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Review

TACE versus TAE as therapy for hepatocellular carcinoma

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Pages 1623-1641 | Published online: 10 Jan 2014

References

  • Parkin DM, Bray F, Ferlay J et al. Global cancer statistics, 2002. CA Cancer J. Clin.55(2), 74–108 (2005).
  • El-Serag HB, Mason AC. Rising incidence of hepatocellular carcinoma in the United States. N. Engl. J. Med.340(10), 745–750 (1999).
  • Llovet JM, Burroughs A, Bruix J. Hepatocellular carcinoma. Lancet362(9399), 1907–1917 (2003).
  • Doyon D, Mouzon A, Jourde AM et al. [Hepatic, arterial embolization in patients with malignant liver tumours (author’s transl)]. Ann. Radiol. (Paris)17(6), 593–603 (1974).
  • Llovet JM, Real MI, Montana X et al. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet359(9319), 1734–1739 (2002).
  • Lo CM, Ngan H, Tso WK et al. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology35(5), 1164–1171 (2002).
  • Camma C, Schepis F, Orlando A et al. Transarterial chemoembolization for unresectable hepatocellular carcinoma: meta-analysis of randomized controlled trials. Radiology224(1), 47–54 (2002).
  • Llovet JM, Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology37(2), 429–442 (2003).
  • Marelli L, Stigliano R, Triantos C et al. Transarterial therapy for hepatocellular carcinoma: which technique is more effective? A systematic review of cohort and randomized studies. Cardiovasc. Intervent. Radiol.30(1), 6–25 (2007).
  • Nakashima T, Kojiro M. Pathologic characteristics of hepatocellular carcinoma. Semin. Liver Dis.6(3), 259–266 (1986).
  • Chang JM, Tzeng WS, Pan HB et al. Transcatheter arterial embolization with or without cisplatin treatment of hepatocellular carcinoma. A randomized controlled study. Cancer74(9), 2449–2453 (1994).
  • Kawai S, Okamura J, Ogawa M et al. Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma – a comparison of lipiodol-transcatheter arterial embolization with and without adriamycin (first cooperative study). The Cooperative Study Group for Liver Cancer Treatment of Japan. Cancer Chemother. Pharmacol.31(Suppl.), S1–S6 (1992).
  • Graziadei IW, Sandmueller H, Waldenberger P et al. Chemoembolization followed by liver transplantation for hepatocellular carcinoma impedes tumor progression while on the waiting list and leads to excellent outcome. Liver Transpl.9(6), 557–563 (2003).
  • Llovet JM, Fuster J, Bruix J. The Barcelona approach: diagnosis, staging, and treatment of hepatocellular carcinoma. Liver Transpl.10(2 Suppl. 1), S115–S120 (2004).
  • Maeda S, Fujiyama S, Tanaka M et al. Survival and local recurrence rates of hepatocellular carcinoma patients treated by transarterial chemolipiodolization with and without embolization. Hepatol. Res.23(3), 202–210 (2002).
  • Damdinsuren B, Nagano H, Monden M. Combined intra-arterial 5-fluorouracil and subcutaneous interferon-α therapy for highly advanced hepatocellular carcinoma. Hepatol. Res.37(Suppl. 2), S238–S250 (2007).
  • Yu SC, Hui EP, Wong J et al. Transarterial ethanol ablation of hepatocellular carcinoma with lipiodol ethanol mixture: Phase II study. J. Vasc. Interv. Radiol.19(1), 95–103 (2008).
  • Lau WY, Lai EC. Treatment of unresectable hepatocellular carcinoma with transarterial radioembolization: iodine-131-lipiodol. ANZ J. Surg.78(5), 331–332 (2008).
  • Gu T, Li CX, Feng Y et al. Trans-arterial gene therapy for hepatocellular carcinoma in a rabbit model. World J. Gastroenterol.13(14), 2113–2117 (2007).
  • Lewis AL, Gonzalez MV, Lloyd AW et al. DC bead: in vitro characterization of a drug-delivery device for transarterial chemoembolization. J. Vasc. Interv. Radiol.17(2 Pt 1), 335–342 (2006).
  • Abe S, Otsuki M. Styrene maleic acid neocarzinostatin treatment for hepatocellular carcinoma. Curr. Med. Chem. Anticancer Agents2(6), 715–726 (2002).
  • Kasugai H, Kojima J, Tatsuta M et al. Treatment of hepatocellular carcinoma by transcatheter arterial embolization combined with intraarterial infusion of a mixture of cisplatin and ethiodized oil. Gastroenterology97(4), 965–971 (1989).
  • Kawai S, Tani M, Okamura J et al. Prospective and randomized trial of lipiodol-transcatheter arterial chemoembolization for treatment of hepatocellular carcinoma: a comparison of epirubicin and doxorubicin (second cooperative study). The Cooperative Study Group for Liver Cancer Treatment of Japan. Semin. Oncol.24(2 Suppl. 6), S6-38–S6-45 (1997).
  • Watanabe S, Nishioka M, Ohta Y et al. Prospective and randomized controlled study of chemoembolization therapy in patients with advanced hepatocellular carcinoma. Cooperative Study Group for Liver Cancer Treatment in Shikoku area. Cancer Chemother. Pharmacol.33(Suppl.), S93–S96 (1994).
  • Ichida T, Kato M, Hayakawa A et al. Treatment of hepatocellular carcinoma with a CDDP–epirubicin–lipiodol suspension: a pilot clinico–pharmacological study. Cancer Chemother. Pharmacol.31(Suppl.), S51–S54 (1992).
  • Ono Y, Yoshimasu T, Ashikaga R et al. Long-term results of lipiodol-transcatheter arterial embolization with cisplatin or doxorubicin for unresectable hepatocellular carcinoma. Am. J. Clin. Oncol.23(6), 564–568 (2000).
  • Xiong ZP, Zhang YD, Huang F et al. [Transhepatic arterial chemoembolization with gemcitabine and carboplatin for the treatment of stage III hepatocellular carcinoma]. Zhonghua Zhong Liu Za Zhi29(8), 623–625 (2007).
  • Lu W, Li Y, He X et al. Transcatheter arterial chemoembolization for hepatocellular carcinoma in patients with cirrhosis: evaluation of two kinds of dosages of anticancer drugs and analysis of prognostic factors. Hepatogastroenterology50(54), 2079–2083 (2003).
  • Bhattacharya S, Novell JR, Winslet MC et al. Iodized oil in the treatment of hepatocellular carcinoma. Br. J. Surg.81(11), 1563–1571 (1994).
  • Kobayashi S, Koizumi S, Katagiri S et al. [Usefulness of hepatic arterial infusion chemotherapy using lecithin-added lipiodol emulsion in hepatocellular carcinoma]. Gan To Kagaku Ryoho34(9), 1433–1437 (2007).
  • Kobayashi S, Narimatsu Y, Ogawa K et al. Transcatheter hepatic arterial chemoembolization using epirubicin-lipiodol: experimental and pharmacological evaluation. Cancer Chemother. Pharmacol.31(Suppl.), S45–S50 (1992).
  • Johnson PJ, Kalayci C, Dobbs N et al. Pharmacokinetics and toxicity of intraarterial adriamycin for hepatocellular carcinoma: effect of coadministration of lipiodol. J. Hepatol.13(1), 120–127 (1991).
  • Dodds HM, Walpole ET, Rivory LP et al. Disposition of epirubicin after intraarterial administration in lipiodol to patients with hepatocellular carcinoma. Ther. Drug. Monit.18(5), 537–543 (1996).
  • Favoulet P, Cercueil JP, Faure P et al. Increased cytotoxicity and stability of lipiodol–pirarubicin emulsion compared to classical doxorubicin–lipiodol: potential advantage for chemoembolization of unresectable hepatocellular carcinoma. Anticancer Drugs12(10), 801–806 (2001).
  • Fujiyama S, Shibata J, Maeda S et al. Phase I clinical study of a novel lipophilic platinum complex (SM-11355) in patients with hepatocellular carcinoma refractory to cisplatin/lipiodol. Br. J. Cancer89(9), 1614–1619 (2003).
  • Chen MS, Li JQ, Zhang YQ et al. High-dose iodized oil transcatheter arterial chemoembolization for patients with large hepatocellular carcinoma. World J. Gastroenterol.8(1), 74–78 (2002).
  • Matsuo N, Uchida H, Sakaguchi H et al. Optimal lipiodol volume in transcatheter arterial chemoembolotherapy for hepatocellular carcinoma: study based on lipiodol accumulation patterns and histopathologic findings. Semin. Oncol.24(2 Suppl. 6), S6-61–S6-70 (1997).
  • Coldwell DM, Stokes KR, Yakes WF. Embolotherapy: agents, clinical applications, and techniques. Radiographics14(3), 623–643 (1994).
  • Chung JW. Transcatheter arterial chemoembolization of hepatocellular carcinoma. Hepatogastroenterology45(Suppl. 3), 1236–1241 (1998).
  • Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology42(5), 1208–1236 (2005).
  • Doppman JL, Dunnick NR, Girton M et al. Bile duct cysts secondary to liver infarcts: report of a case and experimental production by small vessel hepatic artery occlusion. Radiology130(1), 1–5 (1979).
  • Makuuchi M, Sukigara M, Mori T et al. Bile duct necrosis: complication of transcatheter hepatic arterial embolization. Radiology156(2), 331–334 (1985).
  • Nakamura H, Tanaka T, Hori S et al. Transcatheter embolization of hepatocellular carcinoma: assessment of efficacy in cases of resection following embolization. Radiology147(2), 401–405 (1983).
  • Sigurdson ER, Ridge JA, Daly JM. Intra-arterial infusion of doxorubicin with degradable starch microspheres. Improvement of hepatic tumor drug uptake. Arch. Surg.121(11), 1277–1281 (1986).
  • Dakhil S, Ensminger W, Cho K et al. Improved regional selectivity of hepatic arterial BCNU with degradable microspheres. Cancer50(4), 631–635 (1982).
  • Forsberg JO. Transient blood flow reduction induced by intra-arterial injection of degradable starch microspheres. Experiments on rats. Acta Chir. Scand.144(5), 275–281 (1978).
  • Kirchhoff TD, Bleck JS, Dettmer A et al. Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival. Hepatobiliary Pancreat. Dis. Int.6(3), 259–266 (2007).
  • Gunji T, Kawauchi N, Ohnishi S et al. Treatment of hepatocellular carcinoma associated with advanced cirrhosis by transcatheter arterial chemoembolization using autologous blood clot: a preliminary report. Hepatology15(2), 252–257 (1992).
  • Gunji T, Kawauchi N, Akahane M et al. Long-term outcomes of transcatheter arterial chemoembolization with autologous blood clot for unresectable hepatocellular carcinoma. Int. J. Oncol.21(2), 427–432 (2002).
  • Zheng C, Feng G, Liang H. Bletilla striata as a vascular embolizing agent in interventional treatment of primary hepatic carcinoma. Chin. Med. J. (Engl.)111(12), 1060–1063 (1998).
  • Brown DB, Pilgram TK, Darcy MD et al. Hepatic arterial chemoembolization for hepatocellular carcinoma: comparison of survival rates with different embolic agents. J. Vasc. Interv. Radiol.16(12), 1661–1666 (2005).
  • Lewis AL, Gonzalez MV, Leppard SW et al. Doxorubicin eluting beads – 1: effects of drug loading on bead characteristics and drug distribution. J. Mater. Sci. Mater. Med.18(9), 1691–1699 (2007).
  • Varela M, Real MI, Burrel M et al. Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics. J. Hepatol.46(3), 474–481 (2007).
  • Poon RT, Tso WK, Pang RW et al. A Phase I/II trial of chemoembolization for hepatocellular carcinoma using a novel intra-arterial drug-eluting bead. Clin. Gastroenterol. Hepatol.5(9), 1100–1108 (2007).
  • Del PP, Maddeo A, Zabbialini G et al. Chemoembolization of hepatocellular carcinoma with drug eluting beads. J. Hepatol.47(1), 157–158 (2007).
  • Malagari K, Chatzimichael K, Alexopoulou E et al. Transarterial chemoembolization of unresectable hepatocellular carcinoma with drug eluting beads: results of an open-label study of 62 patients. Cardiovasc. Intervent. Radiol.31(2), 269–280 (2008).
  • Georgiades CS, Hong K, D’Angelo M et al. Safety and efficacy of transarterial chemoembolization in patients with unresectable hepatocellular carcinoma and portal vein thrombosis. J. Vasc. Interv. Radiol.16(12), 1653–1659 (2005).
  • Nicolini A, Fasani P, Manini MA et al. Transarterial embolization with microspheres in the treatment of monofocal HCC. Dig. Liver Dis. (2008) (Epub ahead of print).
  • Rand T, Loewe C, Schoder M et al. Arterial embolization of unresectable hepatocellular carcinoma with use of microspheres, lipiodol, and cyanoacrylate. Cardiovasc. Intervent. Radiol.28(3), 313–318 (2005).
  • Amesur NB, Zajko AB, Carr BI. Chemo-embolization for unresectable hepatocellular carcinoma with different sizes of embolization particles. Dig. Dis. Sci.53(5), 1400–1404 (2008).
  • Chung JW, Park JH, Han JK et al. Hepatic tumors: predisposing factors for complications of transcatheter oily chemoembolization. Radiology198(1), 33–40 (1996).
  • Burroughs A, Hochhauser D, Meyer T. Systemic treatment and liver transplantation for hepatocellular carcinoma: two ends of the therapeutic spectrum. Lancet Oncol.5(7), 409–418 (2004).
  • Geschwind JF, Ramsey DE, Cleffken B et al. Transcatheter arterial chemoembolization of liver tumors: effects of embolization protocol on injectable volume of chemotherapy and subsequent arterial patency. Cardiovasc. Intervent. Radiol.26(2), 111–117 (2003).
  • Ernst O, Sergent G, Mizrahi D et al. Treatment of hepatocellular carcinoma by transcatheter arterial chemoembolization: comparison of planned periodic chemoembolization and chemoembolization based on tumor response. AJR Am. J. Roentgenol.172(1), 59–64 (1999).
  • Matsui O, Kadoya M, Yoshikawa J et al. Subsegmental transcatheter arterial embolization for small hepatocellular carcinomas: local therapeutic effect and 5-year survival rate. Cancer Chemother. Pharmacol.33(Suppl.), S84–S88 (1994).
  • Nishimine K, Uchida H, Matsuo N et al. Segmental transarterial chemoembolization with lipiodol mixed with anticancer drugs for nonresectable hepatocellular carcinoma: follow-up CT and therapeutic results. Cancer Chemother. Pharmacol.33(Suppl.), S60–S68 (1994).
  • Jaeger HJ, Mehring UM, Castaneda F et al. Sequential transarterial chemoembolization for unresectable advanced hepatocellular carcinoma. Cardiovasc. Intervent. Radiol.19(6), 388–396 (1996).
  • Lin DY, Liaw YF, Lee TY et al. Hepatic arterial embolization in patients with unresectable hepatocellular carcinoma – a randomized controlled trial. Gastroenterology94(2), 453–456 (1988).
  • Monna T, Kanno T, Marumo T et al. A comparison of transcatheter arterial embolization with one shot therapy for the patients with hepatic cell carcinoma. Gastroenterol. Jpn17(6), 542–549 (1982).
  • Takayasu K, Arii S, Ikai I et al. Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients. Gastroenterology131(2), 461–469 (2006).
  • Yamashita Y, Torashima M, Oguni T et al. Liver parenchymal changes after transcatheter arterial embolization therapy for hepatoma: CT evaluation. Abdom. Imaging18(4), 352–356 (1993).
  • Marelli L, Shusang V, Senzolo M et al. Repeated courses of transarterial embolization with polyvinyl alcohol particles: ‘long life elixir’ in a cirrhotic patient with unresectable hepatocellular carcinoma. Eur. J. Gastroenterol. Hepatol.19(4), 329–332 (2007).
  • Plentz RR, Lankisch TO, Basturk M et al. Prospective analysis of German patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization with or without prophylactic antibiotic therapy. J. Gastroenterol. Hepatol.20(7), 1134–1136 (2005).
  • Takayasu K, Shima Y, Muramatsu Y et al. Hepatocellular carcinoma: treatment with intraarterial iodized oil with and without chemotherapeutic agents. Radiology163(2), 345–351 (1987).
  • Hatanaka Y, Yamashita Y, Takahashi M et al. Unresectable hepatocellular carcinoma: analysis of prognostic factors in transcatheter management. Radiology195(3), 747–752 (1995).
  • Ramsey DE, Kernagis LY, Soulen MC et al. Chemoembolization of hepatocellular carcinoma. J. Vasc. Interv. Radiol.13(9 Pt 2), S211–S221 (2002).
  • Kobayashi N, Ishii M, Ueno Y et al. Co-expression of Bcl-2 protein and vascular endothelial growth factor in hepatocellular carcinomas treated by chemoembolization. Liver19(1), 25–31 (1999).
  • Liou TC, Shih SC, Kao CR et al. Pulmonary metastasis of hepatocellular carcinoma associated with transarterial chemoembolization. J. Hepatol.23(5), 563–568 (1995).
  • Louha M, Poussin K, Ganne N et al. Spontaneous and iatrogenic spreading of liver-derived cells into peripheral blood of patients with primary liver cancer. Hepatology26(4), 998–1005 (1997).
  • Stigliano R, Marelli L, Yu D et al. Seeding following percutaneous diagnostic and therapeutic approaches for hepatocellular carcinoma. What is the risk and the outcome? Seeding risk for percutaneous approach of HCC. Cancer Treat. Rev.33(5), 437–447 (2007).
  • Ikeda K, Saitoh S, Koida I et al. A prospective randomized evaluation of a compound of tegafur and uracil as an adjuvant chemotherapy for hepatocellular carcinoma treated with transcatheter arterial chemoembolization. Am. J. Clin. Oncol.18(3), 204–210 (1995).
  • Ikeda K, Saitoh S, Suzuki Y et al. A prospective randomized administration of 5´-deoxy-5-fluorouridine as adjuvant chemotherapy for hepatocellular carcinoma treated with transcatheter arterial chemoembolization. Am. J. Clin. Oncol.20(2), 202–208 (1997).
  • Kawata S, Yamasaki E, Nagase T et al. Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial. Br. J. Cancer84(7), 886–891 (2001).
  • Yan JJ, Shen F, Wang K et al. Patients with advanced primary hepatocellular carcinoma treated by melatonin and transcatheter arterial chemoembolization: a prospective study. Hepatobiliary Pancreat. Dis. Int.1(2), 183–186 (2002).
  • Stefanini GF, Foschi FG, Castelli E et al. α-1-thymosin and transcatheter arterial chemoembolization in hepatocellular carcinoma patients: a preliminary experience. Hepatogastroenterology45(19), 209–215 (1998).
  • Williams KJ, Telfer BA, Xenaki D et al. Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1. Radiother. Oncol.75(1), 89–98 (2005).
  • Wu XZ, Xie GR, Chen D. Hypoxia and hepatocellular carcinoma: the therapeutic target for hepatocellular carcinoma. J. Gastroenterol. Hepatol.22(8), 1178–1182 (2007).
  • von MZ, Cramer T, Hocker M et al. Dual mechanism of vascular endothelial growth factor upregulation by hypoxia in human hepatocellular carcinoma. Gut48(1), 87–96 (2001).
  • Xiong ZP, Yang SR, Liang ZY et al. Association between vascular endothelial growth factor and metastasis after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma. Hepatobiliary Pancreat. Dis. Int.3(3), 386–390 (2004).
  • Jiang H, Meng Q, Tan H et al. Antiangiogenic therapy enhances the efficacy of transcatheter arterial embolization for hepatocellular carcinomas. Int. J. Cancer121(2), 416–424 (2007).
  • Therasse P, Arbuck SG, Eisenhauer EA et al. New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J. Natl Cancer Inst.92(3), 205–216 (2000).
  • Yang WT, Johnson PJ. Monitoring response to treatment in liver tumours. Baillieres Best Pract. Res. Clin. Gastroenterol.13(4), 637–654 (1999).
  • Filmus J, Capurro M. Glypican-3 and α-fetoprotein as diagnostic tests for hepatocellular carcinoma. Mol. Diagn.8(4), 207–212 (2004).
  • Hosoki T, Yosioka Y, Matsubara T et al. Power Doppler sonography of hepatocellular carcinoma treated by transcatheter arterial chemoembolization. Assessment of the therapeutic effect. Acta Radiol.40(6), 639–643 (1999).
  • Ito K, Honjo K, Fujita T et al. Therapeutic efficacy of transcatheter arterial chemoembolization for hepatocellular carcinoma: MRI and pathology. J. Comput. Assist. Tomogr.19(2), 198–203 (1995).
  • Yamashita Y, Yoshimatsu S, Sumi M et al. Dynamic MR imaging of hepatoma treated by transcatheter arterial embolization therapy. Assessment of treatment effect. Acta Radiol.34(3), 303–308 (1993).
  • Miraglia R, Pietrosi G, Maruzzelli L et al. Efficacy of transcatheter embolization/chemoembolization (TAE/TACE) for the treatment of single hepatocellular carcinoma. World J. Gastroenterol.13(21), 2952–2955 (2007).
  • Miraglia R, Pietrosi G, Maruzzelli L et al. Predictive factors of tumor response to trans-catheter treatment in cirrhotic patients with hepatocellular carcinoma: a multivariate analysis of pre-treatment findings. World J. Gastroenterol.13(45), 6022–6026 (2007).
  • Tezuka M, Hayashi K, Kubota K et al. Growth rate of locally recurrent hepatocellular carcinoma after transcatheter arterial chemoembolization: comparing the growth rate of locally recurrent tumor with that of primary hepatocellular carcinoma. Dig. Dis. Sci.52(3), 783–788 (2007).
  • Kubota K, Ina H, Okada Y et al. Growth rate of primary single hepatocellular carcinoma: determining optimal screening interval with contrast enhanced computed tomography. Dig. Dis. Sci.48(3), 581–586 (2003).
  • Molinari M, Kachura JR, Dixon E et al. Transarterial chemoembolisation for advanced hepatocellular carcinoma: results from a North American cancer centre. Clin. Oncol. (R. Coll. Radiol.)18(9), 684–692 (2006).
  • Simonetti RG, Liberati A, Angiolini C et al. Treatment of hepatocellular carcinoma: a systematic review of randomized controlled trials. Ann. Oncol.8(2), 117–136 (1997).
  • Trevisani F, De Notariis S, Rossi C et al. Randomized control trials on chemoembolization for hepatocellular carcinoma: is there room for new studies? J. Clin. Gastroenterol.32(5), 383–389 (2001).
  • Trinchet JC, Ganne-Carrie N, Beaugrand M. Intra-arterial chemoembolization in patients with hepatocellular carcinoma. Hepatogastroenterology45(Suppl. 3), 1242–1247 (1998).
  • Geschwind JF, Ramsey DE, Choti MA et al. Chemoembolization of hepatocellular carcinoma: results of a metaanalysis. Am. J. Clin. Oncol.26(4), 344–349 (2003).
  • Shen H, Agarwal D, Qi R et al. Predictors of outcome in patients with unresectable hepatocellular carcinoma receiving transcatheter arterial chemoembolization. Aliment. Pharmacol. Ther.26(3), 393–400 (2007).
  • Dvorchik I, Carr BI. A simple prognostic scoring system for patients with unresectable hepatocellular carcinoma treated by chemo-embolization. Cancer Detect. Prev.31(2), 154–160 (2007).
  • Cho YK, Chung JW, Kim JK et al. Comparison of 7 staging systems for patients with hepatocellular carcinoma undergoing transarterial chemoembolization. Cancer112(2), 352–361 (2008).
  • Brown DB, Chapman WC, Cook RD et al. Chemoembolization of hepatocellular carcinoma: patient status at presentation and outcome over 15 years at a single center. AJR Am. J. Roentgenol.190(3), 608–615 (2008).
  • Herber SC, Otto G, Schneider J et al. Transarterial chemoembolization in patients not eligible for liver transplantation: single-center results. AJR Am. J. Roentgenol.190(4), 1035–1042 (2008).
  • Lewis AL, Taylor RR, Hall B et al. Pharmacokinetic and safety study of doxorubicin-eluting beads in a porcine model of hepatic arterial embolization. J. Vasc. Interv. Radiol.17(8), 1335–1343 (2006).
  • Tanaka T, Ikeda M, Okusaka T et al. A Phase II trial of transcatheter arterial infusion chemotherapy with an epirubicin–lipiodol emulsion for advanced hepatocellular carcinoma refractory to transcatheter arterial embolization. Cancer Chemother. Pharmacol.61(4), 683–688 (2008).
  • Castells A, Bruix J, Ayuso C et al. Transarterial embolization for hepatocellular carcinoma. Antibiotic prophylaxis and clinical meaning of postembolization fever. J. Hepatol.22(4), 410–415 (1995).
  • Bismuth H, Morino M, Sherlock D et al. Primary treatment of hepatocellular carcinoma by arterial chemoembolization. Am. J. Surg.163(4), 387–394 (1992).
  • Hwang TL, Chen MF, Lee TY et al. Resection of hepatocellular carcinoma after transcatheter arterial embolization. Reevaluation of the advantages and disadvantages of preoperative embolization. Arch. Surg.122(7), 756–759 (1987).
  • Takenaka K, Yoshida K, Nishizaki T et al. Postoperative prophylactic lipiodolization reduces the intrahepatic recurrence of hepatocellular carcinoma. Am. J. Surg.169(4), 400–404 (1995).
  • Paye F, Farges O, Dahmane M et al. Cytolysis following chemoembolization for hepatocellular carcinoma. Br. J. Surg.86(2), 176–180 (1999).
  • Wigmore SJ, Redhead DN, Thomson BN et al. Postchemoembolisation syndrome – tumour necrosis or hepatocyte injury? Br. J. Cancer89(8), 1423–1427 (2003).
  • Wang ZX, Liu SL, Sun CH et al. Psychological intervention reduces postembolization pain during hepatic arterial chemoembolization therapy: a complementary approach to drug analgesia. World J. Gastroenterol.14(6), 931–935 (2008).
  • Chan AO, Yuen MF, Hui CK et al. A prospective study regarding the complications of transcatheter intraarterial lipiodol chemoembolization in patients with hepatocellular carcinoma. Cancer94(6), 1747–1752 (2002).
  • Lu W, Li YH, Yu ZJ et al. A comparative study of damage to liver function after TACE with use of low-dose versus conventional-dose of anticancer drugs in hepatocellular carcinoma. Hepatogastroenterology54(77), 1499–1502 (2007).
  • Feng YL, Ling CQ, Chen Z et al. [Ginsenosides and dexamethasone in managing the liver injury and renal function after transcatheter arterial chemoembolization for hepatic carcinoma patient]. Zhonghua Zhong Liu Za Zhi28(11), 844–847 (2006).
  • Tarazov PG, Polysalov VN, Prozorovskij KV et al. Ischemic complications of transcatheter arterial chemoembolization in liver malignancies. Acta Radiol.41(2), 156–160 (2000).
  • Chen C, Chen PJ, Yang PM et al. Clinical and microbiological features of liver abscess after transarterial embolization for hepatocellular carcinoma. Am. J. Gastroenterol.92(12), 2257–2259 (1997).
  • Cohen SE, Safadi R, Verstandig A et al. Liver-spleen infarcts following transcatheter chemoembolization: a case report and review of the literature on adverse effects. Dig. Dis. Sci.42(5), 938–943 (1997).
  • Kim HK, Chung YH, Song BC et al. Ischemic bile duct injury as a serious complication after transarterial chemoembolization in patients with hepatocellular carcinoma. J. Clin. Gastroenterol.32(5), 423–427 (2001).
  • Leung TK, Lee CM, Chen HC. Anatomic and technical skill factor of gastroduodenal complication in post-transarterial embolization for hepatocellular carcinoma: a retrospective study of 280 cases. World J. Gastroenterol.11(10), 1554–1557 (2005).
  • Morante A, Romano M, Cuomo A et al. Massive gastric ulceration after transarterial chemoembolization for hepatocellular carcinoma. Gastrointest. Endosc.63(4), 718–720 (2006).
  • Huo TI, Wu JC, Lee PC et al. Incidence and risk factors for acute renal failure in patients with hepatocellular carcinoma undergoing transarterial chemoembolization: a prospective study. Liver Int.24(3), 210–215 (2004).
  • Guevara M, Fernandez-Esparrach G, Alessandria C et al. Effects of contrast media on renal function in patients with cirrhosis: a prospective study. Hepatology40(3), 646–651 (2004).
  • Birck R, Krzossok S, Markowetz F et al. Acetylcysteine for prevention of contrast nephropathy: meta-analysis. Lancet362(9384), 598–603 (2003).
  • Kelly AM, Dwamena B, Cronin P et al. Meta-analysis: effectiveness of drugs for preventing contrast-induced nephropathy. Ann. Intern. Med.148(4), 284–294 (2008).
  • Duong MH, MacKenzie TA, Malenka DJ. N-acetylcysteine prophylaxis significantly reduces the risk of radiocontrast-induced nephropathy: comprehensive meta-analysis. Catheter Cardiovasc. Interv.64(4), 471–479 (2005).
  • Liu R, Nair D, Ix J et al.N-acetylcysteine for the prevention of contrast-induced nephropathy. A systematic review and meta-analysis. J. Gen. Intern. Med.20(2), 193–200 (2005).
  • Gonzales DA, Norsworthy KJ, Kern SJ et al. A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity. BMC Med.5, 32 (2007).
  • Bagshaw SM, Ghali WA. Acetylcysteine for prevention of contrast-induced nephropathy after intravascular angiography: a systematic review and meta-analysis. BMC Med.2, 38 (2004).
  • Bagshaw SM, McAlister FA, Manns BJ et al. Acetylcysteine in the prevention of contrast-induced nephropathy: a case study of the pitfalls in the evolution of evidence. Arch. Intern. Med.166(2), 161–166 (2006).
  • Nallamothu BK, Shojania KG, Saint S et al. Is acetylcysteine effective in preventing contrast-related nephropathy? A meta-analysis. Am. J. Med.117(12), 938–947 (2004).
  • Pannu N, Manns B, Lee H et al. Systematic review of the impact of N-acetylcysteine on contrast nephropathy. Kidney Int.65(4), 1366–1374 (2004).
  • Cholongitas E, Shusang V, Marelli L et al. Review article: renal function assessment in cirrhosis – difficulties and alternative measurements. Aliment. Pharmacol. Ther.26(7), 969–978 (2007).
  • Noguera JJ, Martinez-Cuesta A, Sangro B et al. [Fatal pulmonary embolism after embolization of a hepatocellular carcinoma using microspheres.]. Radiologia50(3), 248–250 (2008).
  • Czauderna P, Zbrzezniak G, Narozanski W et al. Pulmonary embolism: a fatal complication of arterial chemoembolization for advanced hepatocellular carcinoma. J. Pediatr. Surg.40(10), 1647–1650 (2005).
  • Yoo KM, Yoo BG, Kim KS et al. Cerebral lipiodol embolism during transcatheter arterial chemoembolization. Neurology63(1), 181–183 (2004).
  • Buscarini L, Buscarini E, Di Stasi M et al. Percutaneous radiofrequency thermal ablation combined with transcatheter arterial embolization in the treatment of large hepatocellular carcinoma. Ultraschall. Med.20(2), 47–53 (1999).
  • Seki T, Tamai T, Nakagawa T et al. Combination therapy with transcatheter arterial chemoembolization and percutaneous microwave coagulation therapy for hepatocellular carcinoma. Cancer89(6), 1245–1251 (2000).
  • Yamakado K, Nakatsuka A, Akeboshi M et al. Combination therapy with radiofrequency ablation and transcatheter chemoembolization for the treatment of hepatocellular carcinoma: short-term recurrences and survival. Oncol. Rep.11(1), 105–109 (2004).
  • Veltri A, Moretto P, Doriguzzi A et al. Radiofrequency thermal ablation (RFA) after transarterial chemoembolization (TACE) as a combined therapy for unresectable non-early hepatocellular carcinoma (HCC). Eur. Radiol.16(3), 661–669 (2006).
  • Cheng BQ, Jia CQ, Liu CT et al. Chemoembolization combined with radiofrequency ablation for patients with hepatocellular carcinoma larger than 3 cm: a randomized controlled trial. JAMA299(14), 1669–1677 (2008).
  • Yamagiwa K, Shiraki K, Yamakado K et al. Survival rates according to the Cancer of the Liver Italian Program scores of 345 hepatocellular carcinoma patients after multimodality treatments during a 10-year period in a retrospective study. J. Gastroenterol. Hepatol.23(3), 482–490 (2008).
  • Yamakado K, Nakatsuka A, Takaki H et al. Early-stage hepatocellular carcinoma: radiofrequency ablation combined with chemoembolization versus hepatectomy. Radiology247(1), 260–266 (2008).
  • Takaki H, Yamakado K, Nakatsuka A et al. Radiofrequency ablation combined with chemoembolization for the treatment of hepatocellular carcinomas 5 cm or smaller: risk factors for local tumor progression. J. Vasc. Interv. Radiol.18(7), 856–861 (2007).
  • Koda M, Ueki M, Maeda Y et al. The influence on liver parenchymal function and complications of radiofrequency ablation or the combination with transcatheter arterial embolization for hepatocellular carcinoma. Hepatol. Res.29(1), 18–23 (2004).
  • Bartolozzi C, Lencioni R, Caramella D et al. Treatment of large HCC: transcatheter arterial chemoembolization combined with percutaneous ethanol injection versus repeated transcatheter arterial chemoembolization. Radiology197(3), 812–818 (1995).
  • Koda M, Murawaki Y, Mitsuda A et al. Combination therapy with transcatheter arterial chemoembolization and percutaneous ethanol injection compared with percutaneous ethanol injection alone for patients with small hepatocellular carcinoma: a randomized control study. Cancer92(6), 1516–1524 (2001).
  • Dettmer A, Kirchhoff TD, Gebel M et al. Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma. World J. Gastroenterol.12(23), 3707–3715 (2006).
  • Marelli L, Stigliano R, Triantos C et al. Treatment outcomes for hepatocellular carcinoma using chemoembolization in combination with other therapies. Cancer Treat. Rev.32(8), 594–606 (2006).
  • Akamatsu M, Yoshida H, Obi S et al. Evaluation of transcatheter arterial embolization prior to percutaneous tumor ablation in patients with hepatocellular carcinoma: a randomized controlled trial. Liver Int.24(6), 625–629 (2004).
  • Liao GS, Yu CY, Shih ML et al. Radiofrequency ablation after transarterial embolization as therapy for patients with unresectable hepatocellular carcinoma. Eur. J. Surg. Oncol.34(1), 61–66 (2008).
  • Maluccio M, Covey AM, Gandhi R et al. Comparison of survival rates after bland arterial embolization and ablation versus surgical resection for treating solitary hepatocellular carcinoma up to 7 cm. J. Vasc. Interv. Radiol.16(7), 955–961 (2005).
  • Chan ES, Chow PK, Tai B et al. Neoadjuvant and adjuvant therapy for operable hepatocellular carcinoma. Cochrane Database Syst. Rev. (2), CD001199 (2000).
  • Schwartz JD, Schwartz M, Mandeli J et al. Neoadjuvant and adjuvant therapy for resectable hepatocellular carcinoma: review of the randomised clinical trials. Lancet Oncol.3(10), 593–603 (2002).
  • Wu CC, Ho YZ, Ho WL et al. Preoperative transcatheter arterial chemoembolization for resectable large hepatocellular carcinoma: a reappraisal. Br. J. Surg.82(1), 122–126 (1995).
  • Li Q, Wang J, Sun Y et al. Postoperative transhepatic arterial chemoembolization and portal vein chemotherapy for patients with hepatocellular carcinoma: a randomized study with 131 cases. Dig. Surg.23(4), 235–240 (2006).
  • Li Q, Wang J, Sun Y et al. Efficacy of postoperative transarterial chemoembolization and portal vein chemotherapy for patients with hepatocellular carcinoma complicated by portal vein tumor thrombosis – a randomized study. World J. Surg.30(11), 2004–2011 (2006).
  • Mazzaferro V, Regalia E, Doci R et al. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N. Engl. J. Med.334(11), 693–699 (1996).
  • Ravaioli M, Grazi GL, Ercolani G et al. Partial necrosis on hepatocellular carcinoma nodules facilitates tumor recurrence after liver transplantation. Transplantation78(12), 1780–1786 (2004).
  • Hayashi K, Ina H, Tezuka M et al. Local therapeutic results of computed tomography-guided transcatheter arterial chemoembolization for hepatocellular carcinoma: results of 265 tumors in 79 patients. Cardiovasc. Intervent. Radiol.30(6), 1144–1155 (2007).
  • Roayaie S, Frischer JS, Emre SH et al. Long-term results with multimodal adjuvant therapy and liver transplantation for the treatment of hepatocellular carcinomas larger than 5 centimeters. Ann. Surg.235(4), 533–539 (2002).
  • Majno P, Giostra E, Mentha G. Management of hepatocellular carcinoma on the waiting list before liver transplantation: time for controlled trials? Liver Transpl.13(11 Suppl. 2), S27–S35 (2007).
  • Brown DB, Geschwind JF, Soulen MC et al. Society of Interventional Radiology position statement on chemoembolization of hepatic malignancies. J. Vasc. Interv. Radiol.17(2 Pt 1), 217–223 (2006).
  • Decaens T, Roudot-Thoraval F, Bresson-Hadni S et al. Impact of pretransplantation transarterial chemoembolization on survival and recurrence after liver transplantation for hepatocellular carcinoma. Liver Transpl.11(7), 767–775 (2005).
  • Majno PE, Adam R, Bismuth H et al. Influence of preoperative transarterial lipiodol chemoembolization on resection and transplantation for hepatocellular carcinoma in patients with cirrhosis. Ann. Surg.226(6), 688–701 (1997).
  • Oldhafer KJ, Chavan A, Fruhauf NR et al. Arterial chemoembolization before liver transplantation in patients with hepatocellular carcinoma: marked tumor necrosis, but no survival benefit? J. Hepatol.29(6), 953–959 (1998).
  • Perez SB, Meneu JC, Moreno E et al. Is transarterial chemoembolization necessary before liver transplantation for hepatocellular carcinoma? Am. J. Surg.190(3), 383–387 (2005).
  • Yao FY, Kinkhabwala M, LaBerge JM et al. The impact of pre-operative loco-regional therapy on outcome after liver transplantation for hepatocellular carcinoma. Am. J. Transplant.5(4 Pt 1), 795–804 (2005).
  • Dharancy S, Boitard J, Decaens T et al. Comparison of two techniques of transarterial chemoembolization before liver transplantation for hepatocellular carcinoma: a case–control study. Liver Transpl.13(5), 665–671 (2007).
  • Lesurtel M, Mullhaupt B, Pestalozzi BC et al. Transarterial chemoembolization as a bridge to liver transplantation for hepatocellular carcinoma: an evidence-based analysis. Am. J. Transplant.6(11), 2644–2650 (2006).
  • Richard HM III, Silberzweig JE, Mitty HA et al. Hepatic arterial complications in liver transplant recipients treated with pretransplantation chemoembolization for hepatocellular carcinoma. Radiology214(3), 775–779 (2000).
  • Yao FY, Hirose R, LaBerge JM et al. A prospective study on downstaging of hepatocellular carcinoma prior to liver transplantation. Liver Transpl.11(12), 1505–1514 (2005).
  • Grasso A, Stigliano R, Morisco F et al. Liver transplantation and recurrent hepatocellular carcinoma: predictive value of nodule size in a retrospective and explant study. Transplantation81(11), 1532–1541 (2006).

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