97
Views
3
CrossRef citations to date
0
Altmetric
Review

Gene transfer to induce insulin production for the treatment of diabetes mellitus

& , MD
Pages 967-977 | Published online: 29 Aug 2008

Bibliography

  • Group TDR. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977-86
  • Ohkubo Y, Kishikawa H, Araki E, et al. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract 1995;28:103-17
  • Group U. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998;352:854-65
  • Group U. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998;352:837-53
  • AACE. AACE diabetes management guidelines. Endocr Pract 2002;8(Suppl 1):40-65
  • ADA. Standards of medical care in diabetes. Diabetes Care 2008;31(Suppl 1):S12-54
  • Nanji SA, Shapiro AMJ. Advances in pancreatic islet transplantation in humans. Diabetes Obes Metab 2006;8(1):15-25
  • Shapiro AMJ, Ricordi C, Hering BJ, et al. International trial of the edmonton protocol for islet transplantation. N Engl J Med 2006;355(13):1318-30
  • Ryan EA, Paty BW, Senior PA, et al. Five-year follow-up after clinical islet transplantation. Diabetes 2005;54(7):2060-9
  • Eberhard D, Tosh D. Transdifferentiation and metaplasia as a paradigm for understanding development and disease. Cell Mol Life Sci 2008;65(1):33-40
  • Eguchi G, Kodama R. Transdifferentiation. Curr Opin Cell Biol 1993;5(6):1023-8
  • Horb ME, Shen C-N, Tosh D, Slack JMW. Experimental conversion of liver to pancreas. Curr Biol 2003;13:105-15
  • Watada H, Kajimoto Y, Miyagawa J, et al. PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin. Diabetes 1996;45(12):1826-31
  • Serup P, Jensen J, Andersen FG, et al. Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1. Proc Natl Acad Sci USA 1996;93(17):9015-20
  • Ferber S, Halkin A, Cohen H, et al. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia [see comments]. Nat Med 2000;6(5):568-72
  • Ber I, Shternhall K, Perl S, et al. Functional, persistent, and extended liver to pancreas transdifferentiation. J Biol Chem 2003;278(34):31950-7
  • Kaneto H, Nakatani Y, Miyatsuka T, et al. PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. Diabetes 2005;54(4):1009-22
  • Sapir T, Shternhall K, Meivar-Levy I, et al. Cell-replacement therapy for diabetes: generating functional insulin-producing tissue from adult human liver cells. Proc Natl Acad Sci USA 2005;102(22):7964-9
  • Kaneto H, Matsuoka T-A, Nakatani Y, et al. A crucial role of MafA as a novel therapeutic target for diabetes. J Biol Chem 2005;280(15):15047-52
  • Kojima H, Fujimiya M, Matsumura K, et al. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 2003;9(5):596-603
  • Imai J, Katagiri H, Yamada T, et al. Constitutively active PDX1 induced efficient insulin production in adult murine liver. Biochem Biophys Res Commun 2005;326(2):402-9
  • Jaffe HA, Danel C, Longenecker G, et al. Adenovirus-mediated in vivo gene transfer and expression in normal rat liver. Nat Genet 1992;1:372-8
  • Irit Meivar-Levy, Tamar Sapir, Shiraz Gefen-Halevi. Pancreatic and duodenal homeobox gene 1 induces hepatic dedifferentiation by suppressing the expression of CCAAT/enhancer-binding protein. Hepatology 2007;46(3):898-905
  • Fodor A, Harel C, Fodor L, et al. Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach. Diabetologia 2007;50(1):121-30
  • Fujimiya M, Kojima H, Ichinose M, et al. Fusion of proinsulin-producing bone marrow-derived cells with hepatocytes in diabetes. Proc Natl Acad Sci USA 2007;104(10):4030-5
  • Kojima H, Fujimiya M, Matsumura K, et al. Extrapancreatic insulin-producing cells in multiple organs in diabetes. Proc Natl Acad Sci USA 2004;101(8):2458-63
  • Karnieli O, Izhar-Prato Y, Bulvik S, Efrat S. Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by genetic manipulation. Stem Cells 2007;25(11):2837-44
  • Zalzman M, Anker-Kitai L, Efrat S. Differentiation of human liver-derived, insulin-producing cells toward the beta-cell phenotype. Diabetes 2005;54(9):2568-75
  • Cao L-Z, Tang D-Q, Horb ME, et al. High glucose is necessary for complete maturation of Pdx1-VP16-expressing hepatic cells into functional insulin-producing cells. Diabetes 2004;53(12):3168-78
  • Taniguchi H, Yamato E, Tashiro F, et al. b-cell neogenesis induced by adenovirus-mediated gene delivery of transcription factor pdx-1 into mouse pancreas. Gene Ther 2003;10(1):15-23
  • Kojima H, Nakamura T, Fujita Y, et al. Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin. Diabetes 2002;51(5):1398-408
  • Hashimoto T, Nakamura T, Maegawa H, et al. Regulation of ATP-sensitive potassium channel subunit Kir6.2 expression in rat intestinal insulin-producing progenitor cells. J Biol Chem 2005;280(3):1893-900
  • Nomura S, Nakamura T, Hashimoto T, et al. MafA differentiates rat intestinal cells into insulin-producing cells. Biochem Biophys Res Commun 2006;349(1):136-43
  • Zalzman M, Gupta S, Giri RK, et al. Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells. Proc Natl Acad Sci USA 2003;100(12):7253-8
  • Selden RF, Skoskiewicz MJ, Howie KB, et al. Implantation of genetically engineered fibroblasts into mice: implications for gene therapy. Science 1987;236:714-8
  • Groskreutz DJ, Sliwkowski MX, Gorman CM. Genetically engineered proinsulin constitutively processed and secreted as mature, active insulin. J Biol Chem 1994;269:6241-5
  • Simonson GD, Groskreutz DJ, Gorman CM, MacDonald MJ. Synthesis and processing of genetically modified human proinsulin by rat myoblast primary cultures. Hum Gene Ther 1996;7:71-8
  • Faradji RN, Havari E, Chen Q, et al. Glucose-induced toxicity in insulin-producing pituitary cells that coexpress GLUT2 and glucokinase. Implications for metabolic engineering. J Biol Chem 2001;276(39):36695-702
  • Lipes MA, Cooper EM, Skelly R, et al. Insulin-secreting non-islet cells are resistant to autoimmune destruction. Proc Natl Acad Sci USA 1996;93(16):8595-600
  • Wu L, Nicholson W, C-Y Wu MX, et al. Engineering physiologically regulated insulin secretion in non-β cells by expressing glucagon-like peptide 1 receptor. Gene Ther 2003;10:1712-20
  • Shifrin A, Auricchio A, Yu Q-C, et al. Adenoviral vector-mediated insulin gene transfer in the mouse pancreas corrects streptozotocin-induced hyperglycemia. Gene Ther 2001;8:1480-9
  • Nagamatsu S, Nakamichi Y, Ohara-Imaizumi M, et al. Adenovirus-mediated preproinsulin gene transfer into adipose tissues ameliorates hyperglycemia in obese diabetic KKA(y) mice. FEBS Lett 2001;509(1):106-10
  • Tang SC, Sambanis A. Development of genetically engineered human intestinal cells for regulated insulin secretion using rAAV-mediated gene transfer. Biochem Biophys Res Commun 2003;303(2):645-52
  • Lu Y-C, Sternini C, Rozengurt E, Zhukova E. Release of transgenic human insulin from gastric G cells: a novel approach for the amelioration of diabetes. Endocrinology 2005;146(6):2610-9
  • Cheung AT, Dayanandan B, Lewis JT, et al. Glucose-dependent insulin release from genetically engineered K cells. Science 2000;290(8):1959-62
  • Xu J, Lu Y, Ding F, et al. Reversal of diabetes in mice by intrahepatic injection of bone-derived GFP-murine mesenchymal stem cells infected with the recombinant retrovirus-carrying human insulin gene. World J Surg 2007;31(9):1872-82
  • Riu E, Mas A, Ferre T, et al. Counteraction of type 1 diabetic alterations by engineering skeletal muscle to produce insulin: insights from transgenic mice. Diabetes 2002;51(3):704-11
  • Olson D, Paveglio S, Huey P, et al. Glucose responsive hepatic insulin gene therapy of spontaneously diabetic BB/Wor rats. Hum Gene Ther 2003;14(15):1401-13
  • Dong H, Morral N, McEvoy R, et al. Hepatic insulin expression improves glycemic control in type 1 diabetic rats. Diabetes Res Clin Pract 2001;52:153-63
  • Alam T, Sollinger HW. Glucose-regulated insulin production in hepatocytes. Transplantation 2002;74(12):1781-7
  • Valera A, Fillat C, Costa C, et al. Regulated expression of human insulin in the liver of transgenic mice corrects diabetic alterations. FASEB J 1994;8:440-7
  • Sugiyama A, Hattori S, Tanaka S, et al. Defective adenoassociated viral-mediated transfection of insulin gene by direct injection into liver parenchyma decreases blood glucose of diabetic mice. Horm Metab Res 1997;29(12):599-603
  • Kolodka TM, Finegold M, Moss L, Woo SLC. Gene therapy for diabetes mellitus in rats by hepatic expression of insulin. Proc Natl Acad Sci USA 1995;92:3293-7
  • Muzzin P, Eisensmith RC, Copeland KC, Woo SLC. Hepatic insulin gene expression as treatment for type 1 diabetes mellitus in rats. Mol Endocrinol 1997;11:833-7
  • Croze F, Prud'homme GJ. Gene therapy of streptozotocin-induced diabetes by intramuscular delivery of modified preproinsulin genes. J Gene Med 2003;5(5):425-37
  • Shaw JAM, Delday MI, Hart AW, et al. Secretion of bioactive human insulin following plasmid-mediated gene transfer to non-neuroendocrine cell lines, primary cultures and rat skeletal muscle in vivo. J Endocrinol 2002;172(3):653-72
  • Bartlett RJ, Secore SL, Denis M, et al. Toward the biologic release of human insulin from skeletal muscle. Transplant Proc 1997;29(4):2199-200
  • Bartlett RJ, Denis M, Secore SL, et al. Toward engineering skeletal muscle to release peptide hormone from the human pre-proinsulin gene. Transplant Proc 1998;30(2):451
  • Yin D, Tang JG. Gene therapy for streptozotocin-induced diabetic mice by electroporational transfer of naked human insulin precursor DNA into skeletal muscle in vivo. FEBS Lett 2001;495(1-2):16-20
  • Diao W-F, Chen W-Q, Wu Y, et al. Serum, liver, and kidney proteomic analysis for the alloxan-induced type I diabetic mice after insulin gene transfer of naked plasmid through electroporation. Proteomics 2006;6(21):5837-45
  • Mas A, Montane J, Anguela XM, et al. Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle. Diabetes 2006;55(6):1546-53
  • Oh TK, Li MZ, Kim ST. Gene therapy for diabetes mellitus in rats by intramuscular injection of lentivirus containing insulin gene. Diabetes Res Clin Pract 2006;71(3):233-40
  • Otaegui PJ, Ferre T, Pujol A, et al. Expression of glucokinase in skeletal muscle: a new approach to counteract diabetic hyperglycemia. Hum Gene Ther 2000;11(11):1543-52
  • Hsu PY-J, Yang Y-W. Effect of polyethylenimine on recombinant adeno-associated virus mediated insulin gene therapy. J Gene Med 2005;7(10):1311-21
  • Worgall S, Wolff G, Falck-Pedersen E, Crystal RG. Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration. Hum Gene Ther 1997;8(1):37-44
  • Dong H, Woo SL. Hepatic insulin production for type 1 diabetes. Trends Endocrinol Metab 2001;12(10):441-6
  • Lee HC, Kim J-J, Kim K-s, et al. Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue. Nature 2000;408(23):483-8
  • Thule PM, Liu JM. Regulated hepatic insulin gene therapy of STZ-diabetic rats. Gene Ther 2000;7(20):1744-52
  • Chen R, Meseck M, Woo S. Auto-regulated hepatic insulin gene expression in type 1 diabetic rats. Mol Ther 2001;3(4):584-90
  • Thule PM, Campbell AG, Kleinhenz DJ, et al. Hepatic insulin gene therapy prevents deterioration of vascular function and improves adipocytokine profile in STZ-diabetic rats. Am J Physiol Endocrinol Metab 2006;290(1):E114-22
  • Thule PM, Liu J, Phillips LS. Glucose regulated production of human insulin in rat hepatocytes. Gene Ther 2000;7(3):205-14
  • Okitsu T, Kobayashi N, Jun H-S, et al. Transplantation of reversibly immortalized insulin-secreting human hepatocytes controls diabetes in pancreatectomized pigs. Diabetes 2004;53(1):105-12
  • Chen NKF, Wong JS, Kee IHC, et al. Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model. PLoS One (Electronic Resource) 2008;3(3):e1734
  • Auricchio A, Gao GP, Yu QC, et al. Constitutive and regulated expression of processed insulin following in vivo hepatic gene transfer. Gene Ther 2002;9(14):963-71
  • Kim J-M, Kim S-J, Lee H-C, Kim K-S. Development of ligand-dependent regulatory system and its application to gene therapy of insulin-dependent diabetes mellitus. Exp Mol Med 2006;38(4):385-92
  • Tang SC, Sambanis A. Preproinsulin mRNA engineering and its application to the regulation of insulin secretion from human hepatomas. FEBS Lett 2003;537(1-3):193-7
  • Rivera VM, Wang W, Wardwell S, et al. Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science 2000;287(5454):826-30
  • Kawakami Y, Yamaoka T, Hirochika R, et al. Somatic gene therapy for diabetes with an immunological safety system for complete removal of transplanted cells. Diabetes 1992;41:956-61
  • Taniguchi H, Fukao K, Nakauchi H. Constant delivery of proinsulin by encapsulation of transfected cells. J Surg Res 1997;70(1):41-5
  • Kong AP-S, Chan NN, Chan JC-N. The role of adipocytokines and neurohormonal dysregulation in metabolic syndrome. Curr Diabetes Rev 2006;2(4):397-407
  • Nakamichi Y, Ohara-Imaizumi M, Ishida H, Nagamatsu S. An insulin-related peptide expressed in 3T3L1 adipocytes is localized in GLUT4 vesicles and secreted in response to exogenous insulin, which augments the insulin-stimulated glucose uptake. J Cell Sci 2003;116:73-9
  • Ito M, Bujo H, Takahashi K, et al. Implantation of primary cultured adipocytes that secrete insulin modifies blood glucose levels in diabetic mice. Diabetologia 2005;48(8):1614-20
  • Kato H, Kuwako K-I, Suzuki M, Tanaka S. Gene expression patterns of pro-opiomelanocortin-processing enzymes PC1 and PC2 during postnatal development of rat corticotrophs. J Histochem Cytochem 2004;52(7):943-57
  • Smith DR, Pallen CJ, Murphy D, Lim L. Pituitary-specific transcriptional initiation sites of the rat carboxypeptidase-H gene and the influence of thyroid hormone status. Mol Endocrinol 1992;6(5):713-22
  • Barry SC, Ramesh N, Lejnieks D, et al. Glucose-regulated insulin expression in diabetic rats. Hum Gene Ther 2001;12(2):131-9
  • Porter MH, Paveglio SA, Zhang JA, et al. Host cells reduce glucose uptake and glycogen deposition in response to hepatic insulin gene therapy. J Investig Med 2005;53(4):201-12
  • Dong H, Altomonte J, Morral N, et al. Basal insulin gene expression significantly improves conventional insulin therapy in type 1 diabetic rats. Diabetes 2002;51(1):130-8
  • Short DK, Okada S, Yamauchi K, Pessin JE. Adenovirus-mediated transfer of a modified human proinsulin gene reverses hyperglycemia in diabetic mice. Am J Physiol 1998;275(5 Pt 1):E748-56
  • Tuch BE, Szymanska B, Yao M, et al. Function of a genetically modified human liver cell line that stores, processes and secretes insulin. Gene Ther 2003;10(6):490-503
  • Liu GJ, Simpson AM, Swan MA, et al. ATP-sensitive potassium channels induced in liver cells after transfection with insulin cDNA and the GLUT 2 transporter regulate glucose-stimulated insulin secretion. FASEB J 2003;17(12):1682-4
  • Kim YD, Park KG, Morishita R, et al. Liver-directed gene therapy of diabetic rats using an HVJ-E vector containing EBV plasmids expressing insulin and GLUT 2 transporter. Gene Ther 2006;13(3):216-24
  • Ren B, O'Brien BA, Swan MA, et al. Long-term correction of diabetes in rats after lentiviral hepatic insulin gene therapy. Diabetologia 2007;50(9):1910-20
  • Olson D, Campbell A, Porter M, et al. Hepatic insulin gene therapy normalizes diurnal fluctuation of oxidative metabolism in diabetic BB/Wor rats. Mol Ther 2008;16:1235-42
  • Diamond MP, Hallarman L, Starick-Zych K, et al. Suppression of counterregulatory hormone response to hypoglycemia by insulin per se. J Clin Endocrinol Metab 1991;72(6):1388-90

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.