190
Views
4
CrossRef citations to date
0
Altmetric
Reviews

Identification of targets and inhibitors of protein palmitoylation

, PhD & , PhD
Pages 155-164 | Published online: 07 Jan 2010

Bibliography

  • Linder ME, Deschenes RJ. Palmitoylation: policing protein stability and traffic. Nat Rev Mol Cell Biol 2007;8:74-84
  • Buglino JA, Resh MD. Hhat is a palmitoylacyltransferase with specificity for N-palmitoylation of sonic hedgehog. J Biol Chem 2008;283:22076-88
  • Hofmann K. A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling. Trends Biochem Sci 2000;25:111-2
  • Mitchell DA, Vasudevan A, Linder ME, Deschenes RJ. Protein palmitoylation by a family of DHHC protein S-acyltransferases. J Lipid Res 2006;47:1118-27
  • Zacharias DA, Violin JD, Newton AC, Tsien RY. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science (NY) 2002;296:913-6
  • Ohno Y, Kihara A, Sano T, Igarashi Y. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Biochim Biophys Acta 2006;1761:474-83
  • Zhang J, Planey SL, Ceballos C, Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method. Mol Cell Proteomics 2008;7:1378-88
  • Politis EG, Roth AF, Davis NG. Transmembrane topology of the protein palmitoyl transferase Akr1. J Biol Chem 2005;280:10156-63
  • Claros MG, von Heijne G. TopPred II: an improved software for membrane protein structure predictions. Comput Appl Biosci 1994;10:685-6
  • Freedman RB, Dunn AD, Ruddock LW. Protein folding: a missing redox link in the endoplasmic reticulum. Curr Biol 1998;8:R468-70
  • Huppa JB, Ploegh HL. The eS-Sence of -SH in the ER. Cell 1998;92:145-8
  • Mukai J, Liu H, Burt RA, Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia. Nat Genet 2004;36:725-31
  • Yanai A, Huang K, Kang R, Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Nat Neurosci 2006;9:824-31
  • Mansouri MR, Marklund L, Gustavsson P, Loss of ZDHHC15 expression in a woman with a balanced translocation t(X;15)(q13.3;cen) and severe mental retardation. Eur J Hum Genet 2005;13:970-7
  • Raymond FL, Tarpey PS, Edkins S, Mutations in ZDHHC9, which encodes a palmitoyltransferase of NRAS and HRAS, cause X-linked mental retardation associated with a marfanoid habitus. Am J Hum Genet 2007;80:982-7
  • Oyama T, Miyoshi Y, Koyama K, Isolation of a novel gene on 8p21.3-22 whose expression is reduced significantly in human colorectal cancers with liver metastasis. Genes Chromosomes Cancer 2000;29:9-15
  • Yamamoto Y, Chochi Y, Matsuyama H, Gain of 5p15.33 is associated with progression of bladder cancer. Oncology 2007;72:132-8
  • Mansilla F, Birkenkamp-Demtroder K, Kruhoffer M, Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups. Br J Cancer 2007;96:1896-903
  • Ducker CE, Stettler EM, French KJ, Huntingtin interacting protein 14 is an oncogenic human protein: palmitoyl acyltransferase. Oncogene 2004;23:9230-7
  • Swarthout JT, Lobo S, Farh L, DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. J Biol Chem 2005;280:31141-8
  • Goytain A, Hines RM, Quamme GA. Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport. J Biol Chem 2008;283:33365-74
  • Schlingmann KP, Gudermann T. A critical role of TRPM channel-kinase for human magnesium transport. J Physiol 2005;566:301-8
  • Schlingmann KP, Waldegger S, Konrad M, TRPM6 and TRPM7–Gatekeepers of human magnesium metabolism. Biochim Biophys Acta 2007;1772:813-21
  • Goytain A, Hines RM, Quamme GA. Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions: palmitoyl acytransferase and Mg2+ transport. J Biol Chem 2008;283(48):33365-74
  • Ren J, Wen L, Gao X, CSS-Palm 2.0: an updated software for palmitoylation sites prediction. Protein Eng Des Sel 2008;21:639-44
  • Xue Y, Chen H, Jin C, NBA-Palm: prediction of palmitoylation site implemented in Naive Bayes algorithm. BMC Bioinformatics 2006;7:458
  • Zhou F, Xue Y, Yao X, Xu Y. A general user interface for prediction servers of proteins' post-translational modification sites. Nat Protocols 2006;1:1318-21
  • Zhou F, Xue Y, Yao X, Xu Y. CSS-Palm: palmitoylation site prediction with a clustering and scoring strategy (CSS). Bioinformatics 2006;22:894-6
  • Ren J, Wen L, Gao X, CSS-Palm 2.0: an updated software for palmitoylation sites prediction. Protein Eng Des Sel 2008;21(11):639-44
  • Roth AF, Wan J, Bailey AO, Global analysis of protein palmitoylation in yeast. Cell 2006;125:1003-13
  • Fukata Y, Iwanaga T, Fukata M. Systematic screening for palmitoyl transferase activity of the DHHC protein family in mammalian cells. Methods 2006;40:177-82
  • Drisdel RC, Green WN. Labeling and quantifying sites of protein palmitoylation. Biotechniques 2004;36:276-85
  • Wan J, Roth AF, Bailey AO, Davis NG. Palmitoylated proteins: purification and identification. Nature Protocols 2007;2:1573-84
  • Schweizer A, Rohrer J, Jeno P, A reversibly palmitoylated resident protein (p63) of an ER-Golgi intermediate compartment is related to a circulatory shock resuscitation protein. J Cell Sci 1993;104(Pt 3):685-94
  • Zhang J, Zacharias DA. Global analysis of the dynamic palmitoylosome. In: Pike LA, Edidin MA, editors, Lipid rafts and cell funciton. Steamboat Springs, Keystone Symposia, Colorado; 2006. p. 69
  • Martin BR, Cravatt BF. Large-scale profiling of protein palmitoylation in mammalian cells. Nat Methods 2009;6:135-8
  • Hang HC, Geutjes EJ, Grotenbreg G, Chemical probes for the rapid detection of fatty-acylated proteins in mammalian cells. J Am Chem Soc 2007;129:2744-5
  • Heal WP, Wickramasinghe SR, Leatherbarrow RJ, Tate EW. N-Myristoyl transferase-mediated protein labelling in vivo. Org Biomol Chem 2008;6:2308-15
  • Kostiuk MA, Corvi MM, Keller BO, Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue. FASEB J 2008;22:721-32
  • Kostiuk MA, Keller BO, Berthiaume LG. Non-radioactive detection of palmitoylated mitochondrial proteins using an azido-palmitate analogue. Methods Enzymol 2009;457:149-65
  • Gebremedhin D, Ma YH, Imig JD, Role of cytochrome P-450 in elevating renal vascular tone in spontaneously hypertensive rats. J Vasc Res 1993;30:53-60
  • Shak S, Reich NO, Goldstein IM, Ortiz de Montellano PR. Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids. J Biol Chem 1985;260:13023-8
  • Zou AP, Ma YH, Sui ZH, Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats. J Pharmacol Exp Ther 1994;268:474-81
  • Sun CW, Alonso-Galicia M, Taheri MR, Nitric oxide-20-hydroxyeicosatetraenoic acid interaction in the regulation of K+ channel activity and vascular tone in renal arterioles. Circ Res 1998;83:1069-79
  • Jennings BC, Nadolski MJ, Ling Y, 2-bromopalmitate and 2-(2-Hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitro. J Lipid Res 2008;50(2):233-42
  • Mikic I, Planey S, Zhang J, A live-cell, image based approach to understanding the enzymology and pharmacology of 2-bromopalmitate and palmitoylation. Methods Enzymol 2006;414:150-87
  • Chase JF, Tubbs PK. Specific inhibition of mitochondrial fatty acid oxidation by 2-bromopalmitate and its coenzyme A and carnitine esters. Biochem J 1972;129:55-65
  • Coleman RA, Rao P, Fogelsong RJ, Bardes ES. 2-Bromopalmitoyl-CoA and 2-bromopalmitate: promiscuous inhibitors of membrane-bound enzymes. Biochim Biophys Acta 1992;1125:203-9
  • Draper JM, Smith CD. Palmitoyl acyltransferase assays and inhibitors (Review). Mol Membr Biol 2009;26:5-13
  • Ducker CE, Griffel LK, Smith RA, Discovery and characterization of inhibitors of human palmitoyl acyltransferases. Mol Cancer Ther 2006;5:1647-59
  • Varner AS, Ducker CE, Xia Z, Characterization of human palmitoyl-acyl transferase activity using peptides that mimic distinct palmitoylation motifs. Biochem J 2003;373:91-9
  • Ducker CE, Draper JM, Xia Z, Smith CD. In vitro and cellular assays for palmitoyl acyltransferases using fluorescent lipidated peptides. Methods 2006;40:166-70
  • Fabian MA, Biggs WH, 3rd, Treiber DK, A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol 2005;23:329-36
  • Karaman MW, Herrgard S, Treiber DK, A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol 2008;26:127-32
  • Feng Y, Yin Y, Weiser A, Discovery of substituted 4-(pyrazol-4-yl)- phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem 2008;51:6642-5
  • Huang K, Sanders S, Singaraja R, Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity. FASEB J 2009;23:2605-15
  • Prigozhina NL, Zhong L, Hunter EA, Plasma membrane assays and three-compartment image cytometry for high content screening. Assay Drug Dev Technol 2007;5:29-48
  • Morelock MM, Hunter EA, Moran TJ, Statistics of assay validation in high throughput cell imaging of nuclear factor kappaB nuclear translocation. Assay Drug Dev Technol 2005;3:483-99
  • Wolff M, Kredel S, Wiedenmann J, Cell-based assays in practice: cell markers from autofluorescent proteins of the GFP-family. Comb Chem High Throughput Screen 2008;11:602-9
  • Collins MA. Generating ‘omic knowledge: The Role of Informatics in High Content Screening. Comb Chem High Throughput Screen 2009
  • Shaner NC, Campbell RE, Steinbach PA, Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat Biotechnol 2004;22:1567-72
  • Inglese J, Auld DS, Jadhav A, Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc Natl Acad Sci USA 2006;103:11473-8
  • Chung CC, Ohwaki K, Schneeweis JE, A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production. Assay Drug Dev Technol 2008;6:361-74
  • Hines RM, Kang R, Goytain A, Quamme GA. The golgi-specific DHHC zinc finger protein, GODZ, mediates membrane Ca2+ transport. J Biol Chem 2009 Dec 2 [Epub ahead of print]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.