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Review

Use of needle-free injection systems to alleviate needle phobia and pain at injection

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Pages 467-477 | Published online: 09 Jan 2014

References

  • Humphrey GB, Boon CM, van Linden van den Heuvell GF, van de Wiel HB. The occurrence of high levels of acute behavioral distress in children and adolescents undergoing routine venipunctures. Pediatrics 90, 87–91 (1992).
  • Schechter NL, Blankson V, Pachter LM, Sullivan CM, Costa L. The ouchless place: no pain, children’s gain. Pediatrics 99, 890–894 (1997).
  • May K, Britt R, Newman MM. Pediatric registered nurse usage and perception of EMLA. J. Soc. Pediatr. Nurs. 4, 105–112 (1999).
  • Hamilton JG. Needle phobia: a neglected diagnosis. J. Fam. Pract. 41, 169–175 (1995).
  • Graziano AM, DeGiovanni IS, Ka G. Behavioral treatment of children’s fears: a review. Psychol. Bull. 86, 804–830 (1979).
  • Duff AJ. Incorporating psychological approaches into routine paediatric venepuncture. Arch. Dis. Child. 88, 931–937 (2003).
  • Ost LG. Blood and injection phobia: background and cognitive, physiological, and behavioral variables. J. Abnorm. Psychol. 101, 68–74 (1992).
  • Zeltzer LK, Jay SM, Fisher DM. The management of pain associated with pediatric procedures. Pediatr. Clin. North Am. 36, 941–964 (1989).
  • Costello CG. Fears and phobias in women: a community study. J. Abnorm. Psychol. 91, 280–286 (1982).
  • Arvidsson SB, Ekroth RH, Hansby AM, Lindholm AH, William-Olsson G. Painless venipuncture. A clinical trial of iontophoresis of lidocaine for venipuncture in blood donors. Acta Anaesthesiol. Scand. 28, 209–10 (1984).
  • Oswalt R, Gordon J. Blood donor motivation: a survey of minority college students. Psychol. Rep. 72, 785–786 (1993).
  • van Lieshout JJ, Wieling W, Karemaker JM, Eckberg DL. The vasovagal response. Clin. Sci. 81, 575–586 (1991).
  • Hart PS, Yanny W. Needle phobia and malignant vasovagal syndrome. Anaesthesia 53, 1002–1004 (1998).
  • Nir Y, Paz A, Sabo E, Potasman I. Fear of injections in young adults: prevalence and associations. Am. J. Trop. Med. Hyg. 68, 341–344 (2003).
  • Win NN, Kohase H, Miyamoto T, Umino M. Decreased bispectral index as an indicator of syncope before hypotension and bradycardia in two patients with needle phobia. Br. J. Anaesth. 91, 749–752 (2003).
  • Cooper JA, Bromley LM, Baranowski AP, Barker SG. Evaluation of a needle-free injection system for local anaesthesia prior to venous cannulation. Anaesthesia 55, 247–50 (2000).
  • Palmon SC, Lloyd AT, Kirsch JR. The effect of needle gauge and lidocaine pH on pain during intradermal injection. Anesth. Analg. 86, 379–81 (1998).
  • Harrison N, Langham BT, Bogod DG. Appropriate use of local anaesthetic for venous cannulation. Anaesthesia 47, 210–212 (1992).
  • Matsumoto AH, Reifsnyder AC, Hartwell GD, Angle JF, Selby JB Jr, Tegtmeyer CJ. Reducing the discomfort of lidocaine administration through pH buffering. J. Vasc. Interv. Radiol. 5, 171–175 (1994).
  • Marica LS, O’Day T, Janosky JE, Nystrom EU. Chloroprocaine is less painful than lidocaine for skin infiltration anesthesia. Anesth. Analg. 94, 351–354 (2002).
  • Rohm KD, Schollhorn TA, Gwosdek MJ, Piper SN, Maleck WH, Boldt J. Do we necessarily need local anaesthetics for venous cannulation? A comparison of different cannula sizes. Eur. J. Anaesthesiol. 21, 214216 (2004).
  • Usichenko TI, Pavlovic D, Foellner S, Wendt M. Reducing venipuncture pain by a cough trick: a randomized crossover volunteer study. Anesth. Analg. 98, 343–345 (2004).
  • Richtsmeier AJ, Hatcher JW. Buffered lidocaine for skin infiltration prior to hemodialysis. J. Pain Symptom Manage. 10, 198–203 (1995).
  • Dutta S. Use of eutectic mixture of local anesthetics in children. Indian J. Pediatr. 66, 707–715 (1999).
  • Vaghadia H, al-Ahdal OA, Nevin K. EMLA patch for intravenous cannulation in adult surgical out-patients. Can. J. Anaesth. 44, 798–802 (1997).
  • Young SS, Schwartz R, Sheridan MJ. EMLA cream as a topical anesthetic before office phlebotomy in children. South Med. J. 89, 1184–1187 (1996).
  • Arts SE, Abu-Saad HH, Champion GD et al. Age-related response to lidocaine-prilocaine (EMLA) emulsion and effect of music distraction on the pain of intravenous cannulation. Pediatrics 93, 797–801 (1994).
  • Robieux I, Kumar R, Radhakrishnan S, Koren G. Assessing pain and analgesia with a lidocaine-prilocaine emulsion in infants and toddlers during venipuncture. J. Pediatr. 118, 971–973 (1991).
  • Wig J, Johl KS. Our experience with EMLA Cream (for painless venous cannulation in children). Indian J. Physiol. Pharmacol. 34, 130–132 (1990).
  • Hopkins CS, Buckley CJ, Bush GH. Pain-free injection in infants. Use of a lignocaine-prilocaine cream to prevent pain at intravenous induction of general anaesthesia in 1–5-year-old children. Anaesthesia 43, 198–201 (1988).
  • Cooper CM, Gerrish SP, Hardwick M, Kay R. EMLA cream reduces the pain of venepuncture in children. Eur. J. Anaesthesiol. 4, 441–448 (1987).
  • Lal MK, McClelland J, Phillips J, Taub NA, Beattie RM. Comparison of EMLA cream versus placebo in children receiving distraction therapy for venepuncture. Acta Paediatr. 90, 154–159 (2001).
  • Norman J, Jones PL. Complications of the use of EMLA. Br. J. Anaesth. 64, 403 (1990).
  • Steward DJ. Eutectic mixture of local anesthetics (EMLA): what is it? What does it do? J. Pediatr. 122, S21–S23 (1993).
  • Gajraj NM, Pennant JH, Watcha MF. Eutectic mixture of local anesthetics (EMLA) cream. Anesth. Analg. 78, 574–583 (1994).
  • Frayling IM, Addison GM, Chattergee K, Meakin G. Methaemoglobinaemia in children treated with prilocaine-lignocaine cream. Br. Med. J. 301, 153–154 (1990).
  • Svensson P, Petersen JK. Anesthetic effect of EMLA occluded with Orahesive oral bandages on oral mucosa. A placebo-controlled study. Anesth. Prog. 39, 79–82 (1992).
  • Svensson P, Arendt-Nielsen L, Bjerring P, Kaaber S. Oral mucosal analgesia quantitatively assessed by argon laser-induced thresholds and single-evoked vertex potentials. Anesth. Pain Control Dent. 2, 154–161 (1993).
  • Meechan JG, Donaldson D. The intraoral use of EMLA cream in children: a clinical investigation. ASDC J. Dent. Child. 61, 260–262 (1994).
  • Yamamoto LG, Boychuk RB. A blinded, randomized, paired, placebo-controlled trial of 20-minute EMLA cream to reduce the pain of peripheral IV cannulation in the ED. Am. J. Emerg. Med. 16, 634–636 (1998).
  • McCafferty DF, Woolfson AD, Boston V. In vivo assessment of percutaneous local anaesthetic preparations. Br. J. Anaesth. 62, 17–21 (1989).
  • Lawson RA, Smart NG, Gudgeon AC, Morton NS. Evaluation of an amethocaine gel preparation for percutaneous analgesia before venous cannulation in children. Br. J. Anaesth. 75, 282–285 (1995).
  • Nott MR. EMLA or Ametop, and for how long? Anaesthesia 56, 1026–1027 (2001).
  • Choy L, Collier J, Watson AR. Comparison of lignocaine-prilocaine cream and amethocaine gel for local analgesia before venepuncture in children. Acta Paediatr. 88, 961–964 (1999).
  • Guy RH. Current status and future prospects of transdermal drug delivery. Pharm. Res. 13, 1765–1769 (1996).
  • Wallace MS, Ridgeway B, Jun E, Schulteis G, Rabussay D, Zhang L. Topical delivery of lidocaine in healthy volunteers by electroporation, electroincorporation, or iontophoresis: an evaluation of skin anesthesia. Reg. Anesth. Pain Med. 26, 229–238 (2001).
  • Squire SJ, Kirchhoff KT, Hissong K. Comparing two methods of topical anesthesia used before intravenous cannulation in pediatric patients. J. Pediatr. Healthcare 14, 68–72 (2000).
  • Iomed. Numby Stuff® package insert. Iomed, UT, USA (1998).
  • Greenbaum SS, Bernstein EF. Comparison of iontophoresis of lidocaine with a eutectic mixture of lidocaine and prilocaine (EMLA) for topically administered local anesthesia. J. Dermatol. Surg. Oncol. 20, 579–583 (1994).
  • Galinkin JL, Rose JB, Harris K, Watcha MF. Lidocaine iontophoresis versus eutectic mixture of local anesthetics (EMLA) for IV placement in children. Anesth. Analg. 94, 1484–1488, (2002).
  • Kearns GL, Heacook J, Daly SJ, Singh H, Alander SW, Qu S. Percutaneous lidocaine administration via a new iontophoresis system in children: tolerability and absence of systemic bioavailability. Pediatrics 112, 578–582 (2003).
  • Rose JB, Galinkin JL, Jantzen EC, Chiavacci RM. A study of lidocaine iontophoresis for pediatric venipuncture. Anesth. Analg. 94, 867–871 (2002).
  • Zempsky WT, Parkinson TM. Lidocaine iontophoresis for topical anesthesia before dermatologic procedures in children: a randomized controlled trial. Pediatr. Dermatol. 20, 364–368 (2003).
  • Biro P, Meier T, Cummins AS. Comparison of topical anaesthesia methods for venous cannulation in adults. Eur. J. Pain 1, 37–42 (1997).
  • DeCou JM, Abrams RS, Hammond JH, Lowder LR, Gauderer MW. Iontophoresis: a needle-free, electrical system of local anesthesia delivery for pediatric surgical office procedures. J. Pediatr. Surg. 34, 946–949 (1999).
  • Kim MK, Kini NM, Troshynski TJ, Hennes HM. A randomized clinical trial of dermal anesthesia by iontophoresis for peripheral intravenous catheter placement in children. Ann. Emerg. Med. 33, 395–399 (1999).
  • Schultz AA, Strout TD, Jordan P, Worthing B. Safety, tolerability, and efficacy of iontophoresis with lidocaine for dermal anesthesia in ED pediatric patients. J. Emerg. Nurs. 28, 289–296 (2002).
  • Zeltzer L, Regalado M, Nichter LS, Barton D, Jennings S, Pitt L. Iontophoresis versus subcutaneous injection: a comparison of two methods of local anesthesia delivery in children. Pain 44, 73–78 (1991).
  • Zempsky WT, Sullivan J, Paulson DM, Hoath SB. Evaluation of a low-dose lidocaine iontophoresis system for topical anesthesia in adults and children: a randomized, controlled trial. Clin. Ther. 26, 1110–1119 (2004).
  • Armstrong P, Young C, McKeown D. Ethyl chloride and venepuncture pain: a comparison with intradermal lidocaine. Can. J. Anaesth. 37, 656–658 (1990).
  • Zappa SC, Nabors SB. Use of ethyl chloride topical anesthetic to reduce procedural pain in pediatric oncology patients. Cancer Nurs. 15, 130–136 (1992).
  • Hingson RA, Hughes JG. Clinical studies with jet injection: a new method of drug administration. Anesth. Analg. 26, 221–230 (1947).
  • Cohn L, Hingson RA, Narduzzi JV, Seddon JM. Clinical experience with jet insulin injection in diabetes mellitus therapy: a clue to the pathogenesis of lipodystrophy. ALA J. Med. Sci. 11, 265–273 (1974).
  • Hollingsworth SJ, Hoque K, Linnard D, Corry DG, Barker SG. Delivery of low molecular weight heparin for prophylaxis against deep vein thrombosis using a novel, needle-less injection device (J-Tip). Ann. R. Coll. Surg. Engl. 82, 428–431 (2000).
  • Zsigmond EK, Kovacs V, Fekete G. A new route, jet-injection for anesthetic induction in children: I. Midazolam dose-range finding studies. Int. J. Clin. Pharmacol. Ther. 33, 580–584 (1995).
  • Greenberg RS, Maxwell LG, Zahurak M, Yaster M. Preanesthetic medication of children with midazolam using the Biojector jet injector. Anesthesiology 83, 264–269 (1995).
  • Zsigmond EK, Kovacs V, Fekete G. A new route, jet-injection for anesthetic induction in children. II. Ketamine dose-range finding studies. Int. J. Clin. Pharmacol. Ther. 34, 84–88 (1996).
  • Domino EF, Zsigmond EK, Kovacs V, Fekete G, Stetson P. A new route, jet injection for anesthetic induction in children. III. Ketamine pharmacokinetic studies. Int. J. Clin. Pharmacol. Ther. 35, 527–530 (1997).
  • Domino EF, Zsigmoid EK, Kovacs V, Olajos B, Fekete G. A new route, jet injection for anesthetic induction in children. IV. Midazolam plasma levels. Int. J. Clin. Pharmacol. Ther. 36, 458–462 (1998).
  • Zsigmond EK, Darby P, Koenig HM, Goll EF. Painless intravenous catheterization by intradermal jet injection of lidocaine: a randomized trial. J. Clin. Anesth. 11, 87–94 (1999).
  • Koenig HM, Paisansathan C, Albrecht RF II, Zsigmond EK. Jet injection of local anesthetic decreases pain of arterial cannulation in awake neurosurgical patients. J. Neurosurg. Anesthesiol. 16, 156–159 (2004).
  • Bennett CR, Monheim LM. Production of local anesthesia by jet injection. A clinical study. Oral Surg. Oral Med. Oral Pathol. 32, 526–530 (1971).
  • Saravia ME, Bush JP. The needleless syringe: efficacy of anesthesia and patient preference in child dental patients. J. Clin. Pediatr. Dent. 15, 109–112 (1991).
  • Lehtinen R. Efficiency of jet injection technique in production of local anesthesia. Proc. Finn. Dent. Soc. 75, 13–14 (1979).
  • Tabita PV. Side effect of the jet injector for the production of local anesthesia. Anesth. Prog. 26, 102–104 (1979).
  • Canter J, Mackey K, Good LS et al. An outbreak of hepatitis B associated with jet injections in a weight reduction clinic. Arch. Intern. Med. 150, 1923–1927 (1990).
  • Hoffman PN, Abuknesha RA, Andrews NJ, Samuel D, Lloyd JS. A model to assess the infection potential of jet injectors used in mass immunisation. Vaccine 19, 4020–4027 (2001).
  • Jovanovic-Peterson L, Sparks S, Palmer JP, Peterson CM. Jet-injected insulin is associated with decreased antibody production and postprandial glucose variability when compared with needle-injected insulin in gestational diabetic women. Diabetes Care 16, 1479–1484 (1993).
  • Migdal M, Chudzynska-Pomianowska E, Vause E, Henry E, Lazar J. Rapid, needle-free delivery of lidocaine for reducing the pain of venipuncture among pediatric subjects. Pediatrics 115, E393–E398 (2005).
  • Lysakowski C, Dumont L, Tramer MR, Tassonyi E. A needle-free jet-injection system with lidocaine for peripheral intravenous cannula insertion: a randomized controlled trial with cost–effectiveness analysis. Anesth. Analg. 96, 215–219 (2003).
  • Khalil SN, Vije HN, Kee SS, Farag A, Hanna E, Chuang AZ. A pediatric trial comparing midazolam/Syrpalta mixture with premixed midazolam syrup (Roche). Paediatr. Anaesth. 13, 205–209 (2003).
  • Fine B, Castillo R, McDonald T, Paisansathan C, Zsigmond E, Hoffman WE. Jet injector compared with oral midazolam for preoperative sedation in children. Paediatr. Anaesth. 14, 739–743 (2004).
  • Dialynas M, Hollingsworth SJ, Cooper D, Barker SG. Use of a needle-less injection system for digital ring block anesthesia. J. Am. Podiatr. Med. Assoc. 93, 23–26 (2003).
  • Keshtgar MR, Kocjan G. A novel, pain-free approach to fine needle aspiration cytology. Acta Cytol. 43, 700 (1999).
  • Keshtgar MR, Barker SG, Ell PJ. Needle-free vehicle for administration of radionuclide for sentinel-node biopsy. Lancet 353, 1410–1411 (1999).
  • Veronesi U, Paganelli G, Galimberti V et al. Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph-nodes. Lancet 349, 1864–1867 (1997).
  • Warren J, Ziherl FA, Kish AW, Ziherl LA. Large-scale administration of vaccines by means of an automatic jet injection syringe. J. Am. Med. Assoc. 157, 633–637 (1955).
  • General Recommendations of the Advisory Committee on Immunization Practices (ACIP) and the American Academy of Family Physicians (AAFP). No. RR-2. Morbid. Mortal. Wkly Rep. 51, 12–13 (2002).
  • Jackson LA, Austin G, Chen RT et al. Safety and immunogenicity of varying dosages of trivalent inactivated influenza vaccine administered by needle-free jet injectors. Vaccine 19, 4703–4709 (2001).
  • Zsigmond EK. Findings of study of needle-free jet-injection system with lidocaine are contrary to published reports. Anesth. Analg. 98(5), 1504–1505 (2004).
  • Ekwueme DU, Weniger BG, Chen RT. Model-based estimates of risks of disease transmission and economic costs of seven injection devices in sub-Saharan Africa. Bull. World Health Organ. 80, 859–870 (2002).
  • Rogers TL, Ostrow CL. The use of EMLA cream to decrease venipuncture pain in children. J. Pediatr. Nurs. 19, 33–39 (2004).

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