133
Views
6
CrossRef citations to date
0
Altmetric
Reviews

Gene expression profiling to identify druggable targets in prion diseases

, PhD (Post doc) , (PhD student) , (PhD student) & , PhD (Associate Professor)
Pages 177-202 | Published online: 09 Jan 2010

Bibliography

  • Prusiner SB. Prions. Proc Natl Acad Sci USA 1998;95(23):13363-83
  • Doherr MG. Brief review on the epidemiology of transmissible spongiform encephalopathies (TSE). Vaccine 2007;25(30):5619-24
  • Legname G, Baskakov IV, Nguyen HO, Synthetic mammalian prions. Science 2004;305(5684):673-6
  • Hill AF, Antoniou M, Collinge J. Protease-resistant prion protein produced in vitro lacks detectable infectivity. J Gen Virol 1999;80(Pt 1):11-4
  • Cohen FE, Prusiner SB. Pathologic conformations of prion proteins. Annu Rev Biochem 1998;67:793-819
  • Telling GC, Parchi P, DeArmond SJ, Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity. Science 1996;274(5295):2079-82
  • Laurent M. Autocatalytic processes in cooperative mechanisms of prion diseases. FEBS Lett 1997;407(1):1-6
  • Telling GC, Haga T, Torchia M, Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice. Genes Dev 1996;10(14):1736-50
  • Kanaani J, Prusiner SB, Diacovo J, Recombinant prion protein induces rapid polarization and development of synapses in embryonic rat hippocampal neurons in vitro. J Neurochem 2005;95(5):1373-86
  • Lopes MH, Hajj GN, Muras AG, Interaction of cellular prion and stress-inducible protein 1 promotes neuritogenesis and neuroprotection by distinct signaling pathways. J Neurosci 2005;25(49):11330-9
  • Santuccione A, Sytnyk V, Leshchyns'ka I, Schachner M. Prion protein recruits its neuronal receptor NCAM to lipid rafts to activate p59fyn and to enhance neurite outgrowth. J Cell Biol 2005;169(2):341-54
  • Steele AD, Emsley JG, Ozdinler PH, Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. Proc Natl Acad Sci USA 2006;103(9):3416-21
  • Chen S, Mange A, Dong L, Prion protein as trans-interacting partner for neurons is involved in neurite outgrowth and neuronal survival. Mol Cell Neurosci 2003;22(2):227-33
  • Bounhar Y, Zhang Y, Goodyer CG, LeBlanc A. Prion protein protects human neurons against Bax-mediated apoptosis. J Biol Chem 2001;276(42):39145-9
  • Roucou X, Giannopoulos PN, Zhang Y, Cellular prion protein inhibits proapoptotic Bax conformational change in human neurons and in breast carcinoma MCF-7 cells. Cell Death Differ 2005;12(7):783-95
  • Shyu WC, Chen CP, Saeki K, Hypoglycemia enhances the expression of prion protein and heat-shock protein 70 in a mouse neuroblastoma cell line. J Neurosci Res 2005;80(6):887-94
  • Mitteregger G, Vosko M, Krebs B, The role of the octarepeat region in neuroprotective function of the cellular prion protein. Brain Pathol 2007;17(2):174-83
  • Milhavet O, Lehmann S. Oxidative stress and the prion protein in transmissible spongiform encephalopathies. Brain Res Brain Res Rev 2002;38(3):328-39
  • Schmitt-Ulms G, Legname G, Baldwin MA, Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion protein. J Mol Biol 2001;314(5):1209-25
  • Sales N, Rodolfo K, Hassig R, Cellular prion protein localization in rodent and primate brain. Eur J Neurosci 1998;10(7):2464-71
  • Sanchez-Alavez M, Conti B, Moroncini G, Criado JR. Contributions of neuronal prion protein on sleep recovery and stress response following sleep deprivation. Brain Res 2007;1158:71-80
  • Sanchez-Alavez M, Criado JR, Klein I, Hypothalamic-pituitary-adrenal axis disregulation in PrPC-null mice. Neuroreport 2008;19(15):1473-7
  • Tobler I, Gaus SE, Deboer T, Altered circadian activity rhythms and sleep in mice devoid of prion protein. Nature 1996;380(6575):639-42
  • Rachidi W, Chimienti F, Aouffen M, Prion protein protects against zinc-mediated cytotoxicity by modifying intracellular exchangeable zinc and inducing metallothionein expression. J Trace Elem Med Biol 2009;23(3):214-23
  • Nishida N, Tremblay P, Sugimoto T, A mouse prion protein transgene rescues mice deficient for the prion protein gene from purkinje cell degeneration and demyelination. Lab Invest 1999;79(6):689-97
  • Caughey B, Brown K, Raymond GJ, Binding of the protease-sensitive form of PrP (prion protein) to sulfated glycosaminoglycan and congo red [corrected]. J Virol 1994;68(4):2135-41
  • Yang Y, Adelstein SJ, Kassis AI. Target discovery from data mining approaches. Drug Discov Today 2009;14(3-4):147-54
  • di Bernardo D, Thompson MJ, Gardner TS, Chemogenomic profiling on a genome-wide scale using reverse-engineered gene networks. Nat Biotechnol 2005;23(3):377-83
  • Gardner TS, di Bernardo D, Lorenz D, Collins JJ. Inferring genetic networks and identifying compound mode of action via expression profiling. Science 2003;301(5629):102-5
  • Duguid JR, Rohwer RG, Seed B. Isolation of cDNAs of scrapie-modulated RNAs by subtractive hybridization of a cDNA library. Proc Natl Acad Sci USA 1988;85(15):5738-42
  • Duguid JR, Bohmont CW, Liu NG, Tourtellotte WW. Changes in brain gene expression shared by scrapie and Alzheimer disease. Proc Natl Acad Sci USA 1989;86(18):7260-4
  • Duguid JR, Dinauer MC. Library subtraction of in vitro cDNA libraries to identify differentially expressed genes in scrapie infection. Nucleic Acids Res 1990;18(9):2789-92
  • Brenner M, Johnson AB, Boespflug-Tanguy O, Mutations in GFAP, encoding glial fibrillary acidic protein, are associated with Alexander disease. Nat Genet 2001;27(1):117-20
  • Rodriguez D, Gauthier F, Bertini E, Infantile Alexander disease: spectrum of GFAP mutations and genotype-phenotype correlation. Am J Hum Genet 2001;69(5):1134-40
  • Aoki Y, Haginoya K, Munakata M, A novel mutation in glial fibrillary acidic protein gene in a patient with Alexander disease. Neurosci Lett 2001;312(2):71-4
  • Sawaishi Y, Yano T, Takaku I, Takada G. Juvenile Alexander disease with a novel mutation in glial fibrillary acidic protein gene. Neurology 2002;58(10):1541-3
  • Stumpf E, Masson H, Duquette A, Adult Alexander disease with autosomal dominant transmission: a distinct entity caused by mutation in the glial fibrillary acid protein gene. Arch Neurol 2003;60(9):1307-12
  • Brockmann K, Meins M, Taubert A, A novel GFAP mutation and disseminated white matter lesions: adult Alexander disease? Eur Neurol 2003;50(2):100-5
  • Duguid J, Trzepacz C. Major histocompatibility complex genes have an increased brain expression after scrapie infection. Proc Natl Acad Sci USA 1993;90(1):114-7
  • Ebadi M, Iversen PL, Hao R, Expression and regulation of brain metallothionein. Neurochem Int 1995;27(1):1-22
  • Karin M. Metallothioneins: proteins in search of function. Cell 1985;41(1):9-10
  • May PC, Finch CE. Sulfated glycoprotein 2: new relationships of this multifunctional protein to neurodegeneration. Trends Neurosci 1992;15(10):391-6
  • Stamatos C, Squicciarini J, Fine RE. Chick embryo spinal cord neurons synthesize a transferrin-like myotrophic protein. FEBS Lett 1983;153(2):387-90
  • Chowers I, Wong R, Dentchev T, The iron carrier transferrin is upregulated in retinas from patients with age-related macular degeneration. Invest Ophthalmol Vis Sci 2006;47(5):2135-40
  • Diedrich JF, Minnigan H, Carp RI, Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes. J Virol 1991;65(9):4759-68
  • Doh-ura K, Perryman S, Race R, Chesebro B. Identification of differentially expressed genes in scrapie-infected mouse neuroblastoma cells. Microb Pathog 1995;18(1):1-9
  • Cosseddu GM, Andreoletti O, Maestrale C, Gene expression profiling on sheep brain reveals differential transcripts in scrapie-affected/not-affected animals. Brain Res 2007;1142:217-22
  • Baker CA, Manuelidis L. Unique inflammatory RNA profiles of microglia in Creutzfeldt-Jakob disease. Proc Natl Acad Sci USA 2003;100(2):675-9
  • Greenwood AD, Horsch M, Stengel A, Cell line dependent RNA expression profiles of prion-infected mouse neuronal cells. J Mol Biol 2005;349(3):487-500
  • Martinez T, Pascual A. Identification of genes differentially expressed in SH-SY5Y neuroblastoma cells exposed to the prion peptide 106-126. Eur J Neurosci 2007;26(1):51-9
  • Xiang W, Windl O, Westner IM, Cerebral gene expression profiles in sporadic Creutzfeldt-Jakob disease. Ann Neurol 2005;58(2):242-57
  • Julius C, Hutter G, Wagner U, Transcriptional stability of cultured cells upon prion infection. J Mol Biol 2008;375(5):1222-33
  • Bach C, Gilch S, Rost R, Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells. J Biol Chem 2009;284(45):31260-9
  • Brown AR, Webb J, Rebus S, Identification of up-regulated genes by array analysis in scrapie-infected mouse brains. Neuropathol Appl Neurobiol 2004;30(5):555-67
  • Brown AR, Rebus S, McKimmie CS, Gene expression profiling of the preclinical scrapie-infected hippocampus. Biochem Biophys Res Commun 2005;334(1):86-95
  • Riemer C, Neidhold S, Burwinkel M, Gene expression profiling of scrapie-infected brain tissue. Biochem Biophys Res Commun 2004;323(2):556-64
  • Xiang W, Hummel M, Mitteregger G, Transcriptome analysis reveals altered cholesterol metabolism during the neurodegeneration in mouse scrapie model. J Neurochem 2007;102(3):834-47
  • Booth S, Bowman C, Baumgartner R, Identification of central nervous system genes involved in the host response to the scrapie agent during preclinical and clinical infection. J Gen Virol 2004;85(Pt 11):3459-71
  • Sorensen G, Medina S, Parchaliuk D, Comprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genes. BMC Genomics 2008;9:114
  • Skinner PJ, Abbassi H, Chesebro B, Gene expression alterations in brains of mice infected with three strains of scrapie. BMC Genomics 2006;7:114
  • Xiang W, Windl O, Wunsch G, Identification of differentially expressed genes in scrapie-infected mouse brains by using global gene expression technology. J Virol 2004;78(20):11051-60
  • Miele G, Seeger H, Marino D, Urinary alpha1-antichymotrypsin: a biomarker of prion infection. PLoS One 2008;3(12):e3870
  • Hwang D, Lee IY, Yoo H, A systems approach to prion disease. Mol Syst Biol 2009;5:252
  • Gehlenborg N, Hwang D, Lee IY, The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases. Database 2009, doi: 10.1093/database/bap011
  • Moody LR, Herbst AJ, Yoo HS, Comparative prion disease gene expression profiling using the prion disease mimetic, cuprizone. Prion 2009;3(2):99-109
  • Russelakis-Carneiro M, Saborio GP, Anderes L, Soto C. Changes in the glycosylation pattern of prion protein in murine scrapie. Implications for the mechanism of neurodegeneration in prion diseases. J Biol Chem 2002;277(39):36872-7
  • Barret A, Forestier L, Deslys JP, Glycosylation-related gene expression in prion diseases: PrPSc accumulation in scrapie infected GT1 cells depends on beta-1,4-linked GalNAc-4-SO4 hyposulfation. J Biol Chem 2005;280(11):10516-23
  • Guillerme-Bosselut F, Forestier L, Jayat-Vignoles C, Glycosylation-related gene expression profiling in the brain and spleen of scrapie-affected mouse. Glycobiology 2009;19(8):879-89
  • Aguzzi A, Heikenwalder M. Pathogenesis of prion diseases: current status and future outlook. Nat Rev Microbiol 2006;4:765-75
  • Comelli EM, Head SR, Gilmartin T, A focused microarray approach to functional glycomics: transcriptional regulation of the glycome. Glycobiology 2006;16(2):117-31
  • Costa C, Tortosa R, Vidal E, Central nervous system extracellular matrix changes in a transgenic mouse model of bovine spongiform encephalopathy. Vet J 2009;182(2):306-14
  • Ritchie MA, Gill AC, Deery MJ, Lilley K. Precursor ion scanning for detection and structural characterization of heterogeneous glycopeptide mixtures. J Am Soc Mass Spectrom 2002;13(9):1065-77
  • Sawiris GP, Becker KG, Elliott EJ, Molecular analysis of bovine spongiform encephalopathy infection by cDNA arrays. J Gen Virol 2007;88(Pt 4):1356-62
  • Tang Y, Xiang W, Hawkins SA, Transcriptional changes in the brains of cattle orally infected with the bovine spongiform encephalopathy agent precede detection of infectivity. J Virol 2009;83(18):9464-73
  • Sakaguchi S. Recent developments in therapeutics for prion disease. Expert Opin Ther Patents 2008;18(1):35-9
  • Brajtburg J, Elberg S, Bolard J, Interaction of plasma proteins and lipoproteins with amphotericin B. J Infect Dis 1984;149(6):986-97
  • Pocchiari M, Casaccia P, Ladogana A. Amphotericin B: a novel class of antiscrapie drugs. J Infect Dis 1989;160(5):795-802
  • Trevitt CR, Collinge J. A systematic review of prion therapeutics in experimental models. Brain 2006;129(Pt 9):2241-65
  • Masullo C, Macchi G, Xi YG, Pocchiari M. Failure to ameliorate Creutzfeldt-Jakob disease with amphotericin B therapy. J Infect Dis 1992;165(4):784-5
  • Stewart LA, Rydzewska LH, Keogh GF, Knight RS. Systematic review of therapeutic interventions in human prion disease. Neurology 2008;70(15):1272-81
  • Sviridov D, Nestel P, Watts G. Statins and metabolism of high density lipoprotein. Cardiovasc Hematol Agents Med Chem 2007;5(3):215-21
  • Taraboulos A, Scott M, Semenov A, Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform. J Cell Biol 1995;129(1):121-32
  • Bate C, Salmona M, Diomede L, Williams A. Squalestatin cures prion-infected neurons and protects against prion neurotoxicity. J Biol Chem 2004;279(15):14983-90
  • Mok SW, Thelen KM, Riemer C, Simvastatin prolongs survival times in prion infections of the central nervous system. Biochem Biophys Res Commun 2006;348(2):697-702
  • Kempster S, Bate C, Williams A. Simvastatin treatment prolongs the survival of scrapie-infected mice. Neuroreport 2007;18(5):479-82
  • Doh-Ura K, Iwaki T, Caughey B. Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. J Virol 2000;74(10):4894-7
  • Caughey B, Raymond GJ. Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells. J Virol 1993;67(2):643-50
  • Engelstein R, Grigoriadis N, Greig NH, Inhibition of P53-related apoptosis had no effect on PrP(Sc) accumulation and prion disease incubation time. Neurobiol Dis 2005;18(2):282-5
  • Perovic S, Schroder HC, Pergande G, Effect of flupirtine on Bcl-2 and glutathione level in neuronal cells treated in vitro with the prion protein fragment (PrP106-126). Exp Neurol 1997;147(2):518-24
  • Otto M, Cepek L, Ratzka P, Efficacy of flupirtine on cognitive function in patients with CJD: a double-blind study. Neurology 2004;62(5):714-8
  • Kocisko DA, Baron GS, Rubenstein R, New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products. J Virol 2003;77(19):10288-94
  • Drisko JA. The use of antioxidants in transmissible spongiform encephalopathies: a case report. J Am Coll Nutr 2002;21(1):22-5
  • Soiland H, Soreide K, Janssen EA, Emerging concepts of apolipoprotein D with possible implications for breast cancer. Cell Oncol 2007;29(3):195-209
  • Nordstrom E, Fisone G, Kristensson K. Opposing effects of ERK and p38-JNK MAP kinase pathways on formation of prions in GT1-1 cells. FASEB J 2009;23(2):613-22
  • Sigurdsson EM, Brown DR, Alim MA, Copper chelation delays the onset of prion disease. J Biol Chem 2003;278(47):46199-202
  • Hijazi N, Shaked Y, Rosenmann H, Copper binding to PrPC may inhibit prion disease propagation. Brain Res 2003;993(1-2):192-200
  • Orem NR, Geoghegan JC, Deleault NR, Copper (II) ions potently inhibit purified PrPres amplification. J Neurochem 2006;96(5):1409-15

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.