Nanocarrier-based antioxidant therapy: promise or delusion?

Bibliography

• Stone WL, Smith M. Therapeutic uses of antioxidant liposomes. Mol Biotechnol 2004;27:217-30
   PubMed Web of Science ®Google Scholar
• Du L, Li J, Chen C, Liu Y. Nanocarrier: a potential tool for future antioxidant therapy. Free Radic Res 2014;48:1061-9
   PubMed Web of Science ®Google Scholar
• Yoshitomi T, Nagasaki Y. Reactive oxygen species-scavenging nanomedicines for the treatment of oxidative stress injuries. Adv Healthc Mater 2014;3:1149-61
   Web of Science ®Google Scholar
• Corvo ML, Marinho HS, Marcelino P, et al. Superoxide dismutase enzymosomes: carrier capacity optimization, in vivo behaviour and therapeutic activity. Pharm Res 2015;32:91-102
   PubMed Web of Science ®Google Scholar
• Hood ED, Chorny M, Greineder CF, et al. Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation. Biomaterials 2014;35:3708-15
   PubMed Web of Science ®Google Scholar
• Snow-Lisy DC, Sabanegh ESJr, Samplaski MK, et al. Superoxide dismutase-loaded biodegradable nanoparticles targeted with a follicle-stimulating hormone peptide protect Sertoli cells from oxidative stress. Fertil Steril 2014;101:560-7
   PubMed Web of Science ®Google Scholar
• Yin H, Si J, Xu H, et al. Resveratrol-loaded nanoparticles reduce oxidative stress induced by radiation or amyloid-beta in transgenic Caenorhabditis elegans. J Biomed Nanotechnol 2014;10:1536-44
   PubMed Web of Science ®Google Scholar
• Manca ML, Castangia I, Caddeo C, et al. Improvement of quercetin protective effect against oxidative stress skin damages by incorporation in nanovesicles. Colloids Surf B Biointerfaces 2014;123:566-74
   PubMed Web of Science ®Google Scholar
• Melov S, Schneider JA, Day BJ, et al. A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. Nat Genet 1998;18:159-63
   PubMed Web of Science ®Google Scholar
• Wallace DC, Melov S. Radicals r’aging. Nat Genet 1998;19:105-6
   PubMed Web of Science ®Google Scholar
• Krengel U, Tornroth-Horsefield S. Biochemistry. Coping with oxidative stress. Science 2015;347:125-6
   PubMed Web of Science ®Google Scholar
• Persson T, Popescu BO, Cedazo-Minguez A. Oxidative stress in Alzheimer’s disease: why did antioxidant therapy fail? Oxid Med Cell Longev 2014;2014:427318
   PubMed Web of Science ®Google Scholar
• Johansen JS, Harris AK, Rychly DJ, et al. Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc Diabetol 2005;4:5
   PubMed Web of Science ®Google Scholar
• Pashkow FJ. Oxidative stress and inflammation in heart disease: Do antioxidants have a role in treatment and/or prevention? Int J Inflam 2011;2011:514623
   PubMedGoogle Scholar
• Perfeito R, Cunha-Oliveira T, Rego AC. Reprint of: revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse. Free Radic Biol Med 2013;62:186-201
   PubMed Web of Science ®Google Scholar
• Mecocci P, Polidori MC. Antioxidant clinical trials in mild cognitive impairment and Alzheimer’s disease. Biochim Biophys Acta 2012;1822:631-8
   PubMed Web of Science ®Google Scholar
• Steinhubl SR. Why have antioxidants failed in clinical trials? Am J Cardiol 2008;101:14D-9D
   PubMed Web of Science ®Google Scholar
• Warnholtz A, Munzel T. Why do antioxidants fail to provide clinical benefit? Curr Control Trials Cardiovasc Med 2000;1:38-40
   PubMedGoogle Scholar
• Kris-Etherton PM, Lichtenstein AH, Howard BV, et al. Nutrition Committee of the American Heart Association Council on Nutrition PA, Metabolism. Antioxidant vitamin supplements and cardiovascular disease. Circulation 2004;110:637-41
   PubMed Web of Science ®Google Scholar
• Bjelakovic G, Nikolova D, Simonetti RG, et al. Antioxidant supplements for preventing gastrointestinal cancers. Cochrane Database Syst Rev 2004;CD004183
   Google Scholar
• Bjelakovic G, Nikolova D, Simonetti RG, et al. Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet 2004;364:1219-28
   PubMed Web of Science ®Google Scholar
• Bjelakovic G, Nikolova D, Gluud LL, et al. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 2007;297:842-57
   PubMed Web of Science ®Google Scholar
• Linnane AW, Kios M, Vitetta L. Healthy aging: regulation of the metabolome by cellular redox modulation and prooxidant signaling systems: the essential roles of superoxide anion and hydrogen peroxide. Biogerontology 2007;8:445-67
   PubMed Web of Science ®Google Scholar
• Lawenda BD, Kelly KM, Ladas EJ, et al. Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? J Natl Cancer Inst 2008;100:773-83
   PubMed Web of Science ®Google Scholar
• Kris-Etherton PM, Lichtenstein AH, Howard BV, et al. Antioxidant vitamin supplements and cardiovascular Disease. Circulation 2004;110:637-41
   PubMed Web of Science ®Google Scholar
• Linnane AW, Kios M, Vitetta L. The essential requirement for superoxide radical and nitric oxide formation for normal physiological function and healthy aging. Mitochondrion 2007;7:1-5
   PubMed Web of Science ®Google Scholar
• Bairati I, Meyer F, Jobin E, et al. Antioxidant vitamins supplementation and mortality: a randomized trial in head and neck cancer patients. Int J Cancer 2006;119:2221-4
   PubMed Web of Science ®Google Scholar
• Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS). Lancet 1996;347:781-6
   PubMed Web of Science ®Google Scholar
• The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. N Engl J Med 1994;330:1029-35
   PubMed Web of Science ®Google Scholar
• Omenn GS, Goodman GE, Thornquist MD, et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 1996;334:1150-5
   PubMed Web of Science ®Google Scholar
• Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-92
   PubMed Web of Science ®Google Scholar
• Waters DD, Alderman EL, Hsia J, et al. Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trial. JAMA 2002;288:2432-40
   PubMed Web of Science ®Google Scholar
• Chance B, Sies H, Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979;59:527-605
   PubMed Web of Science ®Google Scholar
• Figueira TR, Barros MH, Camargo AA, et al. Mitochondria as a source of reactive oxygen and nitrogen species: from molecular mechanisms to human health. Antioxid Redox Signal 2013;18:2029-74
   PubMed Web of Science ®Google Scholar
• Brand MD. The sites and topology of mitochondrial superoxide production. Exp Gerontol 2010;45:466-72
   PubMed Web of Science ®Google Scholar
• Sies H. Role of metabolic H2O2 generation: redox signaling and oxidative stress. J Biol Chem 2014;289:8735-41
   PubMed Web of Science ®Google Scholar
• Cordeiro JV, Jacinto A. The role of transcription-independent damage signals in the initiation of epithelial wound healing. Nat Rev Mol Cell Biol 2013;14:249-62
   Web of Science ®Google Scholar
• Edeas M. Strategies to target mitochondria and oxidative stress by antioxidants: key points and perspectives. Pharm Res 2011;28:2771-9
   PubMed Web of Science ®Google Scholar
• Slezak J, Tribulova N, Pristacova J, et al. Hydrogen peroxide changes in ischemic and reperfused heart. Cytochemistry and biochemical and X-ray microanalysis. Am J Pathol 1995;147:772-81
   PubMed Web of Science ®Google Scholar
• Semenza GL. Hypoxia-inducible factor 1: master regulator of O2 homeostasis. Curr Opin Genet Dev 1998;8:588-94
   PubMed Web of Science ®Google Scholar
• Ratcliffe PJ, O’Rourke JF, Maxwell PH, et al. Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression. J Exp Biol 1998;201:1153-62
   PubMed Web of Science ®Google Scholar
• Sun J, Morgan M, Shen RF, et al. Preconditioning results in S-nitrosylation of proteins involved in regulation of mitochondrial energetics and calcium transport. Circ Res 2007;101:1155-63
   PubMed Web of Science ®Google Scholar
• Murphy E, Steenbergen C. Preconditioning: the mitochondrial connection. Annu Rev Physiol 2007;69:51-67
   PubMed Web of Science ®Google Scholar
• Sanjuan-Pla A, Cervera AM, Apostolova N, et al. A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1alpha. FEBS Lett 2005;579:2669-74
   PubMed Web of Science ®Google Scholar
• Kelso GF, Porteous CM, Coulter CV, et al. Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem 2001;276:4588-96
   PubMed Web of Science ®Google Scholar
• Feillet-Coudray C, Fouret G, Ebabe Elle R, et al. The mitochondrial-targeted antioxidant MitoQ ameliorates metabolic syndrome features in obesogenic diet-fed rats better than Apocynin or Allopurinol. Free Radic Res 2014;48:1232-46
   PubMed Web of Science ®Google Scholar
• Gioscia-Ryan RA, LaRocca TJ, Sindler AL, et al. Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice. J Physiol 2014;592:2549-61
   PubMed Web of Science ®Google Scholar
• Miquel E, Cassina A, Martinez-Palma L, et al. Neuroprotective effects of the mitochondria-targeted antioxidant MitoQ in a model of inherited amyotrophic lateral sclerosis. Free Radic Biol Med 2014;70:204-13
   PubMed Web of Science ®Google Scholar
• Dashdorj A, Jyothi KR, Lim S, et al. Mitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines. BMC Med 2013;11:178
   PubMed Web of Science ®Google Scholar
• Solesio ME, Prime TA, Logan A, et al. The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson’s disease. Biochim Biophys Acta 2013;1832:174-82
   PubMed Web of Science ®Google Scholar
• Bailey DM, Raman S, McEneny J, et al. Vitamin C prophylaxis promotes oxidative lipid damage during surgical ischemia-reperfusion. Free Radic Biol Med 2006;40:591-600
   PubMed Web of Science ®Google Scholar
• Martin KR, Barrett JC. Reactive oxygen species as double-edged swords in cellular processes: low-dose cell signaling versus high-dose toxicity. Hum Exp Toxicol 2002;21:71-5
   PubMed Web of Science ®Google Scholar
• Chen Q, Espey MG, Krishna MC, et al. Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A 2005;102:13604-9
   PubMed Web of Science ®Google Scholar
• Schaar CE, Dues DJ, Spielbauer KK, et al. Mitochondrial and cytoplasmic ROS have opposing effects on lifespan. PLoS Genet 2015;11:e1004972
   PubMed Web of Science ®Google Scholar