SCHEUPLEIN RJ, BLANK IH: Permeability of the skin. PhysioL Rev. (1971) 51(4):702–747.
  • GUY RH: Current status and future prospects of transdermal drug delivery. Pharm. Res. (1996) 13(12):1765–1769.
  • CHOI H-K, FLYNN GL, AMIDON GL: Transdermal delivery of bioactive peptides: The effect of N-decylmethyl sulfoxide, pH, and inhibitors on enkephalin metabolism and transport. Pharm. Res. (1990) 7(11):1099–1106.
  • BANERJEE PS, RITSCHEL WA: Transdermal permeation of vasopressin. I. Influence of pH, concentration, shaving and surfactant on in vitro permeation. Int. J. Pharm. (1989) 49:189–197.
  • SHAH PK, BORCHARDT RT: A comparison of peptidase activities and peptide metabolism in cultured mouse keratinocytes and neonatal mouse epidermis. Pharm. Res. (1991) 8:70–75.
  • FRAKI JE, LAZARUS GS, HOPSU-HAVU VK: Protein catabolism in the skin. In: Biochemistry and Physiology of the Skin. Goldsmith LA (Ed.), Oxford University Press, New York, USA (1983):338–362.
  • MARTIN RJ, DENYER SP, HADGRAFT J: Skin metabolism of topically applied compounds. Int. j Pharm. (1987) 39:23–32.
  • MORIMOTO K, IWAKURA Y, NAKATANI E et al.: Effects of proteolytic enzyme inhibitors as absorption enhancers on the transdermal iontophoretic delivery of calcitonin in rats. J. Pharm. PharmacoL (1992) 44(3):216–218.
  • MORIMOTO K, IWAKURA Y, MIYAZAKI M et al.: Effects of proteolytic enzyme inhibitors of enhancement of transdermal iontophoretic delivery of vasopressin and an analogue in rats. Int. J. Pharm. (1992) 81:119–125.
  • RIESZ P, KONDO T: Free radical formation induced by ultrasound and its biological implications. Free Radical Biol. Med. (1992) 13:247–270.
  • HIKIMA T, HIRAI Y, TOJO K: The effect of ultrasound application on skin metabolism of prednisolone 21-acetate. Pharm. Res. (1998) 15:1680–1683.
  • SMITH EW, MAIBACH HI: Percutaneous Penetration Enhancers. CRC Press, Boca Raton, Florida, USA (1995).
  • WILLIAMS AC, BARRY BW: Penetration enhancers. Adv. Drug Deliv. Rev. (2004) 56:603–618.
  • MARRO D, DELGADO-CHARRO MB, GUY RH: Peptides and proteins - transdermal absorption. In: Encyclopedia of Pharmaceutical Technology. J S JC Boylan (Eds), Marcel Dekker, New York, USA (2002):2125–2140.
  • LASHMAR UT, HADGRAFT J, THOMAS N: Topical application of penetration enhancers to the skin of nude mice: a histopathological study. J. Pharm. PharmacoL (1989) 41(2):118–122.
  • GOZES I, RESHEF A, SALAH D et al.:Stearyl-norleucine-vasoactive intestinal peptide (VIP): a novel VIP analog for noninvasive impotence treatment. Endocrinology (1994) 134:2121–2125.
  • FOLDVARI M, ATTAH-POKU S, HUGHES H et al.: Palmitoyl derivatives of interferon alpha: potential for cutaneous delivery. J. Pharm. Sci. (1998) 87(10):1203–1208.
  • WARANUCH N, RAMACHANDRAN C, WEINER N: Controlled topical delivery of cyclosporin A from nonionic liposomal formulations: mechanistic aspects. J. Liposome Res. (1998) 8(2):225–238.
  • FOLDVARI M, BACA-ESTRADA ME, HE Z et al.: Dermal and transdermal delivery of protein pharmaceuticals: lipid-based delivery systems for interferon a. Biotechnol. AppL Biochem. (1999) 30:129–137.
  • CEVC G: Transferosomes, liposomes and other lipid suspensions on the skin: permeation enhancement, vesicle penetration, and transdermal drug delivery. Crit. Rev.Therap. Drug Carrier Syst. (1996) 13:257–388.
  • CEVC G, GEBAUER D, STIEBER Jet al.:Ultraflexible vesicles, transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin. Biochim. Biophys. Acta (1998) 1368:201–215.
  • TOUITOU E, GODIN B, WEISS C: Enhanced delivery of drugs into and across the skin by ethosomal carriers. Drug Dev. Res. (2000) 50:406–415.
  • TOUITOU E, DAYAN N, BERGELSON Let al.: Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties. J. Control. Release (2000) 65:403–418.
  • DAYAN N, TOUITOU E: Carriers for skindelivery of trihexyphenidyl HC1: ethosomes vs liposomes. Biomaterials (2000) 21:1879–1885.
  • JAIN S, UMAMAHESHWARI RB, BHADRA D et al.: Ethosomes: a novel vesicular carrier for enhanced transdermal delivery of an anti-HIV agent. Ind. J. Pharma. Sci. (2004) 66(1):72–81.
  • DKEIDEK I, TOUITOU E: Transdermal absorption of polypeptides. AAPS Pharm. Sci. (1999) 1:S202.
  • BANGA AK, KATAKAM M, MITRA R: Transdermal iontophoretic delivery and degradation of vasopressin across human cadaver skin. Int. j Pharm. (1995) 166:211–216.
  • SARPOTDAR PPDCR, LIVERSIDGE GG, STERNSON LA: Facilitated iontophoretic delivery of thyrotropin releasing hormone (TRH) across cadaver skin by optimization of formulation variables. Pharm. Res. (1989) 6(Suppl.):5107.
  • CLEMESSY M, COUARRAZE G, BEVAN B et al.: Mechanisms involved in iontophoretic transport of angiotensin. Pharm. Res. (1995) 12(7):998–1002.
  • LAU DTW, SHARKEY JW, PETRYK L et al.: Effect of current magnitude and drug concentration on iontophoretic delivery of octreotide acetate (sandostatin) in the rabbit. Pharm. Res. (1994) 11(12):1742–1746.
  • HEIT MC, MONTEIRO-RIVIERE NA, JAYES FL et al.: Transdermal iontophoretic delivery of luteinzing hormone releasing hormone (LHRH): effect of repeated administration. Pharm. Res. (1994) 11 (7): 1000–1003.
  • MILLER LL, KOLASKIE CJ, SMITH GA et al.: Transdermal iontophoresis of gonadotropin releasing hormone (LHRH) and two analogues./ Pharm. Sci. (1990) 79(6):490–493.
  • KNOBLAUCH P, MOLL F: In vitro pulsatile and continuous transdermal
  • RODRIGUEZ BAYON AM, GUY RH: Iontophoresis of nafarelin across human skin in vitro. Pharm. Res. (1996) 13(5):798–800.
  • MEYER BR, KREIS W, ESCHBACHE J et al.: Successfitl transdermal administration of therapeutic doses of a polypeptide to normal human volunteers. Clin. Pharmaco
  • CRAAN-VAN HINSBERG WH BAX L, FLINTERMAN NH et al: Iontophoresis of a model peptide across human skin in vitro: effects of iontophoresis protocol, pH, and 11(9):1296–1300.
  • THYSMAN S, HANCHARD C, PRÉAT V: Human calcitonin delivery in rats by iontophoresis. j Pharm. PharmacoL (1994) 46: 725–730.
  • MEDI BM, SINGH J: Electronically facilitated transdermal delivery of human parathyroid hormone (1-34). Int. J. Pharm. (2003) 263:25–33.
  • SAGE BH: Insulin iontophoresis. In: Protein Delivery - Physical Systems. LM S RW Hendren (Eds), Plenum Publishing Corporation, New York, USA (1997):319–341.
  • GUY RH, KALIA YN, DELGADO-CHARRO MB et al: Iontophoresis: electrorepulsion and electroosmosis. J. Control. Release (2000) 64(1-3):129–132.
  • HIRVONEN J, GUY RH: Iontophoretic delivery across the skin: electroosmosis and its modulation by drug substances. Pharm. Res. (1997) 14(9):1258–1263.
  • DELGADO-CHARRO MB, GUY RH: Characterisation of convective solvent flow during iontophoresis. Pharm. Res. (1994) 11(7):929–935.
  • DELGADO-CHARRO MB, GUY RH: Iontophoretic delivery of nafarelin across the skin. Int. J. Pharm. (1995) 117:165–172.
  • HIRVONEN J, KALIA YN, GUY RH: Transdermal delivery of peptides by iontophoresis. Nat. Biotechnol. (1996) 14(13):1710–1713.
  • HIRVONEN J, GUY RH: Transdermal by polypeptides. J. Control. Release (1998) 50:283–289.
  • ROBERTS MS, KREIS W, ESCHBACHE J et al.: Transdermal versus subcutaneous leuprolide: A comparison of acute pharmacodynamic effect. Clin. Pharmacol. Ther. (1990) 48(4):340–345.
  • HOOGSTRAATE AJ, SRINIVASAN V, SIMS SM et al.: Iontophoretic enhancement of peptides: behaviour of leuprolide versus model permeants. J. Control. Release (1994) 31:41–47.
  • KUMAR S, CHAR H, PATEL S et al: In vivo transdermal iontophoretic delivery of growth hormone releasing factor GRF (1-44) in hairless guinea pigs. J. Control. Release (1992) 18:213–220.
  • LANGKJAER L, BRANGE J, GRODSKY GM et al.: Iontophoresis of monomeric insulin analogues in vitro: effects of insulin charge and skin pretreatment. J. Control. Release (1998) 51:47–56.
  • KALIA YN, NAIK A, GARRISON J et al.: Iontophoretic drug delivery. Adv. Drug Deliv. Rev. (2004) 56(5):619–658.
  • • A comprehensive review of iontophoretic mechanisms and therapeutic applications. Part of a special issue of Advanced Drug Delivery Reviews (2004) 56(5) devoted to transdermal drug delivery technologies (e.g. [53,81]).
  • DENET A-R, VANBEVER R, PRÉAT V: Skin electroporation for transdermal and topical delivery. Adv. Drug Deliv. Rev. (2004) 56:659–674.
  • SEN A, DALY ME, HUI SW: Transdermal insulin delivery using lipid enhanced electroporation. Biochim. Biophys. Acta (2002) 1564:5–8.
  • PRAUSNITZ MR, EDELMAN ER, ELAZER R et al.: Transdermal delivery of heparin by skin electroporation. Biotechnology (1995) 13(11):1205–1209.
  • SERSA G, CEMAZAR M, RUDOLF Z: Electrochemotherapy: advantages and drawbacks in treatment of cancer patients. Cancer Ther. (2003) 1:133–142.
  • KOST J: Phonophoresis. In: Electronically Controlled Drug Delivery. B B SM Dinh (Eds), CRC Press, Boca Raton, Florida, USA (1998):215–228.
  • TEZEL A, SENS A, TUSCHERER J et al.: Frequency dependence of sonophoresis. Pharm. Res. (2001) 18:1694–1700.
  • CHIEN YW, SIDDIQUI 0, SHI W-M et al.: Direct current iontophoretic transdermal delivery of peptide and protein drugs. J. Pharm. Sci. (1989) 78(5):376–383.
  • ALVAREZ-ROMAN R, MERINO G, KALIA YN et al.: Skin permeability enhancement by low frequency sonophoresis: lipid extraction and transport pathways. J. Pharm. Sci. (2003) 92(6):1138–1146.
  • MERINO G, KALIA YN, GUY RH: Ultrasound-enhanced transdermal transport. J. Pharm. Sci. (2003) 92(6):1125–1137.
  • BOMMANNAN D, MENON GK, OKUYAMA H et al: Sonophoresis: II. Examination of the mechanism(s) of ultrasound-enhanced transdermal drug delivery. Pharm. Res. (1992) 9:1043–1047.
  • MITRAGOTRI S, EDWARDS D, BLANKSCHTEIN D et al.: A mechanistic study of ultrasonically enhanced transdermal drug delivery. J. Pharm. Sci. (1995) 84(6):697–706.
  • TEZEL A, SENS A, MITRAGOTRI S: Investigations of the role of cavitation in low-frequency sonophoresis using acoustic spectroscopy. J. Pharm. Sci. (2002) 91:444–453.
  • TEZEL A, MITRAGOTRI S: Interactionsof inertial cavitation colapses with stratum corneum lipid bilayers. Biophys. J. (2003) 85:1–11.
  • MITRAGOTRI S, BLANKSCHTEIN D, LANGER R: Ultrasound-mediated transdermal protein delivery. Science (1995) 269:850–853.
  • KRALL LP: World Book of Diabetes in Practice. Elsevier, New York, USA (1988).
  • BOUCAUD A, GARRIGUE MA, MACHET Let al.: Effect of sonication parameters on transdermal delivery of insulin to hairless rats. J. Control. Release (2002) 81:113–119.
  • KATZ NP, SHAPIRO DE, HERRMANN TE et al.: Rapid onset of cutaneous anesthesia with EMLA cream after pretreatment with a new ultrasound-emitting device. Anesth. Analg. (2004) 98:371–376.
  • SINGER AJ, HOMAN CS, CHURCH AL et al.: Low-frequency sonophoresis: pathologic and thermal effects in dogs. Acad. Emerg. Med. (1998) 5(1):35–40.
  • DOWN JA, HARVEY NG: Minimally invasive systems for transdermal drug delivery. In: Transdermal Drug Delivery. RH G J Hadgraft (Eds), Marcel Dekker, New York, USA (2003):327–359.
  • ••A thorough review of minimally invasive technologies covering the devices, potential applications and limitations.
  • MCALLISTER DV WANG PM, DAVIS SP et al.: Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies. Proc. NatL Acad. Sci. USA (2003) 100(24):13755–13760.
  • MARTANTO W, DAVIS SP, HOLIDAY NR et al.: Transdermal delivery of insulin using microneedles in vivo. Pharm. Res. (2004) 21(61:947–952.
  • CORMIER M, JOHNSON B, AMERI M et al.: Transdermal delivery of desmopressin using a coated microneedle array patch system. J. Control. Release (2004) 97:503–511.
  • CORMIER M, DADDONA P: Macroflux® technology for transdermal delivery of therapeutic proteins and vaccines. In: Modified Release Drug Delivery Systems. MJ R J H MS Roberts MS (Eds), Marcel Dekker, New York, USA (2002):589–598.
  • FJELLESTAD-PAULSEN A, HOGLUND P, LUNDIN S et al.: Pharmacokinetics of 1-deamino-8-D-arginine vasopressin after various routes of administration in healthy volunteers. Clin. EndocrinoL (1993) 38(2):177–182.
  • MATRIANO JA, CORMIER M, JOHNSON J et al.: Macroflux microprojection array patch technology: a new and efficient approach for intracutaneous immunization. Pharm. Res. (2002) 19(1):63–70.
  • HENRYS, MCALLISTER DV, ALLEN MG et al.: Microfabricated microneedles: a novel approach to transdermal drug delivery. J. Pharm. Sci. (1998) 87(8):922–925.
  • KAUSHIK S, HORD AH, DENSON DD et al.: Lack of pain associated with microfabricated microneedles. Anesth. Analg (2001) 92:502–504.
  • PRAUSNITZ MR: Microneedles for transdermal drug delivery. Adv. Drug Deliv. Rev. (2004) 56:581–587.
  • SCHRAMM J, MITRAGOTRI S: Transdermal drug delivery by jet injectors: energetics of jet formation and penetration. Pharm. Res. (2002) 19(11):1673–1679.
  • WENIGER BG: Needle-free jet injectionbibliography, device & manufacturer roster and patent list. (2004).
  • KING T: Protein delivery via pre-filled needle-free liquid injection. Drug Delivery Technology (2003) 3(7):52–57.
  • •A concise summary of the state-of-the-art in the technology.
  • BURKOTH TL, BELLHOUSE BJ, HEWSON G et al.: Transdermal and transmucosal powdered drug delivery. Crit. Rev. Therap. Drug Carrier Syst. (1999) 16(4):331–384.
  • DEAN HJ, FULLER D, OSORIO JE: Powder and particle-mediated approaches for delivery of DNA and protein vaccines into the epidermis. Comp. ImmunoL MicrobioL Infect. Dis. (2003) 26:373–388.
  • SCHNEIDER U, BIRNBACHER R, SCHOBER E: Painfulness of needle and jet injection in children with diabetes mellitus. Eur. J. Pediatr. (1994) 153(6):409–410.
  • DORR HG, ZABRANSKY S, KELLER E et al.: Are needle-free injections a useful alternative for growth hormone therapy in children? Safety and pharmacokinetics of growth hormone delivered by a new needle-free injection device compared to a fine gauge needle. J. Pediatr. EndocrinoL Metab. (2003) 16(3):383–392.
  • AGERSO H, MOLLER-PEDERSEN J, CAPPI S et al.: Pharmacokinetics and pharmacodynamics of a new formulation of recombinant human growth hormone administered by ZomaJet 2 Vision, a new needle-free device, compared to subcutaneous administration using a conventional syringe. J. Clin. Pharma. (2002) 42:1262–1268.
  • VERRIPS GH, HIRASING RA, FEKKES M et al.: Psychological responses to the needle-free Medi-Jector or the multidose Disetronic injection pen in human growth hormone therapy. Acta Paediatrica (1998) 87(2):154–158.
  • BENNETT J, NICHOLS F, ROSENBLUM M et al.: Subcutaneous administration of midazolam: a comparison of the Bioject jet injector with the conventional syringe and needle. J. Oral Maxillofac. Surg (1998) 56(11):1249–1254.
  • MURRAY FT: HIV patient acceptance of a needle-free device (SeroJetTm) for administering recombinant human growth hormone in the treatment of HIV infection-associated cachexia. Today's Therapeutic Trends (2001) 19(4):283–295.
  • MURRAY FT, WRIGHT GJ, LANDY H et al.: Comparative bioequivalence and patient acceptance of recombinant human growth hormone administered by a needle- free jet injector device or standard syringe injection. Today's Therapeutic Trends (2001) 19:137–155.
  • SVEDMAN P, LUNDI S, SVEDMAN C: Administration of antidiuretic peptide (DDAVP) by way of suction de-epithelialised skin. Lancet (1991) 337: 1506–1509.
  • LUNDIN S, SVEDMAN P, HOGLUND P et al.: Absorption of an oxytocin antagonist (Antocin) and a vasopressin analogue (dDAVP) through a standardized skin erosion in volunteers. Pharm. Res. (1995) 12(12):2024–2029.
  • WESTERLING D, HOGLUND P, LUNDIN S et al.: Transdermal administration of morphine to healthy subjects. Br. J. Clin. PharmacoL (1994) 37(6):571–576.
  • SVEDMAN P, LUNDI S, HOGLUND P et al.: Passive drug diffusion via standardized skin mini-erosion; methodological aspects and clinical findings with new device. Pharm. Res. (1996) 13(9):1354–1359.
  • MANALOTO RMP, ALSTER T: Erbium:YAG laser resurfacing for refractory melasma. DermatoL Surg (1999) 25(2):121–123.
  • LEE W-R, SHEN S-C, WANG K-H et al:The effect of laser treatment on skin to enhance and control transdermal deliver of 5-fluorouracil. j Pharm. Sci. (2002) 91(7):1613–1626.
  • NELSON JS, MCCULLOUGH JL, GLENN TC et al.: Mid-infrared laser ablation of stratum corneum enhances in vitro percutaneous transport of drugs. J. Invest. DermatoL (1991) 97(5):874–879.
  • SINTOV AC, KRYMBERK I, DANIEL D et al.: Radiofrequency-driven skin microchanneling as a new way for electrically assisted transdermal delivery of hydrophilic drugs./ Control. Release (2003) 89:311–320.
  • LEVIN G, GERSHONOWITZ A, SHERMAN A et al.: ViadermTm - novel microelectronic device enhances skin permeability of human growth hormone. (2003).
  • MITRAGOTRI S: Synergistic effect of enhancers for transdermal drug delivery. Pharm. Res. (2000) 17(11):1354–1359.
  • CHOI EH, LEE SH, AHN SK et al.: The pretreatment effect of chemical skin penetration enhancers in transdermal drug delivery using iontophoresis. Skin PharmacoL AppL Skin PhysioL (1999) 12:326–335.
  • PILLAI O, NAIR V, PANCHAGNULA R: Transdermal iontophoresis of insulin: IV. Influence of chemical enhancers. Int. J. Pharm. (2004) 269(1):109–120.
  • BOMMANNAN DB: Effect of electroporation on transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH) in vitro. Pharm. Res. (1994) 11(12):1809–1814.
  • SUGIBAYASHI K, KAGINO M, NUMAJIRI S et al.: Synergistic effects of iontophoresis and jet injector pretreatment on the in-vitro skin permeation of diclofenac and angiotensin. J. Pharm. Pharmacol. (2000) 52:1179–1186.
  • MEEHAN E, GROSS Y, DAVIDSON D et al.: A microinfusor device for the delivery of therapeutic levels of peptides and macromolecules. J. Control. Release (1996) 46:107–116.
  • DOUKAS AG, FLOTTE TJ: Physical characteristics and biological effects of laser-induced stress waves. Ultrasound Med. Biol. (1996) 22:151–164.
  • DOUKAS AG, MCAULIFFE DJ, LEE S et al.: Physical factors involved in stress-wave-induced cell injury: The effect of stress gradient. Ultrasound Med. Biol. (1995) 21:961–967.
  • LEES, KOLLIAS N, MCAULIFFE DJ et al.: Topical drug delivery in humans with a single photomechanical wave. Pharm. Res. (1999) 16(11):1717–1721.
  • LEE S, MCAULIFFE DJ, FLOTTE TJ et al.: Photomechanical transcutaneous delivery of macromolecules. J. Invest. DermatoL (1998) 111:925–929.
  • LEE S, MCAULIFFE DJ, FLOTTE TJ et al.: Photomechanical transdermal delivery: the effect of laser confinement. Lasers Surg Med. (2001) 28(4):344–347.
  • LEE S, MCAULIFFE DJ, KOLLIAS N et al.: Photomechanical delivery of 100-nm microspheres through the stratum corneum: implications for transdermal drug delivery. Lasers Surg Med. (2002) 31(3):207–210.
  • LEE S, MCAULIFFE DJ, MULHOLLAND SE et al.: Photomechanical transdermal delivery of insulin in vivo. Lasers Surg. Med. (2001) 28(3):282–285.
  • SHOMAKER TS, ZHANG J, LOVE G et al.: Evaluating skin anesthesia after administration of local anesthetic system consisting of an S-Caine patch and a controlled heat-aided drug delivery (CHADD) patch in volunteers. Clin. Pain (2000) 16(3):200–204.
  • HERNDON TO, GONZALEZ S, GOWRISHANKAR TR et al.: Transdermal microconduits by microscission for drug delivery and sample acquisition. BMC Medicine (2004) 2(1):12.
  • OBERYÉ J, MANNAERTS B, HUISMAN J et al.: Local tolerance, pharmacokinetics, and dynamics of ganirelix (orgalutran) administration by Medi-Jector compared to conventional needle injections. Hum. Reprod. (2000) 15(2):245–249.
  • Cool.click: a needle-free device for growth hormone delivery. Med. Lett. Drugs Therap. (2001) 43:2–3.
  • HOUDIJK E, HERDES E, DELEMARRE-VAN WAAL H: Pharmacokinetics and pharmacodynamics of recombinant human growth hormone by subcutaneous jet- or needle-injection in patients with growth hormone deficiency. Acta Paediatrica (1997) 86:1301–1307.

Website

  • http://www.cdc.govinip/dev/Jetinject-Bib.pdf Needle-free injection technology: bibliographic references, device & manufacturer roster and patents list.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.