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Drug Profile

Capecitabine: the new generation of fluoropyrimidines in colorectal cancer

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Pages 947-955 | Published online: 10 Jan 2014

References

  • Jemal A, Tiwari RC, Murray T et al. Cancer statistics, 2004. CA Cancer J. Cilia. 54, 8–29 (2004).
  • American Cancer Society. 2004 Cancer Facts and Figures. American Cancer Society, NY, USA (2004).
  • Meta-Analysis Group in Cancer. Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. J. Clin. Oncoll 16, 301–308 (1998).
  • Meta-Analysis Group In Cancer. Toxicity of fluorouracil in patients with advanced colorectal cancer: effect of administration schedule and prognostic factors. J. Clin. Oncoll 16, 3537–3541 (1998).
  • Goldberg RM, Sargent DJ, Morton RF et al. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. 1 Clin Oncoll 22, 23–30 (2004).
  • Tournigand C, Andre T, Achille E et al. FOLFIRI followed by FOLFOX6 or thereverse sequence in advanced colorectalcancer: a randomized GERCOR study.Clin. Oncoll 22,229–237 (2004).
  • Kabbinavar F, Hurwitz HI, Fehrenbacher L et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. Clin. Oncol. 21, 60–65 (2003).
  • Hurwitz H, Fehrenbacher L, Novotny W et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl. J Med. 350, 2335–2342 (2004).
  • Andre T, Boni C, Mounedji-Boudiaf L et al. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl. J Med. 350, 2343–2351 (2004).
  • ••Combination chemotherapy with 5-fluorouracilileucovorin/oxaliplatin (FOLFOX4) is superior to standard 5-fluorouracil (5-FU)/leucovorin (LV) in adjuvant treatment of colorectal cancer.
  • Sargent DJ, Wieand S, Benedetti J et al. Disease-free survival (DFS) vs. overall survival (OS) as a primary end point for adjuvant colon cancer studies: individual patient data from 12,915 patients on 15 randomized trials. Proc. Am. Soc. Clin. Oncol. (2004) (Abstract 3502).
  • Wolmark N, Wieand S, Lembersky B et al. A Phase III trial comparing oral UFT to FULV in stage II and II carcinoma of the colon: results of NSABP Protocol C-06. Proc Am. Soc. Clin. Oncol. (2004) (Abstract 3508).
  • Miwa M, Ura M, Nishida M et al. Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue. Etmj Cancer 34, 1274–1281 (1998).
  • Budman DR, Meropol NJ, Reigner B et al. Preliminary studies of a novel oral fluoropyrimidine carbamate: capecitabine. Clin Oncol. 16, 1795–1802 (1998).
  • Schuller J, Cassidy J, Dumont E et al. Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients. Cancer Chernother. Pharmacol. 45, 291–297 (2000).
  • Reigner B, Blesch K, Weidekamm E. Clinical pharmacokinetics of capecitabine. Clin. Pharmacokinet. 40, 85–104 (2001).
  • Reigner B, Verweij J, Dirix L et al. Effect of food on the pharmacokinetics of capecitabine and its metabolites following oral administration in cancer patients. Clin. Cancer Res. 4, 941–948 (1998).
  • Judson IR, Beale PJ, Trigo JM. et al. A human capecitabine excretion balance and pharmacokinetic study after administration of a single oral dose of 14 C-labelled drug. Invest. New Drugs 17, 49–56 (1999).
  • Cassidy J, Twelves C, Cameron D et al. Bioequivalence of two tablet formulations of capecitabine and exploration of age, gender, body surface area, and creatinine clearance as factors influencing systemic exposure in cancer patients. Cancer Chernother. Pharmacol. 44, 453–560 (1999).
  • Poole C, Gardiner J, Twelves C et al. Effect of renal impairment on the pharmacokinetics and tolerability of capecitabine (Xeloda) in cancer patients. Cancer Chernother. Pharmacol. 49, 225–234 (2002).
  • Roche. Xeloda Package Insert. Roche, NY, USA (2003).
  • Twelves C, Glynne-Jones R, Cassidy J et al. Effect of hepatic dysfunction due to liver metastases on the pharmacokinetics of capecitabine and its metabolites. Clin. Cancer Res. 5, 1696–1702 (1999).
  • Buyck HC, Buckley N, Leslie MD, Plowman PN. Capecitabine-induced potentiation of warfarin. Clin. Oncol. a?. Co]]. Radio].) 15, 297 (2003).
  • Van Cutsem E, Findlay M, Osterwalder B et al. Capecitabine, an oral fluoropyrimidine carbamate with substantial activity in advanced colorectal cancer: results of a randomized Phase II study. J Clin. Oncol. 18, 1337–1345 (2000).
  • ••Revealed equivalence of capecitabine to5-FU/LV (Mayo Clinic) regimen with an improved toxicity profile in the metastatic setting.
  • Van Cutsem E, Hoff PM, Harper P et al. Oral capecitabine vs. intravenous 5-fluorouracil and leucovorin: integrated efficacy data and novel analyses from two large, randomised, Phase III trials. BE J Cancer 90, 1190–1197 (2004).
  • Hoff PM, Ansari R, Batist G et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized Phase III study. J Clin. Oncol. 19, 2282–2292 (2001).
  • ••Revealed equivalence of capecitabine to5-FU/LV with an improved toxicity profile in the metastatic setting.
  • Cassidy J, Tabernero J, Twelves C et al. XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer. J Clin. Oncol. 22, 2084–2091 (2004).
  • Scheithauer W, Kornek GV, Raderer M et al. Randomized multicenter Phase II trial of two different schedules of capecitabine plus oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin. Oncol. 21, 1307–1312 (2003).
  • Shields AF, Zalupski MM, Marshall JL, Meropol NJ. Treatment of advanced colorectal carcinoma with oxaliplatin and capecitabine: a Phase II trial. Cancer 100, 531–537 (2004).
  • Patt YZ, Lin E, Leibmann J et al. Capecitabine plus irinotecan for chemotherapy-naive patients with metastatic colorectal cancer (MCRC): US multicenter Phase II trial. Proc. Am. Soc. Cilia. Oncol. (2003) (Abstract 1130).
  • Grothey A, Jordan K, Kellner 0 et al. Capecitabine/irinotecan (Caplri) and capecitabine/oxaliplatin (Cap0x) are active second-line protocols in patients with advanced colorectal cancer (ACRC) after failure of first-line combination therapy: results of a randomized Phase II study. Proc. Am. Soc. Clin. Oncol. (2004) (Abstract 3534).
  • ••Combination therapy with capecitabine replacing infusional 5-FU demonstrates no difference in efficacy for patients with metastatic colorectal cancer treated second line.
  • Borner MM, Dietrich D, Stupp R et al. Phase II study of capecitabine and oxaliplatin in first- and second-line treatment of advanced or metastatic colorectal cancer. J Clin. Oncol. 20, 1759–1766 (2002).
  • Carreca I, Comella P, Maiorino L et al. Oral capecitabine plus oxaliplatin (XELOX regimen) in elderly patients with advanced colorectal carcinoma (ACC). Southern Italy Co-operative Oncology Group (SICOG 0108) Phase II study. Proc Am. Soc. Cilia. Oncol. (2003) (Abstract 2939).
  • Cassata A, Stani SC, AM M et al. Ongoing Phase II trial with two schedules of irinotecan (CPT-11) in combination with capecitabine as first line chemotherapy in patients with advanced colorectal cancer (ACRC). Proc. Am. Soc. Clin. Oncol. (2001) (Abstract 573).
  • Schleucher N, Tewes M, Achterrath W et al. Extended Phase I Study of capecitabine in combination with a weekly schedule of irinotecan as first-line chemotherapy in metastatic colorectal cancer. Proc Am. Soc. Cilia. Oncol. (2001) (Abstract 561) .
  • Slater S, Shamash J, Gallagher C et al. A Phase I/II study of CPT-11 in combination with capecitabine as first line chemoterapy for metastatatic colorectal cancer (mcRq. Proc. Am. Soc. Clin. Oncol. (2002) (Abstract 643).
  • Patt YZ, Liebmann J, Diamandidis D et al. Capecitabine (X) plus irinotecan (XELIRI) as first-line treatment for metastatic colorectal cancer (mcRq: final safety findings from a Phase II trial. Proc. Am. Soc. Oncol. (2004) (Abstract 3602).
  • Munoz A, Salut A, Escudero P et al. Irinotecan (CPT-11) and capecitabine (C) as first line treatment of locally advanced or metastatic colorectal cancer (CRC). Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 1271).
  • Borner MM, Dietrich D, Popescu R et al. A randomized Phase II trial of capecitabine (CAP) and two different schedules of irinotecan (IRI) in first-line treatment of metastatic colorectal cancer (MCC). Proc. Am. Soc. Clin. Oncol. (2003) (Abstract 1068).
  • Cassidy J, Scheithauer W McKendrick J et al. Capecitabine (X) vs. bolus 5-Hilleucovorin (LV) as adjuvant therapy for colon cancer (the X-ACT study): efficacy results of a Phase III trial. Proc. Am. Soc. Cum Oncol. (2004) (Abstract 3509).
  • ••Equivalence of capecitabine and 5-EU/LVwas established in the adjuvant setting.
  • Salonga D, Danenberg KD, Johnson M et al. Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin. Cancer Res. 6, 1322–1327 (2000).
  • Meropol NJ, Gold PJ, Diasio RB et al. Correlation of thymidine phosphorylase (TP), thymidylate synthase (TS), and dihydropyrimidine dehyrogenase (DPD) expression in primary and metastatic sites with response to capecitabine plus iriontecan in patients with colorectal cancer. Proc. Am. Soc. Clin. Oncol. (2004) (Abstract 3520).
  • •• Thymidine phosphorylase expression correlates with response to therapy.
  • Park DJ, Stoehlmacher J, Zhang W et al. Thymidylate synthase gene polymorphism predicts response to capecitabine in advanced colorectal cancer. Int. J. Colorectal Dis. 17, 46–49 (2002).

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