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Expert Opinion on Drug Delivery Volume 5, 2008 - Issue 9
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Review

Drug delivery systems for the treatment of rheumatoid arthritis

Ingo H Tarner Justus-Liebig-University of Giessen, Department of Internal Medicine and Rheumatology, Division of Rheumatology and Clinical Immunology, Kerckhoff-Klinik, Benekestrasse 2-8, D-61231 Bad Nauheim, Germany +49 6032 996 2101; +49 6032 996 2104; [email protected]
, MD &
Ulf Müller-Ladner Justus-Liebig-University of Giessen, Department of Internal Medicine and Rheumatology, Division of Rheumatology and Clinical Immunology, Kerckhoff-Klinik, Benekestrasse 2-8, D-61231 Bad Nauheim, Germany +49 6032 996 2101; +49 6032 996 2104; [email protected]
, MD
Pages 1027-1037 | Published online: 29 Aug 2008

Bibliography

  • Lee DM, Weinblatt ME. Rheumatoid arthritis. Lancet 2001;358(9285):903-11
  • Tarner IH, Härle P, Müller-Ladner U, et al. The different stages of synovitis: acute vs chronic, early vs late and non-erosive vs erosive. Best Pract Res Clin Rheumatol 2005;19(1):19-35
  • Huber LC, Distler O, Tarner I, et al. Synovial fibroblasts: key players in rheumatoid arthritis. Rheumatology (Oxford) 2006;45(6):669-75
  • Kvien TK. Epidemiology and burden of illness of rheumatoid arthritis. Pharmacoeconomics 2004;22(2 Suppl 1):1-12
  • Alamanos Y, Voulgari PV, Drosos AA. Incidence and prevalence of rheumatoid arthritis, based on the 1987 American College of Rheumatology criteria: a systematic review. Semin Arthritis Rheum 2006;36(3):182-8
  • Wolfe F, Mitchell DM, Sibley JT, et al. The mortality of rheumatoid arthritis. Arthritis Rheum 1994;37(4):481-94
  • Gabriel SE, Crowson CS, Kremers HM, et al. Survival in rheumatoid arthritis: a population-based analysis of trends over 40 years. Arthritis Rheum 2003;48(1):54-8
  • Cooper NJ. Economic burden of rheumatoid arthritis: a systematic review. Rheumatology (Oxford) 2000;39(1):28-33
  • Scheinecker C, Redlich K, Smolen JS. Cytokines as therapeutic targets: advances and limitations. Immunity 2008;28(4):440-4
  • Tarner IH, Müller-Ladner U, Gay S. Emerging targets of biologic therapies for rheumatoid arthritis. Nat Clin Pract Rheumatol 2007;3(6):336-45
  • Furst DE, Breedveld FC, Kalden JR, et al. Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2007. Ann Rheum Dis 2007;66(Suppl 3):iii2-22
  • Van Everdingen AA, Jacobs JW, Siewertsz Van Reesema DR, Bijlsma JW. Low-dose prednisone therapy for patients with early active rheumatoid arthritis: clinical efficacy, disease-modifying properties, and side effects: a randomized, double-blind, placebo-controlled clinical trial. Ann Intern Med 2002;136(1):1-12
  • Choy EH, Kingsley GH, Khoshaba B, et al. A two year randomised controlled trial of intramuscular depot steroids in patients with established rheumatoid arthritis who have shown an incomplete response to disease modifying antirheumatic drugs. Ann Rheum Dis 2005;64(9):1288-93
  • Makrygiannakis D, af Klint E, Catrina SB, et al. Intraarticular corticosteroids decrease synovial RANKL expression in inflammatory arthritis. Arthritis Rheum 2006;54(5):1463-72
  • Goekoop-Ruiterman YP, de Vries-Bouwstra JK, Allaart CF, et al. Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial. Arthritis Rheum 2008;58(2 Suppl):S126-35
  • Derendorf H, Mollmann H, Gruner A, Haack D, Gyselby G. Pharmacokinetics and pharmacodynamics of glucocorticoid suspensions after intra-articular administration. Clin Pharmacol Ther 1986;39(3):313-7
  • Kawakami S, Hashida M. Targeted delivery systems of small interfering RNA by systemic administration. Drug Metab Pharmacokinet 2007;22(3):142-51
  • Gregoriadis G, Neerunjun ED. Homing of liposomes to target cells. Biochem Biophys Res Commun 1975;65(2):537-44
  • Fahmy TM, Fong PM, Park J, et al. Nanosystems for simultaneous imaging and drug delivery to T cells. AAPS J 2007;9(2):E171-80
  • Romberg B, Oussoren C, Snel CJ, et al. Effect of liposome characteristics and dose on the pharmacokinetics of liposomes coated with poly(amino acid)s. Pharm Res 2007;24(12):2394-401
  • Metselaar JM, Wauben MH, Wagenaar-Hilbers JP, et al. Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes. Arthritis Rheum 2003;48(7):2059-66
  • Shehata T, Ogawara KI, Higaki K, Kimura T. Prolongation of residence time of liposome by surface-modification with mixture of hydrophilic polymers. Int J Pharm 2008;359(1-2):272-9
  • Ma Z, Li J, He F, et al. Cationic lipids enhance siRNA-mediated interferon response in mice. Biochem Biophys Res Commun 2005;330(3):755-9
  • Khoury M, Louis-Plence P, Escriou V, et al. Efficient new cationic liposome formulation for systemic delivery of small interfering RNA silencing tumor necrosis factor alpha in experimental arthritis. Arthritis Rheum 2006;54(6):1867-77
  • Szebeni J, Baranyi L, Savay S, et al. Role of complement activation in hypersensitivity reactions to doxil and hynic PEG liposomes: experimental and clinical studies. J Liposome Res 2002;12(1-2):165-72
  • Moghimi SM, Hamad I, Andresen TL, et al. Methylation of the phosphate oxygen moiety of phospholipid-methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production. FASEB J 2006;20(14):2591-3
  • Metselaar JM, van den Berg WB, Holthuysen AE, et al. Liposomal targeting of glucocorticoids to synovial lining cells strongly increases therapeutic benefit in collagen type II arthritis. Ann Rheum Dis 2004;63(4):348-53
  • Koning GA, Schiffelers RM, Wauben MH, et al. Targeting of angiogenic endothelial cells at sites of inflammation by dexamethasone phosphate-containing RGD peptide liposomes inhibits experimental arthritis. Arthritis Rheum 2006;54(4):1198-208
  • Gaspar MM, Boerman OC, Laverman P, et al. Enzymosomes with surface-exposed superoxide dismutase: in vivo behaviour and therapeutic activity in a model of adjuvant arthritis. J Control Release 2007;117(2):186-95
  • Avnir Y, Ulmansky R, Wasserman V, et al. Amphipathic weak acid glucocorticoid prodrugs remote-loaded into sterically stabilized nanoliposomes evaluated in arthritic rats and in a Beagle dog: a novel approach to treating autoimmune arthritis. Arthritis Rheum 2008;58(1):119-29
  • Van Lent PL, Holthuysen AE, Van Rooijen N, et al. Local removal of phagocytic synovial lining cells by clodronate-liposomes decreases cartilage destruction during collagen type II arthritis. Ann Rheum Dis 1998;57(7):408-13
  • Barrera P, Blom A, van Lent PL, et al. Synovial macrophage depletion with clodronate-containing liposomes in rheumatoid arthritis. Arthritis Rheum 2000;43(9):1951-9
  • Williams AS, Camilleri JP, Williams BD. Suppression of adjuvant-induced arthritis by liposomally conjugated methotrexate in the rat. Br J Rheumatol 1994;33(6):530-3
  • Higaki M, Ishihara T, Izumo N, et al. Treatment of experimental arthritis with poly(D,L-lactic/glycolic acid) nanoparticles encapsulating betamethasone sodium phosphate. Ann Rheum Dis 2005;64(8):1132-6
  • Chandrasekar D, Sistla R, Ahmad FJ, et al. Folate coupled poly(ethyleneglycol) conjugates of anionic poly(amidoamine) dendrimer for inflammatory tissue specific drug delivery. J Biomed Mater Res A 2007;82(1):92-103
  • Levick JR. Permeability of rheumatoid and normal human synovium to specific plasma proteins. Arthritis Rheum 1981;24(12):1550-60
  • Fiehn C, Muller-Ladner U, Gay S, et al. Albumin-coupled methotrexate (MTX-HSA) is a new anti-arthritic drug which acts synergistically to MTX. Rheumatology (Oxford) 2004;43(9):1097-105
  • Fiehn C, Neumann E, Wunder A, et al. Methotrexate (MTX) and albumin coupled with MTX (MTX-HSA) suppress synovial fibroblast invasion and cartilage degradation in vivo. Ann Rheum Dis 2004;63(7):884-6
  • Fiehn C, Kratz F, Sass G, et al. Targeted drug delivery by in vivo coupling to endogenous albumin: an albumin-binding prodrug of methotrexate (MTX) is superior to MTX in the treatment of murine collagen-induced arthritis. Ann Rheum Dis 2008;67(8):1188-91
  • Treuhaft PS, MCCarty DJ. Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases. Arthritis Rheum 1971;14(4):475-84
  • Levick JR. Hypoxia and acidosis in chronic inflammatory arthritis; relation to vascular supply and dynamic effusion pressure. J Rheumatol 1990;17(5):579-82
  • Naughton DP. Drug targeting to hypoxic tissue using self-inactivating bioreductive delivery systems. Adv Drug Deliv Rev 2001;53(2):229-33
  • Borchardt RT, Cohen LA. Stereopopulation control. 3. Facilitation of intramolecular conjugate addition of the carboxyl group. J Am Chem Soc 1972;94(26):9175-82
  • Wang D, Miller SC, Liu XM, et al. Novel dexamethasone-HPMA copolymer conjugate and its potential application in treatment of rheumatoid arthritis. Arthritis Res Ther 2007;9(1):R2
  • Wang D, Miller SC, Sima M, et al. The arthrotropism of macromolecules in adjuvant-induced arthritis rat model: a preliminary study. Pharm Res 2004;21(10):1741-9
  • Szekanecz Z, Koch AE. Mechanisms of Disease: angiogenesis in inflammatory diseases. Nat Clin Pract Rheumatol 2007;3(11):635-43
  • Koch AE, Distler O. Vasculopathy and disordered angiogenesis in selected rheumatic diseases: rheumatoid arthritis and systemic sclerosis. Arthritis Res Ther 2007;9(Suppl 2):S3
  • Jamar F, Chapman PT, Harrison AA, et al. Inflammatory arthritis: imaging of endothelial cell activation with an indium-111-labeled F(ab′)2 fragment of anti-E-selectin monoclonal antibody. Radiology 1995;194(3):843-50
  • Jamar F, Houssiau FA, Devogelaer JP, et al. Scintigraphy using a technetium 99m-labelled anti-E-selectin Fab fragment in rheumatoid arthritis. Rheumatology (Oxford) 2002;41(1):53-61
  • Koivunen E, Wang B, Ruoslahti E. Phage libraries displaying cyclic peptides with different ring sizes: ligand specificities of the RGD-directed integrins. Biotechnology (NY) 1995;13(3):265-70
  • Halin C, Zardi L, Neri D. Antibody-based targeting of angiogenesis. News Physiol Sci 2001;16:191-4
  • Trachsel E, Bootz F, Silacci M, et al. Antibody-mediated delivery of IL-10 inhibits the progression of established collagen-induced arthritis. Arthritis Res Ther 2007;9(1):R9
  • Berndorff D, Borkowski S, Moosmayer D, et al. Imaging of tumor angiogenesis using 99mTc-labeled human recombinant anti-ED-B fibronectin antibody fragments. J Nucl Med 2006;47(10):1707-16
  • Kaspar M, Trachsel E, Neri D. The antibody-mediated targeted delivery of interleukin-15 and GM-CSF to the tumor neovasculature inhibits tumor growth and metastasis. Cancer Res 2007;67(10):4940-8
  • El-Emir E, Dearling JL, Huhalov A, et al. Characterisation and radioimmunotherapy of L19-SIP, an anti-angiogenic antibody against the extra domain B of fibronectin, in colorectal tumour models. Br J Cancer 2007;96(12):1862-70
  • Tarli L, Balza E, Viti F, et al. A high-affinity human antibody that targets tumoral blood vessels. Blood 1999;94(1):192-8
  • Lee L, Buckley C, Blades MC, et al. Identification of synovium-specific homing peptides by in vivo phage display selection. Arthritis Rheum 2002;46(8):2109-20
  • Rajotte D, Arap W, Hagedorn M, et al. Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display. J Clin Invest 1998;102(2):430-7
  • Müller-Ladner U, Kriegsmann J, Franklin BN, et al. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol 1996;149(5):1607-15
  • Song H, Qiao F, Atkinson C, et al. A complement C3 inhibitor specifically targeted to sites of complement activation effectively ameliorates collagen-induced arthritis in DBA/1J mice. J Immunol 2007;179(11):7860-7
  • Goodfellow RM, Williams AS, Levin JL, et al. Soluble complement receptor one (sCR1) inhibits the development and progression of rat collagen-induced arthritis. Clin Exp Immunol 2000;119(1):210-6
  • Van Roon JA, van Vuuren AJ, Wijngaarden S, et al. Selective elimination of synovial inflammatory macrophages in rheumatoid arthritis by an Fcgamma receptor I-directed immunotoxin. Arthritis Rheum 2003;48(5):1229-38
  • Van Roon JA, Bijlsma JW, van de Winkel JG, Lafeber FP. Depletion of synovial macrophages in rheumatoid arthritis by an anti-FcgammaRI-calicheamicin immunoconjugate. Ann Rheum Dis 2005;64(6):865-70
  • Van Vuuren AJ, van Roon JA, Walraven V, et al. CD64-directed immunotoxin inhibits arthritis in a novel CD64 transgenic rat model. J Immunol 2006;176(10):5833-8
  • Nagayoshi R, Nagai T, Matsushita K, et al. Effectiveness of anti-folate receptor beta antibody conjugated with truncated Pseudomonas exotoxin in the targeting of rheumatoid arthritis synovial macrophages. Arthritis Rheum 2005;52(9):2666-75
  • Paulos CM, Turk MJ, Breur GJ, Low PS. Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis. Adv Drug Deliv Rev 2004;56(8):1205-17
  • Nagai T, Tanaka M, Tsuneyoshi Y, et al. In vitro and in vivo efficacy of a recombinant immunotoxin against folate receptor beta on the activation and proliferation of rheumatoid arthritis synovial cells. Arthritis Rheum 2006;54(10):3126-34
  • Paulos CM, Varghese B, Widmer WR, et al. Folate-targeted immunotherapy effectively treats established adjuvant and collagen-induced arthritis. Arthritis Res Ther 2006;8(3):R77
  • Wang D, Brömme D. Drug delivery strategies for cathepsin inhibitors in joint diseases. Expert Opin Drug Deliv 2005;2(6):1015-28

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