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Hyperpolarized 13C-pyruvate magnetic resonance imaging in cancer diagnostics

, , & (Professor)
Pages 335-345 | Published online: 09 May 2012

Bibliography

  • Ross BD. The biochemistry of living tissues: examination by MRS. NMR Biomed 1992;5:215-19
  • Negendank W. Studies of human tumors by MRS: a review. NMR Biomed 1992;5:303-24
  • Howe FA, Barton SJ, Cudlip SA, Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy. Magn Reson Med 2003;49:223-32
  • Simonetti AW, Melssen WJ, van der Graaf M, A chemometric approach for brain tumor classification using magnetic resonance imaging and spectroscopy. Anal Chem 2003;75:5352-61
  • Overhauser AW. Polarization of nuclei in metals. Phys Rev 1953;92:411-15
  • Golman K, in ‘t Zandt R, Lerche M, Metabolic imaging by hyperpolarized 13C Magnetic Resonance Imaging for in vivo tumor diagnosis. Cancer Res 2006;66:10855-60
  • Gallagher FA, Kettunen MI, Brindle KM. Biomedical applications of hyperpolarized 13C magnetic resonance imaging. Prog Nucl Magn Reson Spectrosc 2009;55:285-95
  • Kurhanewicz J, Vigneron DB, Brindle K, Analysis of cancer metabolism by Imaging hyperpolarized nuclei: prospects for translation to clinical research. Neoplasia 2011;13:81-97
  • Kettunen MI, Hu D-E, Witney TH, Magnetization transfer measurements of exchange between hyperpolarized [1-13C]pyruvate and [1-13C]lactate in a murine lymphoma. Magn Reson Med 2010;63:872-80
  • Brindle KM, Bohndiek SE, Gallagher FA, Kettunen MI. Tumor imaging using hyperpolarized 13C magnetic resonance spectroscopy. Magn Reson Med 2011;66:505-19
  • Larson PEZ, Bok R, Kerr AB, Investigation of tumor hyperpolarized [1-13C]-Pyruvate dynamics using time-resolved multiband RF excitation Echo-Planar MRSI. Magn Reson Med 2010;63:582-91
  • Lau AZ, Chen AP, Hurd RE, Cunningham CH. Spectral-spatial excitation for rapid imaging of DNP compounds. NMR Biomed 2011;24:988-96
  • Smith MR, Peterson ET, Gordon JW, In Vivo imaging and spectroscopy of dynamic metabolism using simultaneous (13)C and (1)H MRI. IEEE Trans Biomed Eng 2011;59:45-9
  • Chen AP, Hurd RE, Cunningham CH. Spin tagging for hyperpolarized 13C metabolic studies. J Magn Reson 2012;214:319-23
  • Altes TA, Salerno M. Hyperpolarized gas MR Imaging of the lung. J Thorac Imaging 2004;19:250-8
  • Oros AM, Shah NJ. Hyperpolarized xenon in NMR and MRI. Phys Med Biol 2004;49:R105-53
  • Matsuoka S, Patz S, Albert MS, Hyperpolarized gas MR Imaging of the lung: current status as a research tool. J Thorac Imaging 2009;24:181-8
  • Schroder L, Lowery TJ, Hilty C, Molecular imaging using a targeted magnetic resonance hyperpolarized biosensor. Science 2006;314:446-9
  • Natterer J, Bargon J. Parahydrogen induced polarization. Prog Nucl Magn Reson Spectrosc 1997;31:293-315
  • Duckett SB, Sleigh CJ. Applications of the parahydrogen phenomenon: a chemical perspective. Prog Nucl Magn Reson Spectrosc 1999;34:71-92
  • Viale A, Aime S. Current concepts on hyperpolarized molecules in MRI. Curr Opin Chem Biol 2010;14:90-6
  • Jensen PR, Karlsson M, Meier S, Hyperpolarized amino acids for in vivo assays of transaminase activity. Chem Eur J 2009;15:10010-12
  • Jensen PR, Peitersen T, Karlsson M, Tissue-specific short chain fatty acid metabolism and slow metabolic recovery after ischemia from hyperpolarized NMR in vivo. J Biol Chem 2009;284:36077-82
  • Karlsson M, Jensen PR, in‘t Zandt R, Imaging of branched chain amino acid metabolism in tumors with hyperpolarized 13C ketoisocaproate. Int J Cancer 2010;127:729-36
  • Wilson DM, Keshari KR, Larson PEZ, Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. J Magn Reson 2010;205:141-7
  • Hu S, Zhu M, Yoshihara HAI, In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-13C]alanine. Magn Reson Imaging 2011;29:1035-40
  • Kohler SJ, Yen Y, Wolber J, In vivo 13Carbon metabolic imaging at 3T with hyperpolarized 13C-1-Pyruvate. Magn Reson Med 2007;58:65-9
  • Golman K, in ‘t Zandt R, Thaning M. Real-time metabolic imaging. Proc Natl Am Soc 2006;103:11270-5
  • Gallagher FA, Kettunen MI, Hua D-E, Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors. Proc Natl Am Soc 2009;106:19801-6
  • Gallagher FA, Kettunen MI, Day SE, Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate. Nature 2008;453:940-4
  • Abragam A, Goldman M. Principles of dynamic nuclear polarisation. Rep Prog Phys 1978;41:395-467
  • Comment A, van den Brandt B, Uffmann K, Design and performance of a DNP prepolarizer coupled to a rodent MRI scanner. Conc Magn Reson B 2007;31B:255-69
  • Golman K, Petersson JS, Magnusson P, Cardiac metabolism measured noninvasively by hyperpolarized 13C MRI. Magn Reson Med 2008;59:1005-13
  • Schroeder MA, Cochlin LE, Heather LC, In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance. Proc Natl Am Soc 2008;105:12051-6
  • Merritt ME, Harrison C, Storey C, Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3-. Magn Reson Med 2008;60:1029-36
  • Bhattacharya P, Ross BD, Bunger R. Cardiovascular applications of hyperpolarized contrast media and metabolic tracers. Exp Biol Med 2009;234:1395-416
  • Schroeder MA, Atherton HJ, Ball DR, Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy. FASEB J 2009;23:2529-38
  • Schroeder MA, Atherton HJ, Cochlin LE, The effect of hyperpolarized tracer concentration on myocardial uptake and metabolism. Magn Reson Med 2009;61:1007-14
  • Lau AZ, Chen AP, Ghugre NR, Rapid multislice imaging of hyperpolarized 13C Pyruvate and bicarbonate in the heart. Magn Reson Med 2010;64:1323-31
  • Malloya CR, Merritt ME, Sherry AD. Could 13C MRI assist clinical decision‐making for patients with heart disease? NMR Biomed 2011;24:973-9
  • Spielman DM, Mayer D, Yen Y-F, In vivo measurement of ethanol metabolism in the rat liver using magnetic resonance spectroscopy of hyperpolarized [1-13C]pyruvate. Magn Reson Med 2009;62:307-13
  • Hu S, Chen AP, Zierhut ML, In vivo Carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate. Mol Imaging Biol 2009;11:399-407
  • Merritt ME, Harrison C, Sherry AD, Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance. Proc Natl Am Soc 2011;47:19084-9
  • Hu S, Lustig M, Balakrishnan A, 3D compressed sensing for highly accelerated Hyperpolarized 13C MRSI with in vivo applications to transgenic mouse models of cancer. Magn Reson Med 2010;63:312-21
  • Yen Y-F, Le Roux P, Mayer D, T2 relaxation times of 13C metabolites in a rat hepatocellular carcinoma model measured in vivo using 13C-MRS of hyperpolarized [1-13C]pyruvate. NMR Biomed 2010;23:414-23
  • Darpolora MM, Yen Y-F, Chu M-S, In vivo MRSI of hyperpolarized [1-13C]pyruvate metabolism in rat hepatocellular carcinoma. NMR Biomed 2011;24:506-13
  • Hu S, Balakrishnan A, Bok RA, 13C-Pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression. Cell Metabolism 2011;14:131-42
  • Chen AP, Albers MJ, Cunningham CH, Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T – initial experience. Magn Reson Med 2007;58:1099-106
  • Albers MJ, Bok R, Chen AP, Hyperpolarized 13C lactate, pyruvate, and alanine: non-invasive biomarkers for prostate cancer detection and grading. Cancer Res 2008;68:8607-15
  • Lupo JM, Chen AP, Zierhuta ML, Analysis of hyperpolarized dynamic 13C lactate imaging in a transgenic mouse model of prostate cancer. Magn Reson Imaging 2010;28:153-62
  • Nelson SJ, Vigneron D, Kurhanewicz J, DNP-Hyperpolarized 13C magnetic resonance metabolic imaging for cancer applications. Appl Magn Reson 2008;34:533-44
  • Park I, Larson PEZ, Zierhut ML, Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors. Neuro-Oncol 2010;12:133-44
  • Harris T, Eliyahu G, Frydman L, Degani H. Kinetics of hyperpolarized 13C1-pyruvate transport and metabolism in living human breast cancer cells. Proc Natl Am Soc 2009;106:18131-6
  • Day SE, Kettunen MI, Gallagher FA, Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy. Nat Med 2007;13:1382-7
  • Witney TH, Kettunen MI, Day SE, A comparison between radiolabeled Fluorodeoxyglucose uptake and hyperpolarized 13C-labelled pyruvate utilization as methods for detecting tumor response to treatment. Neoplasia 2009;11:574-82
  • Bohndiek SE, Kettunen MI, Hu D, Detection of tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy. Mol Cancer Ther 2010;9:3278-88
  • Ward CS, Venkatesh HS, Chaumeil MM, Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy. Cancer Res 2010;70:1296-305
  • Chaumeil MM, Ozawa T, Park I, Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma. Neuroimage 2012;59:193-201
  • Dafni H, Larson PEZ, Hu S, Hyperpolarized 13C Spectroscopic Imaging informs on hypoxia-inducible Factor-1 and Myc activity downstream of platelet-derived growth factor receptor. Cancer Res 2010;70:7400-10
  • Seth P, Grant A, Tang J, On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate. Neoplasia 2011;13:60-71
  • Chen AP, Bok R, Zhang W, Serial hyperpolarized 13C 3D-MRSI following therapy in a mouse model of prostate cancer. Proc Int Soc Magn Reson Med 2008;16:888
  • Day SE, Kettunen MI, Cherukuri MK, Detecting response of rat C6 glioma tumors to radiotherapy using hyperpolarized [1-13C]Pyruvate and 13C magnetic resonance spectroscopic Imaging. Magn Reson Med 2011;65:557-63
  • Park I, Bok R, Ozawa T, Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging. J Magn Reson Imaging 2011;33:1284-90
  • Board M, Humm S, Newsholme EA. Maximum activities of key enzymes of glycolysis, glutaminolysis, pentose phosphate pathway and tricarboxylic acid cycle in normal, neoplastic and suppressed cells. Biochem J 1990;265:503-9
  • Dastidar SG, Sharma SK. Activities of glycolytic enzymes in rapidly proliferating and differentiated C6 glioma cells. Exp Cell Biol 1989;57:159-64
  • Available from: http://clinicaltrials.gov/show/NCT01229618
  • Witney TH, Kettunen MI, Hu D-E, Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarate. Br J Cancer 2010;103:1400-6
  • Gabellieri C, Reynolds S, Lavie A, Therapeutic target metabolism observed using hyperpolarized 15N Choline. J Am Chem Soc 2008;130:4598-9

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