7
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

The significance of computational modelling in murine cardiac ventricular cells

Pages 107-114 | Published online: 08 Jul 2010

References

  • Antzelevitch C, Yan G-X, Shimuzu W etal 1999. Electrical heterogeneity, the ECG, and cardiac arrhythmias. In Zipes DP, Jalife J, eds. Cardiac electrophysiology: from cell to bedside. 3rd ed. Philadelphia: WB Saunders. p 222-38.
  • Barry , DM , Xu , H Schuessler , RB . 1998 . Functional knockout of the transient outward current, long-QT syndrome, and cardiac remodeling in mice expressing a dominant-negative Kv4 alpha subunit . Circ Res , 83 : 560 – 567 .
  • Beeler , GW and Reuter , H . 1977 . Reconstruction of the action potential of ventricular myocardial fibres . J Physiol , 268 : 177 – 210 .
  • Bers DM. 2001. Excitation-contraction coupling and cardiac contractile force. 2nd ed. The Netherlands: Kluwer Acad Publ.
  • Bouchard , RA , Clark , RB and Giles , WR . 1995 . Effects of action potential duration on excitation-contraction coupling in rat ventricular myocytes. Action potential voltage-clamp measurements . Circ Res , 76 : 790 – 801 .
  • Bryant , SM , Shipsey , SJ and Hart , G . 1999 . Normal regional distribution of membrane current density in rat left ventricle is altered in catecholamine induced hypertrophy . Cardiovasc Res , 42 : 391 – 401 .
  • Budden R, Detweiler DK, Zbinden G, eds. 1980. The rat electrocardiogram in pharmacology and toxicology. Oxford, NY: Pergamon Pr.
  • Cheung , PH , Pugsley , MK and Walker , MJ . 1993 . Arrhythmia models in the rat . J Pharmacol Toxicol Methods , 29 : 179 – 184 .
  • Chien , KR . 2000 . Genomic circuits and the integrative biology of cardiac diseases . Nature , 407 : 227 – 232 .
  • Chien , KR . 2001 . To Cre or not to Cre: the next generation of mouse models of human cardiac diseases . Circ Res , 88 : 546 – 549 .
  • Clancy , CE and Rudy , Y . 1999 . Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia . Nature , 400 : 566 – 569 .
  • Clark , RB , Bouchard , RA Salinas-Stefanon , E . 1993 . Heterogeneity of action potential waveforms and potassium currents in rat ventricle . Cardiovasc Res , 27 : 1795 – 1799 .
  • Damaraju E. 2003. A computational model of action potential heterogeneity in adult mouse left ventricular myocytes [MSc thesis]. Memphis: University of Memphis.
  • Demir , SS , O'Rourke , B Tomaselli , GF . 1996 . Action potential variation in canine ventricle: a modeling study . IEEE Comput Cardiol , 1996 : 221 – 224 .
  • Drouhard , J and Roberge , FA . 1987 . Revised formulation of the Hodgkin- Huxley representation of the sodium current in cardiac cells . Comput Biomed Res , 20 : 333 – 350 .
  • Fiset , C , Clark , RB Larsen , TS . 1997 . A rapidly activating sustained K+current modulates repolarization and excitation-contraction coupling in adult mouse ventricle . J Physiol , 504 : 557 – 563 .
  • Fox , JJ , McHarg , JL and Gilmour , RF . 2002 . Ionic mechanism of electrical alternans . Am J Physiol Heart Circ Physiol , 282 : H516 – H530 .
  • Franz , WM , Mueller , OJ Hartong , R . 1997 . Transgenic animal models: new avenues in cardiovascular physiology . J Mol Med , 75 : 115 – 129 .
  • Gehrmann , J and Berul , CI . 2000 . Cardiac electrophysiology in genetically engineered mice . J Cardiovasc Electrophysiol , 11 : 354 – 368 .
  • Gussak , I , Chaitman , BR Kopecky , SL . 2000 . Rapid ventricular repolarization in rodents: electrocardiographic manifestations, molecular mechanisms, and clinical insights . J Electrocardiol , 33 : 159 – 170 .
  • Hodgkin , L and Huxley , AF . 1952 . A quantitative description of membrane current and its application to conduction and excitation in nerve . J Physiol , 117 : 500 – 544 .
  • Jalife , J , Morley , GE and Vaidya , D . 1999 . Connexins and impulse propagation in the mouse heart . J Cardiovasc Electrophysiol , 10 : 1649 – 1663 .
  • Keating , MT and Sanguinetti , MC . 2001 . Molecular and cellular mechanisms of cardiac arrhythmias . Cell , 104 : 569 – 580 .
  • Kuo , HC , Cheng , CF Clark , RB . 2001 . A defect in the Kv channelinteracting protein 2 (KChIP2) gene leads to a complete loss of Ito and confers susceptibility to ventricular tachycardia . Cell , 107 : 801 – 813 .
  • Lijnen , P and Petrov , V . 1999 . Renin-angiotensin system, hypertrophy and gene expression in cardiac myocytes . J Mol Cell Cardiol , 31 : 949 – 970 .
  • Luo , CH and Rudy , Y . 1991 . A model of the ventricular cardiac action potential . Circ Res , 68 : 1501 – 1526 .
  • Luo , CH and Rudy , Y . 1994 . A dynamic model of the cardiac ventricular action potential. I. Simulation of ionic currents and concentration changes . Circ Res , 74 : 1071 – 1096 .
  • Members . 2001 . New approaches to antiarrhythmic therapy . Circulation , 104 : 2865 – 2873 . . Part I: Emerging therapeutic applications of the cell biology of cardiac arrhythmias.
  • Minamisawa , S , Hoshijima , M Chu , G . 1999 . Chronic phospholambansarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy . Cell , 99 : 313 – 322 .
  • Nerbonne JM. 2001. Molecular analysis of voltage-gated K + channel diversity and functioning in the mammalian heart. In Page E, Fozzard HA, Solaro RJ, eds. Handbook of physiology: the cardiovascular system. New York: Oxford Univ Pr. p 568-94.
  • Nerbonne , JM , Nichols , CG Schwarz , TL . 2001 . Genetic manipulation of cardiac K+ channel function in mice: what have we learned, and where do we go from here . Circ Res , 89 : 944 – 956 .
  • Nguyen-Tran , VT , Kubalak , SW Minamisawa , S . 2000 . A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages . Cell , 102 : 671 – 682 .
  • Noble , D . 1962 . A modification of the Hodgkin-Huxley equations applicable to Purkinje fibre action and pace-maker potentials . J Physiol , 160 : 317 – 352 .
  • Noble , D , Varghese , A Kohl , P . 1998 . Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processess . Can J Cardiol , 14 : 123 – 134 .
  • Nordin , C . 1993 . Computer model of membrane current and intracellular Ca2+ flux in the isolated guinea pig ventricular myocyte . Am J Physiol , 265 : H2117 – H2136 .
  • Padmala , S and Demir , SS . 2003 . A computational model of the ventricular action potential in adult spontaneously hypertensive rats . J Cardiovasc Electrophysiol , 14 : 990 – 995 .
  • Pandit SV. 2002. Electrical activity in murine ventricular myocytes: simulation studies [PhD thesis]. Memphis: University of Memphis.
  • Pandit , SV , Clark , RB Giles , WR . 2001 . A mathematical model of action potential heterogeneity in adult rat left ventricular myocytes . Biophys J , 81 : 3029 – 3051 .
  • Pandit , SV , Giles , WR and Demir , SS . 2003 . A mathematical model of the electrophysiological alterations in rat ventricular myocytes in type-I diabetes . Biophys J , 84 : 832 – 841 .
  • Priebe , L and Beuckelmann , D . 1998 . Simulation study of cellular electric properties in heart failure . Circ Res , 82 : 1206 – 1223 .
  • Puglisi , JL and Bers , DM . 2001 . LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport . Am J Physiol Cell Physiol , 281 : C2049 – C2060 .
  • Qin , D , Zhang , ZH Caref , EB . 1996 . Cellular and ionic basis of arrhythmias in postinfarction remodeled ventricular myocardium . Circ Res , 79 : 461 – 473 .
  • Riemer , TL , Sobie , A and Tung , L . 1998 . Stretch-induced changes in arrhythmogenesis and excitability in experimentally based heart cell models . Am J Physiol , 275 : H431 – H442 .
  • Robbins , J . 2000 . Toward the new millennium . Annu Rev Physiol , 62 : 961 – 963 .
  • Rudy , Y . 2000 . From genome to physiome: integrative models of cardiac excitation . Ann Biomed Eng , 28 : 945 – 950 .
  • Seidman , JG and Seidman , C . 2001 . The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms . Cell , 104 : 557 – 567 .
  • Shimoni , Y , Firek , L Severson , D . 1994 . Short-term diabetes alters K+ currents in rat ventricular myocytes . Circ Res , 74 : 620 – 628 .
  • Shimoni , Y , Light , PE and French , RJ . 1998 . Altered ATP sensitivity of ATPdependent K+ channels in diabetic rat hearts . Am J Physiol , 275 : E568 – E576 .
  • Shimoni , Y , Severson , D and Giles , WR . 1995 . Thyroid status and diabetes modulate regional differences in potassium currents in rat ventricle . J Physiol , 488 : 673 – 688 .
  • Spooner PM, Rosen MR, eds. 2000. Foundations of cardiac arrhythmias. 1st ed. New York: Marcel Dekker.
  • Ten Tusscher , KH , Noble , D Noble , PJ . 2004 . A model for human ventricular tissue . Am J Physiol Heart Circ Physiol , 286 : H1573 – H1589 .
  • Trepanier-Boulay , V , St-Michel , C Tremblay , A . 2001 . Gender-based differences in cardiac repolarization in mouse ventricle . Circ Res , 89 : 437 – 444 .
  • Ward , CA , Ma , Z Lee , SS . 1997 . Potassium currents in atrial and ventricular myocytes from a rat model of cirrhosis . Am J Physiol , 273 : G537 – G544 .
  • Watanabe , T , Delbridge , LM Bustamante , JO . 1983 . Heterogeneity of the action potential in isolated rat ventricular myocytes and tissue . Circ Res , 52 : 280 – 290 .
  • Winslow , RL , Rice , J Jafri , S . 1999 . Mechanisms of altered excitationcontraction coupling in canine tachycardia-induced heart failure. II: Model studies . Circ Res , 84 : 571 – 586 .
  • Winslow , RL , Scollan , DF Holmes , A . 2000 . Electrophysiological modeling of cardiac ventricular function: from cell to organ . Annu Rev Biomed Eng , 2 : 119 – 155 .
  • Xu , H , Guo , W and Nerbonne , JM . 1999 . Four kinetically distinct depolarizationactivated K+ currents in adult mouse ventricular myocytes . J Gen Physiol , 113 : 661 – 678 .
  • Zeng , J , Laurita , K Rosenbaum , DS . 1995 . Two components of the delayed rectifier K+ current in ventricular myocytes of the guinea pig type: theoretical formulation and their role in repolarization . Circ Res , 77 : 140 – 152 .
  • Zhou , J , Jeron , A London , B . 1998 . Characterization of a slowly inactivating outward current in adult mouse ventricular myocytes . Circ Res , 83 : 806 – 814 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.