Bibliography
- Thomas T, Thomas TJ. Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Cell Mol Life Sci 2001;58:244-58
- Casero RA Jr, Woster PM. Recent advances in the development of polyamine analogues as antitumor agents. J Med Chem 2009;52:4551-73
- Prakash NJ, Schechter PJ, Grove J, Effect of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on L1210 leukemia in mice. Cancer Res 1978;38:3059-62
- Mitchell JL, Thane TK, Sequeira JM, Unusual aspects of the polyamine transport system affect the design of strategies for use of polyamine analogues in chemotherapy. Biochem Soc Trans 2007;35:318-21
- Palmer AJ, Wallace HM. The polyamine transport system as a target for anticancer drug development. Amino Acids 2010;38:415-22
- Satriano J, Isome M, Casero RA Jr, Polyamine transport system mediates agmatine transport in mammalian cells. Am J Physiol Cell Physiol 2001;281:329-34
- Weeks RS, Vanderwerf SM, Carlson CL, Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO. Exp Cell Res 2000;261:293-302
- Burns MR, Graminski GF, Weeks RS, Lipophilic lysine-spermine conjugates are potent polyamine transport inhibitors for use in combination with a polyamine biosynthesis inhibitor. J Med Chem 2009;52:1983-93
- Gardner RA, Delcros JG, Konate F, N1-substituent effects in the selective delivery of polyamine conjugates into cells containing active polyamine transporters. J Med Chem 2004;47:6055-69
- Phanstiel O, Kaur N, Delcros JG. Structure–activity investigations of polyamine anthracene conjugates and their uptake via the polyamine transporter. Amino Acids 2007;33:305-13
- Wang C, Delcros JG, Cannon L, Defining the molecular requirements for the selective delivery of polyamine conjugates into cells containing active polyamine transporters. J Med Chem 2003;46:5129-38
- Wang C, Delcros JG, Biggerstaff J, Molecular requirements for targeting the polyamine transport system. Synthesis and biological evaluation of polyamine-anthracene conjugates. J Med Chem 2003;46:2672-82
- Wang C, Delcros JG, Biggerstaff J, Synthesis and biological evaluation of N1-(anthracen-9-ylmethyl)triamines as molecular recognition elements for the polyamine transporter. J Med Chem 2003;46:2663-71
- Seiler N. Pharmacological aspects of cytotoxic polyamine analogs and derivatives for cancer therapy. Pharmacol Ther 2005;107:99-119
- Cullis PM, Green RE, Merson-Davies L, Probing the mechanism of transport and compartmentalisation of polyamines in mammalian cells. Chem Biol 1999;6:717-29
- Dot J, Lluch M, Blanco I, Polyamine uptake in cultured astrocytes: characterization and modulation by protein kinases. J Neurochem 2000;75:1917-26
- Raksajit W, Yodsang P, Maenpaa P, Characterization of spermidine transport system in a cyanobacterium,synechocystis sp. PCC 6803. J Microbiol Biotechnol 2009;19:447-54
- Kruczynski A, Vandenberghe I, Pillon A, Preclinical activity of F14512, designed to target tumors expressing an active polyamine transport system. Invest News Drugs 2009; doi 10.1007/s10637-009-9328-3
- Kuramoto N, Inoue K, Takano K, A possible novel mechanism underlying temperature-dependent uptake of [3H]spermidine in nuclear fractions of murine brain. Brain Res 2003;981:78-84
- Porter CW, Miller J, Bergeron RJ. Aliphatic chain length specificity of the polyamine transport system in ascites L1210 leukemia cells. Cancer Res 1984;44:126-8
- Seiler N, Delcros JG, Moulinoux JP. Polyamine transport in mammalian cells. An update. Int J Biochem Cell Biol 1996;28:843-61
- Seiler N, Dezeure F. Polyamine transport in mammalian cells. Int J Biochem 1990;22:211-18
- Belting M, Persson S, Fransson LA. Proteoglycan involvement in polyamine uptake. Biochem J 1999;338:317-23
- Welch JE, Bengtson P, Svensson K, Single chain fragment anti-heparan sulfate antibody targets the polyamine transport system and attenuates polyamine-dependent cell proliferation. Int J Oncol 2008;32:749-56
- Soulet D, Gagnon B, Rivest S, A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two step mechanism. J Biol Chem 2004;279:49355-66
- Xie S, Cheng P, Liu G, Synthesis and bioevaluation of N-(arylalkyl)-Homospermidine conjugates. Bioorg Med Chem Lett 2007;17:4471-5
- Xie SQ, Wang JH, Ma HX, Polyamine transporter recognization and antitumor effects of anthracenymethyl homospermidine. Toxicology 2009;263:127-33
- Fischer FG, Bohn H. Die Giftsekrete der Vogelspinnen; (Poisonous secretions of bird spiders). Ann Chem 1957;603:235-50
- Usherwood PNR. Interaction of spider toxins with arthropod and mammalian glutamate receptors. In: Jenner P, editor. Neurotoxins and their pharmacological implications. Raven Press, New York; 1987. p. 133-51
- Williams DE, Lassota P, Andersen RJ. Motuporamines A to C, cytotoxic alkaloids isolated from the marine sponge Xestospongia exigua (Kirkpatrick). J Org Chem 1998;63:4838-41
- Roskelley C, Williams DE, McHardy L, Inhibition of tumor cell invasion and angiogenesis by motuporamines. Cancer Res 2001;61:6788-94
- Moore KS, Wehrli S, Roder H, Squalamine, an aminosterol antibiotic from the shark. Proc Natl Acad Sci 1993;90:1354-8
- Sills AK Jr, Williams JI, Tyler BM, Squalamine inhibits angiogenesis and solid tumor growth in vivo and perturbs embryonic vasculature. Cancer Res 1998;58:2784-92
- Singh R, Sharma M, Joshi P, Rawat DS. Anticancer agents. Med Chem 2008;8:603-17
- Pastre D, Pietrement O, Landousy F, A new approach to DNA bending by polyamines and its implication in DNA condensation. Eur Biophys J 2006;35:214-23
- Holley JL, Mather A, Wheelhouse RT, Targeting of tumor cells and DNA by a chlorambucil-spermidine conjugate. Cancer Res 1992;52:4190-5
- Holley JL, Mather A, Cullis PM, Uptake and cytotoxicity of novel nitroimidazole polyamine conjugates in Ehrlich ascites tumour cells. Biochem Pharmacol 1992;43:763-9
- Eiseman JL, Rogers FA, Guo Y, Tumor-targeted apoptosis by a novel spermine analogue, 1,12-diaziridinyl-4,9-diazadodecane, results in therapeutic efficacy and enhanced radiosensitivity of human prostate cancer. Cancer Res 1998;58:4864-70
- Delcros J, Tomasi S, Carrington S, Effect of spermine conjugation on the cytotoxicity and cellular transport of acridine. J Med Chem 2002;45:5098-111
- Suzuki I, Shigenaga A, Nemoto H, Synthesis and DNA damaging ability of enediynepolyamine conjugates. Tetrahedron Lett 2004;14:1955-9
- Cunha AS, Lima ELS, Pinto AC, Synthesis of novel naphtoquinone-spermidine conjugates and their effects on DNA-topoisomerases I and II-a. J Braz Chem Soc 2006;17:439-42
- Dallavalle S, Giannini G, Alloatti D, Synthesis and cytotoxic activity of polyamine analogues of camptothecin. J Med Chem 2006;49:5177-86
- Pang JY, Long YH, Chen WH, Amplification of DNA-binding affinities of protoberberine alkaloids by appended polyamines. Bioorg Med Chem Lett 2007;17:1018-21
- Guminski Y, Grousseaud M, Cugnasse S, Synthesis of conjugated spermine derivatives with 7-nitrobenzoxadiazole (NBD), rhodamine and bodipy as new fluorescent probes for the polyamine transport system. Bioorg Med Chem Lett 2009;19:2474-7
- Annereau JP, Brel V, Dumontet C, A fluorescent biomarker of the polyamine transport system to select patients with AML for F14512 treatment. Leuk Res 2010; doi:10.1016/j.leukres
- Tian ZY, Xie SQ, Du YW, Synthesis, cytotoxicity and apoptosis of naphthalimide polyamine conjugates as antitumor agents. Eur J Med Chem 2009;44:393-9
- Franceschin M, Maria LC, Pascucci E, The number and distances of positive charges of polyamine side chains in a series of perylene diimides significantly influence their ability to induce G-quadruplex structures and inhibit human telomerase. Bioorg Med Chem 2008;16:2292-304
- Battaglia A, Guerrini A, Baldelli E, Synthesis of 7- and 10-spermine conjugates of paclitaxel and 10-deacetyl-paclitaxel as potential prodrugs. Tetrahedron Lett 2006;47:2667-70
- Barret J, Kruczynski A, Vispe S, F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system. Cancer Res 2008;68:9845-53
- Kaur N, Delcros JG, Imran J, A comparison of chloroambucil- and xylene-containing polyamines leads to improved ligands for accessing the polyamine transport system. J Med Chem 2008;51:1393-401
- Wang J, Xie S, Li Y, Synthesis and evaluation of unsymmetrical polyamine derivatives as antitumor agents. Bioorg Med Chem 2008;16:7005-12
- Delcros JG, Tomasi S, Duhieu S, Effect of polyamine homologation on the transport and biological properties of heterocyclic amidines. J Med Chem 2006;49:232-45
- Crighton D, Ryan KM. Splicing DNA-damage responses to tumour cell death. Biochimica et Biophysica Acta 2004;1705:3-15
- Roos WP, Kaina B. DNA damage-induced cell death by apoptosis. Trends Mol Med 2006;12:440-50
- Tian ZY, Ma HX, Xie SQ, Synthesis, DNA binding and topoisomerase inhibition of mononaphthalimide homospermidine derivatives. Chin Chem Lett 2008;19:509-12
- Nasizadeh S, Myhre L, Thiman L, Importance of polyamines in cell cycle kinetics as studied in a transgenic system. Exp Cell Res 2005;308:254-64
- Fredlund JO, Johansson MC, Dahlberg E, Ornithine decarboxylase and S-adenosylmethionine decarboxylase expression during the cell cycle of Chinese hamster ovary cells. Exp Cell Res 1995;216:86-92
- Thomas TJ, Shah N, Thomas T. Polyamine biosynthetic pathway as a cell cycle target for breast cancer therapy. Molecular targets and cancer therapeutics: discovery, development and clinical validation. Proceedings of AACR-NCI-EORTC International Conference; Washington, DC; 1999. p. 28-9
- Alm K, Berntsson PS, Kramer DL, Treatment of cells with the polyamine analog N1,N11-diethylnorspermine retards S phase progression within one cell cycle. Eur J Biochem 2000;267:4157-64
- Xie SQ, Liu GC, Ma YF, Synergistic antitumor effects of anthracenylmethyl homospermidine and alpha-difluoromethylornithine on promyelocytic leukemia HL60 cells. Toxicol In Vitro 2008;22:352-8
- Xie SQ, Wu YL, Cheng PF, A novel homospermidine conjugate inhibits growth and induces apoptosis in human hepatoma cells. Acta Pharmacol Sin 2007;28:1827-34
- Tian ZY, Xie SQ, Mei ZH, Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway. Org Biomol Chem 2009;7:4651-60
- Bolognesi ML, Calonghi N, Mangano C, Parallel synthesis and cytotoxicity evaluation of a polyamine-quinone conjugates library. J Med Chem 2008;51:5463-7
- Palmer AJ, Ghani RA, Kaur N, A putrescine-anthracene conjugate: a paradigm for selective drug delivery. Biochem J 2009;424:431-8
- Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer 2009;9:153-66
- Chulu JL, Liu HJ. Recent patents on cell cycle regulatory proteins. Recent Pat Biotechnol 2009;3:1-9
- Abukhdeir AM, Park BH. P21 and p27: roles in carcinogenesis and drug resistance. Expert Rev Mol Med 2008;10:e19
- Satyanarayana A, Kaldis P. Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms. Oncogene 2009;28:2925-39
- Dowling RJ, Pollak M, Sonenberg N. Current status and challenges associated with targeting mTOR for cancer therapy. Bio Drugs 2009;23:77-91
- Kroczynska B, Kaur S, Platanias LC. Growth suppressive cytokines and the AKT/mTOR pathway. Cytokine 2009;48:138-43
- Zhao XF, Gartenhaus RB. Phospho-p70S6K and cdc2/cdk1 as therapeutic targets for diffuse large B-cell lymphoma. Expert Opin Ther Targets 2009;13:1085-93
- Ralton LD, Bestwick CS, Milne L, Bisnaphthalimidopropyl spermidine induces apoptosis within colon carcinoma cells. Chem Biol Interact 2009;177:1-6
- Hail H Jr. Mitochondrial reactive oxygen species affect sensitivity to curcumin-induced apoptosis. Free Radic Biol Med 2008;44:1382-93
- Marcocci L, Casadei M, Faso C, Inducible expression of maize polyamine oxidase in the nucleus of MCF-7 human breast cancer cells confers sensitivity to etoposide. Amino Acids 2007;34:403-12
- Richardson A, Kaye SB. Pharmacological inhibition of the Bcl-2 family of apoptosis regulators as cancer therapy. Curr Mol Pharmacol 2008;1:244-54