121
Views
5
CrossRef citations to date
0
Altmetric
Drug Evaluation

Nifedipine gastrointestinal therapeutic system: an overview of its antiatherosclerotic effects

, MD PhD, , MD PhD, , MD & , MD PhD
Pages 769-780 | Published online: 19 Oct 2007

Bibliography

  • SANZ J, MORENO PR, FUSTER V: The year in atherothrombosis. J. Am. Coll. Cardiol. (2007) 49(16):1740-1749.
  • FADINI GP, AGOSTINI C, SARTORE S, AVOGARO A: Endothelial progenitor cells in the natural history of atherosclerosis. Atherosclerosis (2007):(In Press).
  • LIBBY P: Inflammation in atherosclerosis. Nature (2002) 420:868-874.
  • LIBBY P, RIDKER PM, MASERI A: Inflammation and atherosclerosis. Circulation (2002) 105:1135-1143.
  • HIRSCH EZ, CHISOLM GM III, WHITE HM: Reendothelialization and maintenance of endothelial integrity in longitudinal denuded tracks in the thoracic aorta of rats. Atherosclerosis (1983) 46:287-307.
  • ASAHARA T, MUROHARA T, SULLIVAN A et al.: Isolation of putative progenitor endothelial cells for angiogenesis. Science (1997) 275:964-967.
  • REIDY MA, BOWYER DE: Distortion of endothelial repair. The effect of hypercholesterolaemia on regeneration of aortic endothelium following injury by endotoxin. A scanning electron microscope study. Atherosclerosis (1978) 29:459-466.
  • GALLO R, BADIMON JJ, FUSTER V: Pathobiology of coronary ischemic events: clinical implications. Adv. Int. Med. (1998) 43:203-232.
  • JANOWITZ WR, AGATSTON AS, KAPLAN G et al.: Differences in prevalence and extent of coronary artery calcium detected by ultrafast computed tomography in asymptomatic men and women. Am. J. Cardiol. (1993) 72:247-254.
  • FRONTINI MG, SRINIVASAN SR, XU JH et al.: Utility of non-high-density lipoprotein cholesterol versus other lipoprotein measures in detecting subclinical atherosclerosis in young adults (The Bogalusa heart study). Am. J. Cardiol. (2007) 100:64-68.
  • BERENSON GS, SRINIVASAN SR, BAO W: Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa heart study. N. Engl. J. Med. (1998) 338:1650-1656.
  • LI S, CHEN W, SRINIVASAN SR et al.: Childhood cardiovascular risk factors and carotid vascular changes in adulthood: the Bogalusa heart study. JAMA (2003) 290:2271-2276.
  • BERENSON GS: Childhood risk factors predict adult risk associated with subclinical cardiovascular disease. The Bogalusa heart study. Am. J. Cardiol. (2002) 90:L3-L7.
  • PAUL TK, SRINIVASAN SR, BOND MG et al.: Cardiovascular risk profile of asymptomatic healthy young adults with increased femoral artery intima-media thickness: the Bogalusa heart study. Am. J. Med. Sci. (2005) 330:105-110.
  • STRONG JP, MALCOLM GT, MCMAHAN CA et al.: Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the pathobiological determinants of atherosclerosis in youth study. JAMA (1999) 281:727-735.
  • KIECHL S, WILLEIT J: The natural course of atherosclerosis. Part I. Incidence and progression. Arterioscler. Thromb. Vasc. Biol. (1999) 19:1484-1490.
  • WAXMAN S, ISHIBASHI F, MULLER JE: Detection and treatment of vulnerable plaques and vulnerable patients: novel approaches to prevention of coronary events. Circulation (2006) 114:2390-2411.
  • LAROSA JC, HE J, VUPPUTURI S: Effects of statins on risk of coronary disease. A meta-analysis of randomized controlled trials. JAMA (1999) 282:2340-2346.
  • NCEP EXPERT PANEL: Executive summary of the third report of the National cholesterol education program (NCEP) expert panel on detection, evaluation and treatment of high blood cholesterol in adults (Adult treatment panel III). JAMA (2001) 285:2486-2497.
  • HOCKERMAN GH, PETERSON BZ, JOHNSON BD, CATTERALL WA: Molecular determinants of drug binding and action on L-type calcium channels. Annu. Rev. Pharmacol. Toxicol. (1997) 37:361-396.
  • HAMADA T, WATANABE M, KANEDA T et al.: Evaluation of changes in sympathetic nerve activity and heart rate in essential hypertensive patients induced by amlodipine and nifedipine. J. Hypertens. (1998) 16:111-118.
  • WENZEL RR, ALLEGRANZA G, BINGGELI C et al.: Differential activation of cardiac and peripheral sympathetic nervous system by nifedpine: role of pharmacokinetics. J. Am. Coll. Cardiol. (1997) 29:1607-1614.
  • SWANSON DR, BARCLAY BL, WONG PS, THEEUWES F: Nifedipine gastrointestinal therapeutic system. Am. J. Med. (1987) 83(6B):3-9.
  • BREEKVELDT-POSTMA NS, HERINGS RMC: Persistence with antihypertensives related to formulation: the case of nifedipine. Ann. Pharmacother. (2005) 39(2):237-242.
  • MURDOCH D, BROGDEN RN: Sustained release nifedipine formulations: an appraisal of their current uses and prospective roles in the treatment of hypertension, ischaemic heart disease and peripheral vascular disorders. Drugs (1991) 41(5):737-779.
  • BROGDEN RN, McTAVISH D: Nifedipine gastrointestinal therapeutic system (GITS): a review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in hypertension and angina pectoris. Drugs (1995) 50(3):495-512.
  • TING C-T, CHEN J-W, CHANG M-S et al.: Arterial hemodynamics in human hypertension: effects of the calcium channel antagonist nifedipine. Hypertension (1995) 25:1326-1332.
  • BIRKEBAEK NH, GERDES LU, NIELSEN A, FAERGEMAN O, VEJBY-CHRISTENSEN H: Effect of nifedipine and captopril on plasma lipoproteins in hypertensive patients. Curr. Ther. Res. (1989) 46:619-624.
  • LEHTONEN A, TANSKANEN A, LEHTO H, JARVENSIVEN F: The effect of nifedipine on plasma lipids in patients with essential hypertension. Int. J. Clin. Pharmacol. Ther. Toxicol. (1986) 24:357-358.
  • PASANISI F, FERRARA AL, IOVINE C, MANCINI M: Effects of nifedipine on insulin secretion and plasma lipids in hypertensive patients. Curr. Ther. Res. (1986) 39:894-899.
  • HOUSTON MC, OLAFSSON L, BURGER MC, LICHTENSTEIN MJ: Effects of nifedipine GITS and atenolol monotherapy on serum lipids in mild to moderate hypertension. Clin. Res. (1990) 38:A542.
  • KAZUMI T, YOSHINO G, OKUTANI T et al.: Plasma lipoprotein and apolipoprotein concentrations and glycemic control during short-term treatment with nifedipine in hypertensive patients with Type II diabetes mellitus. Curr. Ther. Res. (1989) 46:951-958.
  • SASAKI J, ARAKAWA K: Effect of nifedipine on serum lipids, lipoproteins, and apolipoproteins in patients with essential hypertension. Curr. Ther. Res. (1987) 41:845-851.
  • GRUNDY JS, FOSTER RT: The nifedipine gastrointestinal therapeutic system (GITS): evaluation of pharmaceutical, pharmacokinetic and pharmacological properties. Clin. Pharmacokinet. (1996) 30(1):28-51.
  • SCHUG BS, BRENDEL E, WONNEMANN M et al.: Dosage form-related food interaction observed in a marketed once-daily nifedipine formulation after a high-fat American breakfast. Eur. J. Clin. Pharmacol. (2002) 58(2):119-125.
  • CHUNG M, REITBERG DP, GAFFNEY M, SINGLETON W: Clinical pharmacokinetics of nifedipine gastrointestinal therapeutic system: a controlled-release formulation of nifedipine. Am. J. Med. (1987) 83(Suppl. 6B):10-14.
  • CROOM KF, WELLINGTON K: Modified-release nifedipine: a review of the use of modified-release formulations in the treatment of hypertension and angina pectoris. Drugs (2006) 66(4):498-528.
  • NAKAO J, ITO H, OOYAMA T et al.: Calcium dependency of aortic smooth muscle cell migration induced by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid. Atherosclerosis (1983) 46:309-319.
  • NOMOTO A, HIROSUMI J, SEKIGUCHI C et al.: Antiatherogenic activity of FR34235 (nilvadipine) a new potent calcium antagonist. Atherosclerosis (1987) 64:255-261.
  • BETZ E: The effect of calcium antagonists on intimal cell proliferation in atherogenesis. Ann. NY Acad. Sci. (1988) 522:399-410.
  • BETZ E, HAMMERLE H, STROHSCHNEIDER T: Inhibition of smooth muscle cell proliferation and endothelial permeability with flunarizine in vitro and in experimental atheromas. Res. Exp. Med. (1985) 185:325-340.
  • STROHSCHNEIDER T, BETZ E: Densitometric measurement of increased endothelial permeability in arteriosclerotic plaques and inhibition of permeability under the influence of two calcium antagonists. Atherosclerosis (1989) 75:135-144.
  • HANDLEY DA, VAN VALEN RG, MELDEN MK et al.: Suppression of rat carotid lesion development by the calcium channel blocker PN 200-110. Am. J. Pathol. (1986) 124:88-93.
  • JACKSON LJ, BUSH RC, BOWYER DE: Inhibitory effect of calcium antagonists on balloon catheter-induced arterial smooth muscle cell proliferation and lesion size. Atherosclerosis (1988) 69:115-122.
  • GOTTO AM Jr: Calcium channel blockers and the prevention of atherosclerosis. Am. J. Hypertens. (1990) 3:S342-S346.
  • LICHTOR T: Antiatherosclerotic activity of nifedipine in primates. Cardiovasc. Drug Rev. (1988) 6:339 (Abstract).
  • SEUTER F: Antiatherosclerotic effects of nifedipine and nitrendipine in rats with experimental atherosclerosis. Cardiovasc. Drug Rev. (1988) 6:337.
  • THIERY J: The beneficial influence of nifedipine on the regression of cholesterol-induced atherosclerosis in rabbits. Cardiovasc. Drug Rev. (1988) 6:338-339 (Abstract).
  • HENRY PD, BENTLEY KI: Suppression of atherogenesis in cholesterol-fed rabbits treated with nifedipine. J. Clin. Invest. (1981) 68(5):1366-1369.
  • WILLIS AL, NAGEL B, CHURCHILL V et al.: Antiatherosclerotic effects of nicardipine and nifedipine in cholesterol-fed rabbits. Arteriosclerosis (1985) 5(3):250-255.
  • HAJJAR DP: Role of calcium channel antagonists as antiatherosclerotic agents. Cardiovasc. Drug Rev. (1988) 6:340-341.
  • BLUMLEIN SL, SIEVERS R, KIDD P et al.: Mechanism of protection from atherosclerosis by verapamil in the cholesterol-fed rabbit. Am. J. Cardiol. (1984) 54:884-889.
  • ROULEAU JL, PARMLEY WW, STEVENS J et al.: Verapamil suppresses atherosclerosis in cholesterol-fed rabbits. J. Am. Coll. Cardiol. (1983) 1:1453-1460.
  • SIEVERS RE, RASHID T, GARRETT J et al.: Verapamil and diet halt progression of atherosclerosis in cholesterol fed rabbits. Cardiovasc. Drugs Ther. (1987) 1:65-69.
  • GINSBURG R, DAVIS K, BRISTOW MB et al.: Calcium antagonists suppress atherogenesis in aorta but not in the intramural coronary arteries of cholesterol-fed rabbits. Lab. Invest. (1983) 49:154-158.
  • SUGANO M, NAKASHIMA Y, MATSUSHIMA T et al.: Suppression of atherosclerosis in cholesterol-fed rabbits by diltiazem injection. Arteriosclerosis (1986) 6:237-241.
  • SUGANO M, NAKASHIMA Y, TASAKI H et al.: Effects of diltiazem on suppression and regression of experimental atherosclerosis. Br. J. Exp. Pathol. (1988) 66:515-523.
  • DAUGHERTY A, RATERI DL: Development of experimental designs for atherosclerosis studies in mice. Methods (2005) 36:129-138.
  • WEINSTEIN DB, HEIDER JG: Antiatherogenic properties of calcium antagonists. Am. J. Cardiol. (1987) 59:B163-B172.
  • TSCHUDI MR, CRISCIONE L, NOVOSEL D, PFEIFFER K, LUSCHER TF: Antihypertensive therapy augments endothelium-dependent relaxations in coronary arteries of spontaneously hypertensive rats. Circulation (1994) 89:2212-2218.
  • HABIB JB, BOSSALLER C, WELLS S, WILLIAMS C, MORRISETT JD, HENRY PD: Preservation of endothelium-dependent vascular relaxation in cholesterol-fed rabbit by treatment with the calcium blocker PN 200110. Circ. Res. (1986) 58:305-309.
  • GUIDELINES COMMITTEE: 2003 European society of hypertension – European society of cardiology guidelines for the management of arterial hypertension. J. Hypertens. (2003) 21:1011-1153.
  • SIMON A, GARIEPY J, CHIRONI G, MEGNIEN JL, LEVENSON J: Intima-media thickness: a new tool for diagnosis and treatment of cardiovascular risk. J. Hypertens. (2002) 20(2):159-169.
  • LICHTLEN PR, HUGENHOLTZ PG, RAFFLENBEUL W et al.; on behalf of the INTACT GROUP INVESTIGATORS: Retardation of angiographic progression of coronary artery disease by nifedipine. Lancet (1990) 335:1109-1113.
  • FLECKENSTEIN A, FREY M, THIMM F, FLECKENSTEIN-GRUM G: Excessive mural calcium overload – a predominant causal factor in the development of stenosing coronary plaques in humans. Cardiovasc. Drugs Ther. (1990) 4(Suppl. 5):1005-1014.
  • SHINODA E, YUI Y, KODAMA K et al.: Comparison of nifedipine retard with angiotensis converting enzyme inhibitors in Japanese hypertensive patients with coronary artery disease: the Japan multicenter investigation for cardiovascular diseases-B (JMIC-B side arm study). The Japan multicenter investigation for cardiovascular diseases-B study group. Hypertension (2005) 45:1153-1158.
  • BROWN MJ, PALMER CR, CASTAIGNE A et al.: Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International nifedipine GITS study: intervention as a goal in hypertension treatment (INSIGHT). Lancet (2000) 356:366-372.
  • SELZER RH, HODIS HN, KWONG-FU H et al.: Evaluation of computerized edge tracking for quantifying intima-media thickness of the common carotid artery from B-mode ultrasound image. Atherosclerosis (1994) 111:1-11.
  • GRAF S, GARIEPY J, MASSONNEAU M et al.: Experimental and clinical validation of arterial diameter waveform and intimal media thickness obtained from B-mode ultrasound image processing. Ultrasound Med. Biol. (1999) 25:1353-1363.
  • CHOBANIAN AV: 1989 Corcoran lecture: adaptive and maladaptive response of the arterial wall to hypertension. Hypertension (1990) 15:666-674.
  • LAKKA TA, SALONEN R, KAPLAN GA, SALONEN JT: Blood pressure and the progression of carotid atherosclerosis in middle-aged men. Hypertension (1999) 34:51-56.
  • SIMON A, GARIEPY J, MOYSE D, LEVENSON J: Differential effects of nifedipine and co-amilozide on the progression of early carotid wall changes. Circulation (2001) 103:2949-2954.
  • WEINSTEIN DB, HEIDER JG: Antiatherogenic properties of the calcium antagonists. Am. J. Med. (1989) 86(4A):27-32.
  • HENRY PD: Atherogenesis, calcium and calcium antagonists. Am. J. Cardiol. (1990) 66:31-61.
  • MACARTHY JH, PALMER FJ: Incidence and significance of coronary artery calcification. Br. Heart J. (1974) 36:499-506.
  • MOTRO M, SHEMESH J: Calcium channel blocker nifedipine slows down progression of coronary calcification in hypertensive patients compared with diuretics. Hypertension (2001) 37:1410-1413.
  • SIMONS DB, SCHWARTZ RS, EDWARDS WD, SHEEDY PF, RUMBERGER JA: Noninvasive definition of anatomic coronary artery disease by ultrafast computed tomographic scanning: a quantitative pathologic comparison study. J. Am. Coll. Cardiol. (1992) 20:1118-1126.
  • RUMBERGER JA, SIMONS DB, FITZPATRICK LA, SHEEDY PF, SCHWARTZ RS: Coronary artery calcium area by electron-beam computed tomography and coronary atherosclerotic plaque area: a histopathologic correlative study. Circulation (1995) 92:2157-2162.
  • SHEMESH J, STROH CI, TENENBAUM A et al.: Comparison of coronary calcium in stable angina pectoris and in first acute myocardial infarction utilizing double helical computerized tomography. Am. J. Cardiol. (1998) 81:271-275.
  • DEVEREUX RB, ALDERMAN MH: The role of preclinical cardiovascular disease in the evolution from risk factor exposure to the development of clinical morbid events. Circulation (1993) 88:1444-1455.
  • KOREN MJ, DEVEREUX RB, CASALE PN, SAVAGE DD, LARAGH JH: Relation of left ventricular mass and geometry to morbidity and mortality in uncomplicated essential hypertension. Ann. Intern. Med. (1991) 114:345-352.
  • MENSAH GA, PAPPAS TW, KOREN MJ, ULIN RJ, LARAGH JH, DEVEREUX RB: Comparison of classification of hypertension severity by blood pressure level and World health organization criteria for prediction of concurrent cardiac abnormalities and subsequent complications in essential hypertension. J. Hypertens. (1993) 11:1429-1440.
  • LEVY D, GARRISON RJ, SAVAGE DD, KANNEL WB, CASTELLI WP: Prognostic implications of echocardiographically-determined left ventricular mass in the Framingham heart study. N. Engl. J. Med. (1990) 322:1561-1566.
  • BIKKINA M. LEVY D, EVANS JC et al.: Left ventricular mass and the risk of stroke in an elderly cohort: the Framingham study. JAMA (1994) 272:33-36.
  • GHALI JK, LIAO Y, SIMMONS B, CASTANER A, CAO G, COOPER RS: The prognostic role of left ventricular hypertrophy in patients with or without coronary artery disease. Ann. Intern. Med. (1992) 117:831-836.
  • BOLOGNESE L, DELLAVESA P, ROSSI L, SARASSO G, BONGO AS, SCIANARO MC: Prognostic value of left ventricular mass in uncomplicated acute myocardial infarction and one-vessel coronary artery disease. Am. J. Cardiol. (1994) 73:1-5.
  • DEVEREUX RB, PALMIERI V, SHARPE N et al.: Effects of once-daily angiotensin-converting enzyme enhibition and calcium channel blockade-based antihypertensive treatment regimens on left ventricular hypertrophy and diastolic filling in hypertension. The prospective randomized enalapril study evaluating regression of ventricular enlargement (PRESERVE) trial. Circulation (2001) 104:1248-1254.
  • DAHLOF B, PENNERT K, HANSSON L: Reversal of left ventricular hypertrophy in hypertensive patients: a metaanalysis of 109 treatment studies. Am. J. Hypertens. (1992) 5:95-110.
  • TADDEI S, VIRDIS A, GHIADONE L et al.: Restoration of nitric oxide availability after calcium antagonist treatment in essential hypertension. Hypertension (2001) 37:943-948.
  • THE ENCORE INVESTIGATORS: Effect of nifedipine and cerivastatin on coronary endothelial function in patients with coronary artery disease. The ENCORE I study. Circulation (2003) 107:422-428.
  • SCHELLEKENS S, VERHEUGT FWA: Hotline sessions of the 26th European congress of cardiology. Eur. Heart J. (2004) 25:2164-2166.
  • VERHAAR MC, HONING ML, VAN-DAM T et al.: Nifedipine improves endothelial function in hypercholesterolemia, independently of an effect on blood pressure or plasma lipids. Cardiovasc. Res. (1999) 42:752-760.
  • POOLE-WILSON PA, LUBSEN J, KIRWAN B-A et al.: Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial. Lancet (2004) 364:849-857.
  • LUBSEN J, WAGENER G, KIRWAN B-A et al.: Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with symptomatic stable angina and hypertension: the ACTION trial. J. Hypertens. (2005) 23(3):641-648.
  • LUBSEN J, VOKO Z, POOLE-WILSON PA et al.: Blood pressure reduction in stable angina by nifedipine was related to stroke and heart failure reduction but not to coronary interventions. J. Clin. Epidemiol. (2007) 60(7):720-726).
  • EISEN A, TENENBAUM A, KOREN-MORAG N et al.: Coronary and aortic calcifications inter-relationship in stable angina pectoris: a coronary disease trial investigating outcome with nifedipine GITS (ACTION) – Israeli spiral computed tomography substudy. Isr. Med. Assoc. J. (2007) 9:277-280.
  • TOAL CB, MAHON WA, BARNES C et al.: Nifedipine gastrointestinal therapeutic system (GITS) for hypertensive patients in a primary care setting: results of the extended release adalat Canadian trial (EXACT). The EXACT investigators. Clin. Ther. (1997) 19:924-935.
  • BAYER HEALTHCARE: Data on file (2006).
  • VERHAAR MC, HONING ML, VAN DAM T et al.: Nifedipine improves endothelial function in hypercholesterolemia, independently of an effect on blood pressure or plasma lipids. Cardiovasc. Res. (1999) 42:752-760.
  • National institute of clinical excellence. NICE clinical guideline 18. Management of hypertension in adults in primary care. August (2004).
  • The National collaborating centre for chronic conditions. Management of hypertension in adults in primary care: partial update. May (2006).

Websites

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.