Recent developments in the diagnosis and monitoring of HBV infection and role of the genetic variability of the S gene

References

• Werle-Lapostolle B, Bowden S, Locarnini S et al. Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology126, 1750–1758 (2004).
   PubMed Web of Science ®Google Scholar
• Weber B, Bayer A, Kirch P, Schlüter V, Schlieper D, Melchior W. Improved detection of hepatitis B virus surface antigen by a new rapid automated assay. J. Clin. Microbiol.37, 2639–2647 (1999).
   PubMedGoogle Scholar
• Weber B, Dengler T, Berger A, Doerr HW, Rabenau H. Evaluation of two new automated assays for hepatitis B virus surface antigen (HBsAg) detection: IMMULITE HBsAg and IMMULITE 2000 HBsAg. J. Clin. Microbiol.41, 135–143 (2003).
   PubMed Web of Science ®Google Scholar
• Weber B. The isolated antiHBc reactivity: new developments. J. Lab. Med.26, 451–458 (2002).
   Google Scholar
• Lok ASF, Lai CL, Wu PC. Prevalence of isolated antibody to hepatitis B in an area endemic for hepatitis B. Hepatology8, 766–770 (1988).
   PubMedGoogle Scholar
• Caspary G, Beyer HJ, Elber G et al. Unsatisfactory specificities and sensitivities of six enzyme immunoassays for antibodies to hepatitis B core antigen. J. Clin. Microbiol.27, 2067–2072 (1989).
   PubMedGoogle Scholar
• Robertson EF, Weare JA, Randell R, Holland PV, Madsen G, Decker RH. Characterization of a reduction-sensitive factor from human plasma responsible for apparent false activity in competitive assays for antibody to hepatitis B core antigen. J. Clin. Microbiol.29, 605–610 (1991).
   PubMedGoogle Scholar
• Weber B, Michl U, Mühlbacher A, Paggi G, Bossi V. Evaluation of the new automated Enzymun-Test ® antiHBc Plus for the detection of hepatitis B virus (HBV) core antibody. Intervirology41, 17–23 (1998).
   PubMedGoogle Scholar
• Ural O, Findik D. The response of isolated antiHBc positive subjects to recombinant hepatitis B vaccine. J. Infect.43, 187–190 (2001).
   PubMed Web of Science ®Google Scholar
• Gerlich WH, Schaefer S. Hepadnaviren: hepatitis B virus. In: Medizinische Virologie. Doerr HW, Gerlich HW (Eds), Medizinische Virologie, Stuttgart, Germany, 191–210 (2002).
   Google Scholar
• Weber B, Melchior W, Gehrke R, Berger A, Rabenau HF. Hepatitis B virus (HBV) markers in isolated antiHBc positive individuals. J. Med. Virol.64, 312–319 (2001).
   PubMedGoogle Scholar
• Allain JP. Occult hepatitis B virus infection: implications in transfusion. Vox Sang.86, 83–91 (2004).
   PubMedGoogle Scholar
• Noborg U, Gusdal A, Pisa EK, Hedrum A, Lindh M. Automated quantitative analysis of hepatitis B virus DNA by using the COBAS Amplicor HBV monitor test. J. Clin. Microbiol.37, 2793–2797 (1999).
   PubMedGoogle Scholar
• Kessler HH, Preininger S, Stelzl E et al. Identification of different states of hepatitis B virus infection with a quantitative PCR assay. Clin. Diagn. Lab. Immunol.7, 298–300 (2000).
   PubMedGoogle Scholar
• Stelzl E, Kormann-Klement A, Haas J et al. Evaluation of the automated sample preparation protocol for quantitative detection of hepatitis C virus RNA. J. Clin. Microbiol.40, 1447–1450 (2002).
   PubMed Web of Science ®Google Scholar
• Leb V, Stöcher M, Valentine-Thon E et al. Fully automated internally controlled quantification of hepatitis B virus DNA by real-time PCR by use of the MagNA Pure LC and light cycler instruments. J. Clin. Microbiol.42, 585–590 (2004).
   PubMedGoogle Scholar
• Pawlotsky M. Hepatitis B virus (HBV) DNA assays (methods and practical use) and viral kinetics. J. Hepatol.39, S31–S35 (2003).
   PubMed Web of Science ®Google Scholar
• Saldanha J, Gerlich W, Llelie N, Dawson P, Heermann K, Health A. An international collaborative study to establish a World Health Organization international standard for hepatitis B virus DNA nucleic acid amplification techniques. Vox Sang.80, 63–71 (2001).
   PubMed Web of Science ®Google Scholar
• Allain JP, Candotti D, Soldan K et al. The risk of hepatitis B virus infection by transfusion in Kumasi. Blood101, 2419–2425 (2003).
   PubMed Web of Science ®Google Scholar
• Valla DC. EASL International Consensus Conference on hepatitis. Br. J. Hepatol.38, 533–540 (2003).
   PubMedGoogle Scholar
• Lok AS, McMahon BJ. Practice Guidelines Committee, American Association for the Study of Liver Diseases (AASLD). Chronic hepatitis B. Update on recommendations. Hepatology39, 857–861 (2004).
   PubMed Web of Science ®Google Scholar
• Lok ASF, Zoulim F, Locarnini S et al. Monitoring drug resistance in chronic hepatitis B virus (HBV)-infected patients during lamivudine therapy: evaluation of performance of INNO-LiPA HBV DR assay. J. Clin. Microbiol.40, 3729–3734 (2002).
   PubMed Web of Science ®Google Scholar
• Bartholomeusz A, Schaefer S. Hepatitis B virus genotypes: comparison of genotyping methods. Rev. Med. Virol.14, 3–16 (2004).
   PubMed Web of Science ®Google Scholar
• Mommeja-Marin H, Mondou E, Blum R, Rousseau F. Serum HBV DNA as a marker of efficacy during therapy for chronic HBV infection: analysis and review of the literature. Hepatology37, 1309–1319 (2002).
   Google Scholar
• Biswas R, Tabor E, Hsia CC et al. Comparative sensitivity of HBV NATs and HBsAg assays for detection of acute HBV infection. Transfusion43, 788–798 (2003).
   PubMed Web of Science ®Google Scholar
• Weber B, Simon F, Gueudin M, Ritter J, Volle P, Lesénechal M. Evaluation of a new automated assay for the detection of HBs antigen on the VIDAS analyser. ECCMID, Glasgow, England, P439 (2003)
   Google Scholar
• Meng Q, Wong C, Rangachari A et al. Automated multiplex assay system for simultaneous detection of hepatitis B virus DNA, hepatitis C virus RNA, and human immunodeficiency virus Type 1 RNA. J. Clin. Microbiol.39, 2937–2945 (2001).
   PubMedGoogle Scholar
• Hollinger FB, Liang TJ. Hepatitis B virus. In: Fields Virology, fourth edition. Knipe DM, Howley PM (Eds), Lippincott Williams & Wilkins, PA, USA, 2971–3036 (2001).
   Google Scholar
• Cacciolli I, Pollicino T, Squadrito T et al.Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease. N. Engl. J. Med.341, 22–26 (1999).
   Google Scholar
• Weber B, Gurtler L, Thorstensson R et al. Multicenter evaluation of a new automated fourth-generation human immunodeficiency virus screening assay with a sensitive antigen detection module and high specificity. J. Clin. Microbiol.40, 1938–1946 (2002).
   PubMed Web of Science ®Google Scholar
• Okamoto H, Imai M, Kametani M, Nakamura T, Mayumi M. Genomic heterogeneity of hepatitis B virus in a 54-year-old woman who contracted the infection through materno-fetal transmission. Jpn J. Exp. Med.57, 231–236 (1987).
   PubMedGoogle Scholar
• Sterneck M, Gunther S, Gerlach J et al. Hepatitis B virus sequence changes evolving in liver transplant recipients with fulminant hepatitis. J. Hepatol.26, 754–764 (1997).
   PubMedGoogle Scholar
• François G, Kew M, Van Damme P, Mphahlele MJ, Meheus A. Mutant hepatitis B viruses: a matter of academic interest only or a problem with far-reaching implications? Vaccine19, 3799–2676 (1994).
   Google Scholar
• Gunther S, Fischer L, Pult I, Sterneck M, Will H. Naturally occurring variants of hepatitis B virus. Adv. Virus. Res.52, 25–137 (1999).
   PubMed Web of Science ®Google Scholar
• Yamamoto K, Horikita M, Tsuda F et al. Naturally occurring escape mutants of hepatitis B with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen. J. Virol.68, 2671–2676 (1994).
   PubMedGoogle Scholar
• Shiels MT, Taswell HF, Czaja AJ, Nelson C, Swenke P. Frequency and significance of concurrent hepatitis B surface antigen and antibody in acute and chronic hepatitis B. Gastroenterology93, 675–680 (1987).
   PubMed Web of Science ®Google Scholar
• Kao JH, Chen PJ, Lai MY, Chen DS. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology118, 554–559 (2000).
   PubMed Web of Science ®Google Scholar
• Orito E, Mizokami M, Sakugawa H et al. A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C. Hepatology33, 218–223 (2001).
   PubMedGoogle Scholar
• Akuta N, Suzuki F, Kobayashi M et al. The influence of hepatitis B virus genotype on the development of lamivudine resistance during long-term treatment. J. Hepatol.38, 315–312 (2003).
   PubMedGoogle Scholar
• Kao JH, Wu NH, Chen PJ, Lai MY, Chen DS. Hepatitis B genotypes and the response to interferon therapy. J. Hepatol.33, 998–1001 (2000).
   PubMed Web of Science ®Google Scholar
• Heijtink RA, Bergen P, Melber K, Janowicz ZA, Osterhaus AD. Hepatitis B surface antigen (HBsAg) derived from yeast cells (Hansenula polymorpha) used to establish an influence of antigenic subtype (adw(2), adr, ayw(3)) in measuring the immune response after vaccination. Vaccine20, 2191–2196 (2002).
   PubMedGoogle Scholar
• Hess G, Karayiannis P, Babiel R, Thomas HC. Variants of the hepatitis B virus: a diagnostic and vaccine challenge. In: Viral Hepatitis and Liver Disease. Rizetto M, Purcell RH, Gerin JL, Verne G (Eds), Edizioni Minerva Medica, Torino, Italy, 974–976 (1997).
   Google Scholar
• Yao JD, Beld MG, Oon LL et al. Multicenter evaluation of the VERSANT hepatitis B virus DNA 3.0 assay. J. Clin. Microbiol.42, 800–806 (2004).
   PubMed Web of Science ®Google Scholar
• Schaefer S, Glebe D, Wend UC, Oyunbileg J, Gerlich WH. Universal primers for real-time amplification of DNA from all known Orthohepadnavirus species. J. Clin. Virol.27, 30–37 (2003).
   PubMedGoogle Scholar
• Weiss J, Wu H, Farrenkopf B et al. Real time TaqMan PCR detection and quantitation of HBV genotypes A–G with the use of an internal quantitation standard. J. Clin. Virol.30, 86–93 (2004).
   PubMedGoogle Scholar
• Zanetti AR, Tanzi E, Manzillo G et al. Hepatitis B variant in Europe. Lancet2, 1132–1133 (1988).
   PubMedGoogle Scholar
• Carman WF, Zanetti AR, Karayiannis P et al. Vaccine-induced escape mutant of hepatitis B virus. Lancet336, 325–329 (1990).
   PubMed Web of Science ®Google Scholar
• Hsu HY, Chang MH, Liaw SH, Ni YH, Chen HL. Changes of hepatitis B surface antigen variants in carrier children before and after universal vaccination in Taiwan. Hepatology30, 1312–1317 (1999).
   PubMed Web of Science ®Google Scholar
• Hsu HY, Chang MH, Ni YH, Chen HL. Survey of hepatitis B surface variant infection in children after a nationwide vaccination programme in Taiwan. Gut53, 1499–1503 (2004).
   PubMed Web of Science ®Google Scholar
• Wilson JN, Nokes DJ, Carman WF. Predictions of the emergence of vaccine-resistant hepatitis B in The Gambia using a mathematical model. Epidemiol. Infect.124, 295–307 (2000).
   PubMedGoogle Scholar
• Oon CJ, Chen WN, Goo KS, Goh KT. Intra-familial evidence of horizontal transmission of hepatitis B virus surface antigen mutant G145R. J. Infect.41, 260–264 (2000).
   PubMedGoogle Scholar
• Chakravarty R, Neogi M, Roychowdhury S, Panda CK. Presence of hepatitis B surface antigen mutant G145R DNA in the peripheral blood leukocytes of the family members of an asymptomatic carrier and evidence of its horizontal transmission. Virus Res.90, 133–141 (2000).
   Google Scholar
• Seddigh-Tonekaboni S, Waters JA, Jeffers S et al. Effect of variation in the common ‘a’ determinant on the antigenicity of hepatitis B surface antigen. J. Med.Virol.60, 113–121 (2000).
   PubMedGoogle Scholar
• Carman WF. Infections associated with medical intervention: hepatitis viruses and HGV. Br. Med. Bull.54, 731–748 (1998).
   PubMedGoogle Scholar
• Oon CJ, Lim GK, Ye Z et al. Molecular epidemiology of hepatitis B virus vaccine variants in Singapore. Vaccine13, 699–702 (1995).
   PubMed Web of Science ®Google Scholar
• Nainan OV, Khristova ML, Byun K et al. Genetic variation of hepatitis B surface antigen coding region among infants with chronic hepatitis B virus infection. J. Med. Virol.68, 319–327 (2002).
   PubMed Web of Science ®Google Scholar
• Protzer-Knolle U, Naumann U, Bartenschlager R et al. Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation. Hepatology27, 254–263 (1998).
   PubMed Web of Science ®Google Scholar
• Avellon A, Echevarria JM. HBsAg variants among unselected HBV carriers from Spain. 2nd European Virology, Madrid, Spain, 15–22 (2004).
   Google Scholar
• Thedja MD, Roni M, Muljono D, Harahap A, Siregar NC. Occult Hepatitis B in Indonesian Blood Donors. Poster Abstract (2004).
   Google Scholar
• Alhababi F, Sallman TA, Tong CYW. The significance of antiHBc only in the clinical virology laboratory. J. Clin. Virol.27, 162–169 (2003).
   PubMedGoogle Scholar
• Ghany MG, Ayola B, Villamil FG et al. Hepatitis B virus S mutants in liver transplant recipients who were reinfected despite hepatitis B immune globulin prophylaxis. Hepatology27, 213–222 (1998).
   PubMed Web of Science ®Google Scholar
• Grethe S, Monazahian M, Boehme I, Thomssen R. Characterization of unusual escape variants of hepatitis B virus isolated from a hepatitis B surface antigen-negative subject. J. Virol.72, 7692–7696 (1998).
   PubMedGoogle Scholar
• Rodriguez-Frias F, Brti M, Jardi R et al. Genetic alterations in the S gene of hepatitis B virus in patients with acute hepatitis B, chronic hepatitis B and hepatitis B liver cirrhosis before and after liver transplantation. Liver19, 177–182 (1999).
   PubMedGoogle Scholar
• Carmann WF, Korula J, Wallace L, MacPhee R, Mimms L, Decker R. Fulminant reactivation of hepatitis B due to envelope protein mutant that escaped detection by monoclonal HBsAg ELISA. Lancet345, 1406–1407 (1995).
   PubMedGoogle Scholar
• Hou J, Karyiannis P, Waters J, Luo K, Liang C, Thomas HC. A unique insertion in the S gene of surface antigen negative hepatitis B virus chinese carriers. Hepatology21, 273–278 (1995).
   PubMedGoogle Scholar
• Kalinina T, Riu A, Fischer L, Will H, Sterneck M. A dominant hepatitis B virus population defective in virus secretion because of several S-gene mutations from a patient with fulminant hepatitis. Hepatology34, 385–394 (2001).
   PubMedGoogle Scholar
• Schories M, Peters T, Rasenack J. Isolation, characterization and biological significance of hepatitis B virus mutants from serum of a patient with immunologically negative HBV infection. J. Hepatol.33, 799–811 (2000).
   PubMedGoogle Scholar
• Jongerius JM, Wester M, Cuypers HT et al. New hepatitis B virus mutant form in a blood donor that is undetectable in several hepatitis B surface antigen screening assays. Transfusion38, 56–59 (1998).
   PubMed Web of Science ®Google Scholar
• Levicnik-Stezinar S. Hepatitis B surface antigen escape mutant in a first time blood donor potentially missed by a routine screening assay. Clin. Lab.50, 49–51 (2004).
   PubMedGoogle Scholar
• Coleman PF, Chen YC, Mushahwar IK. Immunoassay detection of hepatitis B surface antigen mutants. J. Med. Virol.59, 19–24 (1999).
   PubMedGoogle Scholar
• Ireland JH, O’Donnell B, Basuni AA et al. Reactivity of 13 in vitro expressed hepatitis B surface antigen variants in 7 commercial diagnostic assays. Hepatology31, 1176–1182 (2000).
   PubMedGoogle Scholar
• Jeantet D, Chemin I, Mandrand B et al. Cloning and expression of surface antigens from occult chronic hepatitis B virus infections and their recognition by commercial detection assays. J. Med. Virol.73, 508–515 (2004).
   PubMedGoogle Scholar
• Moerman B, Moons V, Sommer H, Schitt Y, Stetter M. Evaluation of sensitivity for wild type and mutant forms of hepatitis B surface antigen by four commercial HBsAg assays. Clin. Lab.50, 159–162 (2004).
   PubMedGoogle Scholar
• Weber B, Van der Taelem-Brulé N. Performance of hepatitis B surface antigen (HBsAg) assays for the detection of recombinant and native HBsAg mutants and screening for HBsAg mutants in isolated antiHBc positive sera. 14th ECCMID, Prague, Czeck Republic, P1076 (2004).
   Google Scholar
• Grob P, Jilg W, Bornhak H et al. Serological pattern anti-HBc alone: report on a workshop. J. Med. Virol.62, 450–455 (2000).
   PubMedGoogle Scholar
• Jilg W, Hottentrager B, Weinberger K et al. Prevalence of markers of hepatitis B in the adult German population. J. Med. Virol.63, 96–102 (2001).
   PubMedGoogle Scholar
• Bart PA, Jacquier P, Zuber PLF, Lavanchy D, Frei PC. Seroprevalence of HBV (antiHBc, HBsAg, and antiHBs) and HDV infections among 9006 women at delivery. Liver16, 110–115 (1996).
   PubMedGoogle Scholar
• Berger A, Doerr HW, Rabenau HF, Weber B. High frequency of HCV infection in individuals with isolated antibody to hepatitis B core antigen. Intervirology43, 71–76 (2000).
   PubMedGoogle Scholar
• Grob PJ, Pontisso P. Does the healthy carrier of HCV exist? In: Viral Hepatitis And Liver Disease. Rizetto M, Purcell RH, Gerin JL,Verne G (Eds), Edizioni Minerva Medica, Torino, Italy, 879–887 (1997).
   Google Scholar
• Ackerman Z, Wands JR, Gazitt Y, Brechot C, Kew MC, Shouval D. Enhancement of HBsAg detection in serum of patients with chronic liver disease following removal of circulating immune complexes. J. Hepatol.3, 398–404 (1994).
   Google Scholar
• Joller-Jemelka HI, Wicki An, Grob PJ. Detection of HBs antigen in ‘anti-HBc alone’ positive sera. J. Hepatol.21, 269–272 (1994).
   PubMed Web of Science ®Google Scholar
• Shih CM, Lo SJ, Miyamura T, Chen SY, Lee YH. Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells. J. Virol.67, 5823–5832 (1993).
   PubMed Web of Science ®Google Scholar
• Carman WF, Van Deursen FJ, Mimms LT et al. The prevalence of surface antigen variants of hepatitis B virus in Papua New Guinea, South Africa, and Sardinia. Hepatology26, 1658–1666 (1997).
   PubMed Web of Science ®Google Scholar
• Feitelson MA, Duan LX, Guo J et al. Precore and X region mutants in hepatitis B virus infections among renal dialysis patients. J. Viral Hepatitis.2, 19–31 (1995).
   PubMedGoogle Scholar
• Weinberger KM, Bauer T, Bohm S, Jilg W. High genetic variability of the group-specific a-determinant of hepatitis B virus surface antigen (HBsAg) and the corresponding fragment of the viral polymerase in chronic virus carriers lacking detectable HBsAg in serum. J. Gen. Virol.81, 1165–1174 (2000).
   PubMedGoogle Scholar
• Allain JP, Hewitt PE, Tedder RS, Williamson LM. Evidence that antiHBc but not HBV DNA testing may prevent some HBV transmission by transfusion. Br. J. Haematol.107, 186–195 (1999).
   PubMedGoogle Scholar
• Dodson SF, Issa S, Araya V et al. Infectivity of hepatic allografts with antibodies to hepatitis B virus. Transplantation64, 1582–1584 (1997).
   PubMedGoogle Scholar
• Zuckerman AJ. Effect of hepatitis B virus mutants on efficacy of vaccination. Lancet355, 1382–1384 (2000).
   PubMed Web of Science ®Google Scholar
• Cooreman MP, van Roosmalen MH, te Morsche R et al. Characterization of the reactivity pattern of murine monoclonal antibodies against wild type hepatitis B surface antigen to G145R and other naturally occurring ‘a’ loop escape muations. Hepatology30, 1287–1292 (1999).
   PubMed Web of Science ®Google Scholar