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Drug Evaluation

Management of symptons associated with advanced cancer: olanzapine and mirtazapine

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Pages 365-376 | Published online: 10 Jan 2014

References

  • ••
  • Waller A, Caroline NL. Handbook of Palliative Care in Cancer (2nd Edition). Butterworth-Heinemann (2000).
  • Davis MP, Dickerson ED. Olanzapine: another psychotropic? Am. j Hospice Palliative Care 18(2), 129–132 (2001).
  • Strange PG. Antipsychotic drugs: importance of dopamine receptors for mechanisms of therapeutic actions and side effects. Pharmacological Rev 53(1), 119–133 (2001).
  • •A major pharmacodynamic difference between typical and atypical antipsychotics is D2 and D3 receptor binding affinity. This article reviews the differences between the various antipsychotics.
  • Moore NA, Leander JD, Benvenga MJ etal. Behavioral pharmacology of olanzapine: a novel antipsychotic drug. Clin. Psychiatry 10,37–44 (1997).
  • Stephenson CME, Pilowsky LS. Psychopharmacology of olanzapine: a review. Br. PTchiatry174(38S), 52–58 (1999).
  • •A well written review on olanzapinepharmacology and clinical outcomes.
  • Worrell JA, Marken PA, Beckman SE et al A typical antipsychotic agents: a critical review. Am. j Health Syst. Phatm. 57(3), 238–255 (2000).
  • Raedler TJ, Knable B, Jones DW etal. In vivo olanzapine occupancy of muscarinic acetylcholine receptors in patients with schizophrenia. Neuropsychophamacology 23(1), 56–68 (2000).
  • Bymaster FP, Falcone JF, Bauzon D et al Potent antagonism of 5-HT(3) and 5-HT(6) receptors by olanzapine. Eur. Phalmacol 430(2–3), 341–349 (2001).
  • Callaghan JT, Bergstrom RF, Ptak LR etal. Olanzapine: Pharmacokinetic and pharmacodynamic profile. Clin. Phatmcokinet. 37(3),177-93 (1999).
  • ••Summarizes the use of olanzapine inspecial populations (i.e., the elderly and those with renal and hepatic impairment). This article also reviews olanzapine drug interactions.
  • Lucas RA, Gilfillan DJ, Bergstrom RF. A pharmacokinetic interaction between carbamazepine and olanzapine: observations on possible mechanism. Eur. Clin. Pharmacol. 54(8), 639–643 (1998).
  • Hagg S, Spigset O, Lakso HA etal. Olanzapine disposition in humans is unrelated to CYP1A2 and CYP2D6 phenotypes. Eur. Clin. Pharmacol 57(6–7), 493–497 (2001).
  • Melkersson K, Khan A, Hilding A et al. Different effects of antipsychotic drugs on insulin release in vitro. Eur. Neuropsychopharmacolll (5), 327–332 (2001).
  • Melkersson KI, Hulting Al, Brismar KE. Elevated levels of insulin, leptin and blood lipids in olanzapine-treated patients with schizophrenia or related psychoses. J. Clin. PTchiatry61 (10), 742–749 (2000).
  • Stephenson CM, Pilowsky LS. Psychopharmacology of olanzapine. A review. BE J. Psychiatry (Suppl. 38), 52–58 (1999).
  • Beasley CM, Tollefson G, Tran P et al. Olanzapine versus placebo and haloperidol: acute phase results of the North American double-blind olanzapine trial. Neuropsychopharmacology14(2), 111–123 (1996).
  • Sacristan JA, Gomez JC, Montejo AL et al. Doses of olanzapine, risperidone and haloperidol used in clinical practice: results of a prospective pharmaepidemiologic study. Clin. Ther 22(5), 583–599 (1999).
  • Gilbody SM, Bagnall AM, Duggan L et al. Risperidone versus other atypical antipsychotic medication for schizophrenia. Cochrane Database Syst. Rev 3:CD002306 (2000).
  • Markowitz JS, Brown CS, Moore TR. Atypical antipsychotics. Part I: pharmacology, pharmacokinetic efficacy. Ann. Pharmacother. 33(1), 73–85 (1999).
  • Gomez JC, Sarcristan JA, Hernandez J et al. The safety of olanzapine compared with other antipsychotic drugs: results of an observational prospective study in patients with schizophrenia (EFESO Study). Pharmacoepidemiologic Study of Olanzapine in Schizophrenia. J. Clin. PTchiatry61 (5), 335–43 (2000).
  • Tran PV, Dellva MA, Tollefson GD et al Extrapyramidal symptoms and tolerability of olanzapine versushaloperidol in the acute treatment of schizophrenia. J. Clin. PTchiatry58(5), 205–211 (1997).
  • Keck PE, Stakowski SM, McElroy SL. The efficacy of atypical antipsychotics in the treatment of depressive symptoms, hostility and suicidality in patients with schizophrenia. J. Clin. fiychiatry61 (3), 4–9 (2000).
  • Beasley CM, Hamilton SH, Crawford AM et al Acute phase results of the international double-blind olanzapine trial. Eur Neuropsychopharmacol 7(2), 125–137 (1997).
  • Voruganti L, Cortese L, Oyewumi L et al Comparative evaluation of conventional and novel antipsychotic drugs with reference to their subjective tolerability, side effect profile and impact on quality of life. Schizophr Res. 43(2-3), 135–143 (2000).
  • Madhusoodanan S, Brenner R, Suresh P etal Efficacy and tolerability of olanzapine in elderly patients with psychotic disorders: a prospective study. Ann. Clin. Psychiatry 12(1), 11–18 (2000).
  • Kim KS, Pae CU, Chae JH et al. An open pilot trial of olanzapine for delirium in the Korean population. Psychiatry Clin. Neumsci. 55 (5), 515–519.
  • Sipahimalani A, Masand PS. Olanzapine in the treatment of delirium. Psychosomatics 39,422–430 (1998).
  • •This trial demonstrates the benefits of olanzapine in the management of delirium.
  • Costa E Silva JA, Alvarez N, Mazzoti G etal Olanzapine as alternative therapy for patients with halperidol-induced extrapyramidal symptoms: results of a multicenter, collaborative trial in Latin America. J. Clin. PTchopharmcol 21 (4), 375–381 (2001).
  • •This article provides evidence that olanzapine can be safely used in individuals who experience extrapyramidal symptoms with classical antipsychotics.
  • Lundbert J, Passik S. Controlling opioid-induced nausea with olanzapine. Prim. Care Cancer 20,5–7 (2000).
  • Sanford-Kiser R, Cohen HM, Freedenfeld RN etal Olanzapine for the treatment of fibromyalgia symptoms. J. Pain Sym. Man. 22(2), 704–708 (2001).
  • Rozen TD. Olazapine as an abortive agent for cluster headache. Headache 41(8), 813–816 (2001).
  • Beasley CM, Tollefson GD, Tran PV. Safety in olanzapine. j Clin. Psychiatry 58 (10), 13–17 (1997).
  • Bhana N, Foster RII, Olney R et al Olanzapine: an updated review of its use in the management of schizophrenia. Drugs 61(1), 111–161 (2001).
  • •This is the most extensive review of olanzapine available to date.
  • Jarventausta K, Leinonen E. Neuroleptic malignant syndrome during olanzapine and levompromazine treatment. Acta Psychiatrica Scandinavica 102(3), 231–233 (2000).
  • Conely RR, Meltzer HY. Adverse events related to olanzapine. Adverse events related to olanzapine. j Clin. fiychiatry 61 (8), 26-29(2000).
  • Lindenmayer JP, Nathan AM, Smith RC. Hyperglycemia associated with the use of atypical antipsychotics. j Clin. Psychiatry 23,30–38 (2001).
  • Green B. Focus on olanzapine. CUI7: Med. Res. Opin. 15(2), 79–85 (1999).
  • Czekalla J, Kollack—Walker S, Beasley CM Jr. Cardiac safety parameters of olanzapine: comparison with other atypical and typical antipsychotics. j Clin. PTchiatry 62 (2), 35–40 (2001).
  • Foster RII, Goa KL. Olanzapine. A pharmacoeconomic review of it use in schizophrenia. Pharmacoeconomics 15 (6), 611–640 (1999).
  • Puzantian T Mirtazapine, an antidepressant. Am. J. Health Syst Pharm. 55(1), 44–49 (1998).
  • ••An excellent review of the pharmacologyand clinical efficacy of mirtazapine.
  • Davis MP, Dickerson ED, Pappagallo M et al Mirtazapine: heir apparent to amitriptyline? Am J. Hospice Palliative Care 18(1), 42–46 (2001).
  • Frazer A. Pharmacology of antidepressants. Clin. PTchophannacy17(2S), 1–36
  • ••This review is a comprehensive referenceon comparisons of various antidepressants.
  • de Boer TD. The pharmacologic profile of mirtazapine. j Clin. Psychiatry57(4), 19–25 (1996).
  • Gorman JM. Mirtazapine: clinical overview. J. Clin. PTchiatry 60 (17), 9–13.
  • •An excellent short and concise review of mirtazapine's unique characteristics.
  • Burrows GD, Kremer CM. Mirtazapine: clinical advantages in the treatment of depression. J. Clin. Bychopharmacol 1, 34S-93 (1997).
  • Blier P Possible neurobiological mechanisms underlying faster onset of antidepressant action. J. Clin. Psychiatry62(4), 7–11 (2001).
  • •Though somewhat controversial, mirtazapine's antidepressant benefits appear to occur earlier compared with SSR1s. This article reviews the possible mechanisms for the rapid onset of mirtazapine's antidepressant benefit.
  • Fawcett J, Barkin RL. Review of the results from clinical studies on the efficacy, safety and tolerability of mirtazapine for the treatment of patients with major depression. j Affective Disorders 51 (3), 267–285 (1998).
  • ••One of the best reviews on mirtazapine.
  • Richelson E. Pharmacokinetic drug interactions of new antidepressants: a review of the effects on the metabolism of other drugs. Mayo Clin. Proc. 72(9), 835–847 (1997).
  • ••For those who have trouble puttingtogether antidepressants and drug interactions related to hepatic cytochrome enzymology, this is an excellent reference.
  • Timmer CJ, Sitsen JM, Delbressine LP Clinical pharmacokinetics of mirtazapine. Clin. Pharmacokinetics 38 (6), 461–474 (2000).
  • ••Another excellent synopsis of mirtazapinepharmacology.
  • Delbressine LPC, Vos RME. The clinical relevance of preclinical data: mirtazapine, a model compound. j Clin. Psycopharmacol 17(25), 29S-33S (1997).
  • Stormer E, von Moltke LL, Shader RI et al Metabolism of the antidepressant mirtazapine in vitro: contribution of cytochromes P450 1A2, 2D6 and 3A4. Drug Metabol Disp. 28(10), 1168–1175 (2000).
  • Davis MP, Homsi J. The importance of cytochrome P450 monoxygenase CYP2D6 in palliative medicine. Support Care Cancer 9,442–451 (2001).
  • Anttila SA, Leinonen EV. A review of pharmacological and clinical profile of mirtazapine. CNS Drug-Rev. 7(3), 246–264 (2001).
  • Stahl S, Zivkov M, Reimitz PE et al. Meta-analysis of randomized, double-blind, placebo-controlled, efficacy and safety studies of mirtazapine versus amitriptyline in major depression. Acta PTchiatrica Scam 391,22–30 (1997).
  • Guelfi JD, Ansseau M, Timmerman L et al Mirtazapine versus in hospitalized severely depressed patients with melancholic features. j Clin. PTchopharmacology21 (4), 425–431 (2001).
  • Montgomery SA, Reimitz PE, Zivkov M. Mirtazapine versus amitriptyline in the long-term treatment of depression: a double-blind placebo-controlled study. Int. Clin. PTchopharmacology13(2), 63–73 (1998).
  • Kasper S. Efficacy of antidepressants in the treatment of severe depression: the place of mirtazapine. j Clin. PTchopharmacology 17(2S), 19S-28S (1997).
  • •Mirtazapine is as effective in severe depression as tricyclic antidepressants.
  • Kasper S, Praschak-Rieder N, Tauscher J et al A risk-benefit assessment of mirtazapine in the treatment of depression. Drub Safety17 (4), 251–264 (1997).
  • Holm KJ, Markham A. Mirtazapine: a review of its use in major depression. Database Abstracts Rev Effectiveness1,1–7 (2001).
  • •This database review of 12 randomized control trials demonstrates mirtazapine's comparable efficacy to tricyclic antidepressants and earlier onset of antidepressant activity compared with SSR1s.
  • Thase ME. Antidepressant treatment of the depressed patient with insomnia. j Clin. Psychiatry60(17), 28–31 (1999).
  • Kast KE. Mirtazapine may be useful in treating nausea and insomnia of cancer chemotherapy. Support Care Cancer9, 469–470 (2001).
  • Nutt DJ. Care of depressed patients with anxiety symptoms. j Clin. Psychiatry 60(17), 23–27 (1999).
  • Thompson C. Mirtazapine versus selective serotonin re-uptake inhibitors. J. Clin. Psychiatry60(17), 18–22 (1999).
  • Carpenter LL, Jocic Z, Hall JM et al Mirtazapine augmentation in the treatment of refractory depression. j Clin. Psychiatry 60(1), 45–49 (1999).
  • •Demonstrates mirtazapine's ability to augment standard antidepressants in patients with refractory depression without risk or increasing side effects.
  • Carpenter LL, Leon Z, Yasmin S et al Clinical experience with mirtazapine in the treatment of panic disorder. Ann. Clin. Psychiatry 11 (2), 6 (1999).
  • Boshuisen ML, Slaap BR, Vester-Bloldand ED et al The effect of mirtazapine in panic disorder: an open label pilot study with a single-blind placebo run-in period. Int. Clin. PTchopharmacology16(6), 363–368 (2001).
  • Bruijn JA, Moleman P, Mulder PG et al Depressed in-patients respond differently to imipramine and mirtazapine. Pharmacopsychiatry32(3), 87–92 (1999).
  • Riberio L, Busnello JV, Kauer-Sant'Anna M et al. Mirtazapine versus fluoxetine in the treatment of panic disorder. Brazilian J. Merl Biol. Res. 34(10), 1303–1307 (2001).
  • Waldinger MD. Sexual side effects of antidepressants. Nederland's TijcIschrift voor Ceneeskuncle 143(37), 1853–1857 (1999).
  • Koutouvidis N, Pratikakis M, Fotiadou A. The use of mirtazapine in a group of 11 patients following poor compliance to selective serotonin re-uptake inhibitor treatment due to sexual dysfunction. Inter Clin. PTchopharmacology14(4), 253–255 (1999).
  • Nutt D. Mirtazapine: pharmacology in relation to adverse effects. Acta Psychiatrica Scam 391,31–37 (1997).
  • •A well-worth reading comparison of the different side effect profiles of mirtazapine, tricyclic antidepressants and SSR1s.
  • Gelenberg AJ, Laukes C, McGahuey C et al Mirtazapine substitution in SSRI-induced sexual dysfuntion. j Clin. PTchiatry61 (5), 356–320 (2000).
  • Waldinger MD, Berendsen I11 I, Schweitzer DH. Treatment of hot flashes with mirtazapine: four case reports. Matutitas 36(3), 165–168 (2000).
  • Poyurovsky M, Weizman A. Mirtazapine for neuroleptic-induced akathisia. Am. j PTchiatry158(5), 819 (2001).
  • Thompson DS. Mirtazapine for the treatment of depression and nausea in breast and gynecological oncology. PTchosomatics 41(4), 356–359 (2000).
  • •This case series of women with gynecological and breast cancers gives us a hint of the multiple symptom benefits of mirtazapine in cancer patients.
  • Pedersen L, Klysner R. Antagonism of selective serotonin re-uptake inhibitor-induced nausea by mirtazapine. Inter Clin. PTchopharmacology12(1), 59–60 (1997).
  • Hoes MJ, Zeijpveld JH. Mirtazapine as treatment for serotonin syndrome. Pharmacopsychiatry29(2), 81 (1996).
  • Jung AC, Staiger T, Sullivan M. Review: selective serotonin re-uptake inhibitors are effective for mixed chronic pain. ACP Journal Club 128,3 (1998).
  • Jung AC, Staiger T, Sullivan M. The efficacy of selective serotonin re-uptake inhibitors for the management of chronic pain. Database of Abstracts of Reviews of Effectiveness 1, 1–5 (2001).
  • Brannon GE, Stone KD. The use of mirtazapine in a patient with chronic pain. J. Pain Symptom Management 18(5), 382–385 (1999).
  • Elliott AJ, Roy-Byrne PR Mirtazapine for depression in patients with human immunodeficiency virus. J. Gun. Psychwhalmacology20(2), 265–267 (2000).
  • Egberts ACG, Lenderink AW, de Koning FHP et al Channeling of three newly introduced antidepressants to patients not responding satisfactorily to previous treatment. J. Gun. Bychophatmacology 17(3), 149–155 (1997).
  • Bremner JD, Wingard P, Walshe TA. Safety of mirtazapine in overdose. J. Clin. fiychiatry59(5), 233–235 (1998).
  • Holm KJ, Jarvis B, Foster RII. Mirtazapine. A pharmacologic review of its use in depression. Phatmacoeconomics 17(5), 515–534 (2000).
  • •A review of the economic advantage of mirtazapine despite its higher acquisition cost.
  • Brown MC, Nimmerrichter AA, Guest JE Cost-effectiveness of mirtazapine compared to amitriptyline and fluoxetine in the treatment of moderate and severe depression in Austria. Eur. Psychiatry 14(4), 230–244 (1999).
  • Sitsen JM, Mans FA, Timmer CJ. Concomitant use of mirtazapine and cimetidine: a drug—drug interaction study in healthy male subjects. Eur j Clin. Pharmacol 56(5), 389–394 (2000).
  • Sitsen J, Mans F, Timmer C. Drug—drug interaction studies with mirtazapine and carbamazepine in healthy male subjects. Eur. J. Drug Metabolism Phalmacokinetics 26(1–2), 109–121 (2001).
  • Sitsen JM, Voortman G, Timmer CJ. Pharmacokinetics of mirtazapine and lithium in healthy male subjects. PTchophatmacology14(2), 172–176 (2000).
  • Konstantinidis A, Stastny J, Ptak-Butta J et al. Intravenous mirtazapine in the treatment of depressed in-patients. Eur Neumpsychopharmacology 12 (1), 57–50 (2002).

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