8
Views
0
CrossRef citations to date
0
Altmetric
Review

Economic assessments of low molecular weight heparin in venous thromboembolism

, , &
Pages 39-47 | Published online: 09 Jan 2014

References

  • Koopman MW Prandoni F Provella F et al Treatment of venous thrombosis with intravenous unfractionated heparin administered in the hospital as compared with subcutaneous low molecular weight heparin administered at home. N. Engl. J Merl 334(11), 682— 687 (1996).
  • Levine M, Gent M, Hirsh J et al. A comparison of low molecular weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis. N. Engl. Merl 334(11), 677–681 (1996).
  • White RII. The epidemiology of venous thromboembolism. Circulation7(23 Suppl. 1), 14–18 (2003).
  • •Coherent review of the epidemiology literature systematically summarizing the available evidence, and explaining the limitations of the various approaches adopted by the studies.
  • Silverstein MD, Heft JA, Mohr DN et al Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern. Med. 158(6), 585–593 (1998).
  • Murin S, Romano PS, White RII. Comparison of outcomes after hospitalization for deep venous thrombosisor pulmonary embolism. Thmmb. Haemost. 88(3), 407–414 (2002).
  • Kahn SR, Solymoss S, Lamping DL, Abenhaim L. Long-term outcomes after deep vein thrombosis: postphlebitic syndrome and quality of life. j Gen. Intern. Med. 15(6), 425–429 (2000).
  • •Reviews the literature on the incidence of postphlebitis syndrome, risk factors and treatment, and the impact on the patient's quality of life. The authors provide insightful comments on the limitations of the data available.
  • Tillman DJ, Charland SL, Witt DM. Effectiveness and economic impact associated with a program for outpatient management of acute deep vein thrombosis in a group model health maintenance organization. Arch Intern. Med. 160(19), 2926–2932 (2000).
  • van den Belt AG, Bossuyt PM, Prins MET, Gallus AS, Buller HR for the TASMAN Study Group. Replacing inpatient care by outpatient care in the treatment of deep venous thrombosis — an economic evaluation. TASMAN Study Group. Thromb. Haemost. 79(2), 259–263 (1998).
  • O'Brien B, Levine M, Willan A et al Economic evaluation of outpatient treatment with low molecular weight heparin for proximal vein thrombosis. Anh Intern. Med. 159(19), 2298–2304 (1999).
  • Pearson SD, Blair R, Halpert A, Eddy E, McKean S. An outpatient program to treat deep venous thrombosis with low molecular weight heparin. Effective Gun. Prac. 2, 210–217 (1999).
  • Boccalon H, Elias A, Chale JJ, Cadene A, Gabriel S. Clinical outcome and cost of hospital vs home treatment of proximal deep vein thrombosis with a low molecular weight heparin: the Vascular Midi-Pyrenees study. Arch Intern. Med. 160(12), 1769–1773 (2000).
  • Smith BJ, Weeldey JS, Pilotto L, Howe T, Beven R. Cost comparison of at-home treatment of deep venous thrombosis with low molecular weight heparin to inpatient treatment with unfractionated heparin. Intern. Merl 32(1–2), 29–34 (2002).
  • Lapidus L, Borretzen J, Fahlen M et al. Home treatment of deep vein thrombosis. An outpatient treatment model with once-daily injection of low molecular weight heparin (tinzaparin) in 555 patients. Pathophysiol 1-Lemost. Thromb. 32 (2), 59–66 (2002).
  • Spyropoulos AC, Hurley JS, Ciesla GN, de Lissovoy G. Management of acute proximal deep vein thrombosis: pharmacoeconomic evaluation of outpatient treatment with enoxaparin vs inpatient treatment with unfractionated heparin. Chest 122(1), 108–114 (2002).
  • Groce JB III. Patient outcomes and cost analysis associated with an outpatient deep venous thrombosis treatment program. Phaimacotherapy18(6 Pt 3), S175—S180 (1998).
  • Huse DM, Cummins G, Taylor DC, Russell MW Outpatient treatment of venous thromboembolism with low molecular weight heparin: an economic evaluation. Am. j Manag. Cam 8 (1 Suppl.), S10—S16 (2002).
  • de Lissovoy G, Yusen RD, Spiro TE, Krupski WC, Champion AH, Sorensen SV. Cost for inpatient care of venous thrombosis: a trial of enoxaparin vs standard heparin. Arch. Intern Med. 160(20), 3160–3165 (2000).
  • Leong WA. Outpatient deep vein thrombosis treatment models. Phaimacotherapy 18(6 Pt 3), S170—S174 (1998).
  • Boucher M, Rodger M, Johnson JA, Tierney M. Shifting from inpatient to outpatient treatment of deep vein thrombosis in a tertiary care center: a cost-minimization analysis. Pharmacotherapy 23(3), 301–309 (2003).
  • Wells PS, Kovacs MJ, Bormanis J et al. Expanding eligibility for outpatient treatment of deep vein thrombosis and pulmonary embolism with low molecular weight heparin. Arch Intern Med. 158, 1809–1812 (1998).
  • Segal JB, Bolger DT, Jenckes MW et al Outpatient therapy with low molecular weight heparin for the treatment of venous thromboembolism: a review of efficacy, safety and costs. Am. j Med. 115(4), 298–308 (2003).
  • •Recent review of the evidence on the efficacy and safety of treating deep vein thrombosis (DVT) in the an out- versus inpatient setting and the cost-effectiveness of low molecular weight heparin (LMWH) or unfractionated heparin.
  • O'Brien JA, Caro JJ. Direct medical costs of managing deep venous thrombosis according to the occurrence of complications. PharmacoEconomics 20 (9), 603–615 (2002).
  • •Detailed costing study of managing DVT and its complications, including estimates for the cost of treatment in various inpatient and outpatient settings, this paper provides recent and comprehensive US cost estimates. Cost estimates from this study were used in an economic evaluation of tinzaparin versus unfractionated heparin (UFH) for the treatment of DVT
  • Rodger M, Bredeson C, Wells P, Beck J, Kearns B, Huebsch LB. Cost-effectiveness of low-molecular-weight heparin and unfractionated heparin in the treatment of deep vein thrombosis. Can. j Med. Assoc. 59(8), 931–938 (1998).
  • Gould MK, Dembitzer AD, Sanders GD, Garber AM. Low molecular weight heparins compared to unfractionated heparin for treatment of acute deep vein thrombosis. A cost-effectiveness analysis. Ann Intern. Med. 130(10), 789–799 (1999).
  • •First pharrnacoeconomic model to compare long-term outcomes for the treatment of DVT with UFH and LMWH. Previous modeling efforts had limited their time horizon to the duration of short-term clinical trials.
  • Estrada CA, Mansfield CJ, Heudebert GR. Cost-effectiveness of low-molecular-weight heparin in the treatment of proximal deep vein thrombosis. j Gen. Intern Med. 15 (2), 108–115 (2000).
  • Caro JJ, Getsios D, Caro I, O'Brien JA. Cost effectiveness of tinzaparin sodium versus unfractionated heparin in the treatment of proximal deep vein thrombosis. PharmacoEconomics 20 (9), 593–602 (2002).
  • Hull RD, Raskob GE, Pineo GF, et al. Subcutaneous low-molecular-weight heparin compared with continuous intravenous heparin in the treatment of proximal-vein thrombosis. N Engl. I Med. 326(15), 975–982 (1992).
  • Prandoni P, Lensing AWA, Cogo A et al The long-term clinical course of the deep venous thrombosis. Ann. Intern. Med. 125, 1–7 (1997).
  • Bergqvist D, Hendteg S, Johansen J, Persson U, Odegaard K. Cost of long-term complications of deep-venous thrombosis of the lower extremities: an analysis of a defined patient population in Sweden. Ann. Intern. Med. 126,454-457 (1997).
  • Lenert LA, Soetikno RM. Automated computer interviews to elicit utilities: potential applications in the treatment of deep vein thrombosis. j A. Med. Inform. Assoc. 4,89–102 (1997).
  • McCart GM, Kayser SR Therapeutic equivalency of low-molecular-weight heparins. Ann. Phaimacother 36(6),1042–1057(2002).
  • Michalis LK, Katsouras CS, Papamichael N, Adamides K, Naka KK, Goudevenos J, Sideris DA. Enoxaparin versus tinzaparin in nonST-segment elevation acute coronary syndromes: the EVET trial. Am. Hear t 146(2), 304–310 (2003).
  • Dolovich LR, Ginsberg JS, Douketis JD, Holbrook AM, Cheah G. A meta-analysis comparing low molecular weight heparins with unfractionated heparin in the treatment of venous thromboembolism. Examining some unanswered questions regarding location of treatment, product type, and dosing frequency. Arch. Intern. Med. 160,181–188 (2000).
  • Gould MK, Dembitzer AD, Doyle RL, Hastie TJ, Garber AM. Low molecular weight heparins compared with unfractionated heparin for treatment of acute deep vein thrombosis. A meta-analysis of randomized, controlled trials. Ann. Intern. Med. 130(10), 800–809 (1999).
  • Ageno W, Steidl L, Marchesi C et al Selecting patients for home treatment of deep vein thrombosis: the problem of cancer. Haematologica 87 (3), 286–291 (2002) .
  • Dunn AS, Schechter C, Gotlin A et al. Outpatient treatment of deep venous thrombosis in diverse inner-city patients. Am. Merl 110(6), 458–462 (2001).
  • Kovacs MJ, Anderson D, Morrow B, Gray L, Touchie D, Wells PS. Outpatient treatment of pulmonary embolism with dalteparin. Thromb. Haemost. 83(2), 209–211 (2000) .
  • Heit JA, Mohr DN, Silverstein MD et al Predictors of recurrence after deep vein thrombosis and pulmonary embolism: a population-based cohort study. Arch Intern Med. 160(6), 761–768 (2000).
  • Ganz DA, Glynn RJ, Mogun H, Knight EL, Bohn RL, Avorn J. Adherence to guidelines for oral anticoagulation after venous thrombosis and pulmonary embolism. j Gen Intern. Med. 15 (11), 776–781 (2000).
  • Heit JA, Silverstein MD, Mohr DN, Petterson TM, OFallon WM, Melton III U. Predictors of survival after deep vein thrombosis and pulmonary embolism. A population-based, cohort study. Arch Intern. Med. 158,445–453 (1999).
  • Grau E, Tenias JM, Real E, Medrano J, Ferrer R, Pastor E, Selfa S. Home treatment of deep venous thrombosis with low molecular weight heparin: long-term incidence of recurrent venous thromboembolism. Am. .1. Remota 67 (1), 10–14 (2001).
  • Spyropoulos AC. Outpatient-based treatment protocols in the management of venous thromboembolic disease. Aim Man. Care 6(20 Suppl), S1034—S1044 (2000).
  • Huisman MV on behalf of the THRIVE treatment study investigators. Efficacy and safety of the oral direct thrombin inhibitor ximelagatran for acute deep vein thrombosis with or without pulmonary embolism. XLYCongress of the International Society on Thrombosis and Haemostasir, Birmingham, UK. July 12–18 (2003).
  • Van Oers MHJ on behalf of the The Matisse Investigators. Fondaparinux (Arixtra) in comparison to (low molecular weight) heparin for the initial treatment of symptomatic deep venous thrombosis or pulmonary embolism — The Matisse Clinical Outcome Studies. 44th Annual Meeting of the American Society of Hematology, PA, USA. December 7–10. (2002).
  • Hull RD, Pineo GF, Raskob GE. The economic impact of treating deep vein thrombosis with low molecular weight heparin: outcome of therapy and health economy aspects. Haemostasis 28\(Suppl. 3), 8–16 (1998).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.