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Original Research

Identification of the metabolites of myricitrin produced by human intestinal bacteria in vitro using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry

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Bibliography

  • Chen W, Zhuang J, Li Y, et al. Myricitrin protects against peroxynitrite-mediated DNA damage and cytotoxicity in astrocytes. Food Chem 2013;141:927-33
  • Sun GB, Qin M, Ye JX, et al. Inhibitory effects of myricitrin on oxidative stress-induced endothelialdamage and early atherosclerosis in ApoE/ mice. Toxicol Appl Pharmacol 2013;271:114-26
  • Pereira M, Siba IP, Chioca LR, et al. Myricitrin, a nitric oxide and protein kinase C inhibitor, exerts antipsychotic-like effects in animal models. Prog Neuropsychopharmacol Biol Psychiatry 2011;35:1636-44
  • Kim HH, Kim DH, Kim MH, et al. Flavonoid constituents in the leaves of Myrica rubra sieb. et zucc. with anti-inflammatory activity. Arch Pharm Res 2013;36:1533-40
  • Yoshimura M, Yamakami S, Amakura Y, et al. Diarylheptanoid sulfates and related compounds from Myrica rubra bark. J Nat Prod 2012;75:1798-802
  • Schutte ME, van de Sandt JJ, Alink GM, et al. Myricetin stimulates the absorption of the pro-carcinogen PhIP. Cancer Lett 2006;231:36-42
  • Meotti FC, Luiz AP, Pizzolatti MG, et al. Analysis of the antinociceptive effect of the flavonoid myricitrin: evidence for a role of the L-arginine-nitric oxide and protein kinase C pathways. J Pharmacol Exp Ther 2006;316:789-96
  • Chen W, Feng L, Shen Y, et al. Myricitrin inhibits acrylamide-mediated cytotoxicity in human Caco-2 cells by preventing oxidative stress. Biomed Res Int 2013;2013:724183
  • Eckburg PB, Bik EM, Bernstein CN, et al. Diversity of the human intestinal microbial flora. Science 2005;308:1635-8
  • Proctor LM. The human microbiome project in 2011 and beyond. Cell Host Microbe 2011;10:287-91
  • Blaut M, Braune A, Wunderlich S, et al. Mutagenicity of arbutin in mammalian cells after activation by human intestinal bacteria. Food Chem Toxicol 2006;44:1940-7
  • Sousa T, Paterson R, Moore V, et al. The gastrointestinal microbiota as a site for the biotransformation of drugs. Int J Pharm 2008;363:1-25
  • Kang MJ, Kim HG, Kim JS, et al. The effect of gut microbiota on drug metabolism. Expert Opin Drug Metab Toxicol 2013;9:1295-308
  • Shen H, Leung WI, Ruan JQ, et al. Biotransformation of ginsenoside Rb1 via the gypenoside pathway by human gut bacteria. Chin Med 2013;8(1):22
  • Ye R, Kong X, Yang Q, et al. Ginsenoside Rd attenuates redox imbalance and improves stroke outcome after focal cerebral ischemia in aged mice. Neuropharmacology 2011;61:815-24
  • Shen J, Yang C, Wu C, et al. Identification of the major metabolites of quinocetone in swine urine using ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Commun Mass Spectrom 2010;24:375-83
  • Han H, Yang L, Xu Y, et al. Identification of metabolites of geniposide in rat urine using ultra-performance liquid chromatography combined with electrospray ionization quadrupole time-of-flight tandem mass spectrometry. Rapid Commun Mass Spectrom 2011;25:3339-50
  • Hur HG, Lay JO Jr, Beger RD, et al. Isolation of human intestinal bacteria metabolizing the natural isoflavone glycosides daidzin and genistin. Arch Microbiol 2000;174:422-8
  • Minamida K, Tanaka M, Abe A, et al. Production of equol from daidzein by gram-positive rod-shaped bacterium isolated from rat intestine. J Biosci Bioeng 2006;102:247-50
  • Iqbal M, Alam A, Wani TA, et al. Simultaneous determination of reserpine, rescinnamine, and yohimbine in human plasma by ultraperformance liquid chromatography tandem mass spectrometry. J Anal Methods Chem 2013;2013:940861
  • Ishii S, Sadowsky MJ. Escherichia coli in the environment: implications for water quality and human health. Microbes Environ 2008;23:101-8
  • Nirmala P, Ramanathan M. Effect of myricetin on 1, 2 dimethylhydrazine induced rat colon carcinogenesis. J Exp Ther Oncol 2011;9:101-8
  • DeToma AS, Choi JS, Braymer JJ, et al. Myricetin: a naturally occurring regulator of metal-induced amyloid-beta aggregation and neurotoxicity. Chembiochem 2011;12:1198-201
  • Liu IM, Liou SS, Lan TW, et al. Myricetin as the active principle of Abelmoschus moschatus to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med 2005;71:617-21
  • Jung SK, Lee KW, Kim HY, et al. Myricetin suppresses UVB-induced wrinkle formation and MMP-9 expression by inhibiting Raf. Biochem Pharmacol 2010;79:1455-61
  • Shin JC, Jung HY, Harikishore A, et al. The flavonoid myricetin reduces nocturnal melatonin levels in the blood through the inhibition of serotonin N-acetyltransferase. Biochem Biophys Res Commun 2013;440:312-16
  • Yokomizo A, Moriwaki M. Myricitrin degraded by simulated digestion inhibits oxidation of human low-density lipoprotein. Biosci Biotechnol Biochem 2005;69:693-9
  • Ma X, Tian W, Wu L, et al. Isolation of quercetin-3-O-L-rhamnoside from Acer truncatum Bunge by high-speed counter-current chromatography. J Chromatogr A 2005;1070:211-14
  • Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 2008;585:325-37
  • Kleemann R, Verschuren L, Morrison M, et al. Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models. Atherosclerosis 2011;218:44-52
  • Dajas F. Life or death: neuroprotective and anticancer effects of quercetin. J Ethnopharmacol 2012;143:383-96
  • Masimirembwa CM, Bredberg U, Andersson TB. Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges. Clin Pharmacokinet 2003;42:515-28
  • Gomez-Lechon MJ, Castell JV, Donatoa MT. Hepatocytes-the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo. Chem Biol Interact 2007;168:30-50
  • Graefe EU, Wittig J, Mueller S, et al. Pharmacokinetics and bioavailability of quercetin glycosides in humans. J Clin Pharmacol 2001;41:492-9

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