Advanced search
Publication Cover
Expert Review of Molecular Diagnostics Volume 6, 2006 - Issue 3
Submit an article Journal homepage
3,938
Views
64
CrossRef citations to date
0
Altmetric
Editorial

Towards a simple, saliva-based test for the detection of oral cancer.

‘Oral fluid (saliva), which is the mirror of the body, is a perfect medium to be explored for health and disease surveillance.’

David T Wong University of California Los Angeles, School of Dentistry & Dental Research Institute, 73-017 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA; School of Engineering; Division of Head & Neck Surgery/Otolaryngology, Jonsson Comprehensive Cancer Center; Molecular Biology Institute, Los Angeles, CA, USA. [email protected]
Pages 267-272 | Published online: 09 Jan 2014

References

  • Schantz SP. Carcinogenesis, markers, staging, and prognosis of head and neck cancer. Curr. Opin. Oncol.5(3), 483–490 (1993).
  • Schantz SP. Biologic markers, cellular differentiation, and metastatic head and neck cancer. Eur. Arch. Otorhinolaryngol.250(8), 424–428 (1993).
  • Ferlito A, Shaha AR, Rinaldo A. The incidence of lymph node micrometastases in patients pathologically staged N0 in cancer of oral cavity and oropharynx. Oral Oncol.38(1), 3–5 (2002).
  • Epstein JB, Zhang, L, Rosin, M. Advances in the diagnosis of oral premalignant and malignant lesions. J. Can. Dent. Assoc.68(10), 617–621 (2002).
  • Fong K, Srivastava S, Gopal-Srivastava R, Kramer B et al. Molecular genetic basis for early cancer detection and cancer susceptibility. Mol. Pathol. Early Cancer13–26 (1999).
  • Myers L, Wax M. Positron emission tomography in the evaluation of the negative neck in patients with oral cavity cancer. J. Otolaryngol.27(6), 342–347 (1998).
  • Zhang L, Williams M, Poh CF et al. Toluidine blue staining identifies high-risk primary oral premalignant lesions with poor outcome. Cancer Res.65(17), 8017–8021 (2005).
  • Mashberg A, Samit A. Early diagnosis of asymptomatic oral and oropharyngeal squamous cancers. CA Cancer J. Clin.45(6), 328–351 (1995).
  • Rosin MP, Cheng X, Poh C et al. Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clin. Cancer Res.6(2), 357–362 (2000).
  • Erber R, Conradt C, Homann N et al. TP53 DNA contact mutations are selectively associated with allelic loss and have a strong clinical impact in head and neck cancer. Oncogene16(13), 1671–1679 (1998).
  • Gleich LL, Wang J, Gluckman JL, Fenoglio-Preiser CM. Microsatellite instability as a predictor of survival in head and neck cancer – is there a link with colon cancer? ORL J. Otorhinolaryngol. Relat. Spec.65(4), 193–198 (2003).
  • Paz IB, Cook N, Odom-Maryon T, Xie Y, Wilczynski SP. Human papillomavirus (HPV) in head and neck cancer. An association of HPV 16 with squamous cell carcinoma of Waldeyer’s tonsillar ring. Cancer79(3), 595–604 (1997).
  • Shimakage M, Horii K, Tempaku A, Kakudo K, Shirasaka T, Sasagawa T. Association of Epstein–Barr virus with oral cancers. Hum. Pathol.33(6), 608–614 (2002).
  • Xu XC, Lee JS, Lippman SM, Ro JY, Hong WK, Lotan R. Increased expression of cytokeratins CK8 and CK19 is associated with head and neck carcinogenesis. Cancer Epidemiol. Biomarkers Prev.4(8), 871–876 (1995).
  • Nagler R. Oral cancer – molecular aberrations and tumor markers cellular aberrations. Harefuah142(4), 272–276, 318, 317 (2003).
  • Sidransky D. Emerging molecular markers of cancer. Nature Rev. Cancer3, 210–219 (2002).
  • Ishwad CS, Ferrell RE, Rossie KM et al. Microsatellite instability in oral cancer. Int. J. Cancer64(5), 332–335 (1995).
  • Nunes DN, Kowalski LP, Simpson AJ. Detection of oral and oropharyngeal cancer by microsatellite analysis in mouth washes and lesion brushings. Oral Oncol.36(6), 525–528 (2000).
  • Shin KH, Park KH, Hong HJ et al. Prevalence of microsatellite instability, inactivation of mismatch repair genes, p53 mutation, and human papillomavirus infection in Korean oral cancer patients. Int. J. Oncol.21(2), 297–302 (2002).
  • Liao PH, Chang YC, Huang MF, Tai KW, Chou MY. Mutation of p53 gene codon 63 in saliva as a molecular marker for oral squamous cell carcinomas. Oral Oncol.36(3), 272–276 (2000).
  • El-Naggar AK, Mao L, Staerkel G et al. Genetic heterogeneity in saliva from patients with oral squamous carcinomas: implications in molecular diagnosis and screening. J. Mol. Diagn.3(4), 164–170 (2001).
  • Jiang WW, Masayesva B, Zahurak M et al. Increased mitochondrial DNA content in saliva associated with head and neck cancer. Clin. Cancer Res.11(7), 2486–2491 (2005).
  • Zhao M, Rosenbaum E, Carvalho AL et al. Feasibility of quantitative PCR-based saliva rinse screening of HPV for head and neck cancer. Int. J. Cancer117(4), 605–610 (2005).
  • Phillips C. Rinse and spit: saliva as a cancer biomarker source. In: NCI Cancer Bulletin,3–5 (2006).
  • Hu S, Xie Y, Ramachandran P et al. Large-scale identification of proteins in human salivary proteome by liquid chromatography/mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry. Proteomics5(6), 1714–1728 (2005).
  • Hu S, Denny P, Denny P et al. Differentially expressed protein markers in human submandibular and sublingual secretions. Int. J. Oncol.25(5), 1423–1430 (2004).
  • Alevizos I, Mahadevappa M, Zhang X et al. Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis. Oncogene20(43), 6196–6204 (2001).
  • St John M, Li Y, Zhou X et al. IL-6 and IL-8: potential biomarkers for oral cavity and oropharyngeal SCCA. Arch. Otolaryngol. Head Neck Surg.130, 929–935 (2004).
  • Li Y, Zhou X, St John MA, Wong DT. RNA profiling of cell-free saliva using microarray technology. J. Dent. Res.83(3), 199–203 (2004).
  • Li Y, St John MA, Zhou X et al. Salivary transcriptome diagnostics for oral cancer detection. Clin. Cancer Res.10(24), 8442–8450 (2004).
  • Li Y, Elashoff D, Oh M et al. Serum circulating human mRNA profiling and its utility for oral cancer detection. J. Clin. Oncol.24(11), 1754–1760 (2006).
  • Parry J. Simple and reliable salivary tests for HIV and hepatitis A and B virus diagnosis and surveillance. Ann. NY Acad. Sci.694, 216–233 (1993).
  • Nair P, Schroeder, H. Duct-associated lymphoid tissue (DALT) of minor salivary glands and mucosal immunity. Immunology57, 171–180 (1986).
  • Malamud D. Oral diagnostic testing for detecting human immunodeficiency virus-1 antibodies: a technology whose time has come. Am. J. Med.102(Suppl. 4A), 9–14 (1997).
  • Hodinka R, Nagashunmugam, T, Malamud, D. Detection of human immunodeficiency virus antibodies in oral fluids. Clin. Diagn. Lab. Immunol.5, 419–426 (1998).
  • Sayer R, Law E, Connelly PJ, Breen KC. Association of a salivary acetylcholinesterase with Alzheimer’s disease and response to cholinesterase inhibitors. Clin. Biochem.37, 98–104 (2004).
  • Streckfus C, Bigler L, Tucci M, Thigpen JT. A preliminary study of CA15–3, c-erbB-2, epidermal growth factor receptor, cathepsin-D, and p53 in saliva among women with breast carcinoma. Cancer Invest.18(2), 101–109 (2000).
  • Streckfus C, Bigler L, Dellinger T, Dai X, Kingman A, Thigpen JT. The presence of soluble c-erbB-2 in saliva and serum among women with breast carcinoma: a preliminary study. Clin. Cancer Res.6(6), 2363–2370 (2000).
  • Pepe MS, Etzioni R, Feng Z et al. Phases of biomarker development for early detection of cancer. J. Natl Cancer Inst.93(14), 1054–1061 (2001).
  • Park NJ, Li Y, Yu T, Wong DT et al. Characterization of RNA in Saliva. Clin. Chem. (2006) (In Press).

Website

  • The Oral Cancer Foundation www.oralcancerfoundation.org

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.