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Review

Endocrine therapy and other targeted therapies for metastatic breast cancer

, , &
Pages 1179-1195 | Published online: 10 Jan 2014

References

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  • ••Conducted to compare the efficacy andtolerability of anastrozole with that of tamoxifen as first-line therapy for advanced breast cancer in postmenopausal women. This randomized, double-blind, multicenter study evaluated the efficacy of anastrozole 1 mg once daily relative to tamoxifen 20 mg once daily in patients with tumors that were hormone receptor-positive or of unknown receptor status who were eligible for endocrine therapy. Anastrozole satisfied the predefined criteria for equivalence to tamoxifen. Findings indicated that anastrozole should be considered as first-line therapy.
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