Cyclodextrin-based siRNA delivery nanocarriers: a state-of-the-art review

Bibliography

• Aagaarda L, Rossi JJ. RNAi therapeutics: principles, prospects and challenges. Adv Drug Deliv Rev 2007;59:75-86
   PubMed Web of Science ®Google Scholar
• Sunshine JC, Bishop CJ, Green JJ. Advances in polymeric and inorganic vectors for nonviral nucleic acid delivery. Ther Deliv 2011;2(4):493-521
   PubMedGoogle Scholar
• Zhang S, Zhao B, Jiang H, Cationic lipids and polymers mediated vectors for delivery of siRNA. J Control Release 2007;123(1):1-10
   PubMed Web of Science ®Google Scholar
• Behlke MA. Progress towards in vivo use of siRNAs. Mol Ther 2006;13(4):644-70
   PubMed Web of Science ®Google Scholar
• Wang J, Lu Z, Wientjes MG, Au JLS. Delivery of siRNA therapeutics: barriers and carriers. AAPS J 2010;12(4):492-503
   PubMed Web of Science ®Google Scholar
• Alekseev OM, Richardson RT, Alekseev O, O'Rand MG. Analysis of gene expression profiles in HeLa cells in response to overexpression or siRNA-mediated depletion of NASP. Reprod Biol Endocrinol 2009;7(45):1-17
   PubMedGoogle Scholar
• Davidson BL, Paulson HL. Molecular medicine for the brain: silencing of disease genes with RNA interference. Lancet Neurol 2004;3(3):145-9
   PubMed Web of Science ®Google Scholar
• Li CX, Parker A, Menocal E, Delivery of RNA interference. Cell Cycle 2006;5(18):2103-9
   PubMed Web of Science ®Google Scholar
• Gary DJ, Puri N, Won Y. Polymer-based siRNA delivery: perspectives on the fundamental and phenomenological distinctions from polymer-based DNA delivery. J Control Release 2007;121(1-2):64-73
   PubMed Web of Science ®Google Scholar
• Dykxhoorn DM, Lieberman J. Knocking down disease with siRNAs. Cell 2006;126:231-5
   PubMed Web of Science ®Google Scholar
• Li W, Szoka FC Jr. Lipid-based nanoparticles for nucleic acid delivery. Pharm Res 2007;24(3):438-49
   PubMed Web of Science ®Google Scholar
• Daniela R, Andreas Z. Drug delivery of siRNA therapeutics: potentials and limits of nanosystems. Nanomed Nanotechnol Biol Med 2009;5(1):8-20
   PubMed Web of Science ®Google Scholar
• Opanasopit P, Nishikawa M, Hashida M. Factors affecting drug and gene delivery: effects of interaction with blood components. Crit Rev Ther Drug Carrier Syst 2002;19(3):191-233
   PubMed Web of Science ®Google Scholar
• Rudzinski WE, Aminabhavi TM. Chitosan as a carrier for targeted delivery of small interfering RNA. Int J Pharm 2010;399:1-11
   PubMed Web of Science ®Google Scholar
• Fischer D, Li Y, Ahlemeyer B, In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials 2003;24(7):1121-31
   PubMed Web of Science ®Google Scholar
• Yuan X, Naguib S, Wu Z. Recent advances of siRNA delivery by nanoparticles. Expert Opin Drug Deliv 2011;8(4):521-36
   PubMed Web of Science ®Google Scholar
• Tokatlian T, Segura T. siRNA applications in nanomedicine. WIREs Nanomed Nanobiotechnol 2010;2:305-15
   PubMed Web of Science ®Google Scholar
• Mishra S, Heidel JD, Webster P, Davis ME. Imidazole groups on a linear, cyclodextrin-containing polycation produce enhanced gene delivery via multiple processes. J Control Release 2006;116:179-91
   PubMed Web of Science ®Google Scholar
• Bartlett DW, Davis ME. Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles. Bioconjug Chem 2007;18(2):456-68
   PubMed Web of Science ®Google Scholar
• Davis ME. The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic. Mol Pharm 2009;6(3):659-68
   PubMed Web of Science ®Google Scholar
• Davis ME, Zuckerman JE, Choi CH, Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 2010;464(7291):1067-70
   PubMed Web of Science ®Google Scholar
• Akhtar S, Benter I. Toxicogenomics of non-viral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity. Adv Drug Deliv Rev 2007;59:164-82
   PubMed Web of Science ®Google Scholar
• Hollins AJ, Omidi Y, Benter IF, Akhtar S. Toxicogenomics of drug delivery systems: exploiting delivery system-induced changes in target gene expression to enhance siRNA potency. J Drug Target 2007;15(1):83-8
   PubMed Web of Science ®Google Scholar
• Foged C, Nielsen HM, Frokjaer S. Liposomes for phospholipase A2 triggered siRNA release: preparation and in vitro test. Int J Pharm 2007;331:160-6
   PubMed Web of Science ®Google Scholar
• Guo P, Coban O, Snead NM, Engineering RNA for targeted siRNA delivery and medical application. Adv Drug Deliv Rev 2010;62(6):650-66
   PubMed Web of Science ®Google Scholar
• Liu H, Guo S, Roll R, Phi29 pRNA vector for efficient escort of hammerhead ribozyme targeting surviving in multiple cancer cells. Cancer Biol Ther 2007;6(5):697-704
   PubMed Web of Science ®Google Scholar
• Kim TH, Kim SI, Akaike T, Cho CS. Synergistic effect of poly(ethylenimine) on the transfection efficiency of galactosylated chitosan/DNA complexes. J Control Release 2005;105:354-66
   PubMed Web of Science ®Google Scholar
• Katas H, Alpar HO. Development and characterisation of chitosan nanoparticles for siRNA delivery. J Control Release 2006;115:216-25
   PubMed Web of Science ®Google Scholar
• Akhtar S, Benter IF. Nonviral delivery of synthetic siRNAs in vivo. J Clin Invest 2007;117(12):3623-32
   PubMed Web of Science ®Google Scholar
• Couzin J. Small RNAs make big splash. Science 2002;298:2296-7
   PubMed Web of Science ®Google Scholar
• Gao K, Huang L. Non-viral methods for siRNA delivery. Mol Pharm 2009;6(3):651-8
   PubMedGoogle Scholar
• Wang X, Yu B, Wu Y, Efficient Down-regulation of CDK4 by novel lipid nanoparticle-mediated siRNA delivery. Anticancer Res 2011;31(5):1619-26
   PubMed Web of Science ®Google Scholar
• Hatakeyama H, Akita H, Ito E, Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid. Biomaterials 2011;32:4306-16
   PubMed Web of Science ®Google Scholar
• Zhou J, Li H, Zaia J, Rossi JJ. Novel dual inhibitory function aptamer-siRNA delivery system for HIV-1 therapy. Mol Ther 2008;16(8):1481-9
   PubMed Web of Science ®Google Scholar
• Chollet P, Favrot MC, Hurbin A, Coll JL. Side effects of a systemic injection of linear polyethylenimine–DNA complexes. J Gene Med 2002;4:84-91
   PubMed Web of Science ®Google Scholar
• Hwang SJ, Bellocq NC, Davis ME. Effects of structure of beta-cyclodextrin-containing polymers on gene delivery. Bioconjug Chem 2001;12(2):280-90
   PubMed Web of Science ®Google Scholar
• Szejtli J, Osa T. editors. Cyclodextrins, Comput Supramol Chem 3. Pergamon; Oxford: 1996
   Google Scholar
• Li J, Loh XJ. Cyclodextrin based supramolecular architecture: synthesis, structures and applications for drug and gene delivery. Adv Drug Deliv Rev 2008;60:1000-17
   PubMed Web of Science ®Google Scholar
• Hu-Lieskovan S, Heidel JD, Bartlett DW, Sequence specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma. Cancer Res 2005;65:8984-92
   PubMed Web of Science ®Google Scholar
• Gonzalez H, Hwang SJ, Davis ME. New class of polymers for the delivery of macromolecular therapeutics. Bioconjug Chem 1999;10(6):1068-74
   PubMed Web of Science ®Google Scholar
• Sandier A, Brown W, Mays H, Interaction between an adamantane end-capped poly(ethylene oxide) and a beta-cyclodextrin polymer. Langmuir 2000;16:1634-42
   Web of Science ®Google Scholar
• Pun SH, Davis ME. Development of a nonviral gene delivery vehicle for systemic application. Bioconjug Chem 2002;13(3):630-9
   PubMed Web of Science ®Google Scholar
• Heidel JD, Yu Z, Liu JY, Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA. Proc Natl Acad Sci USA 2007;104(14):5715-21
   PubMed Web of Science ®Google Scholar
• Bartlett DW, Su H, Hildebrandt IJ, Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging. Proc Natl Acad Sci USA 2007;104(39):15549-54
   PubMed Web of Science ®Google Scholar
• Hermanson GT. Bioconjugate techniques. Academic Press; San Diego: 1996
   Google Scholar
• Boe SL, Longva AS, Hovig E. Cyclodextrin-containing polymer delivery system for light-directed siRNA gene silencing. Oligonucleotides 2010;20(4):175-82
   PubMed Web of Science ®Google Scholar
• Brahmamdam P, Watanabe E, Unsinger J, Targeted delivery of siRNA to cell death proteins in sepsis. Shock 2009;32(2):131-9
   PubMed Web of Science ®Google Scholar
• Arima H, Kihara F, Hirayama F, Uekama K. Enhancement of Gene Expression by polyamidoamine dendrimer conjugates with alpha-, beta-, and gamma-cyclodextrins. Bioconjug Chem 2001;12(4):476-84
   PubMed Web of Science ®Google Scholar
• Tsutsumi T, Hirayama F, Uekama K, Arima H. Evaluation of polyamidoamine dendrimer/alpha-cyclodextrin conjugate (generation 3, G3) as a novel carrier for small interfering RNA (siRNA). J Control Release 2007;119(3):349-59
   PubMed Web of Science ®Google Scholar
• Tsutsumi T, Arima H, Hirayama F, Uekama K. Potential use of dendrimer/alpha-cyclodextrin conjugate as a novel carrier for small interfering RNA (siRNA). J Incl Phenom Macrocycl Chem 2006;56:81-4
   Web of Science ®Google Scholar
• Jeong JH, Mok H, Oh YK, Park TG. siRNA conjugate delivery systems. Bioconjug Chem 2009;20:5-14
   PubMed Web of Science ®Google Scholar
• Moschos SA, Jones SW, Perry MM, Lung delivery studies using siRNA conjugated to TAT(48–60) and penetratin reveal peptide induced reduction in gene expression and induction of innate immunity. Bioconjug Chem 2007;18:1450-9
   PubMed Web of Science ®Google Scholar
• De Paula D, Bentley MV, Mahato RI. Hydrophobization and bioconjugation for enhanced siRNA delivery and targeting. RNA 2007;13:431-56
   PubMed Web of Science ®Google Scholar
• Zhang X, Sharma KK, Boeglin M, Transfection ability and intracellular DNA pathway of nanostructured gene-delivery systems. Nano Lett 2008;8(8):2432-6
   PubMed Web of Science ®Google Scholar
• Jessel N, Oulad-Abdelghani M, Meyer F, Multiple and time-scheduled in situ DNA delivery mediated by beta-cyclodextrin embedded in a polyelectrolyte multilayer. Proc Natl Acad Sci USA 2006;103(23):8618-21
   PubMed Web of Science ®Google Scholar
• Huang H, Tang G, Wang Q, Two novel non-viral gene delivery vectors: low molecular weight polyethylenimine cross-linked by (2-hydroxypropyl)-beta-cyclodextrin or (2-hydroxypropyl)-gamma-cyclodextrin. Chem Commun 2006;14(22):2382-4
   Google Scholar
• Yamashita A, Choi HS, Ooya T, Improved cell viability of linear polyethylenimine through gamma-cyclodextrin inclusion for effective gene delivery. Chembiochem 2006;7(2):297-302
   PubMed Web of Science ®Google Scholar
• Cryan SA, Donohue R, Ravoo B, Cationic cyclodextrin amphiphiles as gene delivery vectors. J Drug Deliv Sci Technol 2004;14(1):57-62
   Web of Science ®Google Scholar
• Menuel S, Fontanay S, Clarot I, Synthesis and Complexation Ability of a novel bis-(guanidinium)-tetrakis-(beta-cyclodextrin) dendrimeric tetrapod as a potential gene delivery (DNA and siRNA) system. Study of cellular siRNA transfection. Bioconjug Chem 2008;19:2357-62
   PubMed Web of Science ®Google Scholar
• Suh J, Hah SS, Lee SH. Dendrimer poly (ethylenimine)s linked to beta-cyclodextrin. Bioorg Chem 1997;25:63-75
   Web of Science ®Google Scholar
• Guo S, Huang F, Guo P. Construction of folate-conjugated pRNA of bacteriophage phi29 DNA packaging motor for delivery of chimeric siRNA to nasopharyngeal carcinoma cells. Gene Ther 2006;13:814-20
   PubMed Web of Science ®Google Scholar
• Zhang K, Wang Q, Xie Y, Receptor-mediated delivery of siRNAs by tethered nucleic acid base-paired interactions. RNA 2008;14:577-83
   PubMed Web of Science ®Google Scholar
• Lorenz C, Hadwiger P, John M, Steroid and lipid conjugates of siRNAs to enhance cellular uptake and gene silencing in liver cells. Bioorg Med Chem Lett 2004;14:4975-7
   PubMed Web of Science ®Google Scholar
• Soutschek J, Akinc A, Bramlage B, Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 2004;432:173-8
   PubMed Web of Science ®Google Scholar
• Zimmermann TS, Lee ACH, Akinc A, RNAi-mediated gene silencing in non-human primates. Nature 2006;441:111-14
   PubMed Web of Science ®Google Scholar
• Liszewski K. Conquering RNAi Delivery Challenges. Genetic engineering and biotechnology News 2008 Jul 1; 28(13):[1 screen]. Available from: URL:http://genengnews.com/gen-articles/conquering-rnaideliverychalleng es/2520/
   Google Scholar
• Pack DW, Hoffman AS, Pun S, Stayton PS. Design and development of polymers for gene delivery. Nat Rev Drug Discov 2005;4:581-93
   PubMed Web of Science ®Google Scholar
• Davis ME, Pun SH, Bellocq NC, Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers. Curr Med Chem 2004;11:179-97
   PubMed Web of Science ®Google Scholar
• Schaffert D, Wagner E. Gene therapy progress and prospects: synthetic polymer-based systems. Gene Ther 2008;15:1131-8
   PubMed Web of Science ®Google Scholar
• Rozema DB, Lewis DL, Wakefield DH, Dynamic polyconjugates for targeted in vivo delivery of siRNA to hepatocytes. Proc Natl Acad Sci USA 2007;104:12982-7
   PubMed Web of Science ®Google Scholar
• Oishi M, Nagasaki Y, Itaka K, Lactosylated poly(ethylene glycol)-siRNA conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive polyion complex micelles achieving enhanced gene silencing in hepatoma cells. J Am Chem Soc 2005;127:1624-5
   PubMed Web of Science ®Google Scholar
• Urban-Klein B, Werth S, Abuharbeid S, RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther 2005;12:461-6
   PubMed Web of Science ®Google Scholar
• Thomas M, Lu JJ, Ge Q, Full deacetylation of polyethylenimine dramatically boosts its gene delivery efficiency and specificity to mouse lung. Proc Natl Acad Sci USA 2005;102:5679-84
   PubMed Web of Science ®Google Scholar
• Xie FY, Woodle MC, Lu PY. Harnessing in vivo siRNA delivery for drug discovery and therapeutic development. Drug Discov Today 2006;11:67-73
   PubMed Web of Science ®Google Scholar
• Richards Grayson AC, Doody AM, Putnam D. Biophysical and structural characterization of polyethylenimine-mediated siRNA delivery in vitro. Pharm Res 2006;23(8):1868-76
   PubMed Web of Science ®Google Scholar
• Merkel OM, Librizzi D, Pfestroff A, Stability of siRNA polyplexes from poly (ethylenimine) and poly (ethylenimine)-g poly (ethylene glycol) under in vivo conditions: effects on pharmacokinetics and biodistribution measured by fluorescence fluctuation spectroscopy and single photon emission computed tomography (SPECT) imaging. J Control Release 2009;138:148-59
   PubMed Web of Science ®Google Scholar
• Woodrow KA, Cu Y, Booth CJ, Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA. Nat Mater 2009;8:526-33
   PubMed Web of Science ®Google Scholar
• Murata N, Takashima Y, Toyoshima K, Anti-tumor effects of anti-VEGF siRNA encapsulated with PLGA microspheres in mice. J Control Release 2008;126:246-54
   PubMed Web of Science ®Google Scholar
• Arima H, Yoshimatsu A, Ikeda H, Folate-PEG-appended-PAMAM dendrimer (G3) conjugate with alpha-cyclodextrin as a tumor selective siRNA carrier. AAPS J 2010;12(S2):M1047
   Google Scholar
• Tsutsumi T, Hirayama F, Uekama K, Arima H. Potential use of polyamidoamine dendrimer/alpha-cyclodextrin conjugate (Generation 3, G3) as a novel carrier for short hairpin RNA-expressing plasmid DNA. J Pharm Sci 2008;97(8):3022-34
   PubMed Web of Science ®Google Scholar