1,190
Views
136
CrossRef citations to date
0
Altmetric
Reviews

Novel polyethylenimine-derived nanoparticles for in vivo gene delivery

, PhD & , PhD
Pages 215-228 | Published online: 19 Dec 2012

Bibliography

  • Marschall P, Malik N, Larin Z. Transfer of YACs up to 2.3 Mb intact into human cells with polyethylenimine. Gene Ther 1999;6:1634-7
  • Campeau P, Chapdelaine P, Seigneurin-Venin S, Transfection of large plasmids in primary human myoblasts. Gene Ther 2001;8:1387-94
  • Boussif O, Lezoualc'h F, Zanta MA, A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci USA 1995;92:7297-301
  • Baker A, Saltik M, Lehrmann H, Polyethylenimine (PEI) is a simple, inexpensive and effective reagent for condensing and linking plasmid DNA to adenovirus for gene delivery. Gene Ther 1997;4:773-82
  • Meunier-Durmort C, Grimal H, Sachs LM, Adenovirus enhancement of polyethylenimine-mediated transfer of regulated genes in differentiated cells. Gene Ther 1997;4:808-14
  • Godbey WT, Wu KK, Mikos AG. Size matters: molecular weight affects the efficiency of poly(ethylenimine) as a gene delivery vehicle. J Biomed Mater Res 1999;45:268-75
  • Morimoto K, Nishikawa M, Kawakami S, Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethyleneimine on hepatoma cells and mouse liver. Mol Ther 2003;7:254-61
  • Wightman L, Kircheis R, Rossler V, Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo. J Gene Med 2001;3:362-72
  • Goula D, Remy JS, Erbacher P, Size, diffusibility and transfection performance of linear PEI/DNA complexes in the mouse central nervous system. Gene Ther 1998;5:712-17
  • Merkel OM, Zheng M, Debus H, Kissel T. Pulmonary gene delivery using polymeric nonviral vectors. Bioconjug Chem 2012;23:3-20
  • Godbey WT, Barry MA, Saggau P, Poly(ethylenimine)-mediated transfection: a new paradigm for gene delivery. J Biomed Mater Res 2000;51:321-8
  • Fischer D, Bieber T, Li Y, A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. Pharm Res 1999;16:1273-9
  • Pathak A, Kumar P, Chuttani K, Gene expression, biodistribution and pharmacoscintigraphic evaluation of chondroitin sulfate-PEI nanoconstructs mediated tumor gene therapy. ACS Nano 2009;3:1493-505
  • Pathak A, Swami A, Patnaik S, Efficient tumor targeting by polysaccharide decked polyethylenimine based Nanocomposites. J Biomed Nanotechnol 2009;5:264-77
  • Goyal R, Tripathi SK, Tyagi S, Gellan gum blended PEI nanocomposites as gene delivery agents: evidences from in vitro and in vivo studies. Eur J Pharm Biopharm 2011;79:3-14
  • Tripathi SK, Goyal R, Gupta KC. Surface modification of crosslinked dextran nanoparticles influences transfection efficiency of dextran–polyethylenimine nanocomposites. Soft Matter 2011;7:11360-71
  • Tripathi SK, Goyal R, Ansari KM, Polyglutamic acid-based nanocomposites as efficient non-viral gene carriers in vitro and in vivo. Eur J Pharm Biopharm 2011;79:473-84
  • Patnaik S, Tripathi SK, Goyal R, Polyethylenimine-polyethyleneglycol-bis(aminoethylphosphate) nanoparticles mediated efficient DNA and siRNA transfection in mammalian cells. Soft Matter 2011;7:6103-12
  • Patnaik S, Goyal R, Tripathi SK, Engineered PEI-piperazinyl nanoparticles as efficient gene delivery vectors: evidence from both in vitro and in vivo studies. RSC Adv 2012;2:4335-42
  • Goyal R, Tripathi SK, Tyagi S, Linear PEI nanoparticles: Efficient pDNA/siRNA carriers in vitro and in vivo. Nanomedicine 2012;8:167-75
  • Goyal R, Bansal R, Tyagi S, 1,4-Butanediol diglycidyl ether (BDE)-crosslinked PEI-g-imidazole nanoparticles as nucleic acid-carriers in vitro and in vivo. Mol Biosyst 2011;7:2055-65
  • Park Y, Kwok KY, Boukarim C, Rice KG. Synthesis of sulfhydryl cross-linking poly(ethyleneglycol)-peptides and glycopeptides as carriers for gene delivery. Bioconjug Chem 2002;13:232-9
  • Tang GP, Guo HY, Alexis F, Low molecular weight polyethylenimines linked by beta-cyclodextrin for gene transfer into the nervous system. J Gene Med 2006;8:736-44
  • Kim YH, Park JH, Lee M, Polyethylenimine with acid-labile linkages as a biodegradable gene carrier. J Control Release 2005;103:209-19
  • Kircheis R, Schüller S, Brunner S, Polycation-based DNA complexes for tumor-targeted gene delivery in vivo. J Gene Med 1999;1:111-20
  • Lu X, Ping Y, Xu FJ, Bifunctional conjugates comprising β-cyclodextrin, polyethylenimine, and 5-fluoro-2′- deoxyuridine for drug delivery and gene transfer. Bioconjug Chem 2010;21:1855-63
  • Tripathi SK, Goyal R, Kashyap MP, Depolymerized chitosans functionalized with bPEI as carriers of nucleic acids and tuftsin-tethered conjugate for macrophage targeting. Biomaterials 2012;33:4204-19
  • Li D, Ping Y, Xu F, Construction of a star-shaped copolymer as a vector for FGF receptor-mediated gene delivery in vitro and in vivo. Biomacromolecules 2010;11:2221-9
  • Huang H, Yu H, Tang G, Low molecular weight polyethylenimine cross-linked by 2-hydroxypropyl-gamma-cyclodextrin coupled to peptide targeting HER2 as a gene delivery vector. Biomaterials 2010;31:1830-8
  • Zeng J, Wang X, Wang S. Self-assembled ternary complexes of plasmid DNA, low molecular weight polyethylenimine and targeting peptide for nonviral gene delivery into neurons. Biomaterials 2007;28:1443-51
  • Zhang L, Gao X, Men K, Gene therapy for C-26 colon cancer using heparin-polyethyleneimine nanoparticle-mediated survivin T34A. Int J Nanomed 2011;6:2419-27
  • Gou M, Men K, Zhang J, Efficient inhibition of C-26 colon carcinoma by VSVMP gene delivered by biodegradable cationic nanogel derived from polyethyleneimine. ACS Nano 2010;4:5573-84
  • Jiang Q, Shi P, Li C, (Coixan polysaccharide)-graft-polyethylenimine folate for tumor-targeted gene delivery. Macromol Biosci 2011;11:435-44
  • Sharma A, Tandon A, Tovey JC, Polyethylenimine-conjugated gold nanoparticles: gene transfer potential and low toxicity in the cornea. Nanomedicine 2011;7:505-13
  • Ma K, Hu M, Xie M, Investigation of polyethylenimine-grafted-triamcinolone acetonide as nucleus-targeting gene delivery systems. J Gene Med 2010;12:669-80
  • Ma K, Shen H, Shen S, Development of a successive targeting liposome with multi-ligand for efficient targeting gene delivery. J Gene Med 2011;13:290-301
  • Hyun H, Lee J, Hwang do W, Combinational therapy of ischemic brain stroke by delivery of heme oxygenase-1 gene and dexamethasone. Biomaterials 2011;32:306-15
  • Son S, Hwang do W, Singha K, RVG peptide tethered bioreducible polyethylenimine for gene delivery to brain. J Control Release 2011;155:18-25
  • Kumar P, Wu H, McBride JL, Transvascular delivery of small interfering RNA to the central nervous system. Nature 2007;448:39-43
  • Yang YP, Chien Y, Chiou GY, Inhibition of cancer stem cell-like properties and reduced chemoradioresistance of glioblastoma using microRNA145 with cationic polyurethane-short branch PEI. Biomaterials 2012;33:1462-76
  • Ibrahim AF, Weirauch U, Thomas M, MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma. Cancer Res 2011;71:5214-24
  • Hwang DW, Son S, Jang J, A brain-targeted rabies virus glycoprotein-disulfide linked PEI nanocarrier for delivery of neurogenic microRNA. Biomaterials 2011;32:4968-75
  • Rapoport SI. Advances in osmotic opening of the blood-brain barrier to enhance CNS chemotherapy. Expert Opin Investig Drugs 2001;10:1809-18
  • Kim JS, Yoon TJ, Yu KN, Toxicity and tissue distribution of magnetic nanoparticles in mice. Toxicol Sci 2006;89:338-47
  • Kaestner P, Aigner A, Bastians H. Therapeutic targeting of the mitotic spindle checkpoint through nanoparticle-mediated siRNA delivery inhibits tumor growth in vivo. Cancer Lett 2011;304:128-36
  • Pi Y, Zhang X, Shi J, Targeted delivery of non-viral vectors to cartilage in vivo using a chondrocyte-homing peptide identified by phage display. Biomaterials 2011;32:6324-32
  • Shir A, Ogris M, Roedl W, EGFR-homing dsRNA activates cancer targeted immune response and eliminates disseminated EGFR over-expressing tumors in mice. Clin Cancer Res 2011;17:1033-43
  • Yeh CC, Hsieh HL, Lee J, Polyethylenimine-mediated PUMA gene delivery to orthotopic oral cancer: suppression of tumor growth through apoptosis induction in situ and prolonged survival. Head Neck 2011;33:878-85
  • Xu Z, Shen G, Xia X, Comparisons of three polyethyleneimine-derived nanoparticles as a gene therapy delivery system for renal cell carcinoma. J Transl Med 2011;9:46-55
  • Zhang C, Gao S, Jiang W, Targeted minicircle DNA delivery using folate-poly(ethylene glycol)-polyethylenimine as non-viral carrier. Biomaterials 2010;31:6075-86
  • Kwon EJ, Lasiene J, Jacobson BE, Targeted nonviral delivery vehicles to neural progenitor cells in the mouse subventricular zone. Biomaterials 2010;31:2417-24
  • Kleemann E, Neu M, Jekel N, Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI. J Control Release 2005;109:299-316
  • Chen J, Gao X, Hu K, Galactose-poly(ethylene glycol)-polyethylenimine for improved lung gene transfer. Biochem Biophys Res Commun 2008;375:378-83
  • Kim HW, Park IK, Cho CS, Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice. Cancer Res 2004;64:7971-6
  • Pfeifer C, Hasenpusch G, Uezguen S, Dry powder aerosols of polyethylenimine (PEI)-based gene vectors mediate efficient gene delivery to the lung. J Control Release 2011;154:69-76
  • Zhang J, Duan Y, Wei D, Co-electrospun fibrous scaffold-adsorbed DNA for substrate-mediated gene delivery. J Biomed Mater Res A 2011;96:212-20
  • Wang C, Ravi S, Martinez GV, Dual-purpose magnetic micelles for MRI and gene delivery. J Control Release 2012;163:82-92
  • Yang J, Lee ES, Noh MY, Ambidextrous magnetic nanovectors for synchronous gene transfection and labeling of human MSCs. Biomaterials 2011;32:6174-82
  • Zhan C, Meng Q, Li Q, Cyclic RGD-polyethylene glycol-polyethylenimine for intracranial glioblastoma-targeted gene delivery. Chem Asian J 2012;7:91-6
  • Pham W, Zhao BQ, Lo EH, Crossing the blood-brain barrier: a potential application of myristoylated polyarginine for in vivo neuroimaging. Neuroimage 2005;28:287-92
  • Meng Q, Yu M, Gu B, Myristic acid-conjugated polyethylenimine for brain-targeting delivery: in vivo and ex vivo imaging evaluation. J Drug Target 2010;18:438-46
  • Li J, Gu B, Meng Q, The use of myristic acid as a ligand of polyethylenimine/DNA nanoparticles for targeted gene therapy of glioblastoma. Nanotechnology 2011;22:435101
  • Alshamsan A, Hamdy S, Samuel J, The induction of tumor apoptosis in B16 melanoma following STAT3 siRNA delivery with a lipid-substituted polyethylenimine. Biomaterials 2010;31:1420-8
  • Jeong JH, Kim SH, Lee M, Non-viral systemic delivery of Fas siRNA suppresses cyclophosphamide-induced diabetes in NOD mice. J Control Release 2010;143:88-94
  • Lu ZX, Liu LT, Qi XR. Development of small interfering RNA delivery system using PEI-PEG-APRPG polymer for antiangiogenic vascular endothelial growth factor tumor-targeted therapy. Int J Nanomed 2011;6:1661-73
  • Merkel OM, Beyerle A, Librizzi D, Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance. Mol Pharm 2009;6:1246-60
  • Liu L, Liu H, Visner G, Fletcher BS. Sleeping Beauty-mediated eNOS gene therapy attenuates monocrotaline-induced pulmonary hypertension in rats. FASEB J 2006;20:2594-6
  • Belur LR, Frandsen JL, Dupuy AJ, Gene insertion and long-term expression in lung mediated by the Sleeping Beauty transposon system. Mol Ther 2003;8:501-7
  • Belur LR, Podetz-Pedersen K, Frandsen J, McIvor RS. Lung-directed gene therapy in mice using the nonviral Sleeping Beauty transposon system. Nat Protoc 2007;2:3146-52
  • Liu H, Liu L, Fletcher BS, Visner GA. Sleeping Beauty-based gene therapy with indoleamine 2,3-dioxygenase inhibits lung allograft fibrosis. FASEB J 2006;20:2384-6
  • Chen ZY, Liang K, Qiu RX. Targeted gene delivery in tumor xenografts by the combination of ultrasound-targeted microbubble destruction and polyethylenimine to inhibit survivin gene expression and induce apoptosis. J Exp Clin Cancer Res 2010;29:152-60
  • Chen ZY, Liang K, Qiu RX, Luo LP. Ultrasound- and liposome microbubble-mediated targeted gene transfer to cardiomyocytes in vivo accompanied by polyethylenimine. J Ultrasound Med 2011;30:1247-58
  • Sidi AA, Ohana P, Benjamin S, Phase I/II marker lesion study of intravesical BC-819 DNA plasmid in H19 over expressing superficial bladder cancer refractory to bacillus Calmette-Guerin. J Urol 2008;180:2379-83
  • Bonnet ME, Erbacher P, Bolcato-Bellemin AL. Systemic delivery of DNA or siRNA mediated by linear polyethylenimine (L-PEI) does not induce an inflammatory response. Pharm Res 2008;25:2972-82
  • Hassani Z, Lemkine GF, Erbacher P, Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels. J Gene Med 2005;7:198-207
  • Bolcato-Bellemin AL, Bonnet ME, Creusat G, Sticky overhangs enhance siRNA-mediated gene silencing. Proc Natl Acad Sci USA 2007;104:16050-5
  • Urban-Klein B, Werth S, Abuharbeid S, RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther 2005;12:461-6
  • Ge Q, Filip L, Bai A, Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc Natl Acad Sci USA 2004;101:8676-81

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.