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Drug Evaluation

Valproate: a practical review of its uses in neurological and psychiatric disorders

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Pages 151-165 | Published online: 10 Jan 2014

References

  • Fariello RG, Varasi M, Smith MC. Valproic acid: mechanism of action. In: Anti-epileptic drugs. 4th ed. Levy R, Matson R, Meldrum B (Eds.) Raven Press, New York, NY, USA 581–588 (1995).
  • Chapman A, Keane PE, Meldrum BS, Simiand J, Vernieres JC. Mechanism of anticonvulsant action of Valproate. Frog. Neurobiol. 19,315–399 (1992).
  • Godin Y, Heiner L, Mark J, Mandel P. Effect of di-n-propylacetate, an anticonvulsive compound, on GABA metabolism. j Neurochem. 16,869–873 (1969).
  • Loscher W Correlation between alternations in brain GABA metabolism and seizure excitability following administration of GABA aminotransferase inhibitors and valproic acid-a reevaluation Neurochem. Int. 3, 397–404 (1981).
  • Power LJ, Backford J, John RA. An analysis of the kinetics of the inhibition rabbit GABA-transaminase by sodium N-dipropylacetate and some other simple carboxylic acids. Biochem. Pharmacol. 24, 267–270 (1975).
  • Harvey PKB, Bradford HF, Davisson AN. The inhibitory effect of sodium n-dipropylacetate on the degenerative enzymes of the GABA shunt. FEBS Lett. 52F, 251–254 (1975).
  • Mclean MJ, MacDonald RL. Sodium valproate but ethosuximate, produces use and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture. .1. Pharmacol. Exp. Ther. 237, 1001–1011 (1986).
  • Francesschetti S, Hamon B, Heinenmann U. The action of valproate on spontaneous epileptiform activity in the absence of synaptic transmission and on the evoked changes on (CA+) and (K+) in the hippocampal slice. Brain Res. 386, 1–11 (1986).
  • Schechter PJ, Trainer Y, Grove J. Effect of N-dipropylacetate on amino acid concentration in mouse brain: correlation with anticonvulsant activity. I Neurochem. 3,1325–1327 (1978).
  • Depakote® ER package insert, Abbott Laboratories, USA (2001).
  • Perruca E, Gatti G, Frigo GM. Disposition of sodium valproate in epileptic patients. Br.Clin. Pharmacol (5) 495–499 (1078).
  • Bourgeois, B. Valproate, In: Pediatric epilepsy diagnosis ancl therapy 2ncl ed Pellock J, Dodson W, Bourgeois (Eds.), 433–447 (2001).
  • Cloyd J, Kriel R, Jones-Saete C. Comparison of sprinkle versus syrup formulations of valproate for bioavailability, tolerance and preference. j Pecliatc 8,411–415 (1986).
  • Levy RII, Conraud B, Loiseau P et al. Meal-dependent absorption of enteric-coated sodium valproate. Epilepsia 21,273–280 (1980).
  • Gugler R, Schell A, Eichelbaum M, Froscher W, Schulz HU. Disposition of valproic in man. Eur. j Clin. Phalmacol 12,125–132 (1977).
  • Klotz U, Antonin KH. Pharmacokinetics and bioavailability of sodium valproate. Clin. Pharmacol Ther. 21,736–743 (1977).
  • Cloyd JC, Kriel RL. Bioavailability of rectal administered valproic acid syrup. Neurology 31,1348–1352 (1981).
  • Issakainen J. Pharmacokinetic aspects of sodium valproate suppositories. In: Pmceecling of the Forth International Symposium on Sodium Valproate, and Epilepsy International Congress and Symposium Series. Chadwick (Ed.), 152, 192–194 (1989).
  • Thorpy MJ. Rectal valproate syrup and status epilepticus. Neurology 30,1113–1114 (1980).
  • Holmes GB, Rosenfield WE, Graves NM. Absorption of valproic acid suppositories in human volunteers. Arch. Neural 46,906–909 (1989).
  • Limdi NA, Faught E. The safety of rapid valproic infusion. Epilepsia 41(10), 1342–1345 (2000).
  • Venkataraman V, Wheless JW. Safety of rapid iv. infusion of valproate loading doses in epilepsy patients. Epilepsy Res. 35(2), 147–153 (1999).
  • Cramer JA, Mattson RII, Benett DM, Swick CT Variable free and total valproic acid concentrations in sole- and multidrug therapy. Ther. Drug- Monit. 8,411–415 (1986).
  • Abbott FS, Kassam J, Orr JM, Farrell K. The effect of aspirin on valproic acid metabolism. Clin. Pharmacol The': 40(1), 94–100 (1986).
  • Loscher W, Nau HP Pharmacological evaluation of various metabolites and analogues of valproic acid. Neuropharm. 24, 225–235 (1990).
  • Kesterson JW, Granneman GR, Machinist JM. The hepatotoxisity of valproic acid and its metabolites in rats. I. Toxocologic, biochemical and histopathologic studies. Hepatology 4, 1143–1152 (1984).
  • Cloyd JC, Fisher JH, Kriel RL, Kraus DM. Valproic acid pharmacokinetics in children. Effect of age and anti-epileptic drugs on protein binding and intrinsic clearance. Clin. Phalmacol Ther. 53,22–29 (1993).
  • Löscher W, Nau H, Marescaux C, Vergnes M. Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy. Eur. Pharmac. 99,211-218 (1984).
  • Silver JM, Shin C, McNarnara JO. Anti- epileptic effect of conventional anticonvulsants in the kindling model of epilepsy. Ann. Neuml. 29,356–363 (1991).
  • Burgeois B, Beaumanoir A, Blajev B. Monotherapy with valprote in primary generalized epilepsy. Epilepsia 28\(Suppl. 2), S8—S11 (1987).
  • Karceski S, Morrell M, Carpenter D. The expert consensus guideline series. Treatment of epilepsy. Epilepsy Behavior 2 (Suppl.), A1—A50 (2001).
  • Villareal HJ, Wilder BJ, Willmore LJ et al. Effect of valproic acid in epilepsy on spike and wave discharges in patients with absence seizures. Neurology 28,886–891 (1978).
  • Pisani F, Narbone MC, Trunfio C et al. Valproic acid-ethusuximade interaction: a pharmacokinetic study. Epilepsia 25(2), 229–233 (1984).
  • Iivanainen M, Himberg J. Valproate and clonazepam in treatment of severe progressive myoclonus epilepsy. Arch. Neural 39,236–238 (1982).
  • McCabe P, McNew C, Michael N. Effect of Divalproex-Lamotrigine combination therapy in frontal lobe seizures. Arch. Neural 58(8), 1264–1268 (2001).
  • Kanner AM, Frey M. Adding valproate to lamotrigine: a study of their pharmacokinetic interaction. Neurology 55(4), 588–591 (2000).
  • Brodie M, Yuen A and 105 study group. Lamotrigine substitution study: evidence for synergism with sodium valproate. Epilepsy Res. 26(3), 423–432 (1997).
  • Pisani F, Oteri G, Russo M, Di Pierri R, Perucca E, Richens A. The efficacy of valproate-lamotrigine comedication in refractory complex partial seizures: evidence for a pharmacodynamic interaction. Epilepsia 40(8), 1141–1149 (1999).
  • Mattson R, Cramer JA, Collins JF. A comparison of valproate with carbamezapine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. N Engl. I Med. 327,765–771 (1992).
  • Reynolds E, Heller A, Chadwick D. Valproate versuscarbamazepine for seizures. N Engl. I Med. 328,207–208 (1993).
  • Chez MG, Bourgeois BFD, Pippenger CE, Knowles WD. Pharmacodynamic interactions between phenytoin and valproate: individual and combined anti-epileptic and neurotoxic actions in mice. Clin. Neumphalmacol, 17,32–37 (1994).
  • Yuen AWC, Lang G, Wetherley BC, Peck AW. Sodium valproate acutely inhibits lamotrigine metabolism. BE j Clin. Pharmacol 33,511–513 (1992).
  • Gidal BE, Andreson GD, Rutecki PR, Shaw R, Lanning A. Lack of effect of valproate concentration on lamotrigine pharmacokinetics in developmentally disabled patients with epilepsy. Epilepsy Res. 42,23–32 (2001).
  • Levy RII, Morehead T, Morselli P et al Carbamazepineivalproic acid interaction in man and rhesus monkey. Epilepsia 33,511–513 (1984).
  • Pavone L, Incorpora G, LaRosa M, LiVolti S, Mollica E Treatment of infantile spasms with sodium dipropylacetic acid. Dev. Med. Child Neural 23,454–461 (1981).
  • Patel I, Levy R, Culler R. Phenobarbital- valproic acid interaction. Clin. Phac Thec 27(4), 515–521 (1980).
  • Wagner ML, Graves NM, Leppik IE, Remmel RP, Ward DL, Shumaker RC. The effect of felbamate on valproate disposition. Epilepsia 32 (Suppl. 3), 15 (1991).
  • Dhillon S, Rhichens A. Serum protein binding of diazepam and its displacement by valproic acid in vitt-a BE j Clin. Pham. 12(4), 591–520 (1980).
  • Wheless JW Pediatric use of iv. and itramuscular phenytoin: I Pssions learned. J. Child Aim& (suppl), 11–14; 30–32 (1998).
  • Noritoku DK, Mueed S. Intravenous loading of valproate for epilepsy. Clin. Neuropharmacol 22,101–106 (1999).
  • Davis LL, Ryan W Adinoff B, Petty E Comprehensive review of the psychiatric use of valproate. j Clin. Psychopharm. 20 (Suppl. 1), 1S-17S (2000).
  • Daikilic A, Diaz E, Baker CB, Peasall HB, Woods SW Effect of divalproex versus lithium on length of hospital stays among patients with bipolar disorder. Bych. Sci. 51(9), 1184–1186 (2000).
  • Keck P, Taylor V, Tugrul K et al Valproate treatment of panic disorder in lactate-induced panic attacks. Biol. Psychiatry 33, 542–546 (1993).
  • Wassef AA, Dott SG, Harris A et al Randomized, placebo-controlled pilot study of divolproex sodium in the treatment of acute exacerbations of chronic schizophrenia. J. Clin. Psychopharm. 20(3), 357–361 (2000).
  • Wassef A, Dott S, Harris A et al Critical review of GABA-ergic drugs in the treatment of schizophrenia. J. Clin. PTchopharmacol 19,222–232 (1999).
  • Wasef A, Dott S, Harris A et al Clin. PTchopharmacol 21,21–26 (2001).
  • Cassey et al Presented at the Annual Meeting of the World Federation of Mental Health, Portland, OR, USA, (2001).
  • Wang SL, Cavanaugh J, Shi H, Awni WA, Granneman R. Effects of divalproax sodium on aminotriptyline and nortriptyline pharmacokinetics. Clin. Pharmacol Ther. 60(1), 48–53 (1996).
  • Luccena M, Blanco E, Corrales M, Berthier M. Interaction of fluoxatine an dvalproic acid. AIR I PTchiatry 155 (4), 575–577 (1998).
  • Ishizaki T, Chiba K, Saito M, Kobayashi K, Iiazuka R. The effects of neuroleptics (haloperidol and chlorpromazine) on pharmacokinetics of valproic acid in schizophrenic patients. Jan. PTcophatmacol 4(5), 254–261 (1984).
  • Granneman G, Scheneck D, Cavanaugh J, Witt G. Pharmacokinetic interactions and side effects resulting from concomitant administration of lithium and divalproex sodium. J. Clin. Bychiatry57 (5), 204–206 (1996).
  • Cutrer FM, Limmoroth V, Moskowitz MA. Possible mechanisms of valproate in migraine prophylaxis. Cephalgia 17(2), 93–100 (1997).
  • Welch KM, Chabi E, Bartosh K et al Cerebrospinal gamma-aminobutyric acid levels in migraine. BE Med 3,516–517 (1997).
  • Rothrock JF, Mar KR, Yaksh TL et al Cerebrospinal fluid analysis in migraine patients and controls. Cephalagia 15,489–493 (1995).
  • Mathew NT, Snaper JR, Silberstein SD et al Migraine prophylaxis with divalproex. Arch. Neural 52(3), 281–286 (1995).
  • Silberstein SB, Collins SD. Safety of divalproex sodium in migraine prophylaxis: an open-label, long-term study. Long-term safety of Depakote in headache prophylactic study group. Headache 41(5), 515–517 (1999).
  • Kaneecki RG. A comparison of Divalproex with Propranolol and Placebo for the Prophylaxis of migraine without aura. Arch. Neural 54(9), 1141–1145 (1997).
  • Fraitag FG, Diamond S, Diamond ML, Urban GJ. Divalproex in long-term treatment of chronic daily headache. Headache 41(3), 271–278 (2001).
  • Northon J. Use of iv. valproate sodium in status migraine. Headache 40(9), 755–757 (2000).
  • Mathew NT, Kailasam J, Meadors L, Chernyschev 0, Gentry P. Intravenous valproate sodium (depacone) aborts migraine rapidly: a preliminary report. Headache 40 (9), 720–723 (2000) .
  • Asconape J, Penry J, Dreifuss F, Riela A, Mirza W Valproate-associated pancreatitis. Epilepsia 34,177–183 (1993).
  • Ford DM, Portman RJ, Lum GM. Pancreatitis in children on chronic dialysis treated with valproic acid. Perliatr Nephrol 4(3), 259–261 (1990).
  • Bryant AE 3rd, Dreifus FE. Valproic acid hepatic fatalities. III. US experience since 1986. Neurology46(2), 465–469 (1996).
  • Sugimoto T, Muro H, Woo M, Nisida N, Murakami K. Valproate metabolites in high dose valproate plus phenytoin therapy. Epilepsia 37,1200–1203 (1996).
  • May RB, Sunder TR. Hematologic manifestation of long-term valproate therapy. Epilepsia 34,1098–1101 (1993).
  • Straussberg R, Kivity S, Weitz R, Harel L, Gadoth N. Reversible cortical atrophy and cognitive decline induced by valproic acid. Eur. Paediatr Neural 2(4), 213–218 (1998).
  • Guerrini R, Belmonte A, Canapicchi R, Casalini C, Perucca E. Reversible pseudoatrophy of brain and mental deterioration associated with valproate treatment. Epilepsia 39(1), 27–32 (1998).
  • Kifume A, Kubota F, Shibata N, Akate T, Kikuchi S. Valproic acid-induced hyperammonic encephalopathy with triphasic waves. Epilepsia 41(7), 909–912 (2000).
  • Sheith RD,Wesolowski CA, Jacob JC et al Effect of carbamazepine and valproate on bone mineral density. I Pecliatr 127(2), 256–262 (1995).
  • Herzog, A, Schachter S. Valproate and the polycystic ovarian syndrome: Final thoughts. Epilepsia 42(3), 311–315 (2001).
  • Bauer J, Jarre A, Klingmuller D, Elger C. Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women. Epilepsy Res. 41(2), 163–167 (2000).
  • Genton P, Bauer J, Duncan S et al On the association between valproate and Polycystic Ovary Syndrome. Epilepsia 42(3), 295–304 (2001).
  • Murialdo G, Galimberti CA, Gianelli MV et al Effect of valproate, Phenobarbital and carbamazepine on sex steroid set-up in women with epilepsy. Clin. Neuropharmacol 21,52–58 (1998).
  • Morrell M. Presented at the International Epilepsy Congness, Buenos Aires, AR.
  • Demir E, Aysum S. Weight gain with valproate in childhood. Perliatr Neural 22(5), 361–364 (2000).
  • Panjehshahin MR, Bowmer CJ, Yates MS. Effect of valproic acid, its unsaturated metabolites and some structurally related fatty acids on the binding of warfarin and dansylsarcosine to human albumin. Biochem. Pharmacol 41,1227–1233 (1991).
  • Webster LK, Mihaly GW, Jones DB, Smallwood RA, Phillips JA, Vajda FJ. Effect of cimetidine and ranitidine on carbamazepine and sodium valproate pharmacokinetics. Eur. j Clin. Pharmacol 27(3), 341–343 (1984).
  • Crawford P, Chadwick D, Cleland et al Sodium valproate and oral contraceptive steroids. Br J. Clin. Pharmacol 20, 288–289 (1985).
  • Dulac 0, Stem D, Rey E, Arthius M. Sodium valproate monotherapy in childhood epilepsy. Brain Dev. 8, 47–52 (1986).
  • Minagawa K, Miura H. Phenobarbithal, primidone and sodium valproate in prophylaxis in febrile convulsions. Brain Dev. 3, 385–393 (1981)
  • Herranz JL, Armijo JA, Arteaga R. Effectivness and toxisity of phenobarbital, primidone in the prevention of febrile convulsions, controlled by plasma levels. Epilepsia 25, 89–95 (1984).
  • Robert E, Guibaud P. Maternal valproic acid and congenital neural tube defects. Lancet 2, 937 (1982).
  • Diliberti J, Famdon P, Dennis N et al The fetal valproate syndrome. Am. J. Med. Gen. 19, 473–481 (1984).
  • Adab N, Jacoby A, Smith D, Chadwick D. Additional educational needs in children born to mothers with epilepsy. J Neural Neurosurg. PFhiatty 70, 15–21 (2001).
  • Porsteinsson AP, Tariot PN, Erb R et al Placebo-controlled study of divalproex sodium for agitation in dementia. Am. J. Geriatr Psychiatry 9, 58–66 (2001).
  • Raskind MA. Evaluation and management of aggressive behavior in the elderly demented adult. J. Gun. Psychiatry 60\(Suppl. 5), 45–49 (1999).
  • Brewster D, Muir NC. Valproate plasma protein binding in the uremic condition. Gun. Phatmacol Ther (27), 76–82 (1980).
  • Gugler R, Mueller G. Plasma protein binding of valproic acid in healthy subjects and in patients with renal disease. BE j Gun. Phatmacol 5, 441–446 (1978).
  • Bruni J, Wang LH, Malbury TC et al Protein binding of valproic acid in uremic patients. Neurology 30, 557–559 (1980).
  • Klotz U, Rapp T, Mueller WA. Disposition of valproic acid in patients with liver disease. hiuj Gun. Phatmacol 13, 55–60 (1978).
  • Whitton PS, Fowler U. The effect of valproic acid on 5-hydroxytriptamine and 5 hydroxy-indoleacetic acid concentration in hippocampal dyalisates in vivo. Eur. Pharmacol 200, 167 (1991).
  • Kanner AM, Palac S. Depression in epilepsy: a common but often unrecognized comorbid malady. Epilepsy Behavior 1, 37–51(2000).
  • Yang L, Benardo LS. Valproate prevents epileptiform activity after trauma in an in vitro model in neocortical slices. Epilepsia 41, 1507–1513 (2000).
  • Temkin NR, Dikmen ES, Anderson GD et al Valproate therapy for prevention of post traumatic seizures. A randomized trial. Neurosurg. 91, 593–600 (2000). Affiliations

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