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Expert Opinion on Medical Diagnostics Volume 2, 2008 - Issue 9
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Review

Multispectral imaging and pathology: seeing and doing more

Richard M Levenson CRI, 35B Cabot Road, Woburn, MA 01801, USA +1 781 935 9099, ext. 204; +1 781 935 3388; [email protected]
,
Alessandro Fornari Dana Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA; University of Torino, Department of Biomedical Sciences and Human Oncology, Italy
&
Massimo Loda Dana Farber Cancer Institute, Department of Medical Oncology, Boston, MA, USA; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Pages 1067-1081 | Published online: 15 Sep 2008

Bibliography

  • Gal AA. In search of the origins of modern surgical pathology. Adv Anat Pathol 2001;8(1):1-13
  • Wells WA, Barker PE, MacAulay C, et al. Validation of novel optical imaging technologies: the pathologists' view. J Biomed Opt 2007;12(5):051801
  • Patel K, Nelson DR, Rockey DC, et al. Correlation of FIBROSpect II with histologic and morphometric evaluation of liver fibrosis in chronic hepatitis C. Clin Gastroenterol Hepatol 2008;6(2):242-7
  • Farris AB, Misdraji J, Srivastava A, et al. Sessile serrated adenoma: challenging discrimination from other serrated colonic polyps. Am J Surg Pathol 2008;32(1):30-5
  • Novara G, Martignoni G, Artibani W, Ficarra V. Grading systems in renal cell carcinoma. J Urol 2007;177(2):430-6
  • Martinez AE, Lin L, Dunphy CH. Grading of follicular lymphoma: comparison of routine histology with immunohistochemistry. Arch Pathol Lab Med 2007;131(7):1084-8
  • Kerkhof M, Van Dekken H, Steyerberg EW, et al. Grading of dysplasia in Barrett's oesophagus: substantial interobserver variation between general and gastrointestinal pathologists. Histopathol 2007;50(7):920-7
  • Gerhard R, Da Cunha, Santos G. Inter- and intraobserver reproducibility of thyroid fine needle aspiration cytology: an analysis of discrepant cases. Cytopathology 2007;18(2):105-11
  • Raab SS, Meier FA, Zarbo RJ, et al. The ‘Big Dog’ effect: variability assessing the causes of error in diagnoses of patients with lung cancer. J Clin Oncol 2006;24(18):2808-14
  • Quinn M. Newfoundland launches judicial inquiry. CMAJ 2007;177(1):24-5
  • Goldstein NS, Hunter S, Forbes S, et al. Estrogen receptor antibody incubation time and extent of immunoreactivity in invasive carcinoma of the breast: the importance of optimizing antibody avidity. Appl Immunohistochem Mol Morphol 2007;15(2):203-7
  • Morales AR, Nassiri M, Kanhoush R, et al. Experience with an automated microwave-assisted rapid tissue processing method: validation of histologic quality and impact on the timeliness of diagnostic surgical pathology. Am J Clin Pathol 2004;121(4):528-36
  • Leong AS, Price D. Incorporation of microwave tissue processing into a routine pathology laboratory: impact on turnaround times and laboratory work patterns. Pathology 2004;36(4):321-4
  • Chu WS, Liang Q, Tang Y, et al. Ultrasound-accelerated tissue fixation/processing achieves superior morphology and macromolecule integrity with storage stability. J Histochem Cytochem 2006;54(5):503-13
  • Oyama T, Ishikawa Y, Hayashi M, et al. The effects of fixation, processing and evaluation criteria on immunohistochemical detection of hormone receptors in breast cancer. Breast Cancer 2007;14(2):182-8
  • Bankfalvi A, Boecker W, Reiner A. Comparison of automated and manual determination of HER2 status in breast cancer for diagnostic use: a comparative methodological study using the Ventana BenchMark automated staining system and manual tests. Int J Oncol 2004;25(4):929-35
  • Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 1998;4:844-7
  • Aperio homepage. Available from: http//www.aperio.com [Accessed 12 Aug 2008]
  • Hamamatsu: Virtual Microscopy/NanoZoomer. Available from: http://sales.hamamatsu.com/en/products/system-division/virtual-microscopy.php [Accessed 12 Aug 2008]
  • 3DHISTECH homepage. Available from: http://www.3dhistech.com/ [Accessed 12 Aug 2008]
  • BioImagene homepage. Available from: http://www.bioimagene.com/ [Accessed 12 Aug 2008]
  • Cualing HD, Zhong E, Moscinski L ‘Virtual flow cytometry’ of immunostained lymphocytes on microscopic tissue slides: iHCFlow tissue cytometry. Cytometry B Clin Cytom 2007;72(1):63-76
  • Carl Zeiss homepage. Available from: http://www.zeiss.com/ [Accessed 12 Aug 2008]
  • TissueGnostics homepage. Available from: http://www.tissuegnostics.com//index.php? load=xml/en/home.xml&lang=en [Accessed 12 Aug 2008]
  • Titford M. The long history of hematoxylin. Biotech Histochem 2005;80(2):73-8
  • Heller RE. A requiem for aniline dyes. Perspect Biol Med 1992;35(3):398-400
  • Coleman R. The long-term contribution of dyes and stains to histology and histopathology. Acta Histochem 2006;108(2):81-3
  • Taylor CR, Cote RJ. Immunohistochemical markers of prognostic value in surgical pathology. Histol Histopathol 1997;12(4):1039-55
  • Nelson PT, Baldwin DA, Kloosterman WP, et al. RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain. RNA 2006;12(2):187-91
  • Nelson PT, De Planell-Saguer M, Lamprinaki S, et al. A novel monoclonal antibody against human Argonaute proteins reveals unexpected characteristics of miRNAs in human blood cells. RNA 2007;13(10):1787-92
  • Jeffrey SS. Cancer biomarker profiling with microRNAs. Nat Biotechnol 2008;26(4):400-1
  • Takahashi M, Rhodes DR, Furge KA, et al. Gene expression profiling of clear cell renal cell carcinoma: gene identification and prognostic classification. Proc Natl Acad Sci USA 2001;98(17):9754-9
  • Simone NL, Bonner RF, Gillespie JW, et al. Laser-capture microdissection: opening the microscopic frontier to molecular analysis. Trends Genet 1998;14(7):272-6
  • Fend F, Emmert-Buck MR, Chuaqui R, et al. Immuno-LCM: laser capture microdissection of immunostained frozen sections for mRNA analysis. Am J Pathol 1999;154(1):61-6
  • Lubieniecka JM, Nielsen TO. cDNA microarray-based translational research in soft tissue sarcoma. J Surg Oncol 2005;92(4):267-71
  • Banks RE, Dunn MJ, Forbes MA, et al. The potential use of laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis – preliminary findings. Electrophoresis 1999;20(4-5):689-700
  • Frable WJ. Pathologic classification of soft tissue sarcomas. Semin Surg Oncol 1994;10(5):332-9
  • Bacus SS, Altomare Da, Lyass L, et al. AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival. Oncogene 2002;21(22):3532-40
  • Reddy RK, Mao C, Baumeister P, et al. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. J Biol Chem 2003;278(23):20915-24
  • Cicenas J, Urban P, Vuaroqueaux V, et al. Increased level of phosphorylated akt measured by chemiluminescence-linked immunosorbent assay is a predictor of poor prognosis in primary breast cancer overexpressing ErbB-2. Breast Cancer Res 2005;7(4):R394-401
  • David O, Jett J, Lebeau H, et al. Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage. Clin Cancer Res 2004;10(20):6865-71
  • Tokunaga E, Kimura Y, Oki E, et al. Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients. Int J Cancer 2006;118(2):284-9
  • Lugli A, Zlobec I, Minoo P, et al. Role of the mitogen-activated protein kinase and phosphoinositide 3-kinase/AKT pathways downstream molecules, phosphorylated extracellular signal-regulated kinase, and phosphorylated AKT in colorectal cancer – a tissue microarray-based approach. Hum Pathol 2006;37(8):1022-31
  • Vestey SB, Sen C, Calder CJ, et al. Activated Akt expression in breast cancer: correlation with p53, Hdm2 and patient outcome. Eur J Cancer 2005;41(7):1017-25
  • Yamamoto S, Tomita Y, Hoshida Y, et al. Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma. Clin Cancer Res 2004;10(8):2846-50
  • Luo J, Manning BD, Cantley LC. Targeting the PI3K–Akt pathway in human cancer: rationale and promise. Cancer Cell 2003;4(4):257-62
  • Bergqvist J, Elmberger G, Ohd J, et al. Activated ERK1/2 and phosphorylated oestrogen receptor alpha are associated with improved breast cancer survival in women treated with tamoxifen. Eur J Cancer 2006;42(8):1104-12
  • Digiovanna MP, Stern DF. Activation state-specific monoclonal antibody detects tyrosine phosphorylated p185neu/erbB-2 in a subset of human breast tumors overexpressing this receptor. Cancer Res 1995;55(9):1946-55
  • Akobundu E, Ju J, Blatt L, Mullins CD. Cost-of-Illness studies: a review of current methods. Pharmacoeconomics 2006;24(9):869-90
  • Van Den Akker-Van Marle ME, Gurwitz D, Detmar SB, et al. Cost-effectiveness of pharmacogenomics in clinical practice: a case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe. Pharmacogenomics 2006;7(5):783-92
  • Schacker T, Reilly C, Beilman G, et al. Amount of lymphatic tissue fibrosis in HIV infection predicts magnitude of HAART-associated change in peripheral CD4 cell count. AIDS 2005;19(18):2169-71
  • Ring BZ, Seitz RS, Beck R, et al. Novel prognostic immunohistochemical biomarker panel for estrogen receptor-positive breast cancer. J Clin Oncol 2006;24(19):3039-47
  • Loussouarn D, Brunon J, Avet-Loiseau H, et al. Prognostic value of HER2 expression in meningiomas: an immunohistochemical and fluorescence in situ hybridization study. Hum Pathol 2006;37(4):415-21
  • Wiseman SM, Makretsov N, Nielsen TO, et al. Coexpression of the type 1 growth factor receptor family members HER-1, HER-2, and HER-3 has a synergistic negative prognostic effect on breast carcinoma survival. Cancer 2005;103(9):1770-7
  • Jayaram G, Elsayed EM. Cytologic evaluation of prognostic markers in breast carcinoma. Acta Cytol 2005;49(6):605-10
  • Makretsov NA, Huntsman DG, Nielsen TO, et al. Hierarchical clustering analysis of tissue microarray immunostaining data identifies prognostically significant groups of breast carcinoma. Clin Cancer Res 2004;10(18):6143-51
  • Abdul-Rasool S, Kidson SH, Panieri E, et al. An evaluation of molecular markers for improved detection of breast cancer metastases in sentinel nodes. J Clin Pathol 2006;59(3):289-97
  • Rubin MA, Zerkowski MP, Camp RL, et al. Quantitative determination of expression of the prostate cancer protein alpha-methylacyl-CoA racemase using automated quantitative analysis (AQUA): a novel paradigm for automated and continuous biomarker measurements. Am J Pathol 2004;164(3):831-40
  • Fountaine TJ, Wincovitch SM, Geho DH, et al. Multispectral imaging of clinically relevant cellular targets in tonsil and lymphoid tissue using semiconductor quantum dots. Mod Pathol 2006;19(9):1181-91
  • Mansfield JR, Gossage KW, Hoyt CC, Levenson RM. Autofluorescence removal, multiplexing, and automated analysis methods for in vivo fluorescence imaging. J Biomed Opt 2005;10(4):41207
  • Levenson RM, Mansfield JR. Multispectral imaging in biology and medicine: slices of life. Cytometry A 2006;69(8):748-58
  • Clancy B, Cauller LJ. Reduction of background autofluorescence in brain sections following immersion in sodium borohydride. J Neurosci Methods 1998;83(2):97-102
  • Baschong W, Suetterlin R, Laeng RH. Control of autofluorescence of archival formaldehyde-fixed, paraffin-embedded tissue in confocal laser scanning microscopy (CLSM). J Histochem Cytochem 2001;49(12):1565-72
  • Staughton TJ, Mcgillicuddy CJ, Weinberg PD. Techniques for reducing the interfering effects of autofluorescence in fluorescence microscopy: improved detection of sulphorhodamine B-labelled albumin in arterial tissue. J Microsc 2001;201(Pt 1):70-6
  • Neumann M, Gabel D. Simple method for reduction of autofluorescence in fluorescence microscopy. J Histochem Cytochem 2002;50(3):437-9
  • Taylor CR, Levenson RM. Quantification of immunohistochemistry – issues concerning methods, utility and semiquantitative assessment II. Histopathology 2006;49(4):411-24
  • Zhou R, Hammond EH, Parker DL. A multiple wavelength algorithm in color image analysis and its applications in stain decomposition in microscopy images. Med Phys 1997;23(12):1977-86
  • Levenson RM. Spectral imaging perspective on cytomics. Cytometry A 2006;69(7):592-600
  • Van der Loos CM: Multiple immunoenzyme staining: methods and visualizations for the observation with spectral imaging. J Histochem Cytochem 2008;56(4):313-28
  • Speel EJ, Jansen MP, Ramaekers FC, Hopman AH. A novel triple-color detection procedure for brightfield microscopy, combining in situ hybridization with immunocytochemistry. J Histochem Cytochem 1994;42(10):1299-307
  • Macville MV, Van Der Laak JA, Speel EJ, et al. Spectral imaging of multi-color chromogenic dyes in pathological specimens. Anal Cell Pathol 2001;22(3):133-42
  • Szeszel MK, Crisman CL, Crow L, et al. Quantifying estrogen and progesterone receptor expression in breast cancer by digital imaging. J Histochem Cytochem 2005;53(6):753-62
  • Farkas DL, Du C, Fisher GW, et al. Non-invasive image acquisition and advanced processing in optical bioimaging. Comput Med Imaging Graph 1998;22(2):89-102
  • Garini Y, Young IT, McNamara G. Spectral imaging: principles and applications. Cytometry A 2006;69(8):735-47
  • Bearman G, Levenson R. Biological imaging spectroscopy. In: Vo-Dinh T, editor, Biomedical photonics handbook. Boca Raton: CRC Press; 2003
  • Barber PR, Vojnovic B, Atkin G, et al. Applications of cost-effective spectral imaging microscopy in cancer research. J Phys D Appl Phys 2003;36:1729-38
  • Ghazani AA, Lee JA, Klostranec J, et al. High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals. Nano Lett 2006;6(12):2881-6
  • Levenson R. Putting the ‘more’ back in morphology: spectral imaging and image analysis in the service of pathology. Arch Pathol Lab Med 2008;132:748-57
  • Matkowskyj KA, Cox R, Jensen RT, Benya RV. Quantitative immunohistochemistry by measuring cumulative signal strength accurately measures receptor number. J Histochem Cytochem 2003;51(2):205-14
  • Ermert L, Hocke AC, Duncker HR, et al. Comparison of different detection methods in quantitative microdensitometry. Am J Pathol 2001;158(2):407-17
  • Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. WHO classification of tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues. WHO; 2001
  • Cheson BD. The myelodysplastic syndromes: current approaches to therapy. Ann Intern Med 1990;112(12):932-41
  • Hamblin T. Immunologic abnormalities in myelodysplastic syndromes. Hematol Oncol Clin North Am 1992;6(3):571-86
  • Sebban C, Browman GP, Lepage E, Fiere D. Prognostic value of early response to chemotherapy assessed by the day 15 bone marrow aspiration in adult acute lymphoblastic leukemia: a prospective analysis of 437 cases and its application for designing induction chemotherapy trials. Leuk Res 1995;19(11):861-8
  • Schultz KR, Massing B, Spinelli JJ, et al. Importance of the day 7 bone marrow biopsy as a prognostic measure of the outcome in children with acute lymphoblastic leukaemia. Med Pediatr Oncol 1997;29(1):16-22
  • Sievers EL. Antibody-targeted chemotherapy of acute myeloid leukemia using gemtuzumab ozogamicin (Mylotarg). Blood Cells Mol Dis 2003;31(1):7-10
  • Lambertenghi-Deliliers G, Annaloro C, Oriani A, et al. Prognostic relevance of histological findings on bone marrow biopsy in myelodysplastic syndromes. Ann Hematol 1993;66(2):85-91
  • Oertel J, Oertel B, Schleicher J, Huhn D. Immunotyping of blasts in human bone marrow. Ann Hematol 1996;72(3):125-9
  • Miettinen M, Lasota J. KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl Immunohistochem Mol Morphol 2005;13(3):205-20
  • Dunleavy K, Wilson WH, Jaffe ES. Angioimmunoblastic T cell lymphoma: pathobiological insights and clinical implications. Curr Opin Hematol 2007;14(4):348-53
  • Dupuis J, Boye K, Martin N, et al. Expression of CXCL13 by neoplastic cells in angioimmunoblastic T-cell lymphoma (AITL): a new diagnostic marker providing evidence that AITL derives from follicular helper T cells. Am J Surg Pathol 2006;30(4):490-4
  • Ramsay AD, Smith WJ, Isaacson PG. T-cell-rich B-cell lymphoma. Am J Surg Pathol 1988;12(6):433-43
  • Polyak K, Hahn WC. Roots and stems: stem cells in cancer. Nat Med 2006;12(3):296-300
  • Dalerba P, Cho RW, Clarke MF. Cancer stem cells: models and concepts. Ann Rev Med 2007;58:267-84
  • Shipitsin M, Polyak K. The cancer stem cell hypothesis: in search of definitions, markers, and relevance. Lab Invest 2008;88(5):459-63
  • Adamson JW, Fialkow PJ, Murphy S, et al. Polycythemia vera: stem-cell and probable clonal origin of the disease. N Engl J Med 1976;295(17):913-6
  • Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3(7):730-7
  • Al-Hajj M, Wicha MS, Benito-Hernandez A, et al. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003;100(7):3983-8
  • Ponti D, Costa A, Zaffaroni N, et al. Isolation and in vitro propagation of tumorigenic breast cancer cells with stem/progenitor cell properties. Cancer Res 2005;65(13):5506-11
  • Vescovi AL, Galli R, Reynolds BA. Brain tumour stem cells. Nat Rev Cancer 2006;6(6):425-36
  • Collins AT, Berry PA, Hyde C, et al. Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res 2005;65(23):10946-51
  • Hart LS, El-Deiry WS. Invincible, but not invisible: imaging approaches toward in vivo detection of cancer stem cells. J Clin Oncol 2008;26(17):2901-10
  • Balic M, Lin H, Young L, et al. Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype. Clin Cancer Res 2006;12(19):5615-21
  • Schieker M, Pautke C, Haasters F, et al. Human mesenchymal stem cells at the single-cell level: simultaneous seven-colour immunofluorescence. J Anat 2007;210(5):592-9
  • Camp RL, Chung GG, Rimm DL. Automated subcellular localization and quantification of protein expression in tissue microarrays. Nat Med 2002;8(11):1323-7
  • Haralick RM. Statistical and structural approaches to texture. Proc IEEE 1979;67:786-804
  • Mansoor I, Zalles C, Zahid F, et al. Fine-needle aspiration of follicular adenoma versus parathyroid adenoma: the utility of multispectral imaging in differentiating lesions with subtle cytomorphologic differences. Cancer 2008;114(1):22-6
  • Bachmann IM, Straume O, Puntervoll HE, et al. Importance of P-cadherin, beta-catenin, and Wnt5a/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma. Clin Cancer Res 2005;11(24 Pt 1):8606-14
  • Dolled-Filhart M, Mccabe A, Giltnane J, et al. Quantitative in situ analysis of β-catenin expression in breast cancer shows decreased expression is associated with poor outcome. Cancer Res 2006;66(10):5487-94
  • Weissleder R, Pittet MJ. Imaging in the era of molecular oncology. Nature 2008;452:580-9
  • Lee H, Douglas-Jones AG, Morgan JM, Jasani B. The effect of fixation and processing on the sensitivity of oestrogen receptor assay by immunohistochemistry in breast carcinoma. J Clin Pathol 2002;55(3):236-8
  • Sharifi AM, Roach C, Wakamiya K, Askaa J. Deterioration of phospho-epitopes prior to and during specimen fixation [abstract 748]. Proc Am Assoc Cancer Res 2005;46
  • Weinstein RS. The S-curve framework: predicting the future of anatomic pathology. Arch Pathol Lab Med 2008;132:739-42
  • Friedman BA. A survey of the myriad forces changing anatomic pathology and their consequences. Arch Pathol Lab Med 132:735-8

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