Methods for the discovery of new anti-aging products – targeted approaches

Bibliography

• Hayflick L. How and why we age. Exp Gerontol 1998;33:639-53
   PubMed Web of Science ®Google Scholar
• Kirkwood TB. Understanding the odd science of aging. Cell 2005;120:437-47
   PubMed Web of Science ®Google Scholar
• Falandry C, Gilson E, Rudolph KL. Are aging biomarkers clinically relevant in oncogeriatrics? Crit Rev Oncol Hematol 2013;85:257-65
   PubMed Web of Science ®Google Scholar
• De Loof A, De Haes W, Boerjan B, et al. The fading electricity theory of ageing: the missing biophysical principle? Ageing Res Rev 2013;12:58-66
   PubMed Web of Science ®Google Scholar
• Taylor RC, Dillin A. Aging as an event of proteostasis collapse. Cold Spring Harb Perspect Biol 2011;3: pii: a004440. doi: 10.1101/cshperspect.a004440.
   PubMed Web of Science ®Google Scholar
• Moskalev AA, Shaposhnikov MV, Plyusnina EN, et al. The role of DNA damage and repair in aging through the prism of Koch-like criteria. Ageing Res Rev 2013;12:661-84
   PubMed Web of Science ®Google Scholar
• Sedelnikova OA, Horikawa I, Zimonjic DB, et al. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat Cell Biol 2004;6:168-70
   PubMed Web of Science ®Google Scholar
• Prieur A, Peeper DS. Cellular senescence in vivo: a barrier to tumorigenesis. Curr Opin Cell Biol 2008;20:150-5
   PubMedGoogle Scholar
• Collado M, Serrano M. Senescence in tumours: evidence from mice and humans. Nat Rev Cancer 2010;10:51-7
   PubMed Web of Science ®Google Scholar
• DeGregori J. Evolved tumor suppression: why are we so good at not getting cancer? Cancer Res 2011;71:3739-44
   PubMed Web of Science ®Google Scholar
• Coppe JP, Desprez PY, Krtolica A, et al. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 2010;5:99-118
   PubMed Web of Science ®Google Scholar
• Pereira S, Bourgeois P, Navarro C, et al. HGPS and related premature aging disorders: from genomic identification to the first therapeutic approaches. Mech Ageing Dev 2008;129:449-59
   PubMed Web of Science ®Google Scholar
• Wojda A, Witt M. Manifestations of ageing at the cytogenetic level. J Appl Genet 2003;44:383-99
   PubMed Web of Science ®Google Scholar
• Xing J, Witherspoon DJ, Ray DA, et al. Mobile DNA elements in primate and human evolution. Am J Phys Anthropol 2007;(Suppl 45):2-19
   PubMedGoogle Scholar
• Belancio VP, Roy-Engel AM, Pochampally RR, et al. Somatic expression of LINE-1 elements in human tissues. Nucleic Acids Res 2010;38:3909-22
   Google Scholar
• St Laurent G III, Hammell N, McCaffrey TA. A LINE-1 component to human aging: do LINE elements exact a longevity cost for evolutionary advantage? Mech Ageing Dev 2010;131:299-305
   Google Scholar
• Lu T, Pan Y, Kao SY, et al. Gene regulation and DNA damage in the ageing human brain. Nature 2004;429:883-91
   PubMed Web of Science ®Google Scholar
• Nijnik A, Woodbine L, Marchetti C, et al. DNA repair is limiting for haematopoietic stem cells during ageing. Nature 2007;447:686-90
   PubMed Web of Science ®Google Scholar
• Rossi DJ, Bryder D, Seita J, et al. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 2007;447:725-9
   PubMed Web of Science ®Google Scholar
• Charville GW, Rando TA. Stem cell ageing and non-random chromosome segregation. Philos Trans R Soc Lond B Biol Sci 2011;366:85-93
   PubMed Web of Science ®Google Scholar
• Lavasani M, Robinson AR, Lu A, et al. Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nat Commun 2012;3:608
   PubMed Web of Science ®Google Scholar
• Kato M, Slack FJ. Ageing and the small, non-coding RNA world. Ageing Res Rev 2013;12:429-35
   PubMed Web of Science ®Google Scholar
• Ambros V. MicroRNAs and developmental timing. Curr Opin Genet Dev 2011;21:511-17
   PubMed Web of Science ®Google Scholar
• Kato M, Chen X, Inukai S, et al. Age-associated changes in expression of small, noncoding RNAs, including microRNAs, in C. elegans. RNA 2011;17:1804-20
   PubMed Web of Science ®Google Scholar
• Tuck AC, Tollervey D. RNA in pieces. Trends Genet 2011;27:422-32
   PubMed Web of Science ®Google Scholar
• Zhu C, Ji CB, Zhang CM, et al. The lin-4 gene controls fat accumulation and longevity in Caenorhabditis elegans. Int J Mol Sci 2010;11:4814-25
   PubMed Web of Science ®Google Scholar
• Miska EA, Alvarez-Saavedra E, Abbott AL, et al. Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet 2007;3:e215
   PubMed Web of Science ®Google Scholar
• Kenyon CJ. The genetics of ageing. Nature 2010;464:504-12
   PubMed Web of Science ®Google Scholar
• Ibanez-Ventoso C, Yang M, Guo S, et al. Modulated microRNA expression during adult lifespan in Caenorhabditis elegans. Aging Cell 2006;5:235-46
   PubMed Web of Science ®Google Scholar
• Liu N, Landreh M, Cao K, et al. The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila. Nature 2012;482:519-23
   PubMed Web of Science ®Google Scholar
• Gidalevitz T, Krupinski T, Garcia S, et al. Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity. PLoS Genet 2009;5:e1000399
   PubMed Web of Science ®Google Scholar
• Balch WE, Morimoto RI, Dillin A, et al. Adapting proteostasis for disease intervention. Science 2008;319:916-19
   PubMed Web of Science ®Google Scholar
• Soskic V, Groebe K, Schrattenholz A. Nonenzymatic posttranslational protein modifications in ageing. Exp Gerontol 2008;43:247-57
   PubMed Web of Science ®Google Scholar
• Levin M. Molecular bioelectricity in developmental biology: new tools and recent discoveries: control of cell behavior and pattern formation by transmembrane potential gradients. Bioessays 2012;34:205-17
   PubMed Web of Science ®Google Scholar
• Gerrow K, Triller A. Synaptic stability and plasticity in a floating world. Curr Opin Neurobiol 2010;20:631-9
   PubMed Web of Science ®Google Scholar
• Sama DM, Norris CM. Calcium dysregulation and neuroinflammation: discrete and integrated mechanisms for age-related synaptic dysfunction. Ageing Res Rev 2013;12(4):982-95
   PubMed Web of Science ®Google Scholar
• Thibault O, Gant JC, Landfield PW. Expansion of the calcium hypothesis of brain aging and Alzheimer's disease: minding the store. Aging Cell 2007;6:307-17
   PubMed Web of Science ®Google Scholar
• Oh MM, Oliveira FA, Waters J, et al. Altered calcium metabolism in aging CA1 hippocampal pyramidal neurons. J Neurosci 2013;33:7905-11
   PubMed Web of Science ®Google Scholar
• Gant JC, Sama MM, Landfield PW, et al. Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release. J Neurosci 2006;26:3482-90
   PubMed Web of Science ®Google Scholar
• Norris CM, Blalock EM, Chen KC, et al. Hippocampal ‘zipper’ slice studies reveal a necessary role for calcineurin in the increased activity of L-type Ca(2+) channels with aging. Neurobiol Aging 2010;31:328-38
   PubMed Web of Science ®Google Scholar
• Stutzmann GE, Mattson MP. Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease. Pharmacol Rev 2011;63:700-27
   PubMed Web of Science ®Google Scholar
• Govoni S, Amadio M, Battaini F, et al. Senescence of the brain: focus on cognitive kinases. Curr Pharm Des 2010;16:660-71
   PubMed Web of Science ®Google Scholar
• Foster TC. Calcium homeostasis and modulation of synaptic plasticity in the aged brain. Aging Cell 2007;6:319-25
   PubMed Web of Science ®Google Scholar
• Green KN, LaFerla FM. Linking calcium to Abeta and Alzheimer's disease. Neuron 2008;59:190-4
   PubMed Web of Science ®Google Scholar
• Chen D, Thomas EL, Kapahi P. HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet 2009;5:e1000486
   PubMed Web of Science ®Google Scholar
• Verkhratsky A, Rodriguez JJ, Parpura V. Calcium signalling in astroglia. Mol Cell Endocrinol 2012;353:45-56
   PubMed Web of Science ®Google Scholar
• Beskina O, Miller A, Mazzocco-Spezzia A, et al. Mechanisms of interleukin-1beta-induced Ca2+ signals in mouse cortical astrocytes: roles of store- and receptor-operated Ca2+ entry. Am J Physiol Cell Physiol 2007;293:C1103-11
   Google Scholar
• Lin F, Xin Y, Wang J, et al. Puerarin facilitates Ca(2+)-induced Ca(2+) release triggered by KCl-depolarization in primary cultured rat hippocampal neurons. Eur J Pharmacol 2007;570:43-9
   PubMed Web of Science ®Google Scholar
• Canellada A, Ramirez BG, Minami T, et al. Calcium/calcineurin signaling in primary cortical astrocyte cultures: rcan1-4 and cyclooxygenase-2 as NFAT target genes. Glia 2008;56:709-22
   PubMed Web of Science ®Google Scholar
• Donato R. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 2001;33:637-68
   PubMed Web of Science ®Google Scholar
• Puca AA, Carrizzo A, Villa F, et al. Vascular ageing: the role of oxidative stress. Int J Biochem Cell Biol 2013;45:556-9
   PubMed Web of Science ®Google Scholar
• Devasagayam TP, Tilak JC, Boloor KK, et al. Free radicals and antioxidants in human health: current status and future prospects. J Assoc Physicians India 2004;52:794-804
   PubMedGoogle Scholar
• Hyun DH, Emerson SS, Jo DG, et al. Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging. Proc Natl Acad Sci USA 2006;103:19908-12
   PubMed Web of Science ®Google Scholar
• Uttara B, Singh AV, Zamboni P, et al. Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol 2009;7:65-74
   PubMed Web of Science ®Google Scholar
• Ghanbari S, Yonessi M, Mohammadirad A, et al. Effects of IMOD and. Angipars on mouse D-galactose-induced model of aging. Daru 2012;20:68
   Web of Science ®Google Scholar
• Hasani-Ranjbar S, Khosravi S, Nayebi N, et al. A systematic review of the efficacy and safety of anti-aging herbs in animals and human. Asian J Anim Vet Adv 2012;7:621-40
   Web of Science ®Google Scholar
• Momtaz S, Abdollahi M. A comprehensive review of biochemical and molecular evidences from animal and human studies on the role of oxidative stress in aging: an epiphenomenon or the cause. Asian J Anim Vet Adv 2012;7:1-19
   Web of Science ®Google Scholar
• Saeidnia S, Abdollahi M. Toxicological and pharmacological concerns on oxidative stress and related diseases. Toxicol Appl Pharmacol 2013;273:442-55
   PubMed Web of Science ®Google Scholar
• Saeidnia S, Abdollahi M. Antioxidants: friends or foe in prevention or treatment of cancer: the debate of the century. Toxicol Appl Pharmacol 2013;271:49-63
   PubMed Web of Science ®Google Scholar
• Romano AD, Serviddio G, de Matthaeis A, et al. Oxidative stress and aging. J Nephrol 2010;15:S29-36
   Google Scholar
• Fontana L, Partridge L, Longo VD. Extending healthy life span from yeast to humans. Science 2010;328:321-6
   PubMed Web of Science ®Google Scholar
• Perez VI, Bokov A, Remmen HV, et al. Is the oxidative stress theory of aging dead? Biochim Biophys Acta 2009;1790:1005-14
   PubMed Web of Science ®Google Scholar
• Van Rammsdonk JM, Hekimi S. Deletion of the mitochondrial superoxide dismutase sod-2 extends lifespan in Caenorhabditis elegans. PLoS Genet 2009;5(2):e1000361
   Google Scholar
• Afanasev I. Signaling and damaging functions of free radicals in aging-free radical theory, hormesis, and TOR. Aging Dis 2010;1:75-88
   PubMedGoogle Scholar
• Sasaki T, Unno K, Tahara S, et al. Age-related increase of superoxide generation in the brains of mammals and birds. Aging Cell 2008;7:459-69
   PubMed Web of Science ®Google Scholar
• Mendoza-Nunez VM, Ruiz-Ramos M, Sánchez-Rodríguez MA, et al. Aging-related oxidative stress in healthy humans. Tohoku J Exp Med 2007;213:261-8
   PubMed Web of Science ®Google Scholar
• Lund DD, Chu Y, Miller JD, et al. Protective effect of extracellular superoxide dismutase on endothelial function during aging. Am J Physiol Heart Circ Physiol 2009;296:H1920-H5
   Google Scholar
• Merksamer PI, Liu Y, He W, et al. The sirtuins, oxidative stress and aging: an emerging link. Aging 2013;5:144-50
   PubMedGoogle Scholar
• Bjelakovic G, Nikolova D, Gluud LL, et al. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. J Am Med Assoc 2007;297:842-57
   PubMed Web of Science ®Google Scholar
• Michan S, Sinclair D. Sirtuins in mammals: insights into their biological function. Biochem J 2007;404:1-13
   PubMed Web of Science ®Google Scholar
• Bordone L, Cohen D, Robinson A, et al. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 2007;6:759-67
   PubMed Web of Science ®Google Scholar
• Haigis MC, Yankner BA. The aging stress response. Mol Cell 2010;40:333-44
   PubMed Web of Science ®Google Scholar
• Pan MH, Lai CS, Tsai ML, et al. Molecular mechanisms for anti-aging by natural dietary compounds. Mol Nutr Food Res 2012;56:88-115
   PubMed Web of Science ®Google Scholar
• Johnson SC, Rabinovitch PS, Kaeberlein M. mTOR is a key modulator of ageing and age-related disease. Nature 2013;493:338-45
   PubMed Web of Science ®Google Scholar
• Kaletsky R, Murphy CT. The role of insulin/IGF-like signaling in C. elegans longevity and aging. Dis Model Mech 2010;3:415-19
   PubMed Web of Science ®Google Scholar
• Guertin DA, Stevens DM, Thoreen CC, et al. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 2006;11:859-71
   PubMed Web of Science ®Google Scholar
• Paradies G, Paradies V, Ruggiero FM, et al. Changes in the mitochondrial permeability transition pore in aging and age-associated diseases. Mech Ageing Dev 2013;134:1-9
   PubMed Web of Science ®Google Scholar
• Falkenberg M, Larsson NG, Gustafsson CM. DNA replication and transcription in mammalian mitochondria. Annu Rev Biochem 2007;76:679-99
   PubMed Web of Science ®Google Scholar
• Paradies G, Petrosillo G, Paradies V, et al. Mitochondrial dysfunction in brain aging: role of oxidative stress and cardiolipin. Neurochem Int 2011;58:447-57
   PubMed Web of Science ®Google Scholar
• Pallauf K, Rimbach G. Autophagy, polyphenols and healthy ageing. Ageing Res Rev 2013;12:237-52
   PubMed Web of Science ®Google Scholar
• Hansen M, Chandra A, Mitic LL, et al. A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet 2008;4:e24
   PubMed Web of Science ®Google Scholar
• Terman A, Kurz T, Navratil M, et al. Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging. Antioxid Redox Signal 2010;12:503-35
   PubMed Web of Science ®Google Scholar
• Vina J, Borras C, Miquel J. Theories of ageing. IUBMB Life 2007;59:249-54
   PubMed Web of Science ®Google Scholar
• Simonsen A, Cumming RC, Brech A, et al. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 2008;4:176-84
   PubMed Web of Science ®Google Scholar
• Mizushima N, Yoshimori T, Ohsumi Y. The role of Atg proteins in autophagosome formation. Annu Rev Cell Dev Biol 2011;27:107-32
   PubMed Web of Science ®Google Scholar
• Taylor RC, Cullen SP, Martin SJ. Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 2008;9:231-41
   PubMed Web of Science ®Google Scholar
• Salminen A, Kaarniranta K, Kauppinen A. Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: impact on the aging process. Ageing Res Rev 2013;12:520-34
   PubMed Web of Science ®Google Scholar
• Nakanishi M, Niida H, Murakami H, et al. DNA damage responses in skin biology–implications in tumor prevention and aging acceleration. J Dermatol Sci 2009;56:76-81
   PubMed Web of Science ®Google Scholar
• Jaworska A, Dzbek J, Styczynska M, et al. Analysis of calcium homeostasis in fresh lymphocytes from patients with sporadic Alzheimer's disease or mild cognitive impairment. Biochim Biophys Acta 2013;1833:1692-9
   PubMed Web of Science ®Google Scholar
• Tuohimaa P, Keisala T, Minasyan A, et al. Vitamin D, nervous system and aging. Psychoneuroendocrinology 2009;34(Suppl 1):S278-86
   PubMedGoogle Scholar
• Donmez G, Wang D, Cohen DE, et al. SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. Cell 2010;142:320-32
   PubMed Web of Science ®Google Scholar
• Hauser DN, Hastings TG. Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism. Neurobiol Dis 2013;51:35-42
   PubMed Web of Science ®Google Scholar
• Mastroberardino PG, Hoffman EK, Horowitz MP, et al. A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease. Neurobiol Dis 2009;34:417-31
   PubMed Web of Science ®Google Scholar
• Li M, Chiu JF, Gagne J, et al. Age-related differences in insulin-like growth factor-1 receptor signaling regulates Akt/FOXO3a and ERK/Fos pathways in vascular smooth muscle cells. J Cell Physiol 2008;217:377-87
   PubMed Web of Science ®Google Scholar
• Borradaile NM, Pickering JG. NAD(+), sirtuins, and cardiovascular disease. Curr Pharm Des 2009;15:110-17
   PubMed Web of Science ®Google Scholar
• Ludlow AT, Roth SM. Physical activity and telomere biology: exploring the link with aging-related disease prevention. J Aging Res 2011;2011:790378
   PubMedGoogle Scholar
• Mukherjee PK, Maity N, Nema NK, et al. Bioactive compounds from natural resources against skin aging. Phytomedicine 2011;19:64-73
   PubMed Web of Science ®Google Scholar
• Ramos-e-Silva M, da Silva Carneiro SC. Elderly skin and its rejuvenation: products and procedures for the aging skin. J Cosmet Dermatol 2007;6:40-50
   PubMedGoogle Scholar
• Mukherjee PK, Rai S, Kumar V, et al. Plants of Indian origin in drug discovery. Expert Opin Drug Discov 2007;2:633-57
   PubMed Web of Science ®Google Scholar
• Liu L, Li L, Zhao L. Effects of 2,3,5,40-tetrahydroxyl diphenylethylene-2-Ob-D-glucoside on learning and memory abilities of rats with chronic cerebralischemia. Chin J Pharm Topical 2008;22:108-15
   Google Scholar
• Zhou XX, Yang Q, Xie YH, et al. Protective effect of tetrahydroxystilbene glucoside against D-galactose induced aging process in mice. Phytochem Lett 2013;6:372-8
   Web of Science ®Google Scholar
• Abraham J, Johnson RW. Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice. Rejuvenation Res 2009;12:445-53
   PubMed Web of Science ®Google Scholar
• Morselli E, Marino G, Bennetzen MV, et al. Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol 2011;192:615-29
   PubMed Web of Science ®Google Scholar
• Perez-Lopez FR, Chedraui P, Fernandez-Alonso AM. Vitamin D and aging: beyond calcium and bone metabolism. Maturitas 2011;69:27-36
   PubMed Web of Science ®Google Scholar
• Hagstrom E, Hellman P, Larsson TE, et al. Plasma parathyroid hormone and the risk of cardiovascular mortality in the community. Circulation 2009;119:2765-71
   PubMed Web of Science ®Google Scholar
• Bjorkman MP, Sorva AJ, Tilvis RS. Does elevated parathyroid hormone concentration predict cognitive decline in older people? Aging Clin Exp Res 2010;22:164-9
   PubMed Web of Science ®Google Scholar
• Pilz S, Tomaschitz A, Drechsler C, et al. Parathyroid hormone level is associated with mortality and cardiovascular events in patients undergoing coronary angiography. Eur Heart J 2010;31:1591-8
   PubMed Web of Science ®Google Scholar
• Forouhi NG, Luan J, Cooper A, et al. Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes 2008;57:2619-25
   PubMed Web of Science ®Google Scholar
• Richards JB, Valdes AM, Gardner JP, et al. Higher serum vitamin D concentrations are associated with longer leukocyte telomere length in women. Am J Clin Nutr 2007;86:1420-5
   PubMed Web of Science ®Google Scholar
• Denis I, Potier B, Vancassel S, et al. Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms. Ageing Res Rev 2013;12:579-94
   PubMed Web of Science ®Google Scholar
• Stillwell W, Wassall SR. Docosahexaenoic acid: membrane properties of a unique fatty acid. Chem Phys Lipids 2003;126:1-27
   PubMed Web of Science ®Google Scholar
• Rao JS, Ertley RN, DeMar JC Jr, et al. Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. Mol Psychiatry 2007;12:151-7
   PubMed Web of Science ®Google Scholar
• Pizza V, Agresta A, D'Acunto CW, et al. Neuroinflammation and ageing: current theories and an overview of the data. Rev Recent Clin Trials 2011;6:189-203
   PubMedGoogle Scholar
• Kelly L, Grehan B, Chiesa AD, et al. The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat. Neurobiol Aging 2011;32:2318. e1-15
   PubMedGoogle Scholar
• Su HM. Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. J Nutr Biochem 2010;21:364-73
   PubMed Web of Science ®Google Scholar
• Pletcher SD, Macdonald SJ, Margueri R, et al. Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr Biol 2002;12:712-23
   Google Scholar
• Puca AA, Daly MJ, Brewster SJ, et al. A genome-wide scan for linkage to human exceptional longevity identifies a locus on chromosome 4. Proc Natl Acad Sci USA 2001;98:10505-8
   PubMed Web of Science ®Google Scholar
• de Magalhaes JP, Faragher RG. Cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity. Bioessays 2008;30:567-78
   Google Scholar
• Cristofalo V. I no longer believe that cell death is programmed, an interview with Vincent Cristofalo. Biogerontology 2001;2:283-90
   PubMed Web of Science ®Google Scholar
• Petrascheck M, Ye X, Buck LB. An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature 2007;450:553-6
   PubMed Web of Science ®Google Scholar
• Kaeberlein M, Burtner CR, Kennedy BK. Recent developments in yeast aging. Plos Genet 2007;3:0655-60
   Google Scholar
• Masoro EJ. Overview of caloric restriction and ageing. Mech Ageing Dev 2005;126:913-22
   PubMed Web of Science ®Google Scholar
• Jafari M, Long AD, Mueller LD, et al. The pharmacology of aging in Drosophila. Curr Drug Targets 2006;7:1479-83
   PubMed Web of Science ®Google Scholar
• Moskalev M, Shaposhnikov M. Pharmacological inhibition of NF-kappaB prolongs lifespan of Drosophila melanogaster. Aging 2011;3:391-4
   PubMedGoogle Scholar
• McElwee JJ, Schuster E, Blanc E, et al. Evolutionary conservation of regulated longevity assurance mechanisms. Genome Biol 2007;8:R132
   PubMed Web of Science ®Google Scholar
• Cenci G, Ciapponi L, Gatti M. The mechanism of telomere protection: a comparison between Drosophila and humans. Chromosoma 2005;114:135-45
   PubMed Web of Science ®Google Scholar
• Jafari M, Rose MR. Rules for the use of model organisms in anti-aging pharmacology. Aging Cell 2006;5:17-22
   PubMed Web of Science ®Google Scholar
• Li D, Duan D. Mitochondria-targeted antiaging gene therapy with adeno-associated viral vectors. Methods Mol Biol 2013;1048:161-80
   PubMedGoogle Scholar
• Mendelsohn AR, Larrick JW. Rapamycin as an antiaging therapeutic?: targeting mammalian target of rapamycin to treat Hutchinson-Gilford progeria and neurodegenerative diseases. Rejuvenation Res 2011;14:437-41
   PubMed Web of Science ®Google Scholar
• Lee BC, Lee SY, Lee HJ, et al. Anti-oxidative and photo-protective effects of coumarins isolated from Fraxinus chinensis. Arch Pharm Res 2007;30:1293-301
   PubMed Web of Science ®Google Scholar
• Mohammadirad A, Aghamohammadali-Sarraf F, Badiei S, et al. Anti-Aging effects of some selected Iranian folk medicinal herbs-biochemical evidences. Iran J Basic Med Sci 2013;16:1170-80
   Web of Science ®Google Scholar
• Jin HZ, Du JL, Zhang WD, et al. A new quinazolinedione alkaloid from the fruits of Evodia officinalis. Fitoterapia 2008;79:317-18
   PubMed Web of Science ®Google Scholar
• Sultana Y, Kohli K, Athar M, et al. Effect of pre-treatment of almond oil on ultraviolet B-induced cutaneous photoaging in mice. J Cosmet Dermatol 2007;6:14-19
   PubMedGoogle Scholar
• Lee SY, Kim MR, Choi HS, et al. The effect of curculigoside on the expression of matrix metalloproteinase-1 in cultured human skin fibroblasts. Arch Pharm Res 2009;32:1433-9
   PubMed Web of Science ®Google Scholar
• Naylor RM, Baker DJ, van Deursen JM. Senescent cells: a novel therapeutic target for aging and age-related diseases. Clin Pharmacol Ther 2013;93:105-16
   PubMed Web of Science ®Google Scholar
• Atamna H, Cheung I, Ames BN. A method for detecting abasic sites in living cells: age-dependent changes in base excision repair. Proc Natl Acad Sci USA 2000;97:686-91
   PubMed Web of Science ®Google Scholar
• Kasai H. Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutat Res 1997;387:147-63
   PubMed Web of Science ®Google Scholar
• Degan P, Bonassi S, De Caterina M, et al. In vivo accumulation of 8-hydroxy-2'-deoxyguanosine in DNA correlates with release of reactive oxygen species in Fanconi's anaemia families. Carcinogenesis 1995;16:735-41
   PubMed Web of Science ®Google Scholar
• Machwe A, Ganunis R, Bohr VA, et al. Selective blockage of the 3′–>5′ exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA. Nucleic Acids Res 2000;28:2762-70
   PubMed Web of Science ®Google Scholar
• Fraga CG, Shigenaga MK, Park JW, et al. Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci USA 1990;87:4533-7
   PubMed Web of Science ®Google Scholar
• Lai C, Cao H, Hearst JE, et al. Quantitative analysis of DNA interstrand cross-links and monoadducts formed in human cells induced by psoralens and UVA irradiation. Anal Chem 2008;80:8790-8
   Google Scholar
• Voulgaridou GP, Anestopoulos I, Franco R, et al. DNA damage induced by endogenous aldehydes: current state of knowledge. Mutat Res 2011;711:13-27
   PubMed Web of Science ®Google Scholar
• Breyer V, Becker CM, Pischetsrieder M. Intracellular glycation of nuclear DNA, mitochondrial DNA, and cytosolic proteins during senescence-like growth arrest. DNA Cell Biol 2011;30:681-9
   PubMed Web of Science ®Google Scholar
• Yamamoto O, Fuji I, Yoshida T, et al. Age dependency of base modification in rabbit liver DNA. J Gerontol 1988;43:B132-6
   Google Scholar
• Izzotti A, Cartiglia C, Taningher M, et al. Age-related increases of 8-hydroxy-2'-deoxyguanosine and DNA-protein crosslinks in mouse organs. Mutat Res 1999;446:215-23
   PubMed Web of Science ®Google Scholar
• Newton RK, Ducore JM, Sohal RS. Effect of age on endogenous DNA single-strand breakage, strand break induction and repair in the adult housefly, Musca domestica. Mutat Res 1989;219:113-20
   PubMed Web of Science ®Google Scholar
• Fu CS, Harris SB, Wilhelmi P, et al. Lack of effect of age and dietary restriction on DNA single-stranded breaks in brain, liver, and kidney of (C3H x C57BL/10)F1 mice. J Gerontol 1991;46:B78-80
   Google Scholar
• Morgan WF, Corcoran J, Hartmann A, et al. DNA double-strand breaks, chromosomal rearrangements, and genomic instability. Mutat Res 1998;404:125-8
   PubMed Web of Science ®Google Scholar
• Gorbunova V, Seluanov A, Mao Z, et al. Changes in DNA repair during aging. Nucleic Acids Res 2007;35:7466-74
   PubMed Web of Science ®Google Scholar
• Chiocchetti A, Zhou J, Zhu H, et al. Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span. Exp Gerontol 2007;42:275-86
   PubMed Web of Science ®Google Scholar
• Hansen M, Taubert S, Crawford D, et al. Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans. Aging Cell 2007;6:95-110
   PubMed Web of Science ®Google Scholar
• Pan KZ, Palter JE, Rogers AN, et al. Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans. Aging Cell 2007;6:111-19
   PubMed Web of Science ®Google Scholar
• Bukau B, Weissman J, Horwich A. Molecular chaperones and protein quality control. Cell 2006;125:443-51
   PubMed Web of Science ®Google Scholar
• Behrends C, Langer CA, Boteva R, et al. Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers. Mol Cell 2006;23:887-97
   PubMed Web of Science ®Google Scholar
• Shorter J, Lindquist S. Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers. Science 2004;304:1793-7
   PubMed Web of Science ®Google Scholar
• Mehta R, Steinkraus KA, Sutphin GL, et al. Proteasomal regulation of the hypoxic response modulates aging in C. elegans. Science 2009;324:1196-8
   PubMed Web of Science ®Google Scholar
• Zhang Y, Shao Z, Zhai Z, et al. The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans. PLoS One 2009;4:e6348
   PubMed Web of Science ®Google Scholar
• Ben-Zvi A, Miller EA, Morimoto RI. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci USA 2009;106:14914-19
   PubMed Web of Science ®Google Scholar
• Hamer G, Matilainen O, Holmberg CI. A photoconvertible reporter of the ubiquitin-proteasome system in vivo. Nat Methods 2010;7:473-8
   PubMed Web of Science ®Google Scholar
• Hsu MF, Chiang BH. Stimulating effects of Bacillus subtilis natto-fermented Radix astragali on hyaluronic acid production in human skin cells. J Ethnopharmacol 2009;125:474-81
   PubMed Web of Science ®Google Scholar
• Kim S, Kim Y, Kim JE, et al. Berberine inhibits TPA-induced MMP-9 and IL-6 expression in normal human keratinocytes. Phytomedicine 2008;15:340-7
   PubMed Web of Science ®Google Scholar
• Fonseca YM, Catini CD, Vicentini FT, et al. Protective effect of Calendula officinalis extract against UVB-induced oxidative stress in skin: evaluation of reduced glutathione levels and matrix metalloproteinase secretion. J Ethnopharmacol 2010;127:596-601
   PubMed Web of Science ®Google Scholar
• Jung E, Lee J, Baek J, et al. Effect of Camellia japonica oil on human type I procollagen production and skin barrier function. J Ethnopharmacol 2007;112:127-31
   PubMed Web of Science ®Google Scholar
• Li YH, Wu Y, Wei HC, et al. Protective effects of green tea extracts on photoaging and photommunosuppression. Skin Res Technol 2009;15:338-45
   PubMed Web of Science ®Google Scholar
• Cimino F, Cristani M, Saija A, et al. Protective effects of a red orange extract on UVB-induced damage in human keratinocytes. Biofactors 2007;30:129-38
   PubMed Web of Science ®Google Scholar
• Nema NK, Maity N, Sarkar B, et al. Cucumis sativus fruit-potential antioxidant, anti-hyaluronidase, and anti-elastase agent. Arch Dermatol Res 2011;303:247-52
   PubMed Web of Science ®Google Scholar
• Sumiyoshi M, Kimura Y. Effects of a turmeric extract (Curcuma longa) on chronic ultraviolet B irradiation-induced skin damage in melanin-possessing hairless mice. Phytomedicine 2009;16:1137-43
   PubMed Web of Science ®Google Scholar
• Oh HI, Shim JS, Gwon SH, et al. The effect of xanthorrhizol on the expression of matrix metalloproteinase-1 and type-I procollagen in ultraviolet-irradiated human skin fibroblasts. Phytother Res 2009;23:1299-302
   PubMed Web of Science ®Google Scholar
• Tada Y, Kanda N, Haratake A, et al. Novel effects of diosgenin on skin aging. Steroids 2009;74:504-11
   PubMed Web of Science ®Google Scholar
• Chanvorachote P, Pongrakhananon V, Luanpitpong S, et al. Type I pro-collagen promoting and anti-collagenase activities of Phyllanthus emblica extract in mouse fibroblasts. J Cosmet Sci 2009;60:395-403
   PubMed Web of Science ®Google Scholar
• Tsoyi K, Park HB, Kim YM, et al. Protective effect of anthocyanins from black soybean seed coats on UVB-induced apoptotic cell death in vitro and in vivo. J Agric Food Chem 2008;56:10600-5
   PubMed Web of Science ®Google Scholar
• Shim JS, Choi EJ, Lee CW, et al. Matrix metalloproteinase-1 inhibitory activity of Kaempferia pandurata Roxb. J Med Food 2009;12:601-7
   PubMed Web of Science ®Google Scholar
• Choi HK, Kim DH, Kim JW, et al. Labisia pumila extract protects skin cells from photoaging caused by UVB irradiation. J Biosci Bioeng 2010;109:291-6
   PubMed Web of Science ®Google Scholar
• Moon HI, Jung JC. Effect of meso-dihydroguaiaretic acid from Machilus thunbergii Sieb et Zucc on MMP-1 expression in heat shock-induced cultured primary human fibroblasts. Phytother Res 2006;20:714-16
   PubMed Web of Science ®Google Scholar
• Tanaka K, Hasegawa J, Asamitsu K, et al. Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB. Eur J Pharmacol 2007;565:212-19
   PubMed Web of Science ®Google Scholar
• Cho YH, Kim JH, Sim GS, et al. Inhibitory effects of antioxidant constituents from Melothria heterophylla on matrix metalloproteinase-1 expression in UVA-irradiated human dermal fibroblasts. J Cosmet Sci 2006;57:279-89
   PubMed Web of Science ®Google Scholar
• Mula S, Banerjee D, Patro BS, et al. Inhibitory property of the Piper betel phenolics against photosensitization-induced biological damages. Bioorg Med Chem 2008;16:2932-8
   PubMed Web of Science ®Google Scholar
• Maity N, Nema NK, Abedy MK, et al. Exploring Tagetes erecta Linn flower for the elastase, hyaluronidase and MMP-1 inhibitory activity. J Ethnopharmacol 2011;137:1300-5
   PubMed Web of Science ®Google Scholar
• Kim SJ, Sancheti SA, Sancheti SS, et al. Effect of 1,2,3,4,6-penta-O-galloyl-beta-D-glucose on elastase and hyaluronidase activities and its type II collagen expression. Acta Pol Pharm 2010;67:145-50
   PubMed Web of Science ®Google Scholar
• Mitani H, Ryu A, Suzuki T, et al. Topical application of plant extracts containing xanthine derivatives can prevent UV-induced wrinkle formation in hairless mice. Photodermatol Photoimmunol Photomed 2007;23:86-94
   PubMed Web of Science ®Google Scholar
• Bae JY, Lim SS, Kim SJ, et al. Bog blueberry anthocyanins alleviate photoaging in ultraviolet-B irradiation-induced human dermal fibroblasts. Mol Nutr Food Res 2009;53:726-38
   PubMed Web of Science ®Google Scholar
• Cornacchione S, Sadick NS, Neveu M, et al. In vivo skin antioxidant effect of a new combination based on a specific Vitis vinifera shoot extract and a biotechnological extract. J Drugs Dermatol 2007;6:s8-13
   Google Scholar
• Tsukahara K, Nakagawa H, Moriwaki S, et al. Inhibition of ultraviolet-B-induced wrinkle formation by an elastase-inhibiting herbal extract: implication for the mechanism underlying elastase-associated wrinkles. Int J Dermatol 2006;45:460-8
   PubMed Web of Science ®Google Scholar