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Screening methods for influenza antiviral drug discovery

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Pages 429-438 | Published online: 22 Mar 2012

Bibliography

  • The Molecular Libraries Program. Available from: http://mlinihgov/mli/mlpcn/ [Accessed 19 January 2012]
  • Innovative Medicines Initiative. Available from: http://wwwimieuropaeu/content/5th-call-2012 [Accessed 19 January 2012]
  • European Infrastructure of Open Screening Platforms for Chemical Biology. Available from: http://wwweu-openscreeneu/ [Accessed 19 January 2012]
  • Centers for Disease Control and Prevention. Available from: http://www.cdc.gov/nchs/fastats/lcod.htm 2010. [Accessed 5 March 2012]
  • Szucs T. The socio-economic burden of influenza. J Antimicrob Chemother 1999;44(Suppl B):11-15
  • Hay AJ, Gregory V, Douglas AR, The evolution of human influenza viruses. Philos Trans R Soc Lond B Biol Sci 2001;356(1416):1861-70
  • Smith GJ, Vijaykrishna D, Bahl J, Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature 2009;459(7250):1122-5
  • Matsuzaki Y, Sugawara K, Mizuta K, Antigenic and genetic characterization of influenza C viruses which caused two outbreaks in Yamagata City, Japan, in 1996 and 1998. J Clin Microbiol 2002;40(2):422-9
  • Sittampalam S, Eastwood B, Iturria S, Assay Guidance Manual. Available from: http://assaynihgov/assay/indexphp/Table_of_Contents 2012. [Accessed 1 March 2012]
  • Noah DL, While EL, Noah JW. Development of high-throughput screening assays for influenza. In: Torrence PF, editor. Combating the Threat of Pandemic Influenza: Drug Discovery Approaches. John Wiley & Sons, Inc; Hoboken, NJ: 2007. p. 38-72
  • Stevens J, Blixt O, Paulson JC, Glycan microarray technologies: tools to survey host specificity of influenza viruses. Nat Rev Microbiol 2006;Nov4(11):857-64
  • Szecsi J, Drury R, Josserand V, Targeted retroviral vectors displaying a cleavage site-engineered hemagglutinin (HA) through HA-protease interactions. Mol Ther 2006;14(5):735-44
  • Ferrer M, Kapoor TM, Strassmaier T, Selection of gp41-mediated HIV-1 cell entry inhibitors from biased combinatorial libraries of non-natural binding elements. Nat Struct Biol 1999;6(10):953-60
  • Blick TJ, Tiong T, Sahasrabudhe A, Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en. Virology 1995;214(2):475-84
  • Kongkamnerd J, Milani A, Cattoli G, A screening assay for neuraminidase inhibitors using neuraminidases N1 and N3 from a baculovirus expression system. J Enzyme Inhib Med Chem 2011;27(1):5-11
  • Noah DL, Krug RM. Influenza virus virulence and its molecular determinants. Adv Virus Res 2005;65:121-45
  • Chien CY, Xu Y, Xiao R, Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus: evidence for a novel RNA-binding mode. Biochemistry 2004;43(7):1950-62
  • Li S, Min JY, Krug RM, Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA. Virology 2006;349(1):13-21
  • Maroto M, Fernandez Y, Ortin J, Development of an HTS assay for the search of anti-influenza agents targeting the interaction of viral RNA with the NS1 protein. J Biomol Screen 2008;13(7):581-90
  • Cho EJ, Xia S, Ma LC, Identification of Influenza virus inhibitors targeting NS1A utilizing fluorescence polarization-based high-throughput assay. J Biomol Screen January 5, 2012. doi:10.1177/1087057111431488
  • You L, Cho EJ, Leavitt J, Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors. Bioorg Med Chem Lett 2011;21(10):3007-11
  • Southern Research Specialized Biocontaiment Screening Center. Discovery of Small Molecule Probes for H1N1 Influenza NS1A. Available from: http://pubchemncbinlmnihgov/assay/assaycgi?aid=504399&loc=ea_ras 2012
  • Hooker L, Sully R, Handa B, Quantitative analysis of influenza virus RNP interaction with RNA cap structures and comparison to human cap binding protein eIF4E. Biochemistry 2003;42(20):6234-40
  • Newcomb LL, Kuo RL, Ye Q, Interaction of the influenza a virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication. J Virol 2009;83(1):29-36
  • Baughman BM, Slavish P, Dubois RM, Identification of influenza endonuclease inhibitors using a novel fluorescence polarization assay. ACS Chem Biol 2012;7(3):526-34
  • McCoy MH, Wang E. Use of electric cell-substrate impedance sensing as a tool for quantifying cytopathic effect in influenza A virus infected MDCK cells in real-time. J Virol Methods 2005;130(1-2):157-61
  • Noah JW, Severson W, Noah DL, A cell-based luminescence assay is effective for high-throughput screening of potential influenza antivirals. Antiviral Res 2007;73(1):50-9
  • Severson WE, McDowell M, Ananthan S, High-throughput screening of a 100,000-compound library for inhibitors of influenza A virus (H3N2). J Biomol Screen 2008;13(9):879-87
  • Maddry JA, Chen X, Jonsson CB, Discovery of novel benzoquinazolinones and thiazoloimidazoles, inhibitors of influenza H5N1 and H1N1 viruses, from a cell-based high-throughput screen. J Biomol Screen 2010;16(1):73-81
  • Matrosovich M, Matrosovich T, Garten W, New low-viscosity overlay medium for viral plaque assays. Virol J 2006;3:63
  • Sullivan K, Kloess J, Qian C, High throughput virus plaque quantitation using a flatbed scanner. J Virol Methods 2012;179(1):81-9
  • Huber I, Campe H, Sebah D, A multiplex one-step real-time RT-PCR assay for influenza surveillance. Euro Surveill 2011;16(7):19798-805
  • Zhang J, Liu T, Tong X, Identification of novel virus inhibitors by influenza A virus specific reporter cell based screening. Antiviral Res 2012;93(1):48-54
  • Ghanem A, Mayer D, Chase G, Peptide-mediated interference with influenza A virus polymerase. J Virol 2007;81(14):7801-4
  • Cairns MJ, Sun LQ. Nucleic acid sequence analysis using DNAzymes. Methods Mol Biol 2004;252:291-302
  • Watanabe T, Watanabe S, Kawaoka Y. Cellular networks involved in the influenza virus life cycle. Cell Host Microbe 2010;7(6):427-39
  • Konig R, Stertz S, Zhou Y, Human host factors required for influenza virus replication. Nature 2010;463(7282):813-17
  • Karlas A, Machuy N, Shin Y, Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication. Nature 2010;463(7282):818-22
  • Lietzen N, Ohman T, Rintahaka J, Quantitative subcellular proteome and secretome profiling of influenza A virus-infected human primary macrophages. PLoS Pathog 2011;7(5):e1001340
  • Liu L, Li R, Pan Y, High-throughput screen of protein expression levels induced by cyclooxygenase-2 during influenza a virus infection. Clin Chim Acta 2012;412(11-12):1081-5
  • Tscherne DM, Garcia-Sastre A. An enzymatic assay for detection of viral entry. Curr Protoc Cell Biol 2011; Chapter 26:Unit 26 12
  • Pinto LH, Lamb RA. Viral ion channels as models for ion transport and targets for antiviral drug action. FEBS Lett 2004;560(1-3):1-2
  • Bright RA, Shay DK, Shu B, Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States. Jama 2006;295(8):891-4
  • Perkel JM. High-throughput ion channel screening: a “patch”-work solution. Biotechniques 2010;48(1):25-9
  • Das K, Aramini JM, Ma LC, Structures of influenza A proteins and insights into antiviral drug targets. Nat Struct Mol Biol 2010;17(5):530-8
  • Babu YS, Chand P, Bantia S, BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design. J Med Chem 2000;43(19):3482-6
  • Grienke U, Schmidtke M, von Grafenstein S, Influenza neuraminidase: a druggable target for natural products. Nat Prod Rep 2011;29(1):11-36
  • Lew W, Chen X, Kim CU. Discovery and development of GS 4104 (oseltamivir): an orally active influenza neuraminidase inhibitor. Curr Med Chem 2000;7(6):663-72
  • von Itzstein M, Wu WY, Kok GB, Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature 1993;363(6428):418-23
  • Yamashita M, Tomozawa T, Kakuta M, CS-8958, a prodrug of the new neuraminidase inhibitor R-125489, shows long-acting anti-influenza virus activity. Antimicrob Agents Chemother 2009;53(1):186-92
  • Coloma R, Valpuesta JM, Arranz R, The structure of a biologically active influenza virus ribonucleoprotein complex. PLoS Pathog 2009;5(6):e1000491
  • Ng AK, Zhang H, Tan K, Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. FASEB J 2008;22(10):3638-47
  • Russell RJ, Kerry PS, Stevens DJ, Structure of influenza hemagglutinin in complex with an inhibitor of membrane fusion. Proc Natl Acad Sci USA 2008;105(46):17736-41
  • Schnell JR, Chou JJ. Structure and mechanism of the M2 proton channel of influenza A virus. Nature 2008;451(7178):591-5
  • Xia S, Monzingo AF, Robertus JD. Structure of NS1A effector domain from the influenza A/Udorn/72 virus. Acta Crystallogr D Biol Crystallogr 2009;65(Pt 1):11-17
  • Fukuoka M, Minakuchi M, Kawaguchi A, Structure-based discovery of anti-influenza virus A compounds among medicines. Biochim Biophys Acta 2011;1820(2):90-5
  • Fedichev P, Timakhov R, Pyrkov T, Structure-based drug design of a new chemical class of small molecules active against influenza A nucleoprotein in vitro and in vivo. PLoS Curr 2011;3:RRN1253
  • Pan D, Sun H, Shen Y, Exploring the molecular basis of dsRNA recognition by NS1 protein of influenza A virus using molecular dynamics simulation and free energy calculation. Antiviral Res 2011;92(3):424-33
  • World Health Organization. Table on Clinical trials of pandemic and potentially pandemic influenza vaccines. Available from: http://www.who.int/vaccine_research/diseases/influenza/flu_trials_tables/en/ 2011. [Accessed 13 January 2012]
  • Centers for Disease Control and Prevention. Available from: http://www.cdc.gov/flu/h2n2backgroundqa.htm 2006. [Accessed 3 January 2012]
  • Ludwig S, Pleschka S, Planz O, Ringing the alarm bells: signalling and apoptosis in influenza virus infected cells. Cell Microbiol 2006;8(3):375-86
  • Ludwig S, Wolff T. Influenza A virus TRIMs the type I interferon response. Cell Host Microbe 2009;5(5):420-1
  • World Health Organization. WHO activities in avian influenza and pandemic influenza preparedness. Available from: http://www.who.int/influenza/resources/documents/WHO_CDS_EPR_GIP_2006_6.pdf 2007 [Accessed 3 January 2012]

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