Bibliography
- Miller FR, Medina D, Heppner GH. Preferential growth of mammary tumors in intact mammary fatpads. Cancer Res 1981;41:3863-7
- Wang WR, Sordat B, Piguet D, Sordat M. Human colon tumors in nude mice: implantation site and expression of the invasive phenotype. In: Sordat B, editor, Immune-deficient animals. Karger, Lausanne, Switzerland; 1982. p. 239-45
- Ibrahiem EH, Nigam VN, Brailovsky CA, Orthotopic implantation of primary N-[4-(5-Nitro-2-furyl)-2-thiazolyl] formamide-induced bladder cancer in bladder submucosa: an animal model for bladder cancer study. Cancer Res 1983;43:617-22
- Naito S, von Eschenbach AC, Giavazzi R, Fidler IJ. Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude mice. Cancer Res 1986;46:4109-15
- McLemore TL, Liu MC, Blacker PC, Novel intrapulmonary model for orthotopic propagation of human lung cancers in athymic nude mice. Cancer Res 1987;47:5132-40
- Bresalier RS, Raper SE, Hujanen ES, Kim YS. A new animal model for human colon cancer metastasis. Int J Cancer 1987;39:625-30
- Fidler IJ. Critical factors in the biology of human cancer metastases: twenty-eighth G.H.A Clowes memorial award lecture. Cancer Res 1990;50:6130-8
- Fu XY, Besterman JM, Monosov A, Hoffman RM. Models of human metastatic colon cancer in nude mice orthotopically constructed by using histologically intact patient specimens. Proc Natl Acad Sci USA 1991;88:9345-9
- Wang X, Fu X, Brown PD, Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res 1994;54:4726-8
- An Z, Wang X, Willmott N, Conversion of highly malignant colon cancer from an aggressive to a controlled disease by oral administration of a metalloproteinase inhibitor. Clin Exp Metastasis 1997;15:184-95
- An Z, Wang X, Astoul P, Interferon gamma is highly effective against orthotopically-implanted human pleural adenocarcinoma in nude mice. Anticancer Res 1996;16:2545-51
- Kanai T, Konno H, Tanaka T, Effect of angiogenesis inhibitor TNP-470 on the progression of human gastric cancer xenotransplanted into nude mice. Int J Cancer 1997;71:838-41
- Konno H, Tanaka T, Kanai T, Efficacy of an angiogenesis inhibitor, TNP-470, in xenotransplanted human colorectal cancer with high metastatic potential. Cancer 1996;77:1736-40
- Konno H, Tanaka T, Matsuda I, Comparison of the inhibitory effect of the angiogenesis inhibitor, TNP-470, and mitomycin C on the growth and liver metastasis of human colon cancer. Int J Cancer 1995;61:268-71
- Konno H, Tanaka T, Baba M, Antitumor effect of angiogenesis inhibitors on colon cancer. Biotherapy 1997;11:993-6
- Tanaka T, Konno H, Matsuda I, Prevention of hepatic metastasis of human colon cancer by angiogenesis inhibitor TNP-470. Cancer Res 1995;55:836-9
- Konno H, Arai T, Tanaka T, Antitumor effect of a neutralizing antibody to vascular endothelial growth factor on liver metastasis of endocrine neoplasm. Jpn J Cancer Res 1998;89:933-9
- Chang S-G, Kim JI, Jung J-C, Antimetastatic activity of the new platinum analog {Pt(cis-dach)(DPPE)·(2NO3} in a metastatic model of human bladder cancer. Anticancer Res 1997;17:3239-42
- Furukawa T, Kubota T, Watanabe M, Immunochemotherapy prevents human colon cancer metastasis after orthotopic onplantation of histologically-intact tumor tissue in nude mice. Anticancer Res 1993;13:287-91
- Furukawa T, Kubota T, Watanabe M, Differential chemosensitivity of local and metastatic human gastric cancer after orthotopic transplantation of histologically intact tumor tissue in nude mice. Int J Cancer 1993;54:397-401
- Furukawa T, Kubota T, Watanabe M, A novel “patient-like” treatment model of human pancreatic cancer constructed using orthotopic transplantation of histologically intact human tumor tissue in nude mice. Cancer Res 1993;53:3070-2
- Kuo T-H, Kubota T, Watanabe M, Site-specific chemosensitivity of human small-cell lung carcinoma growing orthotopically compared to subcutaneously in SCID mice: the importance of orthotopic models to obtain relevant drug evaluation data. Anticancer Res 1993;13:627-30
- Fu X, Le P, Hoffman RM. A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer. Anticancer Res 1993;13:901-4
- Astoul P, Colt HG, Wang X, Hoffman RM. Metastatic human pleural ovarian cancer model constructed by orthotopic implantation of fresh histologically-intact patient carcinoma in nude mice. Anticancer Res 1993;13:1999-2002
- Astoul P, Wang X, Hoffman RM. “Patient-like” nude- and SCID-mouse models of human lung and pleural cancer [review]. Int J Oncol 1993;3:713-18
- Kubota T, Inoue S, Furukawa T, Similarity of serum – Tumor pharmacokinetics of antitumor agents in man and nude mice. Anticancer Res 1993;13:1481-4
- Astoul P, Colt HG, Wang X, Hoffman RM. A “patient-like” nude mouse model of parietal pleural human lung adenocarcinoma. Anticancer Res 1994;14:85-91
- Olbina G, Cieslak D, Ruzdijic S, Reversible inhibition of IL-8 receptor B mRNA expression and proliferation in non-small cell lung cancer by antisense oligonucleotides. Anticancer Res 1996;16:3525-30
- Fu X, Theodorescu D, Kerbel RS, Hoffman RM. Extensive multi-organ metastasis following orthotopic onplantation of histologically-intact human bladder carcinoma tissue in nude mice. Int J Cancer 1991;49:938-9
- Fu X, Hoffman RM. Human RT-4 bladder carcinoma is highly metastatic in nude mice and comparable to ras-H-transformed RT-4 when orthotopically onplanted as histologically-intact tissue. Int J Cancer 1992;51:989-91
- Wang X, Fu X, Hoffman RM. A new patient-like metastatic model of human lung cancer constructed orthotopically with intact tissue via thoracotomy in immunodeficient mice. Int J Cancer 1992;51:992-5
- Fu X, Guadagni F, Hoffman RM. A metastatic nude-mouse model of human pancreatic cancer constructed orthotopically from histologically intact patient specimens. Proc Natl Acad Sci USA 1992;89:5645-9
- Kuo T-H, Kubota T, Watanabe M, Orthotopic reconstitution of human small-cell lung carcinoma after intravenous transplantation in SCID mice. Anticancer Res 1992;12:1407-10
- Fu X, Herrera H, Kubota T, Hoffman RM. Extensive liver metastasis from human colon cancer in nude and scid mice after orthotopic onplantation of histologically-intact human colon carcinoma tissue. Anticancer Res 1992;12:1395-7
- Wang X, Fu X, Hoffman RM. A patient-like metastasizing model of human lung adenocarcinoma constructed via thoracotomy in nude mice. Anticancer Res 1992;12:1399-401
- Wang X, Fu X, Kubota T, Hoffman RM. A new patient-like metastatic model of human small-cell lung cancer constructed orthotopically with intact tissue via thoracotomy in nude mice. Anticancer Res 1992;12:1403-6
- Fu X, Herrera H, Hoffman RM. Orthotopic growth and metastasis of human prostate carcinoma in nude mice after transplantation of histologically intact tissue. Int J Cancer 1992;52:987-90
- Hoffman RM. Histoculture and the immunodeficient mouse come to the cancer clinic: rational approaches to individualizing cancer therapy and new drug evaluation [review]. Int J Oncol 1992;1:467-74
- Furukawa T, Fu X, Kubota T, Nude mouse metastatic models of human stomach cancer constructed using orthotopic implantation of histologically intact tissue. Cancer Res 1993;53:1204-8
- Furukawa T, Kubota T, Watanabe M, Orthotopic transplantation of histologically intact clinical specimens of stomach cancer to nude mice: correlation of metastatic sites in mouse and individual patient donors. Int J Cancer 1993;53:608-12
- Fu X, Hoffman RM. Human ovarian carcinoma metastatic models constructed in nude mice by orthotopic transplantation of histologically-intact patient specimens. Anticancer Res 1993;13:283-6
- Kuo T-H, Kubota T, Watanabe M, Early resection of primary orthotopically-growing human colon tumor in nude mouse prevents liver metastasis: further evidence for patient-like hematogenous metastatic route. Anticancer Res 1993;13:293-7
- Furukawa T, Kubota T, Watanabe M, A metastatic model of human colon cancer constructed using cecal implantation of cancer tissue in nude mice. Jpn J Surg 1993;23:420-3
- Astoul P, Colt HG, Wang X, “Patient-like” nude mouse metastatic model of advanced human pleural cancer. J Cell Biochem 1994;56:9-15
- Hoffman RM. Orthotopic is orthodox: why are orthotopic-transplant metastatic models different from all other models? J Cell Biochem 1994;56:1-3
- Togo S, Shimada H, Kubota T, “Seed” to “soil” is a return trip in metastasis. Anticancer Res 1995;15:791-4
- Togo S, Shimada H, Kubota T, Host organ specifically determines cancer progression. Cancer Res 1995;55:681-4
- Kuo T-H, Kubota T, Watanabe M, Liver colonization competence governs colon cancer metastasis. Proc Natl Acad Sci USA 1995;92:12085-9
- Togo S, Wang X, Shimada H, Cancer seed and soil can be highly selective: human-patient colon tumor lung metastasis grows in nude mouse lung but not colon or subcutis. Anticancer Res 1995;15:795-8
- Holzman D. Of mice and metastasis: a new for-profit model emerges. J Natl Cancer Inst 1996;88:396-7
- Leff DN. MetaMouse models colon cancer metastasis with clinical potential. BioWorld Today 1996;7:1
- Sun FX, Tang ZY, Liu KD, Establishment of a metastatic model of human hepatocellular carcinoma in nude mice via orthotopic implantation of histologically intact tissues. Int J Cancer 1996;66:239-43
- An Z, Wang X, Kubota T, A clinical nude mouse metastatic model for highly malignant human pancreatic cancer. Anticancer Res 1996;16:627-31
- Riordan T. A technique is said to ease attachment of tumors to mice, making them “little cancer patients”. New York Times, “Patents” Column, 4 March 1996
- Murray GI, Duncan ME, O'Neil P, Matrix metalloproteinase-1 is associated with poor prognosis in colorectal cancer. Nat Med 1996;2:461-2
- Hoffman RM. Fertile seed and rich soil: the development of patient-like models of human cancer by surgical orthotopic implantation of intact tissue. In: Schimpff SC, , editors, Update series: comprehensive textbook of oncology 3, 1 – 10, Williams & Wilkins, Baltimore; 1996
- Sun F-X, Tang Z-Y, Liu K-D, Metastatic models of human liver cancer in nude mice orthotopically constructed by using histologically intact patient specimens. J Cancer Res Clin Oncol 1996;122:397-402
- Astoul P, Wang X, Colt HG, A patient-like human malignant pleural mesothelioma nude-mouse model. Oncol Rep 1996;3:483-7
- Colt HG, Astoul P, Wang X, Clinical course of human epithelial-type malignant pleural mesothelioma replicated in an orthotopic-transplant nude mouse model. Anticancer Res 1996;16:633-9
- Hoffman RM. Fertile seed and rich soil: the development of clinically relevant models of human cancer by surgical orthotopic implantation of intact tissue. In: Teicher B, editor, Anticancer drug development guide: preclinical screening, clinical trials, and approval. Humana Press, Totowa, NJ; 1997. p. 127-44
- Chishima T, Miyagi Y, Wang X, Cancer invasion and micrometastasis visualized in live tissue by green fluorescent protein expression. Cancer Res 1997;57:2042-7
- Inada T, Ichikawa A, Kubota T, 5-FU-induced apoptosis correlates with efficacy against human gastric and colon cancer xenografts in nude mice. Anticancer Res 1997;17:1965-71
- Chishima T, Miyagi Y, Wang X, Metastatic patterns of lung cancer visualized live and in process by green fluorescent protein expression. Clin Exp Metastasis 1997;15:547-52
- Chishima T, Miyagi Y, Wang X, Visualization of the metastatic process by green fluorescent protein expression. Anticancer Res 1997;17:2377-84
- Chishima T, Yang M, Miyagi Y, Governing step of metastasis visualized in vitro. Proc Natl Acad Sci USA 1997;94:11573-6
- Tomikawa M, Kubota T, Matsuzaki SW, Mitomycin C and cisplatin increase survival in a human pancreatic cancer metastatic model. Anticancer Res 1997;17:3623-5
- Chishima T, Miyagi Y, Li L, Use of histoculture and green fluorescent protein to visualize tumor cell host interaction. In Vitro Cell Dev Biol 1997;33:745-7
- Dev SB, Nanda GS, An Z, Effective electroporation therapy of human pancreatic tumors implanted in nude mice. Drug Deliv 1997;4:293-9
- An Z, Wang X, Geller J, Surgical orthotopic implantation allows high lung and lymph node metastatic expression of human prostate carcinoma cell line PC-3 in nude mice. Prostate 1998;34:169-74
- Nanda GS, Sun FX, Hofmann GA, Electroporation therapy of human larynx tumors HEp-2 implanted in nude mice. Anticancer Res 1998;18:999-1004
- Nanda GS, Sun FX, Hofmann GA, Electroporation enhances therapeutic efficacy of anticancer drugs: treatment of human pancreatic tumor in animal model. Anticancer Res 1998;18:1361-6
- Yang M, Hasegawa S, Jiang P, Widespread skeletal metastatic potential of human lung cancer revealed by green fluorescent protein expression. Cancer Res 1998;58:4217-21
- Sun F-X, Sasson AR, Jiang P, An ultra-metastatic model of human colon cancer in nude mice. Clin Exp Metastasis 1999;17:41-8
- Kiguchi K, Kubota T, Aoki D, A patient-like orthotopic implantation nude mouse model of highly metastatic human ovarian cancer. Clin Exp Metastasis 1999;16:751-6
- Yang M, Jiang P, Sun FX, A fluorescent orthotopic bone metastasis model of human prostate cancer. Cancer Res 1999;59:781-6
- Wang X, An Z, Geller J, Hoffman RM. A high malignancy orthotopic nude mouse model of the human prostate cancer LNCaP. Prostate 1999;39:182-6
- An Z, Jiang P, Wang X, Development of a high metastatic orthotopic model of human renal cell carcinoma in nude mice: benefits of fragment implantation compared to cell-suspension injection. Clin Exp Metastasis 1999;17:265-70
- Yang M, Jiang P, An Z, Genetically fluorescent melanoma bone and organ metastasis models. Clin Cancer Res 1999;5:3549-59
- Hayashi K, Zhao M, Yamauchi K, Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhymurium. Cell Cycle 2009;8:870-5
- Tome Y, Tsuchiya H, Hayashi K, In vivo gene transfer between interacting human osteosarcoma cell lines is associated with acquisition of enhanced metastatic potential. J Cell Biochem 2009;108:362-7
- Hoffman RM. Comment re: preclinical model of spontaneous melanoma metastasis. Cancer Res 2009;69:719
- Hoffman RM, Yang M. Whole-body imaging with fluorescent proteins. Nat Protocol 2006;1:1429-38
- Rashidi B, An Z, Sun F-X, Efficacy of intra-hepatectomy 5-FU on recurrence and metastasis of human hepatocellular carcinoma in nude mice. Int J Cancer 2001;91:231-5
- Mitsiades CS, Mitsiades NS, Bronson RT, Fluorescence imaging of multiple myeloma cells in a clinically relevant SCID/NOD in vivo model: biologic and clinical implications. Cancer Res 2003;63:6689-96
- Liu T, Ding Y, Xie W, An imageable metastatic treatment model of nasopharyngeal carcinoma. Clin Cancer Res 2007;13:3960-7
- Yamamoto N, Yang M, Jiang P, Real-time imaging of individual fluorescent protein color-coded metastatic colonies in vivo. Clin Exp Metastasis 2003;20:633-8
- Paget S. The distribution of secondary growths in cancer of the breast. Lancet 1889;133(3421):571-3
- Wilmanns C, Fan D, O'Brian CA, Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5-fluorouracil. Int J Cancer 1992;52:98-104
- Shimomura O. Discovery of green fluorescent protein (GFP) (Nobel Lecture). Angew Chem Int Ed Engl 2009;48:5590-602
- Shimomura O, Johnson FH, Saiga Y. Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan, Aequorea. J Cell Comp Physiol 1962;59:223-39
- Shimomura O. Structure of the chromophore of Aequorea green fluorescent protein. FEBS Lett 1979;104:220-2
- Tsien RY. Constructing and exploiting the fluorescent protein paintbox (Nobel Lecture). Angew Chem Int Ed Engl 2009;48:5612-26
- Chalfie M. GFP: lighting up life (Nobel Lecture). Angew Chem Int Ed Engl 2009;48:5603-11
- Yang M, Baranov E, Jiang P, Whole-body optical imaging of green fluorescent protein-expressing tumors and metastases. Proc Natl Acad Sci USA 2000;97:1206-11
- Hoffman RM. The multiple uses of fluorescent proteins to visualize cancer in vivo. Nat Rev Cancer 2005;5:796-806
- Morin JG, Hastings JW. Energy transfer in a bioluminescent system. J Cell Physiol 1971;77:313-18
- Morise H, Shimomura O, Johnson FH, Winant J. Intermolecular energy transfer in the bioluminescent system of Aequorea. Biochemistry 1974;13:2656-62
- Prasher DC, Eckenrode VK, Ward WW, Primary structure of the Aequorea victoria green-fluorescent protein. Gene 1992;111:229-33
- Tsien RY. The green fluorescent protein. Annu Rev Biochem 1998;67:509-44
- Cormack BP, Valdivia RH, Falkow S. FACS-optimized mutants of the green fluorescent protein (GFP). Gene 1996;173:33-8
- Matz MV, Fradkov AF, Labas YA, Fluorescent proteins from nonbioluminescent Anthozoa species. Nat Biotechnol 1999;17:969-73
- Shaner NC, Campbell RE, Steinbach PA, Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat Biotechnol 2004;22:1567-72
- Wang L, Jackson WC, Steinbach PA, Tsien RY. Evolution of new nonantibody proteins via iterative somatic hypermutation. Proc Natl Acad Sci USA 2004;101:16745-9
- Yampolsky IV, Kislukhin AA, Amatov TT, Synthesis and properties of the red chromophore of the green-to-red photoconvertible fluorescent protein Kaede and its analogs. Bioorg Chem 2008;36:96-104
- Li X, Chung LW, Mizuno H, A theoretical study on the nature of on- and off-states of reversibly photoswitching fluorescent protein Dronpa: absorption, emission, protonation, and Raman. J Phys Chem B 2010;114:1114-26
- Chalfie M, Tu Y, Euskirchen G, Green fluorescent protein as a marker for gene expression. Science 1994;263:802-5
- Yamamoto N, Jiang P, Yang M, Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Res 2004;64:4251-6
- Hoffman RM, Yang M. Color-coded fluorescence imaging of tumor-host interactions. Nat Protocol 2006;1:928-35
- Hoffman RM, Yang M. Subcellular imaging in the live mouse. Nat Protocol 2006;1:775-82
- Rajput A, Dominguez San Martin I, Rose R, Characterization of HCT116 human colon cancer cells in an orthotopic model. J Surg Res 2008;147:276-81
- Yang M, Jiang P, Yamamoto N, Real-time whole-body imaging of an orthotopic metastatic prostate cancer model expressing red fluorescent protein. Prostate 2005;62:374-9
- Katz MH, Takimoto S, Spivack D, A novel red fluorescent protein orthotopic pancreatic cancer model for the preclinical evaluation of chemotherapeutics. J Surg Res 2003;113:151-60
- Yang M, Baranov E, Li X-M, Whole-body and intravital optical imaging of angiogenesis in orthotopically implanted tumors. Proc Natl Acad Sci USA 2001;98:2616-21
- Hasegawa S, Yang M, Chishima T, In vivo tumor delivery of the green fluorescent protein gene to report future occurrence of metastasis. Cancer Gene Ther 2000;7:1336-40
- Kishimoto H, Urata Y, Tanaka N, Selective metastatic tumor labeling with green fluorescent protein and killing by systemic administration of telomerase-dependent adenoviruses. Mol Cancer Ther 2009;8:3001-8
- Kishimoto H, Zhao M, Hayashi K, In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation. Proc Natl Acad Sci USA 2009;106:14514-17
- Yang M, Reynoso J, Jiang P, Transgenic nude mouse with ubiquitous green fluorescent protein expression as a host for human tumors. Cancer Res 2004;64:8651-6
- Chambers AF. MDA-MB-435 and M14 cell lines: identical but not M14 melanoma? Cancer Res 2009;69:5292-3
- Zhang Q, Fan H, Shen J, Human breast cancer cell lines co-express neuronal, epithelial, and melanocytic differentiation markers in vitro and in vivo. PLoS One 2010;5:e9712
- Yang M, Jiang P, Hoffman RM. Whole-body subcellular multicolor imaging of tumor-host interaction and drug response in real time. Cancer Res 2007;67:5195-200
- Yang M, Reynoso J, Bouvet M, Hoffman RM. A transgenic red fluorescent protein expressing nude mouse for color-coded imaging of the tumor microenvironment. J Cell Biochem 2009;106:279-84
- Tran Cao HS, Reynoso J, Yang M, Development of the transgenic cyan fluorescent protein (CFP)-expressing nude mouse for “Technicolor” cancer imaging. J Cell Biochem 2009;107:328-34
- Yang M, Li L, Jiang P, Dual-color fluorescence imaging distinguishes tumor cells from induced host angiogenic vessels and stromal cells. Proc Natl Acad Sci USA 2003;100:14259-62
- Yamamoto N, Yang M, Jiang P, Determination of clonality of metastasis by cell-specific color-coded fluorescent-protein imaging. Cancer Res 2003;63:7785-90
- Glinskii AB, Smith BA, Jiang P, Viable circulating metastatic cells produced in orthotopic but not ectopic prostate cancer models. Cancer Res 2003;63:4239-43
- Glinsky GV, Glinskii AB, Berezovskaya O, Dual-color-coded imaging of viable circulating prostate carcinoma cells reveals genetic exchange between tumor cells in vivo, contributing to highly metastatic phenotypes. Cell Cycle 2006;5:191-7
- Yang M, Luiken G, Baranov E, Hoffman RM. Facile whole-body imaging of internal fluorescent tumors in mice with an LED flashlight. BioTechniques 2005;39:170-2
- Yamauchi K, Yang M, Jiang P, Development of real-time subcellular dynamic multicolor imaging of cancer cell-trafficking in live mice with a variable-magnification whole-mouse imaging system. Cancer Res 2006;66:4208-14
- Heim R, Cubitt AB, Tsien RY. Improved green fluorescence. Nature 1995;373:663-4
- Delagrave S, Hawtin RE, Silva CM, Red-shifted excitation mutants of the green fluorescent protein. Biotechnology 1995;13:151-4
- Zolotukhin S, Potter M, Hauswirth WW, A “humanized” green fluorescent protein cDNA adapted for high-level expression in mammalian cells. J Virol 1996;70:4646-54
- Cody CW, Prasher DC, Westler VM, Chemical structure of the hexapeptide chromophore of the Aequorea green-fluorescent protein. Biochemistry 1993;32:1212-18
- Ray P, De A, Min JJ, Imaging tri-fusion multimodality reporter gene expression in living subjects. Cancer Res 2004;64:1323-30
- Burgos JS, Rosol M, Moats RA, Time course of bioluminescent signal in orthotopic and heterotopic brain tumors in nude mice. BioTechniques 2003;34:1184-8
- Matsumoto K, Konno H, Tanaka T, Combination therapy with vascular endothelial growth factor neutralizing antibody and mitomycin C on human gastric cancer xenograft. Jpn J Cancer Res 2000;91:748-52
- Kamiyama M, Ichikawa Y, Ishikawa T, VEGF receptor antisense therapy inhibits angiogenesis and peritoneal dissemination of human gastric cancer in nude mice. Cancer Gene Ther 2002;9:197-201
- Rho Y-S, Lee K-T, Jung J-C, Efficacy of new platinum analog DPPE in an orthotopic nude mouse model of human colon cancer. Anticancer Res 1999;19:157-61
- Woessner R, An Z, Li X, Comparison of three approaches to doxorubicin therapy: free doxorubicin, liposomal doxorubicin, and beta-glucuronidase-activated prodrug (HMR 1826). Anticancer Res 2000;20:2289-96
- Sun F-X, Tohgo A, Bouvet M, Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model. Cancer Res 2003;63:80-5
- Katz MH, Bouvet M, Takimoto S, Selective antimetastatic activity of cytosine analog CS-682 in a red fluorescent protein orthotopic model of pancreatic cancer. Cancer Res 2003;63:5521-5
- Wu M, Mazurchuk R, Chaudhary ND, High-resolution magnetic resonance imaging of the efficacy of the cytosine analogue 1-[2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl]-N4-palmitoyl cytosine (CS-682) in a liver-metastasis athymic nude mouse model. Cancer Res 2003;63:2477-82
- Ireson CR, Chander SK, Purohit A, Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents. Br J Cancer 2004;90:932-7
- John CM, Leffler H, Kahl-Knutsson B, Truncated galectin-3 inhibits tumor growth and metastasis in orthotopic nude mouse model of human breast cancer. Clin Cancer Res 2003;9:2374-83
- Lukashev M, LePage D, Wilson C, Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy. Cancer Res 2006;66:9617-24
- Ammons WS, Wang JW, Yang Z, A novel alkylating agent, glufosfamide, enhances the activity of gemcitabine in vitro and in vivo. Neoplasia 2007;9:625-33
- Duan JX, Jiao H, Kaizerman J, Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs. J Med Chem 2008;51:2412-20
- Matsuo Y, Raimondo M, Woodward TA, CXC-chemokine/CXCR2 biological axis promotes angiogenesis in vitro and in vivo in pancreatic cancer. Int J Cancer 2009;125:1027-37
- Yamamoto M, Kikuchi H, Ohta M, TSU68 prevents liver metastasis of colon cancer xenografts by modulating the premetastatic niche. Cancer Res 2008;68:9754-62
- Dusich JM, Oei YA, Purchio T, Jenkins DE. In vivo detection of lung colonization and metastasis using luciferase-expressing human A549 lung cells. Proc Am Assoc Cancer Res 2002;43:1059
- Yang M, Baranov E, Wang J-W, Direct external imaging of nascent cancer, tumor progression, angiogenesis, and metastasis on internal organs in the fluorescent orthotopic model. Proc Natl Acad Sci USA 2002;99:3824-9
- Yamauchi K, Yang M, Jiang P, Real-time in vivo dual-color imaging of intracapillary cancer cell and nucleus deformation and migration. Cancer Res 2005;65:4246-52
- Vooijs M, Jonkers J, Lyons S, Berns A. Noninvasive imaging of spontaneous retinoblastoma pathway-dependent tumors in mice. Cancer Res 2002;62:1862-7
- Shcherbo D, Murphy CS, Ermakova GV, Far-red fluorescent tags for protein imaging in living tissues. Biochem J 2009;418:567-74