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Review

Clinical management of medulloblastoma in adults

Pages 795-802 | Published online: 10 Jan 2014

References

  • Giordana MT, Schiffer P, Lanotte M et al Epidemiology of adult medulloblastoma. Int.j Cancer 80,689–692 (1999).
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  • Brandes AA, Ermani M, Amista P et al. The treatment of adults with medulloblastoma: a prospective study. Int. J. Racliat. Once]. Bid Phys. 57,755–761 (2003).
  • •Recent prospective clinical trial (Phase In of adult medulloblastoma offering treatment stratified for risk group based on classic parameters.
  • Boissel N, Auclerc MF, Lhéritier V et al. Should adolescents with acute lymphoblastic leukemia be treated as old children or young adults? Comparison of the French FRALLE-93 and LALA-94 trials. 1 Clin. Once]. 21,774-780 (2003).
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  • •Clearly delineated prognostic groups in childhood medulloblastoma and provided a basis for the design of prospective randomized clinical trials for average- and poor-risk patients.
  • Kortmann RD, Kahl J, Timmermann B et al Postoperative neoadjuvant chemotherapy before radiotherapy as compared to immediate radiotherapy followed by maintenance chemotherapy in the treatment of medulloblastoma in childhood: results of the German prospective randomized trial HIT '91. Int. j Racliat. Once]. Bid Phys. 46,269-279 (2000).
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  • ••Landmark study demonstrating thatcraniospinal radiation can be reduced safely from 36 to 24.3 Gy with the provision of adjuvant chemotherapy in children with average-risk medulloblastoma.
  • Packer R, Gajjar A, Vezina G et al. Preliminary report of A9961: a Phase III randomized study of craniospinal radiotherapy (CSRT) followed by one of two adjuvant chemotherapy regimens (CCNU, CPDD, VCR or CPM, CPDD, VCR) in children with newly diagnosed average-risk medulloblastoma (MB). Proc. Int. Symp. Pecliatr. Neurooncol (2004) (Abstract Then 61).
  • Ellison DW, Clifford SC, Gajjar A, Gilbertson RJ. What's new in neuro-oncology? Recent advances in medulloblastoma. Eur. j Pecliatr. Neural.7, 53–66 (2003).
  • •Comprehensive review of current treatment strategies and translational research in medulloblastoma.
  • Fisher PG, Burger PC, Eberhart CG. Biologic risk stratification of medulloblastoma: the real time is now. Clin. Oncol 22,971–974 (2004).
  • ••Outstanding review of the application ofclinical features, microarray data and molecular markers to determine prognostic risk factors in medulloblastoma.
  • Gilbertson RJ. Medulloblastoma: signalling a change in treatment. Lancet Once]. 5, 209–218 (2004).
  • ••Excellent review of clinical, pathologic andbiomolecular studies, as well as an overview of the shift towards the utilization of targeted therapies in selected patients.
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  • •Largest retrospective case series in adults, although not all cases were exclusively imaged with magnetic resonance imaging.
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  • •First retrospective adult study to recommend that the principles of management of pediatric medulloblastoma should be applied to adults.
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  • •Classic paper in neuro-oncology.
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  • •Confirms the superiority of lumbar cerebrospinal fluid in the clinical staging of patients with medulloblastoma.
  • Fouladi M, Gajjar A, Boyett JM et al Comparison of CSF cytology and spinal magnetic resonance imaging in the detection of leptomeningeal disease in pediatric medulloblastoma or primitive neuroectodermal tumor. J. Clin. Oncol 17, 3234–3237 (1999).
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  • Eberhart CG, Kepner JL, Goldthwaite PT et al Histopathologic grading of medulloblastoma: a Pediatric Oncology Group Study. Cancer94, 552–560 (2002).
  • •Important contribution documenting large cell/anaplastic medulloblastoma as an independent prognostic factor in pediatric medulloblastoma.
  • Freeman CR, Taylor RE, Kortman RD, Carrie C. Radiotherapy for medulloblastoma in children: a perspective on current international clinical research efforts. Med. Pediatr Oncol 39, 99–108 (2002).
  • Merchant TE, Kun LE, Krasin MJ et al A multi-institution prospective trial of reduced dose craniospinal irradiation (23.4 Gy) followed by conformal posterior fossa (36 Gy) and primary site irradiation (55.8 Gy) and dose-intensive chemotherapy for average-risk medulloblastoma. kit. J. Radiat. Oncol Biol. Phys. 57 (Suppl.), S194—S195 (2003).
  • Carrie C, Muracciole X, Gomez F et al Conformal radiotherapy, reduced boost volume, hyperfractionated radiotherapy and on-line quality control in standard risk medulloblastoma without chemotherapy. Results of the French M-SFOP 98 protocol. Int. .1. Radiat. Oncol Biol. Phys. 57(Suppl.), S195 (2003).
  • Tabori U, Hukin J, Crooks B et al. Medulloblastoma in the second decade of life: a specific group with respect to toxicity and management. A Canadian Paediatric Brain Tumor Consortium Study. Proc. hit. Symp. Pediatr Neumoncol (2004) (Abstract Then 77).
  • Fernandez-Teijeiro A, Betensky RA, Sturla LM et al Combining gene expression profiles and clinical parameters for risk stratification in medulloblastomas. Clin. Oncol 22, 1–5 (2004).
  • •One of the first applications of gene expression profiling combined with clinical risk factors used to determine prognosis in pediatric medulloblastoma.
  • Gajjar A, Heman R, Kocak M etal. Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma. j Clin. Oncol 22, 984–993 (2004).
  • •Another recent paper combining clinicopathologic and molecular studies to assign prognosis in patients with medulloblastoma.

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