Novel approaches to flavivirus drug discovery

Bibliography

• Perry ST, Buck MD, Shresta S. Better late than never: antivirals for dengue. Expert Rev Anti Infect Ther 2011;9(7):755-7
   PubMed Web of Science ®Google Scholar
• Gubler D, Kuno G, Markoff L. Flaviviruses. In: Knipe DM, Howley PM, editors. Fields Virology. Volume 1 5th edition. Lippincott William & Wilkins; Philadelphia, PA: 2007. p. 1153-253
   Google Scholar
• Watanaveeradej V, Simasathien S, Nisalak A, Safety and immunogenicity of a tetravalent live-attenuated dengue vaccine in flavivirus-naive infants. Am J Trop Med Hyg 2011;85(2):341-51
   PubMed Web of Science ®Google Scholar
• Rumyantsev AA, Giel-Moloney M, Liu YX, Characterization of the RepliVax platform for replication-defective flavivirus vaccines. Vaccine 2011;29(32):5184-94
   PubMed Web of Science ®Google Scholar
• Gollins SW, Porterfield JS. Flavivirus infection enhancement in macrophages – radioactive and biological studies on the effect of antibody on viral fate. J Gen Virol 1984;65:1261-72
   PubMed Web of Science ®Google Scholar
• Gollins SW, Porterfield JS. Flavivirus infection enhancement in macrophages – an electron-microscopic study of viral cellular entry. J Gen Virol 1985;66:1969-82
   PubMed Web of Science ®Google Scholar
• Lin CC, Philips L, Xu C, Pharmacokinetics and safety of viramidine, a prodrug of ribavirin, in healthy volunteers. J Clin Pharmacol 2004;44(3):265-75
   PubMed Web of Science ®Google Scholar
• Manns MP, Foster GR, Rockstroh JK, The way forward in HCV treatment - finding the right path. Nat Rev Drug Discov 2007;6(12):991-1000
   PubMed Web of Science ®Google Scholar
• Li L, Lok SM, Yu IM, The flavivirus precursor membrane-envelope protein complex: structure and maturation. Science 2008;319(5871):1830-4
   PubMed Web of Science ®Google Scholar
• Patkar CG, Jones CT, Chang YH, Functional requirements of the yellow fever virus capsid protein. J Virol 2007;81(12):6471-81
   PubMed Web of Science ®Google Scholar
• Lin YJ, Wu SC. Histidine at residue 99 and the transmembrane region of the precursor membrane prM protein are important for the prM-E heterodimeric complex formation of Japanese encephalitis virus. J Virol 2005;79(13):8535-44
   PubMed Web of Science ®Google Scholar
• Smit JM, Moesker B, Rodenhuis-Zybert I, Flavivirus cell entry and membrane fusion. Viruses Basel 2011;3(2):160-71
   PubMed Web of Science ®Google Scholar
• Avirutnan P, Hauhart RE, Somnuke P, Binding of flavivirus nonstructural protein NS1 to C4b binding protein modulates complement activation. J Immunol 2011;Jul187(1):424-33
   PubMed Web of Science ®Google Scholar
• Avirutnan P, Fuchs A, Hauhart RE, Antagonism of the complement component C4 by flavivirus nonstructural protein NS1. J Exp Med 2010;207(4):793-806
   PubMed Web of Science ®Google Scholar
• Chung KM, Liszewski MK, Nybakken G, West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H. Proc Natl Acad Sci USA 2006;103(50):19111-16
   PubMed Web of Science ®Google Scholar
• Wen JL, Hua BC, Xiang JW, Analysis of adaptive mutations in Kunjin virus replicon RNA reveals a novel role for the flavivirus nonstructural protein NS2A in inhibition of beta interferon promoter-driven transcription. J Virol 2004;78(22):12225-35
   PubMed Web of Science ®Google Scholar
• Liu WJ, Chen HB, Khromykh AA. Molecular and functional analyses of Kunjin virus infectious cDNA clones demonstrate the essential roles for NS2A in virus assembly and for a nonconservative residue in NS3 in RNA replication. J Virol 2003;77(14):7804-13
   PubMed Web of Science ®Google Scholar
• Kummerer BM, Rice CM. Mutations in the yellow fever virus nonstructural protein NS2A selectively block production of infectious particles. J Virol 2002;76(10):4773-84
   PubMed Web of Science ®Google Scholar
• Chambers TJ, Weir RC, Grakoui A, Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein. Proc Natl Acad Sci USA 1990;87(22):8898-902
   PubMed Web of Science ®Google Scholar
• Roosendaal J, Westaway EG, Khromykh A, Regulated cleavages at the West Nile virus NS4A-2K-NS4B junctions play a major role in rearranging cytoplasmic membranes and golgi trafficking of the NS4A protein. J Virol 2006;80(9):4623-32
   PubMed Web of Science ®Google Scholar
• Ambrose RL, Mackenzie JM. West Nile virus differentially modulates the unfolded protein response to facilitate replication and immune evasion. J Virol 2011;85(6):2723-32
   PubMed Web of Science ®Google Scholar
• Munoz-Jordan JL, Laurent-Rolle M, Ashour J, Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses. J Virol 2005;79(13):8004-13
   PubMed Web of Science ®Google Scholar
• Grant D, Tan GK, Qing M, A Single amino acid in nonstructural protein NS4B confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis. J Virol 2011;85(15):7775-87
   PubMed Web of Science ®Google Scholar
• Dong HP, Zhang B, Shi PY. Flavivirus methyltransferase: a novel antiviral target. Antiviral Res 2008;80(1):1-10
   PubMed Web of Science ®Google Scholar
• Iglesias NG, Filomatori CV, Gamarnik AV. The F1 motif of dengue virus polymerase NS5 is involved in promoter-dependent RNA synthesis. J Virol 2011;85(12):5745-56
   PubMed Web of Science ®Google Scholar
• Issur M, Geiss BJ, Bougie I, The flavivirus NS5 protein is a true RNA guanylyltransferase that catalyzes a two-step reaction to form the RNA cap structure. RNA 2009;15(12):2340-50
   PubMed Web of Science ®Google Scholar
• Zhang N, Chen HM, Koch V, Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against Flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus. J Med Chem 2003;46(19):4149-64
   PubMed Web of Science ®Google Scholar
• Ray D, Shi P-Y. Recent advances in flavivirus antiviral drug discovery and vaccine development. Recent Patents Anti Infect Drug Discov 2006;1(1):45-55
   PubMedGoogle Scholar
• Ishak R, Tovey DG, Howard CR. Morphogenesis of yellow fever virus 17D in infected cell cultures. J Gen Virol 1988;69:325-35
   PubMed Web of Science ®Google Scholar
• van der Schaar HM, Rust MJ, Waarts B-L, Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking. J Virol 2007;81(21):12019-28
   PubMed Web of Science ®Google Scholar
• Bressanelli S, Stiasny K, Allison SL, Structure of a flavivirus envelope glycoprotein in its low-pH-induced membrane fusion conformation. Embo J 2004;23(4):728-38
   PubMed Web of Science ®Google Scholar
• Modis Y, Ogata S, Clements D, A ligand-binding pocket in the dengue virus envelope glycoprotein. Proc Natl Acad Sci USA 2003;100(12):6986-91
   PubMed Web of Science ®Google Scholar
• Nemesio H, Palomares-Jerez F, Villalain J. The membrane-active regions of the dengue virus proteins C and E. Biochim Biophys Acta Biomembr 2011;1808(10):2390-402
   PubMed Web of Science ®Google Scholar
• Mackenzie JM, Khromykh AA, Westaway EG. Stable expression of noncytopathic Kunjin replicons simulates both ultrastructural and biochemical characteristics observed during replication of Kunjin virus. Virology 2001;279(1):161-72
   PubMed Web of Science ®Google Scholar
• Elshuber S, Allison SL, Heinz FX, Cleavage of protein prM is necessary for infection of BHK-21 cells by tick-borne encephalitis virus. J Gen Virol 2003;84:183-91
   PubMed Web of Science ®Google Scholar
• Kuhn RJ, Zhang W, Rossmann MG, Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. Cell 2002;108(5):717-25
   PubMed Web of Science ®Google Scholar
• Li L, Lok SM, Yu IM, The flavivirus precursor membrane-envelope protein complex: structure and maturation. Science 2008;319(5871):1830-4
   PubMed Web of Science ®Google Scholar
• Modis Y, Ogata S, Clements D, Structure of the dengue virus envelope protein after membrane fusion. Nature 2004;427(6972):313-19
   PubMed Web of Science ®Google Scholar
• Mukhopadhyay S, Kuhn RJ, Rossmann MG. A structural perspective of the flavivirus life cycle. Nat Rev Microbiol 2005;3(1):13-22
   PubMed Web of Science ®Google Scholar
• Stadler K, Allison SL, Schalich J, Proteolytic activation of tick-borne encephalitis virus by furin. J Virol 1997;71(11):8475-81
   PubMed Web of Science ®Google Scholar
• Yu IM, Zhang W, Holdaway HA, Structure of the immature dengue virus at low pH primes proteolytic maturation. Science 2008;319(5871):1834-7
   PubMed Web of Science ®Google Scholar
• Zhang W, Chipman PR, Corver J, Visualization of membrane protein domains by cryo-electron microscopy of dengue virus. Nat Struct Biol 2003;10(11):907-12
   PubMedGoogle Scholar
• Perera R, Khaliq M, Kuhn RJ. Closing the door on flaviviruses: entry as a target for antiviral drug design. Antiviral Res 2008;80(1):11-22
   PubMed Web of Science ®Google Scholar
• Poh MK, Yip A, Zhang S, A small molecule fusion inhibitor of dengue virus. Antiviral Res 2009;84(3):260-6
   PubMed Web of Science ®Google Scholar
• Wang Q-Y, Patel SJ, Vangrevelinghe E, A small-molecule dengue virus entry inhibitor. Antimicrob Agents Chemother 2009;53(5):1823-31
   PubMed Web of Science ®Google Scholar
• Altmeyer R. Virus attachment and entry offer numerous targets for antiviral therapy. Curr Pharm Des 2004;10(30):3701-12
   PubMed Web of Science ®Google Scholar
• Yennamalli R, Subbarao N, Kampmann T, Identification of novel target sites and an inhibitor of the dengue virus E protein. J Comput Aided Mol Des 2009;23(6):333-41
   PubMed Web of Science ®Google Scholar
• Li Z, Khaliq M, Zhou Z, Design, synthesis, and biological evaluation of antiviral agents targeting flavivirus envelope proteins. J Med Chem 2008;51(15):4660-71
   PubMed Web of Science ®Google Scholar
• Mayhoub AS, Khaliq M, Kuhn RJ, Design, synthesis, and biological evaluation of thiazoles targeting flavivirus envelope proteins. J Med Chem 2011;54(6):1704-14
   PubMed Web of Science ®Google Scholar
• Zhou Z, Khaliq M, Suk J-E, Antiviral compounds discovered by virtual screening of small-molecule libraries against dengue virus E protein. ACS Chem Biol 2008;3(12):765-75
   PubMed Web of Science ®Google Scholar
• Kampmann T, Yennamalli R, Campbell P, In silico screening of small molecule libraries using the dengue virus envelope E protein has identified compounds with antiviral activity against multiple flaviviruses. Antiviral Res 2009;84(3):234-41
   PubMed Web of Science ®Google Scholar
• Allison SL, Stiasny K, Stadler K, Mapping of functional elements in the stem-anchor region of tick-borne encephalitis virus envelope protein E. J Virol 1999;73(7):5605-12
   PubMed Web of Science ®Google Scholar
• Schmidt AG, Yang PL, Harrison SC. Peptide inhibitors of dengue-virus entry target a late-stage fusion intermediate. PLoS Pathog 2010;6(4):e1000851
   PubMed Web of Science ®Google Scholar
• Schmidt AG, Yang PL, Harrison SC. Peptide inhibitors of flavivirus entry derived from the E protein stem. J Virol 2010;84(24):12549-54
   PubMed Web of Science ®Google Scholar
• Costin JM, Jenwitheesuk E, Lok S-M, Structural optimization and de novo design of dengue virus entry inhibitory peptides. PLoS Negl Trop Dis 2010;4:(6):e721.
   PubMedGoogle Scholar
• Nicholson CO, Costin JM, Rowe DK, Viral entry inhibitors block dengue antibody-dependent enhancement in vitro. Antiviral Res 2011;89(1):71-4
   PubMed Web of Science ®Google Scholar
• Tarallo R, Accardo A, Falanga A, Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type 1 for intracellular drug delivery. Chemistry (Easton) 2011;17(45):12659-68
   Web of Science ®Google Scholar
• Dartois V, Sanchez-Quesada J, Cabezas E, Systemic antibacterial activity of novel synthetic cyclic peptides. Antimicrob Agents Chemother 2005;49(8):3302-10
   PubMed Web of Science ®Google Scholar
• Fernandez-Lopez S, Kim HS, Choi EC, Antibacterial agents based on the cyclic D,L-alpha-peptide architecture. Nature 2001;412(6845):452-5
   PubMed Web of Science ®Google Scholar
• Fletcher JT, Finlay JA, Callow ME, A combinatorial approach to the discovery of biocidal six-residue cyclic D,L-alpha-peptides against the bacteria methicillin-resistant staphylococcus aureus (MRSA) and E-coli and the biofouling algae ulva linza and navicula perminuta. Chem Eur J 2007;13(14):4008-13
   PubMed Web of Science ®Google Scholar
• Horne WS, Wiethoff CM, Cui CL, Antiviral cyclic D,L-alpha-peptides: targeting a general biochemical pathway in virus infections. Bioorg Med Chem 2005;13(17):5145-53
   PubMed Web of Science ®Google Scholar
• Montero A, Gastaminza P, Law M, Self-assembling peptide nanotubes with antiviral activity against hepatitis C virus. Chem Biol 2011;18(11):1453-62
   PubMed Web of Science ®Google Scholar
• Deas TS, Binduga-Gajewska I, Tilgner M, Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication. J Virol 2005;79(8):4599-609
   PubMed Web of Science ®Google Scholar
• Kinney RM, Huang CYH, Rose BC, Inhibition of dengue virus serotypes 1 to 4 in vero cell cultures with morpholino oligomers. J Virol 2005;79(8):5116-28
   PubMed Web of Science ®Google Scholar
• Holden KL, Stein DA, Pierson TC, Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3 ' stem-loop structure. Virology 2006;344(2):439-52
   PubMed Web of Science ®Google Scholar
• Achazi K, Patel P, Paliwal R, RNA interference inhibits replication of tick-borne encephalitis virus in vitro. Antiviral Res 2012;93(1):94-100
   PubMed Web of Science ®Google Scholar
• Pacca CC, Severino AA, Mondini A, RNA interference inhibits yellow fever virus replication in vitro and in vivo. Virus Genes 2009;38(2):224-31
   PubMed Web of Science ®Google Scholar
• Ivacik D, Ely A, Arbuthnot P. Countering hepatitis B virus infection using RNAi: how far are we from the clinic? Rev Med Virol 2011;21(6):383-96
   PubMed Web of Science ®Google Scholar
• Ieven M, Vlietinck AJ, Vandenberghe DA, Plant antiviral agents. 3. Isolation of alkaloids from clivia-minata regel (Amaryllidaceae). J Nat Prod 1982;45(5):564-73
   PubMed Web of Science ®Google Scholar
• Li SY, Chen C, Zhang HQ, Identification of natural compounds with antiviral activities against SARS-associated coronavirus. Antiviral Res 2005;67(1):18-23
   PubMed Web of Science ®Google Scholar
• Renardnozaki J, Kim T, Imakura Y, Effect of alkaloids isolated from Amaryllidaceae on herpes-simplex virus. Res Virol 1989;140(2):115-28
   PubMedGoogle Scholar
• Liu J, Yang Y, Xu Y, Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication. Virol J 2011;8:483-92
   PubMed Web of Science ®Google Scholar
• Zou G, Puig-Basagoiti F, Zhang B, A single-amino acid substitution in West Nile virus 2K peptide between NS4A and NS4B confers resistance to lycorine, a flavivirus inhibitor. Virology 2009;384(1):242-52
   PubMed Web of Science ®Google Scholar
• Mertens E, Kajaste-Rudnitski A, Torres S, Viral determinants in the NS3 helicase and 2K peptide that promote West Nile virus resistance to antiviral action of 2',5'-oligoadenylate synthetase 1b. Virology 2010;399(1):176-85
   PubMed Web of Science ®Google Scholar
• Miller S, Kastner S, Krijnse-Locker J, The non-structural protein 4A of dengue virus is an integral membrane protein inducing membrane alterations in a 2K-regulated manner. J Biol Chem 2007;282(12):8873-82
   PubMed Web of Science ®Google Scholar
• Miller S, Sparacio S, Bartenschlager R. Subcellular localization and membrane topology of the dengue virus type 2 non-structural protein 4B. J Biol Chem 2006;281(13):8854-63
   PubMed Web of Science ®Google Scholar
• Patkar CG, Larsen M, Owston M, Identification of inhibitors of yellow fever virus replication using a replicon-based high-throughput assay. Antimicrob Agents Chemother 2009;53(10):4103-14
   PubMed Web of Science ®Google Scholar
• Xie X, Wang Q-Y, Xu HY, Inhibition of dengue virus by targeting viral NS4B protein. J Virol 2011;85(21):11183-95
   PubMed Web of Science ®Google Scholar
• Umareddy I, Chao A, Sampath A, Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA. J Gen Virol 2006;87:2605-14
   PubMed Web of Science ®Google Scholar
• Ong SP, Chu JJH, Ng ML. Inhibition of West Nile virus replication in cells stably transfected with vector-based shRNA expression system. Virus Res 2008;135(2):292-7
   PubMed Web of Science ®Google Scholar
• Qin CF, Qin ED. Capsid-targeted viral inactivation can destroy dengue 2 virus from within in vitro. Arch Virol 2006;151(2):379-85
   PubMed Web of Science ®Google Scholar
• Lopez C, Gil L, Lazo L, In vitro assembly of nucleocapsid-like particles from purified recombinant capsid protein of dengue-2 virus. Arch Virol 2009;154(4):695-8
   PubMed Web of Science ®Google Scholar
• Molyneux RJ, Roitman JN, Dunnheim G, 6-Epicatanospermine, a novel indolizidine alkaloid that inhibits alpha-glucosidase. Arch Biochem Biophys 1986;251(2):450-7
   PubMed Web of Science ®Google Scholar
• Kang MS. Uptake and metabolism of BuCast: a glycoprotein processing inhibitor and a potential anti-HIV drug. Glycobiology 1996;6(2):209-16
   PubMed Web of Science ®Google Scholar
• Taylor DL, Sunkara PS, Liu PS, 6-0-Butanoylcastanospermine (MDL 28,574) inhibits glycoprotein processing and the growth of HIV. Aids 1991;5(6):693-8
   PubMed Web of Science ®Google Scholar
• Rathore APS, Paradkar PN, Watanabe S, Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model. Antiviral Res 2011;92(3):453-60
   PubMed Web of Science ®Google Scholar
• Somnuke P, Hauhart RE, Atkinson JP, N-linked glycosylation of dengue virus NS1 protein modulates secretion, cell-surface expression, hexamer stability, and interactions with human complement. Virology 2011;413(2):253-64
   PubMed Web of Science ®Google Scholar
• Heaton NS, Perera R, Berger KL, Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. Proc Natl Acad Sci USA 2010;107(40):17345-50
   PubMed Web of Science ®Google Scholar
• Perera R, Riley C, Hopf-Jannasch AS, Dengue virus perturbs lipid metabolism in infected mosquito cells. PLoS Pathog 2012; In press
   PubMed Web of Science ®Google Scholar
• Mukhopadhyay S, Kuhn RJ, Rossmann MG. A structural perspective of the flavivirus life cycle. Nat Rev Microbiol 2005;3(1):13-22
   PubMed Web of Science ®Google Scholar
• Miller S, Krijnse-Locker J. Modification of intracellular membrane structures for virus replication. Nat Rev Microbiol 2008;6(5):363-74
   PubMed Web of Science ®Google Scholar
• Quinkert D, Bartenschlager R, Lohmann V. Quantitative analysis of the hepatitis C virus replication complex. J Virol 2005;79(21):13594-605
   PubMed Web of Science ®Google Scholar