Microdialysis for assessing intratumoral drug disposition in brain cancers: a tool for rational drug development

Bibliography

• CBTRUS Statistical Report: primary brain and central nervous system tumors diagnosed in eighteen states in 2002 – 2006. Published by the central brain tumor registry of the United States, Hinsdale, IL. 2009 – 2010. Available from: www.cbtrus.org
   Google Scholar
• Stupp R, Mason WP, van den Bent MJ, European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups, National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352(10):987-96
   PubMed Web of Science ®Google Scholar
• Merchant TE, Pollack IF, Loeffler JS. Brain tumors across the age spectrum: biology, therapy, and late effects. Semin Radiat Oncol 2010;20(1):58-66
   PubMed Web of Science ®Google Scholar
• Minniti G, Muni R, Lanzetta G, Chemotherapy for glioblastoma: current treatment and future perspectives for cytotoxic and targeted agents. Anticancer Res 2009;29(12):5171-84
   PubMed Web of Science ®Google Scholar
• Omuro AM. Exploring multi-targeting strategies for the treatment of gliomas. Curr Opin Investig Drugs 2008;9(12):1287-95
   PubMed Web of Science ®Google Scholar
• Yung WK, Albright RE, Olson J, A Phase II study of temozolomide vs. procarbazine in patients with glioblastoma multiforme at first relapse. Br J Cancer 2000;83(5):588-93
   PubMed Web of Science ®Google Scholar
• Reardon DA, Wen PY. Therapeutic advances in the treatment of glioblastoma: rationale and potential role of targeted agents. Oncologist 2006;11(2):152-64
   PubMed Web of Science ®Google Scholar
• Dunbar E, Yachnis AT. Glioma diagnosis: immunohistochemistry and beyond. Adv Anat Pathol 2010;17(3):187-201
   PubMed Web of Science ®Google Scholar
• Burger PC, Heinz ER, Shibata T, Kleihues P. Topographic anatomy and CT correlations in the untreated glioblastoma multiforme. J Neurosurg 1988;68(5):698-704
   PubMed Web of Science ®Google Scholar
• Salmaggi A, Boiardi A, Gelati M, Glioblastoma-derived tumorospheres identify a population of tumor stem-like cells with angiogenic potential and enhanced multidrug resistance phenotype. Glia 2006;54(8):850-60
   PubMed Web of Science ®Google Scholar
• Leuraud P, Taillandier L, Medioni J, Distinct responses of xenografted gliomas to different alkylating agents are related to histology and genetic alterations. Cancer Res 2004;64(13):4648-53
   PubMed Web of Science ®Google Scholar
• Bleau AM, Hambardzumyan D, Ozawa T, PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell Stem Cell 2009;4(3):226-35
   PubMed Web of Science ®Google Scholar
• Chua C, Zaiden N, Chong KH, Characterization of a side population of astrocytoma cells in response to temozolomide. J Neurosurg 2008;109(5):856-66
   PubMed Web of Science ®Google Scholar
• Tredan O, Galmarini CM, Patel K, Tannock IF. Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst 2007;99(19):1441-54
   PubMed Web of Science ®Google Scholar
• Colvin OM, Friedman HS, Gamcsik MP, Role of glutathione in cellular resistance to alkylating agents. Adv Enzyme Regul 1993;33:19-26
   PubMedGoogle Scholar
• Siegelin MD, Plescia J, Raskett CM, Global targeting of subcellular heat shock protein-90 networks for therapy of glioblastoma. Mol Cancer Ther 2010;9(6):1638-46
   PubMed Web of Science ®Google Scholar
• Hoelzinger DB, Demuth T, Berens ME. Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment. J Natl Cancer Inst 2007;99(21):1583-93
   PubMed Web of Science ®Google Scholar
• Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005;307(5706):58-62
   PubMed Web of Science ®Google Scholar
• Netti PA, Baxter LT, Boucher Y, Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery. Cancer Res 1995;55(22):5451-8
   PubMed Web of Science ®Google Scholar
• Jain RK. Barriers to drug delivery in solid tumors. Sci Am 1994;271(1):58-65
   PubMed Web of Science ®Google Scholar
• Zhang M, Aguilera D, Das C, Measuring cytotoxicity: a new perspective on LC50. Anticancer Res 2007;27(1A):35-8
   PubMed Web of Science ®Google Scholar
• Wolff JE, Trilling T, Molenkamp G, Chemosensitivity of glioma cells in vitro: a meta analysis. J Cancer Res Clin Oncol 1999;125(8-9):481-6
   PubMed Web of Science ®Google Scholar
• Blakeley J. Drug delivery to brain tumors. Curr Neurol Neurosci Rep 2008;8(3):235-41
   PubMed Web of Science ®Google Scholar
• Cecchelli R, Berezowski V, Lundquist S, Modelling of the blood-brain barrier in drug discovery and development. Nat Rev Drug Discov 2007;6(8):650-61
   PubMed Web of Science ®Google Scholar
• Jones AR, Shusta EV. Blood-brain barrier transport of therapeutics via receptor-mediation. Pharm Res 2007;24(9):1759-71
   PubMed Web of Science ®Google Scholar
• Groothuis DR. The blood-brain and blood-tumor barriers: a review of strategies for increasing drug delivery. Neuro Oncol 2000;2(1):45-59
   PubMed Web of Science ®Google Scholar
• Muldoon LL, Pagel MA, Kroll RA, A physiological barrier distal to the anatomic blood-brain barrier in a model of transvascular delivery. AJNR Am J Neuroradiol 1999;20(2):217-22
   PubMed Web of Science ®Google Scholar
• Colgan OC, Collins NT, Ferguson G, Influence of basolateral condition on the regulation of brain microvascular endothelial tight junction properties and barrier function. Brain Res 2007;1193:84-92
   Google Scholar
• Szakacs G, Paterson JK, Ludwig JA, Targeting multidrug resistance in cancer. Nat Rev Drug Discov 2006;5(3):219-34
   PubMed Web of Science ®Google Scholar
• Agarwal S, Sane R, Gallardo JL, Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active efflux. J Pharmacol Exp Ther 2010;334(1):147-55
   PubMed Web of Science ®Google Scholar
• Chen Y, Agarwal S, Shaik NM, P-glycoprotein and breast cancer resistance protein influence brain distribution of dasatinib. J Pharmacol Exp Ther 2009;330(3):956-63
   PubMed Web of Science ®Google Scholar
• Decleves X, Bihorel S, Debray M, ABC transporters and the accumulation of imatinib and its active metabolite CGP74588 in rat C6 glioma cells. Pharmacol Res 2008;57(3):214-22
   PubMed Web of Science ®Google Scholar
• Nies AT, Jedlitschky G, Konig J, Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain. Neuroscience 2004;129(2):349-60
   PubMed Web of Science ®Google Scholar
• Warnke PC, Kopitzki K, Timmer J, Ostertag CB. Capillary physiology of human medulloblastoma: impact on chemotherapy. Cancer 2006;107(9):2223-7
   PubMed Web of Science ®Google Scholar
• Blakeley JO, Olson J, Grossman SA, ; New Approaches to Brain Tumor Therapy (NABTT) Consortium. Effect of blood brain barrier permeability in recurrent high grade gliomas on the intratumoral pharmacokinetics of methotrexate: a microdialysis study. J Neurooncol 2009;91(1):51-8
   PubMed Web of Science ®Google Scholar
• Zunkeler B, Carson RE, Olson J, Quantification and pharmacokinetics of blood-brain barrier disruption in humans. J Neurosurg 1996;85(6):1056-65
   PubMed Web of Science ®Google Scholar
• de Lange EC, Danhof M. Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain. Clin Pharmacokinet 2002;41(10):691-703
   PubMed Web of Science ®Google Scholar
• Blakeley JO, Laterra J. Neoplastic and paraneoplastic disorders. In: Irani D, editor, Cerebrospinal fluid in clinical practice. Volume 1. Saunders Elsevier, Philadephia, PA; 2009. p. 233
   Google Scholar
• Jacobs S, McCully CL, Murphy RF, Extracellular fluid concentrations of cisplatin, carboplatin, and oxaliplatin in brain, muscle, and blood measured using microdialysis in nonhuman primates. Cancer Chemother Pharmacol 2010;65(5):817-24
   PubMed Web of Science ®Google Scholar
• Portnow J, Badie B, Chen M, The neuropharmacokinetics of temozolomide in patients with resectable brain tumors: potential implications for the current approach to chemoradiation. Clin Cancer Res 2009;15(22):7092-8
   PubMed Web of Science ®Google Scholar
• Lovich MA, Edelman ER. Tissue concentration of heparin, not administered dose, correlates with the biological response of injured arteries in vivo. Proc Natl Acad Sci USA 1999;96(20):11111-16
   PubMed Web of Science ®Google Scholar
• Clarke JL, Pao W, Wu N, High dose weekly erlotinib achieves therapeutic concentrations in CSF and is effective in leptomeningeal metastases from epidermal growth factor receptor mutant lung cancer. J Neurooncol 2010;99(2):283-6
   PubMed Web of Science ®Google Scholar
• Togashi Y, Masago K, Fukudo M, Cerebrospinal fluid concentration of erlotinib and its active metabolite OSI-420 in patients with central nervous system metastases of non-small cell lung cancer. J Thorac Oncol 2010;5(7):950-5
   PubMed Web of Science ®Google Scholar
• Lassman AB, Rossi MR, Raizer JJ, Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01. Clin Cancer Res 2005;11(21):7841-50
   PubMed Web of Science ®Google Scholar
• Raizer JJ, Abrey LE, Lassman AB, ; North American Brain Tumor Consortium. A Phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy. Neuro Oncol 2010;12(1):95-103
   PubMed Web of Science ®Google Scholar
• Holdhoff M, Supko JG, Gallia GL, Intratumoral concentrations of imatinib after oral administration in patients with glioblastoma multiforme. J Neurooncol 2010;97(2):241-5
   PubMed Web of Science ®Google Scholar
• Razis E, Selviaridis P, Labropoulos S, Phase II study of neoadjuvant imatinib in glioblastoma: evaluation of clinical and molecular effects of the treatment. Clin Cancer Res 2009;15(19):6258-66
   PubMed Web of Science ®Google Scholar
• Zamboni WC, Gervais AC, Egorin MJ, Inter- and intratumoral disposition of platinum in solid tumors after administration of cisplatin. Clin Cancer Res 2002;8(9):2992-9
   PubMed Web of Science ®Google Scholar
• Zamboni WC, Houghton PJ, Hulstein JL, Relationship between tumor extracellular fluid exposure to topotecan and tumor response in human neuroblastoma xenograft and cell lines. Cancer Chemother Pharmacol 1999;43(4):269-76
   PubMed Web of Science ®Google Scholar
• Zamboni WC, Stewart CF, Cheshire PJ, Studies of the efficacy and pharmacology of irinotecan against human colon tumor xenograft models. Clin Cancer Res 1998;4(3):743-53
   PubMed Web of Science ®Google Scholar
• Hutschala D, Kinstner C, Skhirtladze K, The impact of perioperative atelectasis on antibiotic penetration into lung tissue: an in vivo microdialysis study. Intensive Care Med 2008;34(10):1827-34
   PubMed Web of Science ®Google Scholar
• Karjagin J, Lefeuvre S, Oselin K, Pharmacokinetics of meropenem determined by microdialysis in the peritoneal fluid of patients with severe peritonitis associated with septic shock. Clin Pharmacol Ther 2008;83(3):452-9
   PubMed Web of Science ®Google Scholar
• Zeitlinger BS, Zeitlinger M, Leitner I, Clinical scoring system for the prediction of target site penetration of antimicrobials in patients with sepsis. Clin Pharmacokinet 2007;46(1):75-83
   PubMed Web of Science ®Google Scholar
• Bellmann R, Kuchling G, Dehghanyar P, Tissue pharmacokinetics of levofloxacin in human soft tissue infections. Br J Clin Pharmacol 2004, 57(5):563-8
   PubMed Web of Science ®Google Scholar
• Tomaselli F, Maier A, Matzi V, Penetration of meropenem into pneumonic human lung tissue as measured by in vivo microdialysis. Antimicrob Agents Chemother 2004;48(6):2228-32
   PubMed Web of Science ®Google Scholar
• Presant CA, Wolf W, Waluch V, Association of intratumoral pharmacokinetics of fluorouracil with clinical response. Lancet 1994;343(8907):1184-7
   PubMed Web of Science ®Google Scholar
• Chaurasia CS, Muller M, Bashaw ED, AAPS-FDA workshop white paper: microdialysis principles, application and regulatory perspectives. Pharm Res 2007;24(5):1014-25
   PubMed Web of Science ®Google Scholar
• Ungerstedt U. Microdialysis–principles and applications for studies in animals and man. J Intern Med 1991;230(4):365-73
   PubMed Web of Science ®Google Scholar
• de Lange EC, de Boer BA, Breimer DD. Microdialysis for pharmacokinetic analysis of drug transport to the brain. Adv Drug Deliv Rev 1999;36(2-3):211-27
   PubMed Web of Science ®Google Scholar
• de Lange EC, Danhof M, de Boer AG, Breimer DD. Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier. Brain Res Brain Res Rev 1997;25(1):27-49
   PubMed Web of Science ®Google Scholar
• Brunner M, Derendorf H. Clinical microdialysis: current applications and potential use in drug development. Trends Anal Chem 2006;25(7):674-80
   Web of Science ®Google Scholar
• Elmquist WF, Sawchuk RJ. Application of microdialysis in pharmacokinetic studies. Pharm Res 1997;14(3):267-88
   PubMed Web of Science ®Google Scholar
• Muller M. Microdialysis in clinical drug delivery studies. Adv Drug Deliv Rev 2000;45(2-3):255-69
   PubMed Web of Science ®Google Scholar
• de Lange EC, de Vries JD, Zurcher C, The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain. Pharm Res 1995;12(12):1924-31
   PubMed Web of Science ®Google Scholar
• Konings IR, Engels FK, Sleijfer S, Application of prolonged microdialysis sampling in carboplatin-treated cancer patients. Cancer Chemother Pharmacol 2009;64(3):509-16
   PubMed Web of Science ®Google Scholar
• Zhou Q, Gallo JM. In vivo microdialysis for PK and PD studies of anticancer drugs. AAPS J 2005;7(3):E659-67
   PubMed Web of Science ®Google Scholar
• Loos WJ, Zamboni WC, Engels FK, Pitfalls of the application of microdialysis in clinical oncology: controversial findings with docetaxel. J Pharm Biomed Anal 2007;45(2):288-94
   PubMed Web of Science ®Google Scholar
• Schuck VJ, Rinas I, Derendorf H. In vitro microdialysis sampling of docetaxel. J Pharm Biomed Anal 2004;36(4):807-13
   PubMed Web of Science ®Google Scholar
• Chu J, Gallo JM. Application of microdialysis to characterize drug disposition in tumors. Adv Drug Deliv Rev 2000;45(2-3):243-53
   PubMed Web of Science ®Google Scholar
• Kehr J. A survey on quantitative microdialysis: theoretical models and practical implications. J Neurosci Methods 1993;48(3):251-61
   PubMed Web of Science ®Google Scholar
• Lonnroth P, Jansson PA, Smith U. A microdialysis method allowing characterization of intercellular water space in humans. Am J Physiol 1987;253(2 Pt 1):E228-31
   PubMed Web of Science ®Google Scholar
• Olson RJ, Justice JB Jr. Quantitative microdialysis under transient conditions. Anal Chem 1993;65(8):1017-22
   PubMed Web of Science ®Google Scholar
• Wang Y, Wong SL, Sawchuk RJ. Microdialysis calibration using retrodialysis and zero-net flux: application to a study of the distribution of zidovudine to rabbit cerebrospinal fluid and thalamus. Pharm Res 1993;10(10):1411-19
   PubMed Web of Science ®Google Scholar
• Carcaboso AM, Elmeliegy MA, Shen J, Tyrosine kinase inhibitor gefitinib enhances topotecan penetration of gliomas. Cancer Res 2010;70(11):4499-508
   PubMed Web of Science ®Google Scholar
• Jacobs S, McCully CL, Murphy RF, Extracellular fluid concentrations of cisplatin, carboplatin, and oxaliplatin in brain, muscle, and blood measured using microdialysis in nonhuman primates. Cancer Chemother Pharmacol 2010;65(5):817-24
   PubMed Web of Science ®Google Scholar
• Sani SN, Henry K, Bohlke M, The effects of drug transporter inhibitors on the pharmacokinetics and tissue distribution of methotrexate in normal and tumor-bearing mice: a microdialysis study. Cancer Chemother Pharmacol 2010;66(1):159-69
   PubMed Web of Science ®Google Scholar
• Apparaju SK, Gudelsky GA, Desai PB. Pharmacokinetics of gemcitabine in tumor and non-tumor extracellular fluid of brain: an in vivo assessment in rats employing intracerebral microdialysis. Cancer Chemother Pharmacol 2008;61(2):223-9
   PubMed Web of Science ®Google Scholar
• Zhou Q, Guo P, Kruh GD, Predicting human tumor drug concentrations from a preclinical pharmacokinetic model of temozolomide brain disposition. Clin Cancer Res 2007;13(14):4271-9
   PubMed Web of Science ®Google Scholar
• Zamboni WC, Gervais AC, Egorin MJ, Systemic and tumor disposition of platinum after administration of cisplatin or STEALTH liposomal-cisplatin formulations (SPI-077 and SPI-077 B103) in a preclinical tumor model of melanoma. Cancer Chemother Pharmacol 2004;53(4):329-36
   PubMed Web of Science ®Google Scholar
• Dukic SF, Kaltenbach ML, Heurtaux T, Influence of C6 and CNS1 brain tumors on methotrexate pharmacokinetics in plasma and brain tissue. J Neurooncol 2004;67(1-2):131-8
   PubMed Web of Science ®Google Scholar
• Johansen MJ, Thapar N, Newman RA, Madden T. Use of microdialysis to study platinum anticancer agent pharmacokinetics in preclinical models. J Exp Ther Oncol 2002;2(3):163-73
   PubMedGoogle Scholar
• Ma J, Li S, Reed K, Pharmacodynamic-mediated effects of the angiogenesis inhibitor SU5416 on the tumor disposition of temozolomide in subcutaneous and intracerebral glioma xenograft models. J Pharmacol Exp Ther 2003;305(3):833-9
   PubMed Web of Science ®Google Scholar
• Ma J, Pulfer S, Li S, Pharmacodynamic-mediated reduction of temozolomide tumor concentrations by the angiogenesis inhibitor TNP-470. Cancer Res 2001;61(14):5491-8
   PubMed Web of Science ®Google Scholar
• Devineni D, Klein-Szanto A, Gallo JM. Uptake of temozolomide in a rat glioma model in the presence and absence of the angiogenesis inhibitor TNP-470. Cancer Res 1996;56(9):1983-7
   PubMed Web of Science ®Google Scholar
• Devineni D, Klein-Szanto A, Gallo JM. In vivo microdialysis to characterize drug transport in brain tumors: analysis of methotrexate uptake in rat glioma-2 (RG-2)-bearing rats. Cancer Chemother Pharmacol 1996;38(6):499-507
   PubMed Web of Science ®Google Scholar
• Brunner M, Muller M. Microdialysis: an in vivo approach for measuring drug delivery in oncology. Eur J Clin Pharmacol 2002;58(4):227-34
   PubMed Web of Science ®Google Scholar
• Hunz M, Jetter A, Warm M, Plasma and tissue pharmacokinetics of epirubicin and Paclitaxel in patients receiving neoadjuvant chemotherapy for locally advanced primary breast cancer. Clin Pharmacol Ther 2007;81(5):659-68
   PubMed Web of Science ®Google Scholar
• Mader RM, Schrolnberger C, Rizovski B, Penetration of capecitabine and its metabolites into malignant and healthy tissues of patients with advanced breast cancer. Br J Cancer 2003;88(5):782-7
   PubMed Web of Science ®Google Scholar
• Muller M, Mader RM, Steiner B, 5-Fluorouracil kinetics in the interstitial tumor space: clinical response in breast cancer patients. Cancer Res 1997;57(13):2598-601
   PubMed Web of Science ®Google Scholar
• Joukhadar C, Klein N, Mader RM, Penetration of dacarbazine and its active metabolite 5-aminoimidazole-4-carboxamide into cutaneous metastases of human malignant melanoma. Cancer 2001;92(8):2190-6
   PubMed Web of Science ®Google Scholar
• Tegeder I, Brautigam L, Seegel M, Cisplatin tumor concentrations after intra-arterial cisplatin infusion or embolization in patients with oral cancer. Clin Pharmacol Ther 2003;73(5):417-26
   PubMed Web of Science ®Google Scholar
• Benveniste H. Brain microdialysis. J Neurochem 1989;52(6):1667-79
   PubMed Web of Science ®Google Scholar
• Salci K, Nilsson P, Howells T, Intracerebral microdialysis and intracranial compliance monitoring of patients with traumatic brain injury. J Clin Monit Comput 2006;20(1):25-31
   PubMedGoogle Scholar
• Vespa P, Boonyaputthikul R, McArthur DL, Intensive insulin therapy reduces microdialysis glucose values without altering glucose utilization or improving the lactate/pyruvate ratio after traumatic brain injury. Crit Care Med 2006;34(3):850-6
   PubMed Web of Science ®Google Scholar
• Chan TV, Ng SC, Lam JM, Monitoring of autoregulation using intracerebral microdialysis in patients with severe head injury. Acta Neurochir Suppl 2005;95:113-16
   PubMedGoogle Scholar
• Vespa P, Bergsneider M, Hattori N, Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study. J Cereb Blood Flow Metab 2005;25(6):763-74
   PubMed Web of Science ®Google Scholar
• Vespa PM, McArthur D, O'Phelan K, Persistently low extracellular glucose correlates with poor outcome 6 months after human traumatic brain injury despite a lack of increased lactate: a microdialysis study. J Cereb Blood Flow Metab 2003;23(7):865-77
   PubMed Web of Science ®Google Scholar
• Goodman JC, Valadka AB, Gopinath SP, Extracellular lactate and glucose alterations in the brain after head injury measured by microdialysis. Crit Care Med 1999;27(9):1965-73
   PubMed Web of Science ®Google Scholar
• Wang E, Ho CL, Lee KK, Changes in brain biochemistry and oxygenation in the zone surrounding primary intracerebral hemorrhage. Acta Neurochir Suppl 2008;102:293-7
   PubMedGoogle Scholar
• Miller CM, Vespa PM, McArthur DL, Frameless stereotactic aspiration and thrombolysis of deep intracerebral hemorrhage is associated with reduced levels of extracellular cerebral glutamate and unchanged lactate pyruvate ratios. Neurocrit Care 2007;6(1):22-9
   PubMed Web of Science ®Google Scholar
• Nilsson OG, Polito A, Saveland H, Are primary supratentorial intracerebral hemorrhages surrounded by a biochemical penumbra? A microdialysis study. Neurosurgery 2006;59(3):521-8; discussion 521-8
   PubMed Web of Science ®Google Scholar
• Sarrafzadeh AS, Sakowitz OW, Kiening KL, Bedside microdialysis: a tool to monitor cerebral metabolism in subarachnoid hemorrhage patients? Crit Care Med 2002;30(5):1062-70
   PubMed Web of Science ®Google Scholar
• Kett-White R, Hutchinson PJ, Al-Rawi PG, Adverse cerebral events detected after subarachnoid hemorrhage using brain oxygen and microdialysis probes. Neurosurgery 2002;50(6):1213-21; discussion 1221-2
   PubMed Web of Science ®Google Scholar
• Staub F, Graf R, Gabel P, Multiple interstitial substances measured by microdialysis in patients with subarachnoid hemorrhage. Neurosurgery 2000;47(5):1106-15; discussion 1115-16
   PubMed Web of Science ®Google Scholar
• During MJ, Spencer DD. Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain. Lancet 1993;341(8861):1607-10
   PubMed Web of Science ®Google Scholar
• Poca MA, Sahuquillo J, Vilalta A, Percutaneous implantation of cerebral microdialysis catheters by twist-drill craniostomy in neurocritical patients: description of the technique and results of a feasibility study in 97 patients. J Neurotrauma 2006;23(10):1510-17
   PubMed Web of Science ®Google Scholar
• Bergenheim AT, Capala J, Roslin M, Henriksson R. Distribution of BPA and metabolic assessment in glioblastoma patients during BNCT treatment: a microdialysis study. J Neurooncol 2005;71(3):287-93
   PubMed Web of Science ®Google Scholar
• Benjamin RK, Hochberg FH, Fox E, Review of microdialysis in brain tumors, from concept to application: first annual Carolyn Frye-Halloran symposium. Neuro Oncol 2004;6(1):65-74
   PubMed Web of Science ®Google Scholar
• Ruggeri M, Zoli M, Grimaldi R, Aspects of neural plasticity in the central nervous system-III. Methodological studies on the microdialysis technique. Neurochem Int 1990;16(4):427-35
   PubMed Web of Science ®Google Scholar
• Benveniste H, Diemer NH. Cellular reactions to implantation of a microdialysis tube in the rat hippocampus. Acta Neuropathol 1987;74(3):234-8
   PubMed Web of Science ®Google Scholar
• Lindberger M, Tomson T, Lars S. Microdialysis sampling of carbamazepine, phenytoin and phenobarbital in subcutaneous extracellular fluid and subdural cerebrospinal fluid in humans: an in vitro and in vivo study of adsorption to the sampling device. Pharmacol Toxicol 2002;91(4):158-65
   PubMedGoogle Scholar
• Scheyer RD, During MJ, Hochholzer JM, Phenytoin concentrations in the human brain: an in vivo microdialysis study. Epilepsy Res 1994;18(3):227-32
   PubMed Web of Science ®Google Scholar
• Hau P, Fabel K, Baumgart U, Pegylated liposomal doxorubicin-efficacy in patients with recurrent high-grade glioma. Cancer 2004;100(6):1199-207
   PubMed Web of Science ®Google Scholar
• Mindermann T, Zimmerli W, Gratzl O. Rifampin concentrations in various compartments of the human brain: a novel method for determining drug levels in the cerebral extracellular space. Antimicrob Agents Chemother 1998;42(10):2626-9
   PubMed Web of Science ®Google Scholar
• Dhodapkar M, Rubin J, Reid JM, Phase I trial of temozolomide (NSC 362856) in patients with advanced cancer. Clin Cancer Res 1997;3(7):1093-100
   PubMed Web of Science ®Google Scholar
• Reid JM, Stevens DC, Rubin J, Ames MM. Pharmacokinetics of 3-methyl-(triazen-1-yl)imidazole-4-carboximide following administration of temozolomide to patients with advanced cancer. Clin Cancer Res 1997;3(12 Pt 1):2393-8
   PubMed Web of Science ®Google Scholar
• Morgan ME, Singhal D, Anderson BD. Quantitative assessment of blood-brain barrier damage during microdialysis. J Pharmacol Exp Ther 1996;277(2):1167-76
   PubMed Web of Science ®Google Scholar
• Groothuis DR, Ward S, Schlageter KE, Changes in blood-brain barrier permeability associated with insertion of brain cannulas and microdialysis probes. Brain Res 1998;803(1-2):218-30
   PubMed Web of Science ®Google Scholar
• Terasaki T, Deguchi Y, Kasama Y, Determination of in vivo steady-state unbound drug concentration in the brain interstitial fluid by microdialysis. Int J Pharmaceut 1992;81:143-52
   Web of Science ®Google Scholar
• Tossman U, Ungerstedt U. Microdialysis in the study of extracellular levels of amino acids in the rat brain. Acta Physiol Scand 1986;128(1):9-14
   PubMedGoogle Scholar
• Marklund N, Blennow K, Zetterberg H, Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury. J Neurosurg 2009;110(6):1227-37
   PubMed Web of Science ®Google Scholar
• Mellergard P, Aneman O, Sjogren F, Changes in extracellular concentrations of some cytokines, chemokines, and neurotrophic factors after insertion of intracerebral microdialysis catheters in neurosurgical patients. Neurosurgery 2008;62(1):151-7, discussion 157-8
   PubMed Web of Science ®Google Scholar
• Hillman J, Aneman O, Persson M, Variations in the response of interleukins in neurosurgical intensive care patients monitored using intracerebral microdialysis. J Neurosurg 2007;106(5):820-5
   PubMed Web of Science ®Google Scholar
• Waelgaard L, Pharo A, Tonnessen TI, Mollnes TE. Microdialysis for monitoring inflammation: efficient recovery of cytokines and anaphylotoxins provided optimal catheter pore size and fluid velocity conditions. Scand J Immunol 2006;64(3):345-52
   PubMed Web of Science ®Google Scholar
• Clough GF. Microdialysis of large molecules. AAPS J 2005;7(3):E686-92
   PubMed Web of Science ®Google Scholar
• Hillman J, Aneman O, Anderson C, A microdialysis technique for routine measurement of macromolecules in the injured human brain. Neurosurgery 2005;56(6):1264-8, discussion 1268-70
   PubMed Web of Science ®Google Scholar
• Hutchinson PJ, O'Connell MT, Nortje J, Cerebral microdialysis methodology–evaluation of 20 kDa and 100 kDa catheters. Physiol Meas 2005;26(4):423-8
   PubMed Web of Science ®Google Scholar
• Badie B, Chen M, Synold T, Portnow J. Assessment of the peritumoral micro-environment following craniotomy using intracerebral microdialysis [abstract #558]. Neuro Oncol 2009;11(5):690
   Google Scholar
• Zhou Q, Gallo JM. Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model. Neuro Oncol 2009;11(3):301-10
   PubMed Web of Science ®Google Scholar
• Friedman HS, Prados MD, Wen PY, Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol 2009;27(28):4733-40
   PubMed Web of Science ®Google Scholar
• Hunz M, Jetter A, Warm M, Plasma and tissue pharmacokinetics of epirubicin and Paclitaxel in patients receiving neoadjuvant chemotherapy for locally advanced primary breast cancer. Clin Pharmacol Ther 2007;81(5):659-68
   PubMed Web of Science ®Google Scholar
• Thompson JF, Siebert GA, Anissimov YG, Microdialysis and response during regional chemotherapy by isolated limb infusion of melphalan for limb malignancies. Br J Cancer 2001;85(2):157-65
   PubMed Web of Science ®Google Scholar