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Expert Review of Molecular Diagnostics Volume 14, 2014 - Issue 2
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Diagnostic Profile

Review of use of a new rapid real-time PCR, the Cepheid GeneXpert® (Xpert) CT/NG assay, for Chlamydia trachomatis and Neisseria gonorrhoeae: results for patients while in a clinical setting

Charlotte A GaydosJohns Hopkins University, 855 North Wolfe Street, Room 530 Rangos Building, Baltimore, MD 20105, USACorrespondence[email protected]
Pages 135-137 | Published online: 23 Jan 2014

References

  • Gaydos CA, Van Der Pol B, Jett-Goheen M; CT/NG Study Group. Performance of the cepheid CT/NG Xpert Rapid PCR test for the detection of Chlamydia trachomatis and Neisseria gonorrhoeae. J Clin Microbiol 2013;51:1666-72
  • Tabrizi S, Unemo M, Golparian D; TTANGO Investigators. Analytical evaluation of GeneXpert CT/NG, the first genetic point-of-care assay for simultaneous detection of Neisseria gonorrhoeae and Chlamydia trachomatis. J Clin Microbiol 2013;51:1945-7
  • Dize L, West S, Williams JA, et al. Comparison of the Abbott m2000 RealTime CT assay and the Cepheid GeneXpert CT/NG assay to the Roche Amplicor CT assay for detection of Chlamydia trachomatis in ocular samples from Tanzania. J Clin Microbiol 2013;51:1611-13
  • Jenson A, Dize L, Mkocha H, et al. Field evaluation of the Cepheid GeneXpert Chlamydia trachomatis assay for detection of infection in a trachoma endemic community in Tanzania. PLoS Negl Trop Dis 2013;7:e2265
  • Goldenberg SD, Finn J, Sedudzi E, et al. Performance of the GeneXpert CT/NG assay compared to that of the Aptima AC2 assay for detection of rectal Chlamydia trachomatis and Neisseria gonorrhoeae by use of residual Aptima Samples. J Clin Microbiol 2012;50:3867-9
  • Pourahmadi F, Taylor M, Kovacs G, et al. Toward a rapid, integrated, and fully automated dna diagnostic assay for Chlamydia trachomatis and Neisseria gonorrhoeae. Clin Chem 2000;46:1511-13
  • Huang W, Gaydos CA, Barnes MR, et al. Comparative effectiveness of a rapid point-of-care test for detection of Chlamydia trachomatis among women in a clinical setting. Sex Transm Infect 2013;89:108-14
  • Expert Consultation Meeting Summary Report: Atlanta, Laboratory diagnostic testing for Chlamydia trachomatis and Neisseria gonorrhoeae. 2009. Available from: www.sfcityclinic.org/providers/CTGCLabGuidelinesMeetingReport.pdf
  • Harding-Esch EM, Holland MJ, Schemann JF, et al. Diagnostic accuracy of a prototype point-of-care test for ocular Chlamydia trachomatis under field conditions in The Gambia and Senegal. PLoS Negl Trop Dis 2011;5(8):e1234
  • Michel CE, Solomon AW, Magbanua JP, et al. Field evaluation of a rapid point-of-care assay for targeting antibiotic treatment for trachoma control: a comparative study. Lancet 2006;367:1585-90

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