Novel biomarkers for asthma stratification and personalized therapy

References

• Holgate ST. Pathogenesis of asthma. Clin Exp Allergy 2008;38(6):872-97
   PubMed Web of Science ®Google Scholar
• Editorial (no authors given). A plea to abandon asthma as a disease concept. Lancet 2006;368(9537):705
   PubMed Web of Science ®Google Scholar
• Alexis NE. Biomarker sampling of the airways in asthma. Curr Opin Pulm Med 2014;20(1):46-52
   PubMedGoogle Scholar
• Deckers J, Branco Madeira F, Hammad H. Innate immune cells in asthma. Trends Immunol 2013;34(11):540-7
   PubMed Web of Science ®Google Scholar
• Willart MA, Deswarte K, Pouliot P, et al. Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33. J Exp Med 2012;209(8):1505-17
   PubMed Web of Science ®Google Scholar
• Suzukawa M, Morita H, Nambu A, et al. Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma. J Immunol 2012;189(7):3641-52
   PubMedGoogle Scholar
• Moro K, Yamada T, Tanabe M, et al. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 2010;463(7280):540-4
   PubMed Web of Science ®Google Scholar
• Sibilano R, Frossi B, Pucillo CE. Mast cell activation: a complex interplay of positive and negative signaling pathways. Eur J Immunol 2014;44(9):2558-66
   PubMed Web of Science ®Google Scholar
• Bradding P, Feather IH, Wilson S, et al. Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation. J Immunol 1993;151:3853-65
   PubMed Web of Science ®Google Scholar
• Arias K, Chu DK, Flader K, et al. Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice. J Allergy Clin Immunol 2011;127(6):1552-61
   PubMed Web of Science ®Google Scholar
• Allakhverdi Z, Smith DE, Comeau MR, Delespesse G. Cutting edge: the ST2 ligand IL-33 potently activates and drives maturation of human mast cells. J Immunol 2007;179(4):2051-4
   PubMed Web of Science ®Google Scholar
• Gleich GJ, Klion AD, Lee JJ, Weller PF. The consequences of not having eosinophils. Allergy 2013;68(7):829-35
   PubMed Web of Science ®Google Scholar
• Jacobsen EA, Zellner KR, Colbert D, et al. Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation. J Immunol 2011;187(11):6059-68
   PubMed Web of Science ®Google Scholar
• Woodruff PG, Modrek B, Choy DF, et al. T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma. Am J Respir Cri Care Med 2009;180(5):388-95
   PubMed Web of Science ®Google Scholar
• Nakagome K, Matsushita S, Nagata M. Neutrophilic inflammation in severe asthma. Int Arch Allergy Immunol 2012;158(Suppl 1):96-102
   PubMedGoogle Scholar
• Durrant DM, Metzger DW. Emerging roles of T helper subsets in the pathogenesis of asthma. Immunol Invest 2010;39(4-5):526-49
   PubMed Web of Science ®Google Scholar
• Busse WW. Asthma diagnosis and treatment: filling in the information gaps. J Allergy Clin Immunol 2011;128(4):740-50
   PubMed Web of Science ®Google Scholar
• Moore WC, Meyers DA, Wenzel SE, et al. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 2010;181(4):315-23
   PubMed Web of Science ®Google Scholar
• Wenzel SE. Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med 2012;18(5):716-25
   PubMed Web of Science ®Google Scholar
• Simpson JL, Scott R, Boyle MJ, Gibson PG. Inflammatory subtypes in asthma: assessment and identification using induced sputum. Respirology 2006;11(1):54-61
   PubMed Web of Science ®Google Scholar
• Green RH, Brightling CE, McKenna S, et al. Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 2002;360(9347):1715-21
   PubMed Web of Science ®Google Scholar
• Chlumský J, Striz I, Terl M, Vondracek J. Strategy aimed at reduction of sputum eosinophils decreases exacerbation rate in patients with asthma. J Int Med Res 2006;34(2):129-39
   PubMed Web of Science ®Google Scholar
• Hastie AT, Moore WC, Li H, et al. Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. J Allergy Clin Immunol 2013;132(1):72-80
   PubMed Web of Science ®Google Scholar
• Hillas G, Kostikas K, Mantzouranis K, et al. Exhaled nitric oxide and exhaled breath condensate pH as predictors of sputum cell counts in optimally treated asthmatic smokers. Respirology 2011;16(5):811-18
   PubMed Web of Science ®Google Scholar
• Thomas RA, Green RH, Brightling CE, et al. The influence of age on induced sputum differential cell counts in normal subjects. Chest 2004;126(6):1811-14
   PubMedGoogle Scholar
• Ducharme ME, Prince P, Hassan N, et al. Expiratory flows and airway inflammation in elderly asthmatic patients. Respir Med 2011;105(9):1284-9
   PubMedGoogle Scholar
• Nadif R, Siroux V, Oryszczyn MP, et al. Heterogeneity of asthma according to blood inflammatory patterns. Thorax 2009;64(5):374-80
   PubMedGoogle Scholar
• Lemière C, Ernst P, Olivenstein R, et al. Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes. J Allergy Clin Immunol 2006;118(5):1033-9
   PubMed Web of Science ®Google Scholar
• Chakir J, Loubaki L, Laviolette M, et al. Monitoring sputum eosinophils in mucosal inflammation and remodelling: a pilot study. Eur Respir J 2010;35(1):48-53
   PubMedGoogle Scholar
• Bornstein P. Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1. J Cell Biol 1995;130:503-6
   PubMed Web of Science ®Google Scholar
• Gillan L, Matei D, Fishman DA, et al. Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility. Cancer Res 2002;62(18):5358-64
   PubMed Web of Science ®Google Scholar
• Wang X, Liu J, Wang Z, et al. Periostin contributes to the acquisition of multipotent stem cell-like properties in human mammary epithelial cells and breast cancer cells. PLoS One 2013;8(8):e72962
   PubMed Web of Science ®Google Scholar
• Sidhu SS, Yuan S, Innes AL, et al. Roles of epithelial cell-derived periostin in TGF-β activation, collagen production, and collagen gel elasticity in asthma. Proc Natl Acad Sci USA 2010;107(32):14170-5
   PubMed Web of Science ®Google Scholar
• Woodruff PG, Boushey HA, Dolganov GM, et al. Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids. Proc Natl Acad Sci USA 2007;104(40):15858-63
   PubMed Web of Science ®Google Scholar
• Corren J, Lemanske RF, Hanania NA, et al. Lebrikizumab treatment in adults with asthma. N Engl J Med 2011;365(12):1088-98
   PubMed Web of Science ®Google Scholar
• Noonan M, Korenblat P, Mosesova S, et al. Dose-ranging study of lebrikizumab in asthmatic patients not receiving inhaled steroids. J Allergy Clin Immunol 2013;132(3):567-74
   PubMed Web of Science ®Google Scholar
• Hanania NA, Wenzel S, Rosén K, et al. Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study. Am J Respir Crit Care Med 2013;187(8):804-11
   PubMed Web of Science ®Google Scholar
• Hanania NA, Alpan O, Hamilos DL, et al. Omalizumab in severe allergic asthma inadequately controlled with standard therapy: a randomized trial. Ann Intern Med 2011;154(9):573-82
   PubMed Web of Science ®Google Scholar
• Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288(5789):373-6
   PubMed Web of Science ®Google Scholar
• Ignarro LJ, Buga GM, Wood KS, et al. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987;84(24):9265-9
   PubMed Web of Science ®Google Scholar
• Szabo C. Gaseotransmitters: new frontiers for translational science. Sci Transl Med 2010;2(59):59
   Google Scholar
• Förstermann U, Closs EI, Pollock JS, et al. Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions. Hypertension 1994;23(6 Pt 2):1121-31
   PubMed Web of Science ®Google Scholar
• Asano K, Chee CB, Gaston B, et al. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lungepithelial cells. Proc Natl Acad Sci USA 1994;91(21):10089-93
   PubMedGoogle Scholar
• Dupont LL, Glynos C, Bracke KR, et al. Role of the nitric oxide-soluble guanylyl cyclase pathway in obstructive airway diseases. Pulm Pharmacol Ther 2014;29(1):1-6
   PubMed Web of Science ®Google Scholar
• Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J 1993;6(9):1368-70
   PubMed Web of Science ®Google Scholar
• Stonham C. Use of exhaled nitric oxide in asthma care. Nurs Times 2013;109(42):22, 24-5
   Google Scholar
• Petsky HL, Cates CJ, Lasserson TJ, et al. A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils). Thorax 2012;67(3):199-208
   PubMed Web of Science ®Google Scholar
• Smith AD, Cowan JO, Brassett KP, et al. Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. N Engl J Med 2005;352(21):2163-73
   PubMed Web of Science ®Google Scholar
• Holt S, Suder A, Weatherall M, et al. Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis. BMJ 2011;323(7307):253-6
   Google Scholar
• Shaw DE, Berry MA, Thomas M, et al. The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial. Am J Respir Crit Care Med 2007;176(3):231-7
   PubMed Web of Science ®Google Scholar
• Calhoun WJ, Ameredes BT, King TS, et al. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA 2012;308(10):987-97
   PubMed Web of Science ®Google Scholar
• Amelink M, de Groot JC, de Nijs SB, et al. Severe adult-onset asthma: a distinct phenotype. J Allergy Clin Immunol 2013;132(2):336-41
   PubMed Web of Science ®Google Scholar
• Ricciardolo FLM. Multiple roles of nitric oxide in the airways. Thorax 2003;58(2):175-82
   PubMed Web of Science ®Google Scholar
• Moore WC, Bleecker ER, Curran-Everett D, et al. Characterization of the severe asthma phenotype by the National Heart, Lung, and BloodInstitute’s Severe Asthma Research Program. J Allergy Clin Immunol 2007;119(2):405-13
   PubMed Web of Science ®Google Scholar
• Holguin F, Comhair SA, Hazen SL, et al. An association between L-arginine/asymmetric dimethyl arginine balance, obesity, and the age of asthma onset phenotype. Am J Respir Crit Care Med 2013;187(2):153-9
   PubMed Web of Science ®Google Scholar
• Komakula S, Khatri S, Mermis J, et al. Body mass index is associated with reduced exhaled nitric oxide and higher exhaled 8-isoprostanes in asthmatics. Respir Res 2007;8:32
   PubMed Web of Science ®Google Scholar
• Kocak H, Oner-Iyidogan Y, Gurdol F, et al. Serum asymmetric dimethylarginine and nitric oxide levels in obese postmenopausal women. J Clin Lab Anal 2011;25(3):174-8
   PubMedGoogle Scholar
• Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65(1):51-9
   PubMed Web of Science ®Google Scholar
• Tomlinson JE, McMahon AD, Chaudhuri R, et al. Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma. Thorax 2005;60(4):282-7
   PubMed Web of Science ®Google Scholar
• McSharry C.P, McKay I.C, Chaudhuri R, et al. Short and long-term effects of cigarette smoking independently influence exhaled nitric oxide concentration in asthma. J Allergy Clin Immunol 2005;116:88-93
   PubMed Web of Science ®Google Scholar
• Spears M, Weir CJ, Smith AD, et al. Bronchial nitric oxide flux (J’aw) is sensitive to oral corticosteroids in smokers with asthma. Respir Med 2011;105(12):1823-30
   PubMedGoogle Scholar
• Cai C, Yang J, Hu S, et al. Relationship between urinary cysteinyl leukotriene E4 levels and clinical response to antileukotriene treatment in patients with asthma. Lung 2007;185(2):105-12
   PubMedGoogle Scholar
• Frossi B, Gri G, Tripodo C, Pucillo C. Exploring a regulatory role for mast cells: ‘MCregs’? Trends Immunol 2010;31(3):97-102
   PubMedGoogle Scholar
• Reuter S, Stassen M, Taube C. Mast cells in allergic asthma and beyond. Yonsei Med J 2010;51(6):797-807
   PubMedGoogle Scholar
• Galli SJ, Tsai M. IgE and mast cells in allergic disease. Nat Med 2012;18(5):693-704
   PubMed Web of Science ®Google Scholar
• Kay LJ, Yeo WW, Peachell PT. Prostaglandin E2 activates EP2 receptors to inhibit human lung mast cell degranulation. Br J Pharmacol 2006;147(7):707-13
   PubMed Web of Science ®Google Scholar
• Sastre B, Fernández-Nieto M, Mollá R, et al. Increased prostaglandin E2 levels in the airway of patients with eosinophilic bronchitis. Allergy 2008;63(1):58-66
   PubMedGoogle Scholar
• Roca-Ferrer J, Garcia-Garcia FJ, Pereda J, et al. Reduced expression of COXs and production of prostaglandin E(2) in patients with nasal polyps with or without aspirin-intolerant asthma. J Allergy Clin Immunol 2011;128(1):66-72
   PubMed Web of Science ®Google Scholar
• Fens N, Roldaan AC, Van Der Schee MP, et al. External validation of exhaled breath profiling using an electronic nose in the discrimination of asthma with fixed airways obstruction and chronic obstructive pulmonary disease. Clin Exp Allergy 2011;41(10):1371-8
   PubMed Web of Science ®Google Scholar
• Dragonieri S, Schot R, Mertens B, et al. An electronic nose in the discrimination of patients with asthma and controls. J Allergy Clin Immunol 2007;120(4):856-62
   PubMed Web of Science ®Google Scholar
• Van der Schee MP, Palmay R, Cowan JO, Taylor DR. Predicting steroid responsiveness in patients with asthma using exhaled breath profiling. Clin Exp Allergy 2013;43(11):1217-25
   PubMed Web of Science ®Google Scholar
• Montuschi P, Santonico M, Mondino C, et al. Diagnostic performance of an electronic nose, fractional exhaled nitric oxide, and lung function testing in asthma. Chest 2010;137(4):790-6
   PubMed Web of Science ®Google Scholar
• Kumar SD, Emery MJ, Atkins ND, et al. Airway mucosal blood flow in bronchial asthma. Am J Respir Crit Care Med 1998;158:153-6
   PubMed Web of Science ®Google Scholar
• García G, Bergna M, Uribe E, et al. Increased exhaled breath temperature in subjects with uncontrolled asthma. Int J Tuberc Lung Dis 2013;17(7):969-72
   PubMed Web of Science ®Google Scholar
• Zhu Z, Zheng T, Homer RJ, et al. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science 2004;304(5677):1678-82
   PubMed Web of Science ®Google Scholar
• Chupp GL, Lee CG, Jarjour N, et al. A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med 2007;357(20):2016-27
   PubMed Web of Science ®Google Scholar
• Konradsen JR, James A, Nordlund B, et al. The chitinase-like protein YKL-40: a possible biomarker of inflammation and airway remodeling in severe pediatric asthma. J Allergy Clin Immunol 2013;132(2):328-35
   PubMed Web of Science ®Google Scholar