Oral fixed drug combination analgesic tramadol/paracetamol: benefits for patients and budgets

References

• Elliott AM, Smith BH, Penny KI, Smith WC, Chambers WA. The epidemiology of chronic pain in the community. Lancet 354(9186), 1248–1252 (1999).
   PubMed Web of Science ®Google Scholar
• Katz WA. Musculoskeletal pain and its socioeconomic implications. Clin. Rheumatol. 21(Suppl. 1), S2–S4 (2002).
   PubMed Web of Science ®Google Scholar
• Waddell G. The back pain revolution. Churchill Livingstone, Edinburgh, UK (1998).
   Google Scholar
• Raffa RB. Pharmacology of oral combination analgesics: rational therapy for pain. J. Clin. Pharm. Ther. 26(4), 257–264 (2001).
   PubMed Web of Science ®Google Scholar
• Bamigbade TA, Langford RM. The clinical use of tramadol hydrochloride. Pain Rev. 5, 155–182 (1998).
   Web of Science ®Google Scholar
• Raber M, Hofman S, Junge K, Momberger H, Kuhn D. Analgesic efficacy and tolerability of tramadol 100 mg sustained-release capsules in patients with moderate to severe chronic low back pain. Clin. Drug Invest. 17, 415–423 (1999).
   Web of Science ®Google Scholar
• Pendleton A, Arden N, Dougados M et al. EULAR recommendations for the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT). Ann. Rheum. Dis. 59(12), 936–944 (2000).
   PubMed Web of Science ®Google Scholar
• Schnitzer TJ, Gray WL, Paster RZ, Kamin M. Efficacy of tramadol in treatment of chronic low back pain. J. Rheumatol. 27(3), 772–778 (2000).
   PubMed Web of Science ®Google Scholar
• Scott LJ, Perry CM. Tramadol: a review of its use in perioperative pain. Drugs 60(1), 139–176 (2000).
   PubMed Web of Science ®Google Scholar
• Jordan KM, Arden NK, Doherty M et al. EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: report of a task force of the standing committee for international clinical studies including therapeutic trials (ESCISIT). Ann. Rheum. Dis. 62(12), 1145–1155 (2003).
   PubMed Web of Science ®Google Scholar
• Medve RA, Wang J, Karim R. Tramadol and acetaminophen tablets for dental pain. Anesth. Prog. 48(3), 79–81 (2001).
   PubMedGoogle Scholar
• Edwards JE, McQuay HJ, Moore RA. Combination analgesic efficacy: individual patient data meta-analysis of single-dose oral tramadol plus acetaminophen in acute postoperative pain. J. Pain. Symptom. Manage. 23(2), 121–130 (2002).
   PubMed Web of Science ®Google Scholar
• Jung YS, Kim DK, Kim MK et al. Onset of analgesia and analgesic efficacy of tramadol/acetaminophen and codeine/acetaminophen/ibuprofen in acute postoperative pain: a single-center, single-dose, randomized, active-controlled, parallel-group study in a dental surgery pain model. Clin. Ther. 26(7), 1037–1045 (2004).
   PubMed Web of Science ®Google Scholar
• Smith AB, Ravikumar TS, Kamin M et al. Combination tramadol plus acetaminophen for postsurgical pain. Am. J. Surg. 187(4), 521–527 (2004).
   PubMed Web of Science ®Google Scholar
• Mullican WS, Lacy JR. Tramadol/acetaminophen combination tablets and codeine/acetaminophen combination capsules for the management of chronic pain: a comparative trial. Clin. Ther. 23(9), 1429–1445 (2001).
   PubMed Web of Science ®Google Scholar
• Perrot S, Krause D. Comparison of treatment safety and patient satisfaction in patients with sub-acute low back pain, treated with the combination tramadol (37,5 mg) plus paracetamol (325 mg) or tramadol alone (50 mg). Proceedings of the Fourth Congress of the European Federation of IASP Chapters (EFIC). Prague, Czech Republic (2003).
   Google Scholar
• Ruoff GE, Rosenthal N, Jordan D, Karim R, Kamin M. Tramadol/acetaminophen combination tablets for the treatment of chronic lower back pain: a multicenter, randomized, double-blind, placebo-controlled outpatient study. Clin. Ther. 25(4), 1123–1141 (2003).
   PubMed Web of Science ®Google Scholar
• Peloso PM, Fortin L, Beaulieu A, Kamin M, Rosenthal N. Analgesic efficacy and safety of tramadol/acetaminophen combination tablets (Ultracet) in treatment of chronic low back pain: a multicenter, outpatient, randomized, double blind, placebo controlled trial. J. Rheumatol. 31(12), 2454–2463 (2004).
   PubMed Web of Science ®Google Scholar
• Silverfield JC, Kamin M, Wu SC, Rosenthal N. Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study. Clin. Ther. 24(2), 282–297 (2002).
   PubMed Web of Science ®Google Scholar
• Emkey R, Rosenthal N, Wu SC, Jordan D, Kamin M. Efficacy and safety of tramadol/acetaminophen tablets (Ultracet) as add-on therapy for osteoarthritis pain in subjects receiving a COX-2 nonsteroidal antiinflammatory drug: a multicenter, randomized, double-blind, placebo-controlled trial. J. Rheumatol. 31(1), 150–156 (2004).
   PubMed Web of Science ®Google Scholar
• Nuijten MJ, Poulsen Nautrup B. Cost–effectiveness analysis of the combination tramadol plus paracetamol versus codeine plus paracetamol for postoperative pain therapy in The Netherlands. Value Health 8(6), A141–A142 (2005).
   Google Scholar
• PoulsenNautrup B, Nuijten MJ. Economic evaluation of Zaldiar® vs. tramadol in acute to subacute low back pain in Spain. Grünenthal internal document (2004).
   Google Scholar
• Nuijten MJ, Poulsen Nautrup B, Liedgens H. Economic evaluation of Zaldiar® vs. tramadol in subacute low back pain in Austria. Grünenthal internal document (2005).
   Google Scholar
• Nuijten MJC, Poulsen Nautrup B. Economic evaluation of a tramadol/paracetamol combination in subacute low back pain in The Netherlands. J. Appl. Ther. Res. 5(4), 17–28 (2005).
   Google Scholar
• Liedgens L, Nuijten MJC, Poulsen Nautrup B. Economic evaluation of tramadol/paracetamol combination tablets for osteoarthritis pain in The Netherlands. Clin. Drug Invest. 25(12), 785–802 (2005).
   PubMed Web of Science ®Google Scholar
• Rowlington JC, Rawal N. Postoperative pain guidelines – targeted to the site of surgery. Reg. Anesth. Pain Med. 28, 265–267 (2003)
   PubMed Web of Science ®Google Scholar
• van Tulder MW, Koes BW, Bouter LM. A cost-of-illness study of back pain in The Netherlands. Pain62(2), 233–240 (1995).
   PubMed Web of Science ®Google Scholar
• Gureje O, Von Korff M, Simon GE, Gater R. Persistent pain and well-being: a World Health Organization Study in primary care. JAMA 280(2), 147–151 (1998).
   PubMed Web of Science ®Google Scholar
• Miceli-Richard C, Le Bars M, Schmidely N, Dougados M. Paracetamol in osteoarthritis of the knee. Ann. Rheum. Dis. 63, 923–930 (2004).
   PubMed Web of Science ®Google Scholar
• Zhang W, Jones A, Doherty M. Does paracetamol (acetaminophen) reduce the pain of osteoarthritis? A meta-analysis of randomised controlled trials. Ann. Rheum. Dis. 63(8), 901–907 (2004).
   PubMed Web of Science ®Google Scholar
• ACR Guidelines. Recommendations for the medical management of osteoarthritis of the hip and knee: 2000 update. American College of Rheumatology Subcommittee on Osteoarthritis Guidelines. Arthritis. Rheum. 43(9), 1905–1915 (2000).
   PubMed Web of Science ®Google Scholar
• Malonne H, Coffiner M, Sonet B, Sereno A, Vanderbist F. Efficacy and tolerability of sustained-release tramadol in the treatment of symptomatic osteoarthritis of the hip or knee: a multicenter, randomized, double-blind, placebo-controlled study. Clin. Ther. 26(11), 1774–1782 (2004).
   PubMed Web of Science ®Google Scholar
• Pincus T, Koch GG, Sokka T et al. A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. Arthritis. Rheum. 44(7), 1587–1598 (2001).
   PubMed Web of Science ®Google Scholar
• Adler L, McDonald C, O’Brien C, Wilson M. A comparison of once-daily tramadol with normal release tramadol in the treatment of pain in osteoarthritis. J. Rheumatol. 29(10), 2196–2199 (2002).
   PubMed Web of Science ®Google Scholar
• Case JP, Baliunas AJ, Block JA. Lack of efficacy of acetaminophen in treating symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled comparison trial with diclofenac sodium. Arch. Intern. Med. 163(2), 169–178 (2003).
   PubMed Web of Science ®Google Scholar
• McClellan K, Scott LJ. Tramadol/paracetamol. Drugs63(11), 1079–1086; discussion 1087–1088 (2003).
   PubMed Web of Science ®Google Scholar
• Zazioco G. COX-2 inhibitors: the battle for market dominance. Drug. Market. Dev. 12(5), 131–137 (2001).
   Google Scholar
• Singh G, Ramey DR, Morfeld D et al. Gastrointestinal tract complications of nonsteroidal anti-inflammatory drug treatment in rheumatoid arthritis. A prospective observational cohort study. Arch. Intern. Med. 156(14), 1530–1536 (1996).
   PubMed Web of Science ®Google Scholar
• Champion GD, Feng PH, Azuma T et al. NSAID-induced gastrointestinal damage. Epidemiology, risk and prevention, with an evaluation of the role of misoprostol. An Asia–Pacific perspective and consensus. Drugs53(1), 6–19 (1997).
   PubMed Web of Science ®Google Scholar
• de Wit GA, Ramsteijn PG, de Charro FT. Economic evaluation of end stage renal disease treatment. Health Policy 44(3), 215–232 (1998).
   PubMed Web of Science ®Google Scholar
• Mukherjee D, Nissen SE, Topol EJ. Risk of cardiovascular events associated with selective COX-2 inhibitors. JAMA 286(8), 954–959 (2001).
   PubMed Web of Science ®Google Scholar
• Cox ER, Motheral B, Mager D. Verification of a decision analytic model assumption using real-world practice data: implications for the cost effectiveness of cyclo-oxygenase 2 inhibitors (COX-2s). Am. J. Manag. Care9(12), 785–794 (2003).
   PubMed Web of Science ®Google Scholar
• Fries JF, Williams CA, Bloch DA, Michel BA. Nonsteroidal anti-inflammatory drug-associated gastropathy: incidence and risk factor models. Am. J. Med. 91(3), 213–222 (1991).
   PubMed Web of Science ®Google Scholar
• Chancellor JV, Hunsche E, de Cruz E, Sarasin FP. Economic evaluation of celecoxib, a new cyclo-oxygenase 2 specific inhibitor, in Switzerland. Pharmacoeconomics19(Suppl. 1), 59–75 (2001).
   PubMed Web of Science ®Google Scholar
• Montero A, Samper D, Cobos R et al. Eficiencia del manejo de la lumbalgia en Atención Primaria de Zaldiar comparado con tramadol. Actas del VI Congreso Nacional de la Sociedad Española del Dolor, Oct 10–5; Las Palmas de Gran Canaria, España (2005) (Abstract).
   Google Scholar
• Cousins MJ, Brennan F, Carr DB. Pain relief: a universal human right. Pain112(1–2), 1–4 (2004).
   PubMed Web of Science ®Google Scholar
• Silverstein FE, Faich G, Goldstein JL et al. Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. JAMA 284(10), 1247–1255 (2000).
   PubMed Web of Science ®Google Scholar
• Ahmad SR, Kortepeter C, Brinker A, Chen M, Beitz J. Renal failure associated with the use of celecoxib and rofecoxib. Drug Saf.25(7), 537–544 (2002).
   PubMed Web of Science ®Google Scholar
• UK Medicines Information. Tramacet (tramadol/paracetamol). New Medicines Profile 04(10), (2004).
   Google Scholar