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Review

Atypical antipsychotics: revolutionary or incremental advance?

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Pages 69-88 | Published online: 10 Jan 2014

References

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  • ••Classic pivotal trial of clozapine.
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  • ••The only extant double-blind, randomized controlled study comparing clozapine, risperidone and olanzapine.
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  • •• Often-quoted industry-sponsored comparison study that has generated much controversy (see also [6]).
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  • ••Industry sponsored multicenter studyfollowing on the heels of another (see also [5]).
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  • •• A noninferiority trial; this methodology is becoming more common.
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  • •Double-blind controlled study that included treatment-intolerant patients.
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  • •Clozapine revisted, a decade after the original pivotal trial.
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  • ••Pivotal trial of risperidone.
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  • ••Pivotal trial of risperidone.
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  • •Important data demonstrating lack of correlation between plasma levels of risperidone and clinical improvement.
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  • ••Pivotal trial of olanzapine.
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  • •First indication that a threshold olanzapine level may be necessary for optimal response.
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  • ••Pivotal trial of quetiapine.
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  • ••Pivotal trial of quetiapine.
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  • ••The only extant double-blind controlledcomparison of three atypical antipsychotics and haloperidol and effect on hostility.
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  • ••Classic epidemiological study.
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  • •Recent review.
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  • •Important cautionary article.
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  • •• An early, influential report.
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  • ••Excellent and current tutorial/review.
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  • ••Excellent overview of this topic.
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  • ••Influential article by well-known leaders inthe field.
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  • •Although sample size is small and restricted to early phase of illness, this study has been influential.
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  • ••Excellent current review.
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