Resveratrol: review on therapeutic potential and recent advances in drug delivery

Bibliography

• Baker DD, Chu M, Oza U, et al. The value of natural products to future pharmaceutical discovery. Nat Prod Rep 2007;24:1225-44
   PubMed Web of Science ®Google Scholar
• Kasiotis KM, Pratsinis H, Kletsas D, et al. Resveratrol and related stilbenes: their anti-aging and anti-angiogenic properties. Food Chem Toxicol 2013;61:112-20
   PubMed Web of Science ®Google Scholar
• Roupe KA, Remsberg CM, Yanez JA, et al. Pharmacometrics of stilbenes: seguing towards the clinic. Curr Clin Pharmacol 2006;1:81-101
   PubMedGoogle Scholar
• Langcake P, Pryce RJ. The production of resveratrol by Vitis vinifera and other members of the vitaceae as a response to infection or injury. Physiol Plant Pathol 1976;9:77-86
   Google Scholar
• Lee MH, Thomas JL, Wang HY, et al. Extraction of resveratrol from polygonum cuspidatum with magnetic orcinol-imprinted poly(ethylene-co-vinyl alcohol) composite particles and their in vitro suppression of human osteogenic sarcoma (HOS) cell line. J Mater Chem 2012;22:24644-51
   Web of Science ®Google Scholar
• Zhuang X, Dong X, Ma S, et al. Selective on-line extraction of trans-resveratrol and emodin from Polygonum cuspidatum using molecularly imprinted polymer. J Chromatogr Sci 2008;46:739-42
   PubMed Web of Science ®Google Scholar
• Ito T, Tanaka T, Iinuma M, et al. New resveratrol oligomers in the stem bark of Vatica pauciflora. Tetrahedron 2003;59:5347-63
   Web of Science ®Google Scholar
• Wang I, Catana F, Yang Y, et al. An LC-MS method for analyzing total resveratrol in grapes juice, cranberry juice, and in wine. J Agric Food Chem 2002;50:431-5
   PubMed Web of Science ®Google Scholar
• Song W, Wang HJ, Bucheli P, et al. Phytochemical profiles of different mulberry (Morus sp.) species from china. J Agric Food Chem 2009;57:9133-40
   PubMed Web of Science ®Google Scholar
• Lippi G, Franchini M, Guidi GC. Red wine and cardiovascular health: the “French paradox” revisited. Int J Wine Res 2010;2:1-7
   Google Scholar
• Renaud S, Lorgeril MD. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992;339:1523-6
   PubMed Web of Science ®Google Scholar
• Szabo G. A glass of red wine to improve mitochondrial biogenesis? Novel mechanisms of resveratrol. Am J Physiol Heart Circ Physiol 2009;297:H8-9
   PubMed Web of Science ®Google Scholar
• Agarwal A, Prabakaran SA. Mechanism, measurement, and prevention of oxidative stress in male reproductive physiology. Indian J Exp Biol 2005;43:963-74
   PubMedGoogle Scholar
• Cal C, Garban H, Jazirehi A, et al. Resveratrol and cancer: chemoprevention, apoptosis, and chemoimmunosensitizing activities. Curr Med Chem-Anti-Cancer Agents 2003;3:77-93
   PubMedGoogle Scholar
• Cao Y, Fu ZD, Wang F, et al. Anti-angiogenic activity of resveratrol, a natural compound from medicinal plants. J Asian Nat Prod Res 2005;7:205-13
   PubMed Web of Science ®Google Scholar
• Kim HJ, Chang EJ, Cho SH, et al. Antioxidative activity of resveratrol and its derivaties isolated from seeds of Paeonia lactiflora. Biosci Biotechnol Biochem 2002;66:1990-3
   PubMed Web of Science ®Google Scholar
• Gulcin I. Antioxidant properties of resveratrol: a structure-activity insight. Innov Food Sci Emerg 2010;11:210-18
   Web of Science ®Google Scholar
• Harikumar HB, Kunnumakkara AB, Sethi G, et al. Resveratrol, a multitargeted agent, can enhance antitumour activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer. Int J cancer 2010;127:257-68
   PubMed Web of Science ®Google Scholar
• Miksits M, Wlcek K, Svoboda M, et al. Antitumour activity of resveratrol and its sulfated metabolites against human breast cancer cells. Planta Med 2009;75:1227-30
   PubMed Web of Science ®Google Scholar
• Hung LM, Chen JK, Huang SS, et al. Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes. Cardiovasc Res 2000;47:549-55
   PubMed Web of Science ®Google Scholar
• Sahu SS, Madhyastha S, Rao GM. Neuroprotective effect of resveratrol against prenatal stress induced cognitive impairment and possible involvement of Na+, K+-ATPase activity. Pharmacol Biochem Behav 2013;103:520-5
   PubMed Web of Science ®Google Scholar
• Palsamy P, Subramanium S. Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats. Biomed Pharmacother 2008;62:598-605
   PubMed Web of Science ®Google Scholar
• Sebastia N, Almonacid M, Villaescusa JI, et al. Radioprotective activity and cytogenetic effect of resveratrol in human lymphocytes: an in vitro evaluation. Food Chem Toxicol 2013;51:391-5
   PubMed Web of Science ®Google Scholar
• Docherty JJ, Fu MM, Hah JM, et al. Effect of resveratrol on herpes simplex virus vaginal infection in the mouse. Antiviral Res 2005;67:155-62
   PubMed Web of Science ®Google Scholar
• Docherty JJ, Sweet TJ, Bailey E, et al. Resveratrol inhibition of varicella-zoster virus replication in vitro. Antiviral Res 2006;72:171-7
   PubMed Web of Science ®Google Scholar
• Khanduja KL, Bhardwaj A. Stable free radical scavenging and antiperoxidative properties of resveratrol compared in vitro with some other bioflavonoids. Indian J Biochem Biophys 2003;40:416-22
   PubMed Web of Science ®Google Scholar
• Das S, Lin HS, Ho PC, et al. The impact of aqueous solubility and dose on the pharmacokinetic profiles of resveratrol. Pharm Res 2008;25:2593-600
   PubMed Web of Science ®Google Scholar
• Jung JC, Lim E, Lee Y, et al. Synthesis of novel trans-stilbene derivatives and evaluation of their potent antioxidant and neuroprotective effects. Eur J Med Chem 2009;44:3166-74
   PubMed Web of Science ®Google Scholar
• Mukherjee S, Lekli I, Gurusamy N, et al. Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol. Free Radic Biol Med 2009;46:573-8
   PubMed Web of Science ®Google Scholar
• Gulcin I, Beydemir S. Phenolic compounds as antioxidants: carbonic anhydrase isoenzymes inhibitors. Mini Rev Med Chem 2013;13(3):408-30
   PubMed Web of Science ®Google Scholar
• Lee JH, Park KH, Lee MH, et al. Identification, characterization, and quantification of phenolic compounds in the antioxidant activity-containing fraction from the seeds of Korean perilla (Perilla frutescens) cultivars. Food Chem 2013;136:843-52
   PubMed Web of Science ®Google Scholar
• Othman NB, Roblain D, Chammen N, et al. Antioxidant phenolic compounds loss during the fermentation of Chetoui olives. Food Chem 2009;116:662-9
   Web of Science ®Google Scholar
• Schinella G, Mosca S, Jovellanos EC, et al. Antioxidant properties of polyphenol-rich cocoa products industrially processed. Food Res Int 2010;43:1614-23
   Web of Science ®Google Scholar
• Gulcin I. Antioxidant activity of food constituents: an overview. Arch Toxicol 2012;86(3):345-96
   PubMed Web of Science ®Google Scholar
• Bursal E, Gulcin I. Polyphenol contents and in vitro antioxidant activities of lyophilized aqueous extract of kiwifruit (Actinidia deliciosa). Food Res Int 2011;44:1482-9
   Web of Science ®Google Scholar
• Frenkel EN, Waterhouse AL, Teissedre PL. Principal phenolic phytochemicals in selected California wines and their antioxidant activity in inhibiting oxidation of human low-density lipoproteins. J Agr Food Chem 1995;43:890-4
   Web of Science ®Google Scholar
• Olas B, Wachowicz B, Juszczak S, et al. Antioxidant activity of resveratrol in endotoxin-stimulated blood platelets. Cell Biol Toxicol 2001;17:117-25
   PubMed Web of Science ®Google Scholar
• Bohm M, Rosenkranz S, Laufs U. Alcohol and red wine: impact on cardiovascular risk. Nephrol Dial Transplant 2004;19:11-16
   PubMed Web of Science ®Google Scholar
• Lin JF, Lin SM, Chih CL, et al. Resveratrol reduces infract size and improves ventricular function after myocardial ischemia in rats. Life Sci 2008;83:313-17
   PubMed Web of Science ®Google Scholar
• Palomer X, Busquets EC, Guardia DA, et al. Resveratrol induces nuclear factor-κB activity in human cardiac cells. Int J Cardiol 2013;167(6):2507-16
   PubMed Web of Science ®Google Scholar
• Oliveira JC, Antonietto CRK, Scalabrini AC, et al. Antioxidant protective effects of the resveratrol on the cardiac and vascular tissues from renal hypertensive rats. Open J Med Chem 2012;2:61-71
   Google Scholar
• Osman AMM, Al-Harthi SE, AlArabi OM, et al. Chemosensitizing and cardioprotective effects of resveratrol in doxorubicin-treated animals. Cancer Cell Int 2013;13:1-8
   PubMedGoogle Scholar
• Xia N, Strand S, Schlufter F, et al. Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol. Nitric Oxide 2013;32:29-35
   PubMed Web of Science ®Google Scholar
• Li T, Fan GX, Wang W, et al. Resveratrol induces apoptosis, influences IL-6 and exerts immunomodulatory effect on mouse lymphocytic leukemia both in vitro and in vivo. Int Immunopharmacol 2007;7:1221-31
   PubMed Web of Science ®Google Scholar
• Soto BL, Hank JA, Darjatmoko SR, et al. Anti-tumor and immunomodulatory activity of resveratrol in vitro and its potential for combining with cancer immunotherapy. Int Immunopharmacol 2011;11:1877-86
   PubMed Web of Science ®Google Scholar
• Barrett JC. Mechanism of multistep carcinogenesis and carcinogen risk assessment. Environ Health Perspect 1993;100:9-20
   PubMed Web of Science ®Google Scholar
• Fresco P, Borges F, Diniz C, et al. New insights on the anticancer properties of dietary polyphenols. Med Res Rev 2006;26:747-66
   PubMed Web of Science ®Google Scholar
• Jang M, Cai L, Udeani GO, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 1997;275:218
   PubMed Web of Science ®Google Scholar
• Subramanian L, Youssef S, Bhattacharya S, et al. Resveratrol: challenges in translation to the clinic – A critical discussion. Clin Cancer Res 2010;16(24):5942-8
   PubMed Web of Science ®Google Scholar
• Ndiaye M, Kumar R, Ahmad N. Resveratrol in cancer management: where are we and where we go from here? Ann NY Acad Sci 2011;1215:144-9
   PubMed Web of Science ®Google Scholar
• Garcia-Zepeda SP, Garcia-Villa E, Diaz-Chavez J, et al. Resveratrol induces cell death in cervical cancer cells through apoptosis and autophagy. Eur J Cancer Prev 2013;22(6):577-84
   PubMed Web of Science ®Google Scholar
• Aydin S, Bacanli M, Taner G, et al. Protective effects of resveratrol on sepsis-induced DNA damage in the lymphocytes of rats. Hum Exp Toxicol 2013;32(10):1048-57
   PubMed Web of Science ®Google Scholar
• Hu Y, Wang S, Wu X, et al. Chinese herbal medicine-derived compounds for cancer therapy: a focus on hepatocellular carcinoma. J Ethnopharmacol 2013;149:601-12
   PubMed Web of Science ®Google Scholar
• Kil JS, Son Y, Cheong YK, et al. An anticancer/cytotoxic activity of resveratrol is not hampered by its ability to induce the expression of the antioxidant/cytoprotective heme oxygenase-1 in RAW264.7 cells. Biomed Prev Nutr 2011;1:146-52
   Google Scholar
• Lwuchukwu OF, Tallarida RJ, Nagar S. Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells. Life Sci 2011;88:1047-54
   PubMed Web of Science ®Google Scholar
• Klahr S. The role of nitric oxide in hypertension and renal disease progression. Nephrol Dial Transplant 2001;16:60-2
   PubMed Web of Science ®Google Scholar
• Sarr M, Chataigneau M, Martins S, et al. Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase. Cardiovasc Res 2006;71:794-802
   PubMed Web of Science ®Google Scholar
• Diebolt M, Bucher B, Andriantsitohaina R. Wine polyphenols decrease blood pressure, Improves NO Vasodilatation, and induce gene expression. Hypertension 2001;38:159-65
   PubMed Web of Science ®Google Scholar
• Bhatt SR, Lokhandwala MF, Banday AA. Resveratrol prevents endothelial nitric oxide synthase uncoupling and attenuates development of hypertension in spontaneously hypertensive rats. Eur J Pharmacol 2011;667:258-64
   PubMed Web of Science ®Google Scholar
• Dolinsky VW, Chakrabarti S, Pereira TJ, et al. Resveratrol prevents hypertension and cardiac hypertrophy in hypertensive rats and mice. Biochim Biophys Acta 2013;1832:1723-33
   PubMed Web of Science ®Google Scholar
• Lastra CA, Villegas I. Resveratrol as an anti-inflammatory and anti-aging agent: mechanism and clinical implications. Mol Nutr Food Res 2005;49:405-30
   PubMed Web of Science ®Google Scholar
• Chuang DY, Chan MH, Zong Y, et al. Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells. J Neuroinflammation 2013;10:1-15
   PubMedGoogle Scholar
• Zhang F, Liu J, Shi JS. Anti-inflammatory activities of resveratrol in the brain: role of resveratrol in microglial activation. Eur J Pharmacol 2010;636:1-7
   PubMed Web of Science ®Google Scholar
• Fidalgo SS, Cardeno A, Villegas I, et al. Dietary supplementation of resveratrol attenuates chronic colonic inflammation in mice. Eur J Pharmacol 2010;633:78-84
   PubMed Web of Science ®Google Scholar
• Prabhakar O. Cerebroprotective effect of resveratrol through antioxidant and anti-inflammatory effects in diabetic rats. Naunyn-Schmiedebergs Arch Pharmacol 2013;386:705-10
   PubMed Web of Science ®Google Scholar
• Subbaramaiah K, Chung WJ, Michaluart P, et al. Resveratrol inhibits cycloxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. J Biol Chem 1998;273:21875-82
   PubMed Web of Science ®Google Scholar
• Donnelly LE, Newton R, Kennedy GE, et al. Anti-inflammatory effects of resveratrol in lungs epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol 2004;287:L774-83
   PubMed Web of Science ®Google Scholar
• Leiro JM, Varela M, Piazzon MC, et al. The anti-inflammatory activity of the polyphenol resveratrol may be partially related to inhibition of tumour necrosis factor-alpha (TNF-alpha) pre-mRNA splicing. Mol Immunol 2010;47:1114-20
   PubMed Web of Science ®Google Scholar
• Zenebe W, Pechanova O, Andriantsitohaina R, et al. Red wine polyphenols induce vasorelaxation by increased nitric oxide bioactivity. Physiol Res 2003;52:425-32
   PubMed Web of Science ®Google Scholar
• Li H, Forstermann U, et al. Resveratrol: a multifunctional compound improving endothelial function. Cardiovasc Drugs Ther 2009;23:425-9
   PubMed Web of Science ®Google Scholar
• Naderali EK, Doyle PJ, Williams G. Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs. Clin Sci 2000;98:537-43
   PubMed Web of Science ®Google Scholar
• Novakovic A, Bukarica LG, Kanjuh V, et al. Potassium chennels-mediated vasorelaxation of rat aorta induced by resveratrol. Basic Clin Pharmacol Toxicol 2006;99:360-4
   PubMed Web of Science ®Google Scholar
• Novakovic A, Bukarica LG, Peric M, et al. The mechanism of endothelium-independent relaxation induced by the wine polyphenol resveratrol in human internal mammary artery. J Pharmacol Sci 2006;101:85-90
   PubMed Web of Science ®Google Scholar
• Aslam SN, Stevenson PC, Kokubun T, et al. Antibacterial and antifungal activity of cicerfuran and related 2-arylbenzofurans and stilbenes. MicroBiol Res 2009;164:191-5
   PubMed Web of Science ®Google Scholar
• Chan MMY. Antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin. Biochem Pharmacol 2002;63:99-104
   PubMed Web of Science ®Google Scholar
• Nawrocki EM, Bedell HW, Humphreys TL. Resveratrol is cidal to both classes of Haemophilus ducreyi. Int J Antimicrob Agents 2013;41:477-9
   PubMed Web of Science ®Google Scholar
• Paolillo R, Carratelli CR, Rizzo A. Effect of resveratrol and quercetin in experimental infection by Salmonella enteria serovar Typhimurium. Int Immunopharmacol 2011;11:149-56
   PubMed Web of Science ®Google Scholar
• Paulo L, Oleastro M, Gallardo E, et al. Anti-Helicobactor pylori and urease inhibitory activities of resveratrol and red wine. Food Res Int 2011;44:964-9
   Web of Science ®Google Scholar
• Animal Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2012;35:S64-71
   PubMed Web of Science ®Google Scholar
• Sharma S, Misra CS, Arumugam S, et al. Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type-2 diabetes. Phytother Res 2011;25:67-73
   PubMed Web of Science ®Google Scholar
• Su HC, Hung LM, Chen JK. Resveratrol, a red wine antioxidant, possesses an insulin-like effect in streptozotocin-induced diabetic rats. Am J Physiol Endocrinol Metab 2006;290:E1339-46
   PubMed Web of Science ®Google Scholar
• Minakawa M, Kawano A, Miura Y, et al. Hypoglycemic effect of resveratrol in type 2 diabetic model db/db mice and its actions in cultured L6 myotubes and RIN-5F pancreatic beta-cells. J Clin Biochem Nutr 2011;48:237-44
   PubMed Web of Science ®Google Scholar
• Londhe JS, Devasagayam TPA, Foo LY, et al. Radioprotective properties of polyphenols from Phyllanthus amarus Linn. J Radiat Res 2009;50:303-9
   PubMed Web of Science ®Google Scholar
• Aziz MH, Afaq A, Ahmad N. Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin. Photochem Photobiol 2005;81:25-31
   PubMed Web of Science ®Google Scholar
• Carsten RE, Bachand AM, Bailey SM, et al. Resveratrol reduces radiation-induced chromosome aberration frequencies in mouse bone marrow cells. Radiat Res 2008;169:633-8
   PubMed Web of Science ®Google Scholar
• Sai Y, Zou Z, Peng K, et al. The Parkinson’s disease-related genes act in mitochondrial homeostasis. Neurosci Biobehav Rev 2012;36:2034-43
   PubMed Web of Science ®Google Scholar
• Okawara M, Katsuki H, Kurimoto E, et al. Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. Biochem Pharmacol 2007;73:550-60
   PubMed Web of Science ®Google Scholar
• Blanchet J, Longpre F, Bureau G, et al. Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:1243-50
   PubMed Web of Science ®Google Scholar
• Gocer H, Akincioglu A, Oztaskin N, et al. Synthesis, antioxidant, and antiacetylcholinesterase activities of sulfonamide derivatives of dopamine-related compounds. Arch Pharm Chem Life Sci 2013;346:783-92
   PubMed Web of Science ®Google Scholar
• Karuppagounder SS, Pinto JT, Xu H, et al. Dietary supplementation with resveratrol reduced plaque pathology in a transgenic model of Alzheimer’s disease. Neurochem Int 2009;54:111-18
   PubMed Web of Science ®Google Scholar
• Marambaud P, Zhao H, Davies P. Resveratrol promotes clearance of Alzheimer’s disease amyloid-beta peptides. J Biol Chem 2005;280:37377-82
   PubMed Web of Science ®Google Scholar
• Virmani A, Pinto L, Binienda Z, Ali S. Food, nutrigenomics, and neurodegeneration—neuroprotection by what you eat. Mol Neurobiol 2013;48:353-62
   PubMed Web of Science ®Google Scholar
• Bocci V, Valacchi G. Free radicals and antioxidants: how to reestablish redox homeostasis in chronic diseases? Curr Med Chem 2013;20(27):3397-415
   PubMed Web of Science ®Google Scholar
• Walle T, Hsieh F, Delegge MH, et al. High absorption but very low solubility of oral resveratrol in humans. Drug Metab Dispos 2004;32:1377-82
   PubMed Web of Science ®Google Scholar
• Brown VA, Patel KR, Viskaduraki M, et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Res 2010;70:9003-11
   PubMed Web of Science ®Google Scholar
• Almeida L, Silva MV, Falcao A, et al. Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Mol Nutr Food Res 2009;53:S7-15
   PubMed Web of Science ®Google Scholar
• Boocock DJ, Fause GES, Patel KR, et al. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev 2007;16:1246-52
   PubMed Web of Science ®Google Scholar
• Nicolas JML, Carmona FG. Aggregation state and pKa values of (E)-resveratrol as determined by fluorescence spectroscopy and UV-Visible absorption. J Agric Food Chem 2008;56:7600-5
   PubMed Web of Science ®Google Scholar
• Yu C, Shin YG, Chow A, et al. Human, rat, and mouse metabolism of resveratrol. Pharm Res 2002;19:1907-14
   PubMed Web of Science ®Google Scholar
• Marier JF, Vachon P, Gritsas A, et al. Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model. J Pharmacol Exp Ther 2002;302:369-73
   PubMed Web of Science ®Google Scholar
• Mendes JBE, Riekes MK, Oliveira VM, et al. PHBV/PCL microparticles for controlled release of resveratrol: Physicochemical characterization, antioxidant potential, and effect on hemolysis of human erythrocytes. ScientificWorldJournal 2012;2012:542937
   PubMedGoogle Scholar
• Valle D, Martin EM. Cyclodextrins and their uses: a review. Process Biochem 2004;39:1033-46
   Web of Science ®Google Scholar
• Gokce EH, Korkmaz E, Dellera E, et al. Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications. Int J Nanomed 2012;7:1841-50
   PubMed Web of Science ®Google Scholar
• Kobierski S, Kwakye KO, Muller RH, et al. Resveratrol nanosuspensions for dermal application-production, characterization, and physical stability. Pharmazie 2009;64:741-7
   PubMed Web of Science ®Google Scholar
• Figueiro F, Bernardi A, Frozza RR, et al. Resveratrol-loaded nanocapsules treatment reduces in vitro and in vivo glioma growth. Porto Alegre 2010;1-31
   Google Scholar
• Bonechi C, Martini S, Ciani L, et al. Using liposomes as carriers for polyphenolic compounds: the case of trans-resveratrol. PLoS One 2012;7:1-11
   Google Scholar
• Pando D, Gutierrez G, Coca J, et al. Preparation and characterization of niosomes containing resveratrol. J Food Eng 2013;117:227-34
   Web of Science ®Google Scholar
• Scognamiglio I, Stefano DD, Campani V, et al. Nanocarriers for topical administration of resveratrol: a comparative study. Int J Pharm 2013;440:179-87
   PubMed Web of Science ®Google Scholar
• Madhav NVS, Kala S. Review on microparticulate drug delivery system. Int J PharmTech Res 2011;3:1242-54
   Google Scholar
• Nam JB, Ryu JH, Kim JW, et al. Stabilization of resveratrol immobilized in monodisoerse cyano-functionalized porous polymeric microspheres. Polymer (Guildf) 2005;46:8956-63
   Web of Science ®Google Scholar
• Peng H, Xiong H, Li J, et al. Vanillin cross-linked chitosan microspheres for controlled release of resveratrol. Food Chem 2010;121:23-8
   Web of Science ®Google Scholar
• Augustin MA, Sanguansri L, Lockett T. Nano- and micro-encapsulated systems for enhancing the delivery of resveratrol. Ann NY Acad Sci 2013;1290:107-12
   PubMed Web of Science ®Google Scholar
• Das S, Ng KY, Ho PC. Design of a pectin-based microparticle formulation using zinc ions as the cross-linking agent and gluteraldehyde as the hardening agent for colonic-specific delivery of resveratrol: in vitro and in vivo evaluations. J Drug Target 2011;19:446-57
   PubMed Web of Science ®Google Scholar
• Loftsson T, Brewster ME. Pharmaceutical application of cyclodextrins. 1. Drug solubilization and stabilization. J Pharm Sci 1996;85:1017-25
   PubMed Web of Science ®Google Scholar
• Bertacche V, Lorenzi N, Nava D, et al. Host-guest interaction study of resveratrol with natural and modified cyclodextrins. J Incl Pheno Macro Chem 2006;55:279-87
   Web of Science ®Google Scholar
• Abellan CL, Fortea MI, Gabaldon JA, et al. Complexation of resveratrol by native and modified cyclodextrins: determination of complexation constant by enzymatic, solubility and fluirimetric assays. Food Chem 2008;111:262-7
   Web of Science ®Google Scholar
• Lu Z, Cheng B, Hu Y, et al. Complexation of resveratrol with cyclodextrins: solubility and antioxidant activity. Food Chem 2009;113:17-20
   Web of Science ®Google Scholar
• Ansari KA, Vavia PR, Trotta F, et al. Cyclodextrin-based nanosponges for delivery of resveratrol: In vitro characterization, stability, cytotoxicity and permeation study. AAPS Pharm Sci Tech 2011;12:279-86
   PubMed Web of Science ®Google Scholar
• Kumar S, Randhawa JK. High melting lipid based approach for drug delivery: solid lipid nanoparticles. Mater Sci Eng C 2013;33:1842-52
   PubMed Web of Science ®Google Scholar
• Teskac K, Kristl J. The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol. Int J Pharm 2010;390:61-9
   PubMed Web of Science ®Google Scholar
• Gokce EH, Korkmaz E, Dellera E, et al. Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications. Int J Nanomed 2012;7:1841-50
   PubMed Web of Science ®Google Scholar
• Patel VR, Agrawal YK. Nanosuspension: an approach to enhance solubility of drugs. J Adv Pharm Tech Res 2011;2:81-7
   PubMedGoogle Scholar
• Kumar GP, Rajeshwarrao P. Nonionic surfactant vesicular systems for effective drug delivery-an overview. Acta Pharm Sinica B 2011;1:208-19
   Web of Science ®Google Scholar
• Caddeo C, Manconi M, Fadda AM, et al. Nanocarriers for antioxidant resveratrol: formulation approach, vesicle self-assembly and stability evaluation. Colloids Surf B Biointerfaces 2013;111:327-32
   PubMed Web of Science ®Google Scholar
• Mignet N, Seguin J, Chabot GG. Bioavailability of polyphenol liposomes: a challenge ahead. Pharmaceutics 2013;5:457-71
   PubMedGoogle Scholar
• Subramanian S, Singireddy A, Krishnamoorthy K, Rajappan M. Nanosponges: a novel class of drug delivery system- Review. J Pharm Pharm Sci 2012;15(1):103-11
   PubMed Web of Science ®Google Scholar
• Ahmed RZ, Patil G, Zaheer Z. Nanosponges- a completely new nano-horizon: pharmaceutical applications and recent advances. Drug Dev Ind Pharm 2013;39(9):1263-72
   PubMed Web of Science ®Google Scholar
• Patel KR, Brown VA, Jones DJL, et al. Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients. Cancer Res 2010;70:7392-9
   PubMed Web of Science ®Google Scholar
• Nguyen AV, Martinez M, Stamos MJ, et al. Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res 2009;1:25-37
   PubMedGoogle Scholar
• Brasnyo P, Molnar GA, Mohas M, et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br J Nutr 2011;106:383-9
   PubMed Web of Science ®Google Scholar
• Bhatt JK, Thomas S, Nanjan MJ. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr Res 2012;32(7):537-41
   PubMed Web of Science ®Google Scholar
• Howells LM, Berry DP, Elliott PJ, et al. Phase I randomized, double-blind study of micronized resveratrol (SRT501) in patients with hepatic metastases-safety, pharmacokinetics, and pharmacodynamics. Cancer Prev Res 2011;4:1419-25
   PubMed Web of Science ®Google Scholar
• Magyar K, Halmosi R, Palfi A, et al. Cardioprotection by resveratrol: a human clinical trial in patients with stable coronary artery disease. Clin Hemorheol Micro 2012;50:179-87
   PubMed Web of Science ®Google Scholar