The importance of interfaces in protein drug delivery – why is protein adsorption of interest in pharmaceutical formulations?

Bibliography

• Rabe M, Verdes D, Seeger S. Understanding protein adsorption phenomena at solid surfaces. Adv Colloid Interface Sci 2011;8:87-106
   Google Scholar
• Haynes CA, Norde W. Globular proteins at solid/liquid interfaces. Colloids Surf B Biointerfaces 1994;2:517-66
   Web of Science ®Google Scholar
• Norde W. Adsorption of proteins from solution at the solid-liquid interface. Adv Colloid Interface Sci 1986;25:267-340
   PubMed Web of Science ®Google Scholar
• Arai T, Norde W. The behaviour of some model proteins at solid-liquid interfaces 1. adsorption from single protein solutions. Colloids Surf 1990;51:1-15
   Google Scholar
• Norde W. Energy and entropy of protein adsorption. J Dispersion Sci Technol 1992;13:363-77
   Web of Science ®Google Scholar
• Norde W. Driving forces for protein adsorption at solid surfaces. In: Malmsten M, editor, Biopolymers at interfaces. Marcel Dekker, New York; 2003. p. 21-43
   Google Scholar
• Norde W, Buijs J, Lyklema J. Adsorption of globular proteins. Fundam Interface Colloid Sci 2005;5:1-59
   Google Scholar
• Norde W, Giacomelli CE. BSA structural changes during homomolecular exchange between the adsorbed and the dissolved states. J Biotechnol 2000;79:259-68
   PubMed Web of Science ®Google Scholar
• Norde W, MacRitchie F, Nowicka G, Protein adsorption at solid-liquid interfaces: reversibility and conformation aspects. J Colloid Interface Sci 1986;112:447-56
   Web of Science ®Google Scholar
• Ramsden JJ. Puzzles and paradoxes in protein adsorption. Chem Soc Rev 1995;24:73-8
   Web of Science ®Google Scholar
• MacRitchie F. Proteins at interfaces. Adv Protein Chem 1978;32:283-326
   PubMedGoogle Scholar
• Hlady V, Buijs J. Protein adsorption on solid surfaces. Brain Res 1996;7:72-7
   Google Scholar
• Gray JJ. The interaction of proteins with solid surfaces. Curr Opin Struct Biol 2004;14:110-15
   PubMed Web of Science ®Google Scholar
• Wahlgren M, Arnebrant T. Protein adsorption to solid surfaces. Trends Biotechnol 1991;9:201-8
   PubMed Web of Science ®Google Scholar
• Sadana A. Protein adsorption and inactivation on surfaces. Influence of heterogeneities. Chem Rev 1992;92:1799-818
   Web of Science ®Google Scholar
• Malmsten M. Formation of adsorbed protein layers. J Colloid Interface Sci 1998;207:186-99
   PubMed Web of Science ®Google Scholar
• Norde W, Lyklema J. Why proteins prefer interfaces. J Biomater Sci Polym Ed 1991;2:183-202
   PubMed Web of Science ®Google Scholar
• Norde W. My voyage of discovery to proteins in flatland. and beyond. Colloids Surf B Biointerfaces 2008;61:1-9
   PubMed Web of Science ®Google Scholar
• Kotsmar C, Pradines V, Alahverdjieva VS, Thermodynamics, adsorption kinetics and rheology of mixed protein-surfactant interfacial layers. Adv Colloid Interface Sci 2009;150:41-54
   PubMed Web of Science ®Google Scholar
• Tzannis ST, Hrushesky WJM, Wood PA, Irreversible inactivation of interleukin 2 in a pump-based delivery environment. Proc Natl Acad Sci U S A 1996;93:5460-5
   PubMed Web of Science ®Google Scholar
• Zoungrana T, Findenegg GH, Norde W. Structure, stability, and activity of adsorbed enzymes. J Colloid Interface Sci 1997;190:437-48
   PubMed Web of Science ®Google Scholar
• Koutsopoulos S, Patzsch K, Bosker WT, Adsorption of trypsin on hydrophilic and hydrophobic surfaces. Langmuir 2007;23:2000-6
   PubMed Web of Science ®Google Scholar
• Vertegel AA, Siegel RW, Dordick JS. Silica nanoparticle size influences the structure and enzymatic activity of adsorbed lysozyme. Langmuir 2004;20:6800-7
   PubMed Web of Science ®Google Scholar
• Bellezza F, Cipiciani A, Quotadamo MA, Structure, stability, and activity of myoglobin adsorbed onto phosphate-grafted zirconia nanoparticles. Langmuir 2007;23:13007-12
   PubMed Web of Science ®Google Scholar
• Anand G, Sharma S, Dutta AK, Conformational transitions of adsorbed proteins on surfaces of varying polarity. Langmuir 2010;26:10803-11
   PubMed Web of Science ®Google Scholar
• Roach P, Farrar D, Perry CC. Surface tailoring for controlled protein adsorption: effect of topography at the nanometer scale and chemistry. J Am Chem Soc 2006;128:3939-45
   PubMed Web of Science ®Google Scholar
• Rechendorff K, Hovgaard MB, Foss M, Enhancement of protein adsorption induced by surface roughness. Langmuir 2006;22:10885-8
   PubMed Web of Science ®Google Scholar
• Kato K, Sano S, Ikada Y. Protein adsorption onto ionic surfaces. Colloids Surf B Biointerfaces 1995;4:221-30
   Web of Science ®Google Scholar
• Roach P, Farrar D, Perry CC. Interpretation of protein adsorption: surface-induced conformational changes. J Am Chem Soc 2005;127:8168-73
   PubMed Web of Science ®Google Scholar
• Almeida AJ, Souto E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv Drug Deliv Rev 2007;59:478-90
   PubMed Web of Science ®Google Scholar
• Ludwig DB, Carpenter JF, Hamel JB, Protein adsorption and excipient effects on kinetic stability of silicone oil emulsions. J Pharm Sci 2010;99:1721-33
   PubMed Web of Science ®Google Scholar
• Nayak A, Dutta AK, Belfort G. Surface-enhanced nucleation of insulin amyloid fibrillation. Biochem Biophys Res Commun 2008;369:303-7
   PubMed Web of Science ®Google Scholar
• Kleijn M, Norde W. The adsorption of proteins from aqueous solution on solid surfaces. Hetero Chem Rev 1995;2:157-72
   Google Scholar
• Lu DR, Lee SJ, Park K. Calculation of solvation interaction energies for protein adsorption on polymer surfaces. J Biomater Sci Polym Ed 1991;3:127-47
   PubMed Web of Science ®Google Scholar
• Liu SM, Haynes CA. Energy landscapes for adsorption of a protein-like HP chain as a function of native-state stability. J Colloid Interface Sci 2005;284:7-13
   PubMed Web of Science ®Google Scholar
• Baldursdottir SG, Fullerton MS, Nielsen SH, Adsorption of proteins at the oil/water interface-Observation of protein adsorption by interfacial shear stress measurements. Colloids Surf B Biointerfaces 2010;79:41-6
   PubMed Web of Science ®Google Scholar
• Barnthip N, Parhi P, Golas A, Volumetric interpretation of protein adsorption: kinetics of protein-adsorption competition from binary solution. Biomaterials 2009;30:6495-513
   PubMed Web of Science ®Google Scholar
• Daly SM, Przybycien TM, Tilton RD. Adsorption of Poly(ethylene glycol)-modified lysozyme to silica. Langmuir 2005;21:1328-37
   PubMed Web of Science ®Google Scholar
• Daly SM, Przybycien TM, Tilton RD. Aggregation of lysozyme and of poly(ethylene glycol)-modified lysozyme after adsorption to silica. Colloids Surf B Biointerfaces 2007;57:81-8
   PubMed Web of Science ®Google Scholar
• Day JPR, Pudney PDA, Bain CD. Ellipsometric study of the displacement of milk proteins from the oil-water interface by the non-ionic surfactant C10E8. Phys Chem Chem Phys 2010;12:4590-9
   PubMed Web of Science ®Google Scholar
• Denis FA, Hanarp P, Sutherland DS, Protein adsorption on model surfaces with controlled nanotopography and chemistry. Langmuir 2002;18:819-28
   Web of Science ®Google Scholar
• Dolatshahi-Pirouz A, Rechendorff K, Hovgaard MB, Bovine serum albumin adsorption on nano-rough platinum surfaces studied by QCM-D. Colloids Surf B Biointerfaces 2008;66:53-9
   PubMed Web of Science ®Google Scholar
• Freij-Larsson C, Nylander T, Jannasch P, Adsorption behaviour of amphiphilic polymers at hydrophobic surfaces: effects on protein adsorption. Biomaterials 1996;17:2199-207
   PubMed Web of Science ®Google Scholar
• Green RJ, Davies MC, Roberts CJ, Competitive protein adsorption as observed by surface plasmon resonance. Biomaterials 1999;20:385-91
   PubMed Web of Science ®Google Scholar
• Green RJ, Hopkinson I, Jones RAL. Unfolding and intermolecular association in globular proteins adsorbed at interfaces. Langmuir 1999;15:5102-10
   Web of Science ®Google Scholar
• Guicai L, Xiaoli S, Ping Y, Investigation of fibrinogen adsorption on solid surface by quartz crystal microbalance with dissipation(QCM-D) and ELISA. Solid State Ion 2008;179:932-5
   Web of Science ®Google Scholar
• Hoehne M, Fauna S, Dong A, Adsorption of monoclonal antibodies to glass microparticles. J Pharm Sci 2010;100(1):123-32
   PubMed Web of Science ®Google Scholar
• Jorgensen L, van de Weert M, Bjerregaard S, Probing structural changes of proteins incorporated into water-in-oil emulsions. J Pharm Sci 2004;93:1847-59
   PubMed Web of Science ®Google Scholar
• Jorgensen L, Kim DH, Vermehren C, Micropipette manipulation a technique to evaluate the stability of water-in-oil emulsions containing proteins. J Pharm Sci 2004;93:2995-3003
   Google Scholar
• Jorgensen L, Wood GK, Rosenkrands I, Protein adsorption and displacement at lipid layers determined by total internal reflection fluorescence (TIRF). J Liposome Res 2009;19:99-104
   PubMed Web of Science ®Google Scholar
• Jorgensen L, Martins S, van de Weert M. Analysis of protein physical stability in lipid based delivery systems – the challenges of lipid drug delivery systems. J Biomed Nanotechnol 2009;5:401-8
   PubMed Web of Science ®Google Scholar
• Joshi O, McGuire J. Adsorption behavior of lysozyme and Tween 80 at hydrophilic and hydrophobic silica-water interfaces. Appl Biochem Biotechnol 2009;152:235-48
   PubMed Web of Science ®Google Scholar
• Kamilya T, Pal P, Talapatra GB. Interaction of ovalbumin with phospholipids langmuir-blodgett film. J Phys Chem B 2007;111:1199-205
   PubMed Web of Science ®Google Scholar
• Kapilashrami A, Malmsten M, Eskilsson K, Ellipsometric studies of nonionic block copolymers adsorbed at the solid/water and oil/water interfaces. Colloid Surf A Phys Chem Eng Aspects 2003;225:181-92
   Web of Science ®Google Scholar
• Karlsson M, Ekeroth J, Elwing H, Reduction of irreversible protein adsorption on solid surfaces by protein engineering for increased stability. J Biol Chem 2005;280:25558-64
   PubMed Web of Science ®Google Scholar
• Knudsen JC, Ogendal LH, Skibsted Droplet surface properties and rheology of concentrated oil in water emulsions stabilized by heat-modified b-lactoglobulin B. Langmuir 2008;24:2603-10
   PubMed Web of Science ®Google Scholar
• Kudryashova EV, de Jongh HHJ. Modulation of the adsorption properties at air-water interfaces of complexes of egg white ovalbumin with pectin by the dielectric constant. J Colloid Interface Sci 2008;318:430-9
   PubMed Web of Science ®Google Scholar
• Lad MD, Birembaut F, Matthew JM, The adsorbed conformation of globular proteins at the air/water interface. Phys Chem Chem Phys 2006;8:2179-86
   PubMed Web of Science ®Google Scholar
• Lee MH, Reich DH, Stebe KJ, Combined passive and active microrheology study of protein-layer formation at an air-water interface. Langmuir. 2009;26:2650-8
   Google Scholar
• Leick S, Degen P, Kohler B, Film formation and surface gelation of gelatin molecules at the water/air interface. Phys Chem Chem Phys 2009;11:2468-74
   PubMed Web of Science ®Google Scholar
• Lu JR, Zhao XB, Yaseen M. Protein adsorption studied by neutron reflection. Curr Opin Colloid Interface Sci 2007;12:9-16
   Web of Science ®Google Scholar
• Lundin M, Elofsson UM, Blomberg E, Adsorption of lysozyme, [beta]-casein and their layer-by-layer formation on hydrophilic surfaces: effect of ionic strength. Colloids Surf B Biointerfaces 2010;77:1-11
   PubMed Web of Science ®Google Scholar
• Makie AR. Structure of adsorbed layers of mixtures of proteins and surfactants. Curr Opin Colloid Interface Sci 2004;9(5):357-61
   Web of Science ®Google Scholar
• Mollmann SH, Elofsson U, Bukrinsky JT, Displacement of adsorbed insulin by Tween 80 monitored using total internal reflection fluorescence and ellipsometry. Pharm Res 2005;22:1931-41
   PubMed Web of Science ®Google Scholar
• Mollmann SH, Jorgensen L, Bukrinsky JT, Interfacial adsorption of insulin - Conformational changes and reversibility of adsorption. Eur J Pharm Sci 2006;27:194-204
   PubMed Web of Science ®Google Scholar
• Nejadnik MR, Garcia CD. Staining proteins: a simple method to increase the sensitivity of ellipsometric measurements in adsorption studies. Colloids Surf B Biointerfaces 2011;82:253-7
   PubMed Web of Science ®Google Scholar
• Noh H, Vogler EA. Volumetric interpretation of protein adsorption: mass and energy balance for albumin adsorption to particulate adsorbents with incrementally increasing hydrophilicity. Biomaterials 2006;27:5801-12
   PubMed Web of Science ®Google Scholar
• Noh H, Vogler EA. Volumetric interpretation of protein adsorption: partition coefficients, interphase volumes, and free energies of adsorption to hydrophobic surfaces. Biomaterials 2006;27:5780-93
   PubMed Web of Science ®Google Scholar
• Otzen D. Differential adsorption of variants of the Thermomyces lanuginosus lipase on a hydrophobic surface suggests a role for local flexibility. Colloids Surf B Biointerfaces 2008;64:223-8
   PubMed Web of Science ®Google Scholar
• Parhi P, Golas A, Barnthip N, Volumetric interpretation of protein adsorption: Capacity scaling with adsorbate molecular weight and adsorbent surface energy. Biomaterials 2009;30:6814-24
   PubMed Web of Science ®Google Scholar
• Pinholt C, Fano M, Wiberg C, Influence of glycosylation on the adsorption of Thermomyces lanuginosus lipase to hydrophobic and hydrophilic surfaces. Eur J Pharm Sci 2010;40:273-81
   PubMed Web of Science ®Google Scholar
• Pinholt C, Bukrinsky JT, Hostrup S, Influence of PEGylation with linear and branched PEG chains on the adsorption of glucagon to hydrophobic surfaces. Eur J Pharm Biopharm 2011;77:139-47
   PubMed Web of Science ®Google Scholar
• Sankaranarayanan K, Dhathathreyan A, Miller R. Assembling fibrinogen at air/water and solid/liquid interfaces using langmuir and langmuir-blodgett films. J Phys Chem B 2010;114:8067-75
   PubMed Web of Science ®Google Scholar
• Sonesson AW, Callisen TH, Brismar H, A comparison between dual polarization interferometry (DPI) and surface plasmon resonance (SPR) for protein adsorption studies. Colloids Surf B Biointerfaces 2007;54:236-40
   PubMed Web of Science ®Google Scholar
• Tantipolphan R, Rades T, McQuillan AJ, Adsorption of bovine serum albumin (BSA) onto lecithin studied by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. Int J Pharm 2007;337:40-7
   PubMed Web of Science ®Google Scholar
• Thomsen AE, Jensen H, Jorgensen L, Studies on human insulin adsorption kinetics at an organic-aqueous interface determined using a label-free electroanalytical approach. Colloids Surf B Biointerfaces 2008;63:243-8
   PubMed Web of Science ®Google Scholar
• Zareh SK, Wang YM. Single-molecule imaging of protein adsorption mechanisms onto surfaces. Microsc Res Tech 17 Nov 2010. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar
• Jorgensen L, Bennedsen P, Hoffmann VN Sr, Adsorption of insulin with varying self-association profiles to a solid Teflon surface–Influence on protein structure, fibrillation tendency and thermal stability. Eur J Pharm Sci 2011;42(5):509-16
   PubMed Web of Science ®Google Scholar
• Bee JS, Davis M, Freund E, Aggregation of a monoclonal antibody induced by adsorption to stainless steel. Biotechnol Bioeng 2010;105:121-9
   PubMed Web of Science ®Google Scholar
• Schwegman JJ, Carpenter JF, Nail SL. Evidence of partial unfolding of proteins at the ice/freeze-concentrate interface by infrared microscopy. J Pharm Sci 2009;98:3239-46
   PubMed Web of Science ®Google Scholar
• Cochran T, Nail SL. Ice nucleation temperature influences recovery of activity of a model protein after freeze drying. J Pharm Sci 2009;98:3495-8
   PubMed Web of Science ®Google Scholar
• Linse S, Cabaleiro-Lago C, Xue W-F, Nucleation of protein fibrillation by nanoparticles. Proc Natl Acad Sci U S A 2007;104:8691-6
   PubMed Web of Science ®Google Scholar
• Clarkson JR, Cui ZF, Darton RC. Protein denaturation in foam - II. Surface activity and conformational change. J Colloid Interface Sci 1999;215:333-8
   PubMed Web of Science ®Google Scholar
• Clarkson JR, Cui ZF, Darton RC. Effect of solution conditions on protein damage in foam. Biochem Eng J 2000;4:107-14
   Web of Science ®Google Scholar
• Nielsen L, Khurana R, Coats A, Effect of environmental factors on the kinetics of insulin fibril formation: elucidation of the molecular mechanism. Biochemistry 2001;40:6036-46
   PubMed Web of Science ®Google Scholar
• Sluzky V, Klibanov AM, Langer R. Mechanism of insulin aggregation and stabilization in agitated aqueous-solutions. Biotechnol Bioeng 1992;40:895-903
   PubMed Web of Science ®Google Scholar
• Kamyshny A, Magdassi S, Relkin P. Chemically modified human immunoglobulin G: hydrophobicity and surface activity at air/solution interface. J Colloid Interface Sci 1999;212:74-80
   PubMed Web of Science ®Google Scholar
• Yano YF, Uruga T, Tanida H, Driving force behind adsorption-induced protein unfolding: a time-resolved x-ray reflectivity study on lysozyme adsorbed at an air/water interface. Langmuir 2008;25:32-5
   Web of Science ®Google Scholar
• Norde W, Favier JP. Structure of adsorbed and desorbed proteins. Colloid Surf 1992;64:87-93
   Web of Science ®Google Scholar
• Pai SS, Przybycien TM, Tilton RD. Protein PEGylation attenuates adsorption and aggregation on a negatively charged and moderately hydrophobic polymer surface. Langmuir 2010;26:18231-8
   PubMed Web of Science ®Google Scholar
• Daly SM, Przybycien TM, Tilton RD. Adsorption of poly(ethylene glycol)-modified ribonuclease A to a poly(lactide-co-glycolide) surface. Biotechnol Bioeng 2005;90:856-68
   PubMed Web of Science ®Google Scholar
• Mollmann SH, Bukrinsky JT, Frokjaer S, Adsorption of human insulin and Asp(B28) insulin on a PTFE-like surface. J Colloid Interface Sci 2005;286:28-35
   PubMed Web of Science ®Google Scholar
• Michaeli I, Absolom DR, Van Oss CJ. Diffusion of adsorbed protein within the plane of adsorption. J Colloid Interface Sci 1980;77:586-7
   Web of Science ®Google Scholar
• Daly SM, Przybycien TM, Tilton RD. Coverage-dependent orientation of lysozyme adsorbed on silica. Langmuir 2003;19:3848-57
   Web of Science ®Google Scholar
• Brosilow BJ, Ziff RM, Vigil RD. Random sequential adsorption of parallel squares. Phys Rev A 1991;43:631-8
   PubMed Web of Science ®Google Scholar
• Feder J. Random sequential adsorption. J Theor Biol 1980;87:237-54
   Web of Science ®Google Scholar
• Hinrichsen EL, Feder J, Jossang T. Geometry of random sequential adsorption. J Stat Phys 1986;44:793-827
   Web of Science ®Google Scholar
• Tanemura M. Random complete packing by disks. Ann I Stat Math 1979;31:351-65
   Web of Science ®Google Scholar
• Holmberg M, Hou X. Competitive protein adsorption- multilayer adsorption and surface induced protein aggregation. Langmuir 2009;25:2081-9
   PubMed Web of Science ®Google Scholar
• Tyagi AK, Randolph TW, Dong A, IgG particle formation during filling pump operation: a case study of heterogeneous nucleation on stainless steel nanoparticles. J Pharm Sci 2009;98:94-104
   PubMed Web of Science ®Google Scholar
• Andrade JD. Principles of protein adsorption. InAndrade JD, editor, Surface and interfacial aspects of biomedical polymers. Plenum Press, New York; 1985. p. 1-80
   Google Scholar
• Soderquist ME, Walton AG. Structural-changes in proteins adsorbed on polymer surfaces. J Colloid Interface Sci 1980;75:386-97
   Web of Science ®Google Scholar
• Lundstrom I, Elwing H. Simple kinetic-models for protein exchange-reactions on solid-surfaces. J Colloid Interface Sci 1990;136:68-84
   Web of Science ®Google Scholar
• Kondo A, Oku S, Higashitani K. Structural-changes in protein molecules adsorbed on ultrafine silica particles. J Colloid Interface Sci 1991;143:214-21
   Web of Science ®Google Scholar
• Wu XY, Narsimhan G. Effect of surface concentration on secondary and tertiary conformational changes of lysozyme adsorbed on silica nanoparticles. Biochim Biophys Acta Proteins Proteomics 2008;1784:1694-701
   PubMed Web of Science ®Google Scholar
• Singla B, Krisdhasima V, McGuire J. Adsorption kinetics of wild type and two synthetic stability mutants of T4 phage lysozyme at silanized silica surfaces. J Colloid Interface Sci 1996;182:292-6
   Web of Science ®Google Scholar
• Joshi O, McGuire J, Wang DQ. Adsorption and function of recombinant Factor VIII at solid-water interfaces in the presence of Tween-80. J Pharm Sci 2008;97:4741-55
   PubMed Web of Science ®Google Scholar
• Ueberbacher R, Haimer E, Hahn R, Hydrophobic interaction chromatography of proteins - V. Quantitative assessment of conformational changes. J Chromatogr A 2008;1198:154-63
   PubMed Web of Science ®Google Scholar
• Chi EY, Weickmann J, Carpenter JF, Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation. J Pharm Sci 2005;94:256-74
   PubMed Web of Science ®Google Scholar
• Cabaleiro-Lago C, Quinlan-Pluck F, Lynch I, Inhibition of amyloid b protein fibrillation by polymeric nanoparticles. J Am Chem Soc 2008;130:15437-43
   PubMed Web of Science ®Google Scholar
• Vermonden T, Giacomelli CE, Norde W. Reversibility of structural rearrangements in bovine serum albumin during homomolecular exchange from AgI particles. Langmuir 2001;17:3734-40
   Web of Science ®Google Scholar
• Nonckreman ClJ, Rouxhet PG, Dupont-Gillain CC. Dual radiolabeling to study protein adsorption competition in relation with hemocompatibility. J Biomed Mater Res 2007;81A:791-802
   Web of Science ®Google Scholar
• Gurdak E, Dupont-Gillain CC, Booth J, Resolution of the vertical and horizontal heterogeneity of adsorbed collagen layers by combination of QCM-D and AFM. Langmuir 2005;21:10684-92
   PubMed Web of Science ®Google Scholar
• Ho HO, Hsiao CC, Sheu MT. Preparation of microemulsions using polyglycerol fatty acid esters as surfactant for the delivery of protein drugs. J Pharm Sci 1996;85:138-43
   PubMed Web of Science ®Google Scholar
• Bilati U, Allemann E, Doelker E. Strategic approaches for overcoming peptide and protein instability within biodegradable nano- and microspheres. Eur J Pharm Biopharm 2005;59:375-88
   PubMed Web of Science ®Google Scholar
• Graf A, McDowell A, Rades T. Poly(alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics - is there real potential? Expert Opin Drug Deliv 2009;6:371-87
   PubMed Web of Science ®Google Scholar
• van de Weert M, Hoechstetter J, Hennink WE, The effect of a water/organic solvent interface on the structural stability of lysozyme. J Control Release 2000;68:3-9
   Google Scholar
• Vemuri S, Rhodes CT. Preparation and characterization of liposomes as therapeutic delivery systems: a review. Pharm Acta Helv 1995;70:95-111
   PubMedGoogle Scholar
• van de Weert M, Hennink WE, Jiskoot W. Protein instability in poly(lactic-co-glycolic acid) microparticles. Pharm Res 2000;17:1159-67
   PubMed Web of Science ®Google Scholar
• Watnasirichaikul S, Davies NM, Rades T, Preparation of biodegradable insulin nanocapsules from biocompatible microemulsions. Pharm Res 2000;17:684-9
   PubMed Web of Science ®Google Scholar
• Dickinson E. Proteins at interfaces and in emulsions - stability, rheology and interactions. J Chem Soc Faraday Trans 1998;94:1657-69
   Web of Science ®Google Scholar
• Cleland JL, Jones AJS. Stable formulations of recombinant human growth hormone and interferon-gamma for microencapsulation in biodegradable microspheres. Pharm Res 1996;13:1464-75
   PubMed Web of Science ®Google Scholar
• Kwon YM, Baudys M, Knutson K, In situ study of insulin aggregation induced by water-organic solvent interface. Pharm Res 2001;18:1754-9
   PubMed Web of Science ®Google Scholar
• Sah H. Protein behavior at the water/methylene chloride interface. J Pharm Sci 1999;88:1320-5
   PubMed Web of Science ®Google Scholar
• Morlock M, Koll H, Winter G, Microencapsulation of rh-erythropoietin, using biodegradable poly(,-lactide-co-glycolide): protein stability and the effects of stabilizing excipients. Eur J Pharm Biopharm 1997;43:29-36
   Web of Science ®Google Scholar
• Raghuvanshi RS, Goyal S, Singh O, Stabilization of dichloromethane-induced protein denaturation during microencapsulation. Pharm Dev Technol 1998;3:269-76
   PubMedGoogle Scholar
• Uchida T, Shiosaki K, Nakada Y, Microencapsulation of hepatitis B core antigen for vaccine preparation. Pharm Res 1998;15:1708-13
   PubMed Web of Science ®Google Scholar
• Sah H. Protein instability toward organic solvent/water emulsification: implications for protein microencapsulation into microspheres. PDA J Pharm Sci Technol 1999;53:3-10
   PubMedGoogle Scholar
• Alonso MJ, Gupta RK, Min C, Biodegradable microspheres as controlled-release tetanus toxoid delivery systems. Vaccine 1994;12:299-306
   PubMed Web of Science ®Google Scholar
• Sturesson C, Carlfors J. Incorporation of protein in PLG-microspheres with retention of bioactivity. J Control Release 2000;67:171-8
   PubMed Web of Science ®Google Scholar
• Hickel A, Radke CJ, Blanch HW. Role of organic solvents on Pa-hydroxynitrile lyase interfacial activity and stability. Biotechnol Bioeng 2001;74:18-28
   PubMed Web of Science ®Google Scholar
• Ghatorae AS, Guerra MJ, Bell G, Immiscible organic-solvent inactivation of urease, chymotrypsin, lipase, and ribonuclease - separation of dissolved solvent and interfacial effects. Biotechnol Bioeng 1994;44:1355-61
   PubMed Web of Science ®Google Scholar
• Zambaux MF, Bonneaux F, Gref R, Preparation and characterization of protein C-loaded PLA nanoparticles. J Control Release 1999;60:179-88
   PubMed Web of Science ®Google Scholar
• Sah H. Stabilization of proteins against methylene chloride water interface-induced denaturation and aggregation. J Control Release 1999;58:143-51
   PubMed Web of Science ®Google Scholar
• Ghaderi R, Carlfors J. Biological activity of lysozyme after entrapment in poly (d,l-lactide-co-glycolide)-microspheres. Pharm Res 1997;14:1556-62
   PubMed Web of Science ®Google Scholar
• Jin T, Zhu HH, Wu F, Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents. J Control Release 2008;128:50-9
   PubMed Web of Science ®Google Scholar
• Stenekes RJH, Franssen O, van Bommel EMG, The preparation of dextran microspheres in an all-aqueous system: effect of the formulation parameters on particle characteristics. Pharm Res 1998;15:557-61
   PubMed Web of Science ®Google Scholar
• Beverung CJ, Radke CJ, Blanch HW. Protein adsorption at the oil/water interface: characterization of adsorption kinetics by dynamic interfacial tension measurements. Biophys Chem 1999;81:59-80
   PubMed Web of Science ®Google Scholar
• Hartvig RA, Mendez MA, van de Weert M, Interfacial complexes between a protein and lipophilic ions at an oil-water interface. Anal Chem 2010;82:7699-705
   PubMed Web of Science ®Google Scholar
• Husband FA, Garrood MJ, Mackie AR, Adsorbed protein secondary and tertiary structures by circular dichroism and infrared spectroscopy with refractive index matched emulsions. J Agric Food Chem 2001;49:859-66
   PubMed Web of Science ®Google Scholar
• Reis P, Holmberg K, Watzke H, Lipases at interfaces: a review. Adv Colloid Interface Sci 2009;147-48:237-50
   Web of Science ®Google Scholar
• Kessler M, Goldsmith D, Schellekens H. Immunogenicity of biopharmaceuticals. Nephrol Dial Transpl 2006;21:9-12
   PubMed Web of Science ®Google Scholar
• Rosenberg AS. Effects of protein aggregates: an immunologic perspective. AAPS J 2006;8:E501-7
   PubMed Web of Science ®Google Scholar
• Carpenter JF, Randolph TW, Jiskoot W, Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality. J Pharm Sci 2009;98:1201-5
   PubMed Web of Science ®Google Scholar
• Lacerda SHD, Park JJ, Meuse C, Interaction of gold nanoparticles with common human blood proteins. ACS Nano 2009;4:365-79
   Web of Science ®Google Scholar
• Sarmento B, Ferreira DC, Jorgensen L, Probing insulin's secondary structure after entrapment into alginate/chitosan nanoparticles. Eur J Pharm Biopharm 2007;65:10-17
   PubMed Web of Science ®Google Scholar
• Pai SS, Tilton RD, Przybycien TM. Poly(ethylene glycol)-modified proteins: implications for poly(lactide-co-glycolide)-based microsphere delivery. AAPS J 2009;11:88-98
   PubMed Web of Science ®Google Scholar
• Zhdanov VP, Kasemo B. Protein adsorption and desorption on lipid bilayers. Biophys Chem 2010;146:60-4
   PubMed Web of Science ®Google Scholar
• Zhdanov VP, Kasemo B. Adsorption of proteins on a lipid bilayer. Eur Biophys J 2010;39:1477-82
   PubMed Web of Science ®Google Scholar
• Graf A, Rades T, Hook SM. Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: optimisation and in vivo evaluation. Eur J Pharm Sci 2009;37:53-61
   PubMed Web of Science ®Google Scholar
• Kafka AP, Kleffmann T, Rades T, Histidine residues in the peptide D-Lys(6)-GnRH: potential for copolymerization in polymeric nanoparticles. Mol Pharm 2009;6:1483-91
   PubMedGoogle Scholar
• Iyer S, HogenEsch H, Hem SL. Effect of the degree of phosphate substitution in aluminum hydroxide adjuvant on the adsorption of phosphorylated proteins. Pharm Dev Technol 2003;8:81-6
   PubMed Web of Science ®Google Scholar
• Jones LS, Peek LJ, Power J, Effects of adsorption to aluminum salt adjuvants on the structure and stability of model protein antigens. J Biol Chem 2005;280:13406-14
   PubMed Web of Science ®Google Scholar
• Vessely C, Estey T, Randolph TW, Stability of a trivalent recombinant protein vaccine formulation against botulinum neurotoxin during storage in aqueous solution. J Pharm Sci 2009;98:2970-93
   PubMed Web of Science ®Google Scholar
• Pereira Arias-Bouda LM, Kuijper S, Deutekom HV, Enzyme-linked immunosorbent assays using immune complexes for the diagnosis of tuberculosis. J Immunol Methods 2003;283:115-24
   PubMed Web of Science ®Google Scholar
• Walsh G. Second-generation biopharmaceuticals. Eur J Pharm Biopharm 2004;58:185-96
   PubMed Web of Science ®Google Scholar
• Kato A, Yutani K. Correlation of surface properties with conformational stabilities of wild-type and six mutant tryptophan synthase a subunits substituted at the same position. Protein Eng 1988;2:153-6
   PubMedGoogle Scholar
• Malmsten M, Veide A. Effects of amino acid composition on protein adsorption. J Colloid Interface Sci 1996;178:160-7
   Web of Science ®Google Scholar
• Malmsten M, Burns N, Veide A. Electrostatic and hydrophobic effects of oligopeptide insertions on protein adsorption. J Colloid Interface Sci 1998;204:104-11
   PubMed Web of Science ®Google Scholar
• Knotts TA IV, Rathore N, de Pablo JJ. An entropic perspective of protein stability on surfaces. Biophys J 2008;94:4473-83
   PubMed Web of Science ®Google Scholar
• Nilsson P, Nylander T, Havelund S. Adsorption of insulin on solid surfaces in relation to the surface properties of the monomeric and oligomeric forms. J Colloid Interface Sci 1991;144:145-52
   Web of Science ®Google Scholar
• Leaver J, Brooksbank DV, Horne DS. Influence of glycosylation and surface charge on the binding of [kappa]-casein to latex particles. J Colloid Interface Sci 1994;162:463-9
   Web of Science ®Google Scholar
• Kang JS, DeLuca PP, Lee KC. Emerging PEGylated drugs. Expert Opin Emerg Drugs 2009;14:363-80
   PubMed Web of Science ®Google Scholar
• Pinholt C, Hostrup S, Bukrinsky JT, Influence of acylation on the adsorption of insulin to hydrophobic surfaces. Pharm Res 2011;28(5):1031-40
   PubMed Web of Science ®Google Scholar
• Hawe A, Frieß W. Formulation development for hydrophobic therapeutic proteins. Pharm Dev Technol 2007;12:223-37
   PubMed Web of Science ®Google Scholar
• Jorgensen L, Hostrup S, Moeller EH, Recent trends in stabilising peptides and proteins in pharmaceutical formulation - considerations in the choice of excipients. Expert Opin Drug Deliv 2009;6:1219-30
   PubMed Web of Science ®Google Scholar
• Pradines V, Fainerman VB, Aksenenko EV, Adsorption of protein-surfactant complexes at the water/oil interface. Langmuir 2010;27:965-71
   PubMed Web of Science ®Google Scholar
• Pradines V, Kragel J, Fainerman VB, Interfacial properties of mixed b-Lactoglobulin-SDS layers at the water/air and water/oil interface. J Phys Chem B 2008;113:745-51
   Web of Science ®Google Scholar
• Miller R, Fainerman VB, Makievski AV, Dynamics of protein and mixed protein/surfactant adsorption layers at the water/fluid interface. Adv Colloid Interface Sci 2000;86:39-82
   PubMed Web of Science ®Google Scholar
• Fainerman VB, Lucassen-Reynders E, Miller R. Adsorption of surfactants and proteins at fluid interfaces. Colloid Surface A Phys chem Eng Aspects 1998;143:141-65
   Web of Science ®Google Scholar
• Engel MFM, Visser AJWG, van Mierlo CPM. Refolding of adsorbed bovine alpha-lactalbumin during surfactant induced displacement from a hydrophobic interface. Langmuir 2003;19:2929-37
   Web of Science ®Google Scholar
• Gunning PA, Mackie AR, Gunning AP, The effect of surfactant type on protein displacement from the air-water interface. Food Hydrocoll 2004;18:509-15
   Web of Science ®Google Scholar
• Joshi O, Chu LP, McGuire J, Adsorption and function of recombinant Factor VIII at the air-water interface in the presence of Tween 80. J Pharm Sci 2009;98:3099-107
   PubMed Web of Science ®Google Scholar
• Taluja A, Bae YH. Role of a novel excipient poly(ethylene glycol)-b-poly(L-histidine) in retention of physical stability of insulin at aqueous/organic interface. Mol Pharm 2007;4:561-70
   PubMed Web of Science ®Google Scholar
• Pean JM, Boury F, Venier-Julienne MC, Why does PEG 400 co-encapsulation improve NGF stability and release from PLGA biodegradable microspheres? Pharm Res 1999;16:1294-9
   PubMed Web of Science ®Google Scholar
• Rosa GD, Iommelli R, La Rotonda MI, Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres. J Control Release 2000;69:283-95
   PubMed Web of Science ®Google Scholar
• Hamishehkar H, Emami J, Najafabadi AR, The effect of formulation variables on the characteristics of insulin-loaded poly(lactic-co-glycolic acid) microspheres prepared by a single phase oil in oil solvent evaporation method. Colloids Surf B Biointerfaces 2009;74:340-9
   PubMed Web of Science ®Google Scholar
• Ruiz-Pena M, Oropesa-Nunez R, Pons T, Physico-chemical studies of molecular interactions between non-ionic surfactants and bovine serum albumin. Colloids Surf B Biointerfaces 2010;75:282-9
   PubMed Web of Science ®Google Scholar
• Farrell M, Beaudoin S. Surface forces and protein adsorption on dextran- and polyethylene glycol-modified polydimethylsiloxane. Colloids Surf B Biointerfaces 2010;81:468-75
   PubMed Web of Science ®Google Scholar
• Fristrup CJ, Jankova K, Hvilsted S. Surface-initiated atom transfer radical polymerization-a technique to develop biofunctional coatings. Soft Matter 2009;5:4623-34
   Web of Science ®Google Scholar
• Malmsten M, Van Alstine JM. Adsorption of poly(ethylene glycol) amphiphiles to form coatings which inhibit protein adsorption. J Colloid Interface Sci 1996;177:502-12
   Web of Science ®Google Scholar
• Holmberg M, Hou X. Competitive protein adsorption of albumin and immunoglobulin G from human serum onto polymer surfaces. Langmuir 2009;26:938-42
   Web of Science ®Google Scholar
• Satulovsky J, Carignano MA, Szleifer I. Kinetic and thermodynamic control of protein adsorption. Proc Natl Acad Sci U S A 2000;97:9037-41
   PubMed Web of Science ®Google Scholar
• Schroen CGPH, Roosjen A, Tang K, In situ quantification of membrane foulant accumulation by reflectometry. J Membr Sci 2010;362:453-9
   Web of Science ®Google Scholar
• Ratner BD. Reducing capsular thickness and enhancing angiogenesis around implant drug release systems. J Control Release 2002;78:211-18
   PubMed Web of Science ®Google Scholar
• Walsh G. Biopharmaceutical benchmarks 2010. Nat Biotechnol 2010;28:917-24
   PubMed Web of Science ®Google Scholar
• Ishihara K, Takai M. Bioinspired interface for nanobiodevices based on phospholipid polymer chemistry. J R Soc Interface 2009;6:S279-91
   PubMed Web of Science ®Google Scholar