Fresh approaches to antidepressant drug discovery

Bibliography

• Andrade L, Caraveo-Anduaga JJ, Berglund P, et al. The epidemiology of major depressive episodes: results from the International Consortium of Psychiatric Epidemiology (ICPE) Surveys. Int J Methods Psychiatr Res 2003;12(1):3-21
   PubMed Web of Science ®Google Scholar
• Available from: http://www.who.int/mediacentre/factsheets/fs369/en/
   Google Scholar
• Thase ME, Haight BR, Richard N, et al. Remission rates following antidepressant therapy with bupropion or selective serotonin reuptake inhibitors: a meta-analysis of original data from 7 randomized controlled trials. J Clin Psychiatry 2005;66(8):974-81
   PubMed Web of Science ®Google Scholar
• Trivedi MH, Rush AJ, Wisniewski SR, et al. Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. Am J Psychiatry 2006;163(1):28-40
   PubMed Web of Science ®Google Scholar
• Freis ED. Mental depression in hypertensive patients treated for long periods with large doses of reserpine. N Engl J Med 1954;251(25):1006-8
   PubMed Web of Science ®Google Scholar
• Krishnan V, Nestler EJ. The molecular neurobiology of depression. Nature 2008;455(7215):894-902
   PubMed Web of Science ®Google Scholar
• Hirschfeld RM. History and evolution of the monoamine hypothesis of depression. J Clin Psychiatry 2000;61(Suppl 6):4-6
   PubMed Web of Science ®Google Scholar
• Schildkraut JJ, Gordon EK, Durell J. Catecholamine metabolism in affective disorders. I. Normetanephrine and VMA excretion in depressed patients treated with imipramine. J Psychiatr Res 1965;3(4):213-28
   PubMed Web of Science ®Google Scholar
• Owens MJ. Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond. J Clin Psychiatry 2004;65(Suppl 4):5-10
   PubMed Web of Science ®Google Scholar
• Carlsson A, Fuxe K, Ungerstedt U. The effect of imipramine on central 5-hydroxytryptamine neurons. J Pharm Pharmacol 1968;20(2):150-1
   PubMed Web of Science ®Google Scholar
• Delgado PL. Depression: the case for a monoamine deficiency. J Clin Psychiatry 2000;61(Suppl 6):7-11
   PubMed Web of Science ®Google Scholar
• Ruhe HG, Mason NS, Schene AH. Mood is indirectly related to serotonin, norepinephrine and dopamine levels in humans: a meta-analysis of monoamine depletion studies. Mol Psychiatry 2007;12(4):331-59
   PubMed Web of Science ®Google Scholar
• Hindmarch I. Beyond the monoamine hypothesis: mechanisms, molecules and methods. Eur Psychiatry 2002;17(Suppl 3):294-9
   PubMedGoogle Scholar
• Cohen LS, Miner C, Brown EW, et al. Premenstrual daily fluoxetine for premenstrual dysphoric disorder: a placebo-controlled, clinical trial using computerized diaries. Obstet Gynecol 2002;100(3):435-44
   PubMed Web of Science ®Google Scholar
• Cuthbert BN, Insel TR. Toward the future of psychiatric diagnosis: the seven pillars of RDoC. BMC Med 2013;11:126
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders. American Psychiatric Association, Arlington, VA; 2013
   Google Scholar
• Nemeroff CB, Weinberger D, Rutter M, et al. DSM-5: a collection of psychiatrist views on the changes, controversies, and future directions. BMC Med 2013;11:202
   PubMed Web of Science ®Google Scholar
• Available from: http://www.nimh.nih.gov/about/strategic-planning-reports/index.shtml#strategic-objective1
   Google Scholar
• Available from: http://www.nimh.nih.gov/research-priorities/rdoc/nimh-research-domain-criteria-rdoc.shtml#toc_matrix
   Google Scholar
• Anacker C, Zunszain PA, Carvalho LA, Pariante CM. The glucocorticoid receptor: pivot of depression and of antidepressant treatment? Psychoneuroendocrinology 2011;36(3):415-25
   PubMed Web of Science ®Google Scholar
• Nemeroff CB, Krishnan KR, Reed D, et al. Adrenal gland enlargement in major depression. A computed tomographic study. Arch Gen Psychiatry 1992;49(5):384-7
   PubMed Web of Science ®Google Scholar
• Pariante CM. Depression, stress and the adrenal axis. J Neuroendocrinol 2003;15(8):811-12
   PubMed Web of Science ®Google Scholar
• Holsboer F, Von Bardeleben U, Gerken A, et al. Blunted corticotropin and normal cortisol response to human corticotropin-releasing factor in depression. N Engl J Med 1984;311(17):1127
   PubMed Web of Science ®Google Scholar
• Bhatnagar S, Meaney MJ. Hypothalamic-pituitary-adrenal function in chronic intermittently cold-stressed neonatally handled and non handled rats. J Neuroendocrinol 1995;7(2):97-108
   PubMed Web of Science ®Google Scholar
• Lupien S, Lecours AR, Lussier I, et al. Basal cortisol levels and cognitive deficits in human aging. J Neurosci 1994;14(5 Pt 1):2893-903
   PubMed Web of Science ®Google Scholar
• Plotsky PM, Thrivikraman KV, Meaney MJ. Central and feedback regulation of hypothalamic corticotropin-releasing factor secretion. Ciba Found Symp 1993;172:59-75; discussion 75-84
   PubMedGoogle Scholar
• Sapolsky RM, Meaney MJ, McEwen BS. The development of the glucocorticoid receptor system in the rat limbic brain. III. Negative-feedback regulation. Brain Res 1985;350(1-2):169-73
   PubMed Web of Science ®Google Scholar
• Meaney MJ, Bhatnagar S, Diorio J, et al. Molecular basis for the development of individual differences in the hypothalamic-pituitary-adrenal stress response. Cell Mol Neurobiol 1993;13(4):321-47
   PubMed Web of Science ®Google Scholar
• Anacker C, Cattaneo A, Luoni A, et al. Glucocorticoid-related molecular signaling pathways regulating hippocampal neurogenesis. Neuropsychopharmacology 2013;38(5):872-83
   PubMed Web of Science ®Google Scholar
• Anacker C, Pariante CM. Can adult neurogenesis buffer stress responses and depressive behaviour? Mol Psychiatry 2012;17(1):9-10
   PubMed Web of Science ®Google Scholar
• Anacker C, Cattaneo A, Musaelyan K, et al. Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis. Proc Natl Acad Sci USA 2013;110(21):8708-13
   PubMed Web of Science ®Google Scholar
• David DJ, Samuels BA, Rainer Q, et al. Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. Neuron 2009;62(4):479-93
   PubMed Web of Science ®Google Scholar
• Murray F, Smith DW, Hutson PH. Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice. Eur J Pharmacol 2008;583(1):115-27
   PubMed Web of Science ®Google Scholar
• Young EA, Haskett RF, Murphy-Weinberg V, et al. Loss of glucocorticoid fast feedback in depression. Arch Gen Psychiatry 1991;48(8):693-9
   PubMed Web of Science ®Google Scholar
• Juruena MF, Cleare AJ, Papadopoulos AS, et al. Different responses to dexamethasone and prednisolone in the same depressed patients. Psychopharmacology (Berl) 2006;189(2):225-35
   PubMed Web of Science ®Google Scholar
• Adam EK, Sutton JM, Doane LD, Mineka S. Incorporating hypothalamic-pituitary-adrenal axis measures into preventive interventions for adolescent depression: are we there yet? Dev Psychopathol 2008;20(3):975-1001
   PubMed Web of Science ®Google Scholar
• Seckl JR, Meaney MJ. Glucocorticoid "programming" and PTSD risk. Ann NY Acad Sci 2006;1071:351-78
   PubMed Web of Science ®Google Scholar
• Vicennati V, Pasquali R. Abnormalities of the hypothalamic-pituitary-adrenal axis in nondepressed women with abdominal obesity and relations with insulin resistance: evidence for a central and a peripheral alteration. J Clin Endocrinol Metab 2000;85(11):4093-8
   PubMed Web of Science ®Google Scholar
• Belvederi Murri M, Pariante CM, Dazzan P, et al. Hypothalamic-pituitary-adrenal axis and clinical symptoms in first-episode psychosis. Psychoneuroendocrinology 2012;37(5):629-44
   PubMed Web of Science ®Google Scholar
• Belanoff JK, Rothschild AJ, Cassidy F, et al. An open label trial of C-1073 (mifepristone) for psychotic major depression. Biol Psychiatry 2002;52(5):386-92
   PubMed Web of Science ®Google Scholar
• Flores BH, Kenna H, Keller J, et al. Clinical and biological effects of mifepristone treatment for psychotic depression. Neuropsychopharmacology 2006;31(3):628-36
   PubMed Web of Science ®Google Scholar
• Zalachoras I, Houtman R, Atucha E, et al. Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator. Proc Natl Acad Sci USA 2013;110(19):7910-15
   PubMed Web of Science ®Google Scholar
• Howren MB, Lamkin DM, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med 2009;71(2):171-86
   PubMed Web of Science ®Google Scholar
• Dowlati Y, Herrmann N, Swardfager W, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry 2010;67(5):446-57
   PubMed Web of Science ®Google Scholar
• Schiepers OJ, Wichers MC, Maes M. Cytokines and major depression. Prog Neuropsychopharmacol Biol Psychiatry 2005;29(2):201-17
   PubMed Web of Science ®Google Scholar
• Iwata M, Ota KT, Duman RS. The inflammasome: pathways linking psychological stress, depression, and systemic illnesses. Brain Behav Immun 2013;31:105-14
   PubMed Web of Science ®Google Scholar
• Koo JW, Duman RS. IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc Natl Acad Sci USA 2008;105(2):751-6
   PubMed Web of Science ®Google Scholar
• Goshen I, Kreisel T, Ben-Menachem-Zidon O, et al. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol Psychiatry 2008;13(7):717-28
   PubMed Web of Science ®Google Scholar
• Capuron L, Miller AH. Cytokines and psychopathology: lessons from interferon-alpha. Biol Psychiatry 2004;56(11):819-24
   PubMed Web of Science ®Google Scholar
• Zunszain PA, Anacker C, Cattaneo A, et al. Interleukin-1beta: a new regulator of the kynurenine pathway affecting human hippocampal neurogenesis. Neuropsychopharmacology 2012;37(4):939-49
   PubMed Web of Science ®Google Scholar
• Zunszain PA, Anacker C, Cattaneo A, et al. Glucocorticoids, cytokines and brain abnormalities in depression. Prog Neuropsychopharmacol Biol Psychiatry 2011;35(3):722-9
   PubMed Web of Science ®Google Scholar
• Pariante CM, Pearce BD, Pisell TL, et al. The proinflammatory cytokine, interleukin-1alpha, reduces glucocorticoid receptor translocation and function. Endocrinology 1999;140(9):4359-66
   PubMed Web of Science ®Google Scholar
• Raison CL, Miller AH. Is depression an inflammatory disorder? Curr Psychiatry Rep 2011;13(6):467-75
   PubMed Web of Science ®Google Scholar
• Na KS, Lee KJ, Lee JS, et al. Efficacy of adjunctive celecoxib treatment for patients with major depressive disorder: a meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry 2014;48:79-85
   PubMed Web of Science ®Google Scholar
• Nanni V, Uher R, Danese A. Childhood maltreatment predicts unfavorable course of illness and treatment outcome in depression: a meta-analysis. Am J Psychiatry 2012;169(2):141-51
   PubMed Web of Science ®Google Scholar
• Danese A, Moffitt TE, Pariante CM, et al. Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Arch Gen Psychiatry 2008;65(4):409-15
   PubMed Web of Science ®Google Scholar
• Ouellet-Morin I, Odgers CL, Danese A, et al. Blunted cortisol responses to stress signal social and behavioral problems among maltreated/bullied 12-year-old children. Biol Psychiatry 2011;70(11):1016-23
   PubMed Web of Science ®Google Scholar
• Liu D, Diorio J, Tannenbaum B, et al. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science 1997;277(5332):1659-62
   PubMed Web of Science ®Google Scholar
• Liu D, Diorio J, Day JC, et al. Maternal care, hippocampal synaptogenesis and cognitive development in rats. Nat Neurosci 2000;3(8):799-806
   PubMed Web of Science ®Google Scholar
• Francis DD, Diorio J, Plotsky PM, Meaney MJ. Environmental enrichment reverses the effects of maternal separation on stress reactivity. J Neurosci 2002;22(18):7840-3
   PubMed Web of Science ®Google Scholar
• Francis DD, Meaney MJ. Maternal care and the development of stress responses. Curr Opin Neurobiol 1999;9(1):128-34
   PubMed Web of Science ®Google Scholar
• Schloesser RJ, Lehmann M, Martinowich K, et al. Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress. Mol Psychiatry 2010;15(12):1152-63
   PubMed Web of Science ®Google Scholar
• Lehmann ML, Herkenham M. Environmental enrichment confers stress resiliency to social defeat through an infralimbic cortex-dependent neuroanatomical pathway. J Neurosci 2011;31(16):6159-73
   PubMed Web of Science ®Google Scholar
• Lehmann ML, Brachman RA, Martinowich K, et al. Glucocorticoids orchestrate divergent effects on mood through adult neurogenesis. J Neurosci 2013;33(7):2961-72
   PubMed Web of Science ®Google Scholar
• Klengel T, Mehta D, Anacker C, et al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci 2013;16(1):33-41
   PubMed Web of Science ®Google Scholar
• Weaver IC, Cervoni N, Champagne FA, et al. Epigenetic programming by maternal behavior. Nat Neurosci 2004;7(8):847-54
   PubMed Web of Science ®Google Scholar
• Tsankova NM, Berton O, Renthal W, et al. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci 2006;9(4):519-25
   PubMed Web of Science ®Google Scholar
• Schroeder FA, Lin CL, Crusio WE, Akbarian S. Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol Psychiatry 2007;62(1):55-64
   PubMed Web of Science ®Google Scholar
• Covington HE, Vialou VF, LaPlant Q, et al. Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition. Neurosci Lett 2011;493(3):122-6
   PubMed Web of Science ®Google Scholar
• Anacker C. Adult hippocampal neurogenesis in depression: behavioral implications and regulation by the stress system. Curr Top Behav Neurosci 2014. [Epub ahead of print]
   PubMedGoogle Scholar
• Boldrini M, Underwood MD, Hen R, et al. Antidepressants increase neural progenitor cells in the human hippocampus. Neuropsychopharmacology 2009;34(11):2376-89
   PubMed Web of Science ®Google Scholar
• Boldrini M, Hen R, Underwood MD, et al. Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression. Biol Psychiatry 2012;72(7):562-71
   PubMed Web of Science ®Google Scholar
• Lucassen PJ, Stumpel MW, Wang Q, Aronica E. Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients. Neuropharmacology 2010;58(6):940-9
   PubMed Web of Science ®Google Scholar
• Surget A, Saxe M, Leman S, et al. Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal. Biol Psychiatry 2008;64(4):293-301
   PubMed Web of Science ®Google Scholar
• Surget A, Tanti A, Leonardo ED, et al. Antidepressants recruit new neurons to improve stress response regulation. Mol Psychiatry 2011;16(12):1177-88
   PubMed Web of Science ®Google Scholar
• Tanti A, Rainer Q, Minier F, et al. Differential environmental regulation of neurogenesis along the septo-temporal axis of the hippocampus. Neuropharmacology 2012;63(3):374-84
   PubMed Web of Science ®Google Scholar
• Snyder JS, Soumier A, Brewer M, et al. Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature 2011;476(7361):458-61
   PubMed Web of Science ®Google Scholar
• Perera TD, Coplan JD, Lisanby SH, et al. Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates. J Neurosci 2007;27(18):4894-901
   PubMed Web of Science ®Google Scholar
• Santarelli L, Saxe M, Gross C, et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003;301(5634):805-9
   PubMed Web of Science ®Google Scholar
• Malberg JE, Eisch AJ, Nestler EJ, Duman RS. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 2000;20(24):9104-10
   PubMed Web of Science ®Google Scholar
• Anacker C, Zunszain PA, Cattaneo A, et al. Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol Psychiatry 2011;16(7):738-50
   PubMed Web of Science ®Google Scholar
• Mateus-Pinheiro A, Pinto L, Bessa JM, et al. Sustained remission from depressive-like behavior depends on hippocampal neurogenesis. Transl Psychiatry 2013;3:e210
   Google Scholar
• van Praag H, Schinder AF, Christie BR, et al. Functional neurogenesis in the adult hippocampus. Nature 2002;415(6875):1030-4
   PubMed Web of Science ®Google Scholar
• Aan Het Rot M, Zarate CA, Charney DS, Mathew SJ. Ketamine for depression: where do we go from here? Biol Psychiatry 2012;72(7):537-47
   PubMed Web of Science ®Google Scholar
• Krystal JH, Sanacora G, Duman RS. Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond. Biol Psychiatry 2013;73(12):1133-41
   PubMed Web of Science ®Google Scholar
• Shiroma PR, Johns B, Kuskowski M, et al. Augmentation of response and remission to serial intravenous subanesthetic ketamine in treatment resistant depression. J Affect Disord 2014;155:123-9
   PubMed Web of Science ®Google Scholar
• Browne CA, Lucki I. Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants. Front Pharmacol 2013;4:161
   PubMed Web of Science ®Google Scholar
• Duman RS, Li N, Liu RJ, et al. Signaling pathways underlying the rapid antidepressant actions of ketamine. Neuropharmacology 2012;62(1):35-41
   PubMed Web of Science ®Google Scholar
• Deisseroth K. Optogenetics. Nat Methods 2011;8(1):26-9
   PubMed Web of Science ®Google Scholar
• Fenno L, Yizhar O, Deisseroth K. The development and application of optogenetics. Annu Rev Neurosci 2011;34:389-412
   PubMed Web of Science ®Google Scholar
• Kheirbek MA, Drew LJ, Burghardt NS, et al. Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron 2013;77(5):955-68
   PubMed Web of Science ®Google Scholar
• Chaudhury D, Walsh JJ, Friedman AK, et al. Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature 2013;493(7433):532-6
   PubMed Web of Science ®Google Scholar
• Tye KM, Mirzabekov JJ, Warden MR, et al. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature 2013;493(7433):537-41
   PubMed Web of Science ®Google Scholar
• Kessler RC. The effects of stressful life events on depression. Annu Rev Psychol 1997;48:191-214
   PubMed Web of Science ®Google Scholar
• Fava M, Kendler KS. Major depressive disorder. Neuron 2000;28(2):335-41
   PubMed Web of Science ®Google Scholar
• McEwen BS. Brain on stress: how the social environment gets under the skin. Proc Natl Acad Sci USA 2012;109(Suppl 2):17180-5
   PubMed Web of Science ®Google Scholar
• Guidotti G, Calabrese F, Anacker C, et al. Glucocorticoid receptor and FKBP5 expression is altered following exposure to chronic stress: modulation by antidepressant treatment. Neuropsychopharmacology 2013;38(4):616-27
   PubMed Web of Science ®Google Scholar
• Tanti A, Westphal WP, Girault V, et al. Region-dependent and stage-specific effects of stress, environmental enrichment, and antidepressant treatment on hippocampal neurogenesis. Hippocampus 2013;23(9):797-811
   PubMed Web of Science ®Google Scholar
• Willner P. Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 2005;52(2):90-110
   PubMed Web of Science ®Google Scholar
• Chaouloff F. Social stress models in depression research: what do they tell us? Cell Tissue Res 2013;354(1):179-90
   PubMed Web of Science ®Google Scholar
• Venzala E, García-García AL, Elizalde N, Tordera RM. Social vs. environmental stress models of depression from a behavioural and neurochemical approach. Eur Neuropsychopharmacol 2013;23(7):697-708
   PubMed Web of Science ®Google Scholar
• Wallace DL, Han MH, Graham DL, et al. CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nat Neurosci 2009;12(2):200-9
   PubMed Web of Science ®Google Scholar
• Golden SA, Covington HE, Berton O, Russo SJ. A standardized protocol for repeated social defeat stress in mice. Nat Protoc 2011;6(8):1183-91
   PubMed Web of Science ®Google Scholar
• McCormick CM, Smythe JW, Sharma S, Meaney MJ. Sex-specific effects of prenatal stress on hypothalamic-pituitary-adrenal responses to stress and brain glucocorticoid receptor density in adult rats. Brain Res Dev Brain Res 1995;84(1):55-61
   PubMedGoogle Scholar
• Coe CL, Kramer M, Czeh B, et al. Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys. Biol Psychiatry 2003;54(10):1025-34
   PubMed Web of Science ®Google Scholar
• Mirescu C, Peters JD, Gould E. Early life experience alters response of adult neurogenesis to stress. Nat Neurosci 2004;7(8):841-6
   PubMed Web of Science ®Google Scholar
• Kronenberg G, Kirste I, Inta D, et al. Reduced hippocampal neurogenesis in the GR(+/-) genetic mouse model of depression. Eur Arch Psychiatry Clin Neurosci 2009;259(8):499-504
   PubMed Web of Science ®Google Scholar
• Boyle MP, Brewer JA, Funatsu M, et al. Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior. Proc Natl Acad Sci USA 2005;102(2):473-8
   PubMed Web of Science ®Google Scholar
• Heisler LK, Chu HM, Brennan TJ, et al. Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proc Natl Acad Sci USA 1998;95(25):15049-54
   PubMed Web of Science ®Google Scholar
• Donaldson ZR, Piel DA, Santos TL, et al. Developmental effects of serotonin 1A autoreceptors on anxiety and social behavior. Neuropsychopharmacology 2014;39(2):291-302
   PubMed Web of Science ®Google Scholar
• Holmes A, Murphy DL, Crawley JN. Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biol Psychiatry 2003;54(10):953-9
   PubMed Web of Science ®Google Scholar
• Molteni R, Cattaneo A, Calabrese F, et al. Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans. Neurobiol Dis 2010;37(3):747-55
   PubMed Web of Science ®Google Scholar
• Overstreet DH, Wegener G. The flinders sensitive line rat model of depression – 25 years and still producing. Pharmacol Rev 2013;65(1):143-55
   PubMed Web of Science ®Google Scholar
• Sheline YI, Wang PW, Gado MH, et al. Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci USA 1996a;93(9):3908-13
   PubMed Web of Science ®Google Scholar
• Videbech P, Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry 2004;161(11):1957-66
   PubMed Web of Science ®Google Scholar
• Brown ES, Hughes CW, McColl R, et al. Association of depressive symptoms with hippocampal volume in 1936 adults. Neuropsychopharmacology 2014;39(3):770-9
   PubMed Web of Science ®Google Scholar
• Kong L, Wu F, Tang Y, et al. Frontal-subcortical volumetric deficits in single episode, medication-naïve depressed patients and the effects of 8 weeks fluoxetine treatment: a VBM-DARTEL study. PLoS One 2014;9(1):e79055
   Google Scholar
• Zhang X, Zhu X, Wang X, et al. First-episode medication-naive major depressive disorder is associated with altered resting brain function in the affective network. PLoS One 2014;9(1):e85241
   Google Scholar
• MacMaster FP, Kusumakar V. MRI study of the pituitary gland in adolescent depression. J Psychiatr Res 2004;38(3):231-6
   PubMed Web of Science ®Google Scholar
• Peterson BS, Wang Z, Horga G, et al. Discriminating risk and resilience endophenotypes from lifetime illness effects in familial major depressive disorder. JAMA Psychiatry 2014;71(2):136-48
   PubMed Web of Science ®Google Scholar
• Sheline YI, Price JL, Yan Z, Mintun MA. Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus. Proc Natl Acad Sci USA 2010;107(24):11020-5
   PubMed Web of Science ®Google Scholar
• Scheidegger M, Walter M, Lehmann M, et al. Ketamine decreases resting state functional network connectivity in healthy subjects: implications for antidepressant drug action. PLoS One 2012;7(9):e44799
   PubMed Web of Science ®Google Scholar
• Golden SA, Christoffel DJ, Heshmati M, et al. Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression. Nat Med 2013;19(3):337-44
   PubMed Web of Science ®Google Scholar
• Cruceanu C, Freemantle E, Alda M, et al. Epigenetic regulation of synapsin genes in mood disorders. Neuropsychopharmacology 2013;38(1):239-41
   PubMed Web of Science ®Google Scholar
• Cattaneo A, Gennarelli M, Uher R, et al. Candidate genes expression profile associated with antidepressants response in the GENDEP study: differentiating between baseline ‘predictors’ and longitudinal ‘targets’. Neuropsychopharmacology 2013;38(3):377-85
   PubMed Web of Science ®Google Scholar
• Carvalho LA, Juruena MF, Papadopoulos AS, et al. Clomipramine in vitro reduces glucocorticoid receptor function in healthy subjects but not in patients with major depression. Neuropsychopharmacology 2008;33(13):3182-9
   PubMed Web of Science ®Google Scholar
• Schatzberg AF, Keller J, Tennakoon L, et al. HPA axis genetic variation, cortisol and psychosis in major depression. Mol Psychiatry 2014;19(2):220-7
   PubMed Web of Science ®Google Scholar
• Brennand KJ, Simone A, Jou J, et al. Modelling schizophrenia using human induced pluripotent stem cells. Nature 2011;473(7346):221-5
   PubMed Web of Science ®Google Scholar
• Brennand KJ, Simone A, Tran N, Gage FH. Modeling psychiatric disorders at the cellular and network levels. Mol Psychiatry 2012;17(12):1239-53
   PubMed Web of Science ®Google Scholar
• Marchetto MC, Brennand KJ, Boyer LF, Gage FH. Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises. Hum Mol Genet 2011;20(R2):R109-15
   PubMedGoogle Scholar
• Mayberg HS, Lozano AM, Voon V, et al. Deep brain stimulation for treatment-resistant depression. Neuron 2005;45(5):651-60
   PubMed Web of Science ®Google Scholar
• Palfi S, Gurruchaga JM, Ralph GS, et al. Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial. Lancet 2014. [Epub ahead of print]
   PubMed Web of Science ®Google Scholar