110
Views
31
CrossRef citations to date
0
Altmetric
Drug Profile

Aprepitant: a neurokinin-1 receptor antagonist for the treatment of chemotherapy-induced nausea and vomiting

Pages 715-724 | Published online: 10 Jan 2014

REFERENCES

  • Navari RM. Pathogenesis-based treatment of chemotherapy induced nausea and vomiting: two new agents. I Support. Oncol. 1,89–103 (2003).
  • ••Current review of chemotherapy-inducednausea and vomiting (CINV).
  • Kris MG. Why do we need another anti-emetic?I Clin. Oncol. 21,4077–4080 (2003).
  • Berger AM, Clark-Snow RA. Adverse effects of treatment. In: Principles and ffactice of Oncology Devita VT Jr, Heiman S, Rosenberg S (Eds), Lippincott Williams & Wilkins, PA, USA, 2869–2880 (2001).
  • Hesketh PJ, Kris MG, Grunberg SM et al. Proposal for classifying the acute emetogenicity of cancer chemotherapy. Clin. Oncol. 15,103–109 (1997).
  • Koeller JM, Aapro MS, Gralla RJ et al Anti-emetic guidelines: creating a more practical treatment approach. Support. Cam Cancer 10, 517–518 (2002).
  • •Guidelines for CINV.
  • Hesketh PJ. Comparative review of 5-HT3 receptor antagonists in the treatment of acute chemotherapy-induced nausea and vomiting. Cancer Invest. 18,163–173 (2000).
  • Simpson K, Spencer CM, McClellan KJ. Topisetron: an update of its use in the prevention of chemotherapy-induced nausea and vomiting. Drugs59,1297–1315 (2000).
  • Taguchi T, Tsukamoto F, Watanabe T et al Usefulness of ramosetron hydrochloride on nausea and vomiting in CMF or CEF therapy for breast cancer. Gan To Kagaku Ryoho 26,1163–1170 (1999).
  • Kimura E, Niimi E, Watanabe A etal. Study on clinical effect of a continuous intravenous infusion of azasetron against nausea and vomiting induced by anticancer drugs including CDDP. Gan To Kagaku Ryoho 23,477–481 (1996).
  • Navari RM, Koeller JM. Electrocardiographic and cardiovascular effects of the 5-hydroxytryptamine-3 receptor antagonists. Ann. Phalmacother. 37,1276-1286 (2003).
  • The Italian Group for Anti-emetic Research. Dexamethasone alone or in combination with ondansetron for the prevention of delayed nausea and vomiting induced by chemotherapy. N Eng. I Med. 342,1554–1559 (2000).
  • Hickok JT, Roscoe JA, Morrow GR et al Nausea and emesis remain significant problems of chemotherapy despite prophylaxis with 5-hydroxytryptamine-3 anti-emetics. Cancer97, 2880–2886 (2003).
  • •Summarizes the limitations of 5-hydroxytryptamine-3 (5-HT3) receptor antagonists in controlling delayed CINV.
  • Eisenberg P, MacKintosh FR, Pitch P et al. Efficacy, safety, and pharmacokinetics of palonosetron in patients receiving highly emetogenic, cisplatin-based chemotherapy: a dose-ranging, clinical study. Ann. Oncol. 15,330–337 (2004).
  • Eisenberg P, Figueroa-Vadillo J, Zamora R et al Improved prevention of moderately emetogenic chemotherapy-induced nausea and vomiting with palonosetron, a pharmacologically novel 5-HT3 receptor antagonist. Results of a Phase III, single-dose trial versus dolasetron. Cancer 98, 2473–2482 (2003).
  • •Data used for approval of palonosetron.
  • Gralla R, Lichinitser M, Van der Vegt S et al Palonosetron improves prevention of chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy: results of a double-blind randomized Phase III trial comparing single doses of palonosetron with ondansetron. Ann. Oncol. 14,1570–1577 (2003).
  • •Data used for approval of palonosetron.
  • Aapro MS, Bertoli L, Lordick F et al. Palonosetron is effective in preventing acute and delayed chemotherapy induced nausea and vomiting in patients receiving highly emetogenic chemotherapy. Support. Care Cancer11,391 (2003) (Abstract 17).
  • •Data used for the approval of palonosetron.
  • Cartmell AD, Ferguson S, Yanagihara R et al Protection against chemotherapy-induced nausea and vomiting is maintained over multiple cycles of moderately or highly emetogenic chemotherapy by palonosetron, a potent 5-HT3 receptor antagonist. Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 3041).
  • Diemunsch P, Grelot L. Potential of substance P antagonists as anti-emetics. Drugs60, 533–546 (2000).
  • ••Review of neurokinin-1 receptorantagonists and their potential use as antiemetics.
  • Watson JW, Gonsalves SF, Rossa AA et al The anti-emetic effects of CP-99,994 in the ferret and dog: role of the NK-1 receptor. Br. Pharmacol 115, 84–94 (1998).
  • Fasth KJ, Bergstrom M, Kilpatrick G et al Brain uptake and receptor binding of two C11 labeled selective high affinity NK-1 antagonists GR203040 and GR205171. .1. Label. Compounds Radiopharm. 40, 665–667 (1997).
  • Tattersall FD, Rycroft W, Francis B et al. Tachykinins NK-1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology35, 1121–1129 (1996).
  • Minami M, Endo T, Yokoda H et al Effects of CP-99,994, a tachykinin NK-1 receptor antagonist, on abdominal afferent vagal activity in ferrets: evidence for involvement of NK-1 and 5-HT3 receptors. Eur. Phalmacol 428, 215–220 (2001).
  • Tattersall FD, Rycroft W, Cumberbatch M et al The novel NK1 receptor antagonist MK-0869 (L-754,030) and its water soluble phosphoryl prodrug, L-758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets. Neuropharmacology39, 652–663 (2000).
  • Blum RA, Majumdar AK, McCrea JB et al Effects of aprepitant on the pharmacokinetics of ondansetron and granisetron in healthy subjects. Clin. flier. 25, 1407–1419 (2003).
  • Feuring M, Lee Y, Orlowski LH et al Lack of effect of aprepitant on digoxin pharmacokinetics in healthy subjects. Clin. Pharmacol 43, 912–917 (2003).
  • McCrea JB, Majumdar AK, Goldberg MR et al Effects of the neurokinin-1 receptor antagonist aprepitant on the pharmacokinetics of dexamethasone and methylprednisolone. Clin. Pharmacol Pier. 74, 17–24 (2003).
  • Majumdar AK, McCrea JB, Panebianco DL et al Effects of aprepitant on cytochrome P450 3A4 activity using midazolam as a probe. Clin. Pharmacol Pier. 74, 150–156 (2003).
  • Kris MG, Radford JE, Pizzo BA et al Use of a NK1 receptor antagonist to prevent delayed emesis after cisplatin (letter). I Natl Cancer Inst. 89, 817–818 (1997).
  • Cocquyt V, Van Belle S, Reinhardt RR et al Comparison of L-758,298, a prodrug for the selective neurokinin-1 antagonist L-754,030, with ondansetron for the prevention of cisplatin-induced emesis. Eur. Cancer 37, 835–842 (2001).
  • Navari RM, Reinhardt RR, Gralla RJ et al Reduction of cisplatin-induced emesis by a selective neurokin-1 receptor antagonist. N. Engl. Med. 340, 190–195 (1999).
  • Hesketh PJ, Gralla RJ, Webb RT et al Randomized Phase II study of the neurokinin-1 receptor antagonist CJ-11,974 in the control of cisplatin-induced emesis. j Clin. Oncol 17, 338–343 (1999).
  • Van Belle S, Liechinitser M, Navari RM et al Prevention of cisplatin- induced acute and delayed emesis by the selective neurokinin-1 antagonists, L-758,298 and MK-0869. Cancer94, 3032–3041 (2002).
  • Campos D, Pereira JR, Reinhardt RR et al Prevention of cisplatin-induced emesis by the oral neurokinin-1 antagonist, MK-869, in combination with granisetron and dexamethasone or with dexamethasone alone.j Clin. Oncol 19, 1759–1767 (2001).
  • Chawla SP, Grunberg SM, Gralla RJ et al Establishing the dose of the oral NK-1 antagonist aprepitant for chemotherapy induced nausea and vomiting. Cancer 97, 2290–2300 (2003).
  • Hesketh PJ, Grunberg SM, Gralla RJ et al The oral neurokinin-1 antagonist aprepitant for the prevention of chemotherapy-induced nausea and vomiting: a multinational, randomized, double-blind placebo-controlled trial in patients receiving high-dose cisplatin — aprepitant protocol 052 study group. Clin. Oncol 21, 4112–4119 (2003).
  • •Data used for the approval of aprepitant.
  • Poli-Bigelli S, Rodrigues-Pereira J, Carides AD et al Addition of the neurokinin-1 receptor antagonist aprepitant to standard anti-emetic therapy improves control of chemotherapy-induced nausea and vomiting. Cancer 97, 3090–3098 (2003).
  • •Data used for the approval of aprepitant.
  • De Witt R, Herrstedt J, Rapoport BL et al Addition of the oral NK1 antagonist aprepitant to standard anti-emetics provides protection against nausea and vomiting during multiple cycles of cisplatin-based chemotherapy. J: Clin. Oncol 21, 4105–4111 (2003).
  • De Witt R, Herrstedt J, Rapoport B et al The oral NK-1 antagonist, aprepitant, given with standard anti-emetics provides protection against nausea and vomiting over multiple cycles of cisplatin-based chemotherapy: a combined analysis of two randomized, placebo-controlled Phase III clinical trials. Eur .1. Cancer 40, 403–410 (2004).
  • Warr DG, Eisenberg P, Hesketh PJ et al Phase III double-blind study to assess an aprepitant-containing regimen for the prevention of nausea and vomiting due to moderately emetogenic chemotherapy. Proc. Am. Soc. Clin. Oncol (2004) (Abstract 8007).
  • ••Data on the use of aprepitant in patientsreceiving moderately emetogenic chemotherapy.
  • Grunberg SM, Deuson R, Mavros P et al Incidence of chemotherapy-induced nausea and emesis after modem anti-emetics: perception versus reality. Cancer 100, 2261–2268 (2004).
  • Fabi A, Barduagni M, Lauro S et al Is delayed chemotherapy-induced emesis well managed in oncological clinical practice? An observational study. Support. Cam Cancer 11, 156–161 (2003).
  • Navari RM, Einhom LH, Loehrer PJ et al A Phase II trial of olanzapine for the prevention of chemotherapy induced nausea and vomiting. Proc. Am Soc. Clin. Oncol (2004) (Abstract 8046).
  • •Use of olanzapine to control CINV.
  • Guttuso T, Roscoe J, Griggs J. Effect of gabapentin on nausea induced by chemotherapy in patients with breast cancer. Lancet361, 1703–1705 (2003).
  • •Use of gabapentin for the control of CINV.

Websites

  • Merck & Co., Inc. Emend (aprepitant) capsules: prescribing information. USA online www.merck.com (Accessed September 2004)
  • ••Prescribing information and potentialtoxicities and adverse events of aprepitant.
  • NCCN Clinical Practice Guidelines in Oncology: antiemesis, version 1 (2004) www.nccn.org (Accessed September 2004)
  • ••2004 guidelines for the prevention of CINV.
  • MASCC Antiemetic Consensus Conference, Perugia, Italy (March 29–31, 2004) www.mascc.org (Accessed September 2004)
  • •2004 guidelines for the prevention of CINV.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.