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Review

Heparanase: a target for therapy of brain invasive tumors?

Pages 459-463 | Published online: 10 Jan 2014

References

  • Liotta LA, Steeg PS, Stetler-Stevenson WG. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64(2), 327–336 (1991).
  • •Comprehensive review of cancer metastasis, angiogenesis and the factors involved in these processes.
  • Iozzo RV, Murdoch AD. Proteoglycans for the extracellular environment: clues from the gene and protein side offer new perspectives in molecular diversity and function. FASEBJ 10,598–614 (1996).
  • •Comprehensive review of the field of proteoglycans.
  • Nakajima M, Irimura T, Nicolson GL. Heparanase and tumor metastasis. J. Cell. Biochem. 36,157–167 (1988).
  • •Review highlighting the relevance of heparanase in cancer metastasis.
  • Nakajima M, Irimura T, Di Ferrante DT, Di Ferrante N, Nicolson GL. Heparan sulfate degradation correlates with tumor invasive and metastatic properties of B16 melanoma sublines. Science 220,611–613 (1983).
  • •First report demonstrating a heparanase activity in melanoma cells.
  • Nakajima M, Irimura T, Nicolson GL. Metastatic melanoma heparanase. j Biol. Chem. 259,2283–2290 (1984).
  • Vlodavsky I, Friedmann Y, Elkin M eta]. Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis. Nat. Med. 5, 793–802 (1999).
  • ••Key paper reporting the successful cloningand functional expression of the human heparanase gene.
  • Hulet MD, Freeman C, Hamdorf BJ, Baker RT, Harris MT, Parish CE. Cloning of mammalian heparanase, an important enzyme in tumor invasion and metastasis. Nat. Med. 5,803–809 (1999).
  • ••Key paper reporting the successful cloningand functional expression of the human heparanase gene.
  • Toyoshima M, Nakajima M. Human heparanase. Bid Chem. 274,24153–24160 (1999).
  • ••Key paper reporting the successful cloningand functional expression of the human heparanase gene.
  • Kussie PH, Hulmes JD, Ludwig DL eta]. Cloning and functional expression of a human heparanase gene. Biochem. Biophys. Res. Comm. 261,183–187 (1999).
  • ••Key paper reporting the successful cloningand functional expression of the human heparanase gene.
  • McKenzie E, Tyson K, Stamps A etal. Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member. Biochem. Biophys. Res. Commun. 276(3), 1170–1177 (2000).
  • •An interesting paper describing a novel mammalian heparanase family member
  • Kosir MA, Foley-Loudon PA, Finkenauer R, Tennenberg SD. Multiple heparanases are expressed in polymorphonuclear cells. J. Surg. Res. 103(1), 100–108 (2002).
  • Parish CR, Freeman C, Brown KJ et al Identification of sulfated oligosaccharide based inhibitors of tumor growth and metastasis using a novel in vitro assay for angiogenesis and heparanase activity. Cancer Res. 14,3433–3441 (1999).
  • Jiang P, Kumar A, Parrillo JE et al Cloning and characterization of the human heparanase-1 (HPR1) gene promoter: role of GA-binding protein and Spl in regulating HPR1 basal promoter activity. Biol. Chem. 277(11), 8989–8998 (2002).
  • •Important manuscript reporting studies using novel and specific heparanase inhibitors.
  • Steck PA, Nicolson GL. Metastases to the central nervous system. In: Molecular Genetics of Nervous System Tumors. Wiley-Liss, Inc. New York, USA, 371–379 (1993).
  • •Comprehensive review of brain metastasis as significant clinical problem in neoplasia.
  • Herrmann JL, Menter DG, Hamada J, Marchetti D, Nakajima M, Nicolson GL. Mediation of NGF-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: melanoma p75 functions independently of tr/cA. MoL Biol. Cell 4, 1205–1216 (1993).
  • Marchetti D, Menter DG, Jin L, Nakajima M, Nicolson GL. Nerve growth factor effects on human and mouse melanoma cell invasion and heparanase production. int. J. Cancer55, 692–699 (1993).
  • ••First report linking nerve growth factorand consequently the family of neurotrophins, to cancer invasion and heparanase production.
  • Marchetti D, McCutcheon I, Ross M, Nicolson GL. Inverse expression of neurotrophins and neurotrophin receptors at the invasion from of human melanoma brain metastases. Int. J. Oncol 7,87–94 (1995).
  • Marchetti D, McQuillan DJ, Spohn WC, Carson, DD, Nicolson GL. Neurotrophin stimulation of human melanoma cell invasion: selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate subpopulations. Cancer Res. 56,2856–2863 (1996).
  • Marchetti D, Liu S, Spohn WC, Carson DD. Heparanase and a synthetic peptide of heparan sulfate-interacting protein recognize common sites on cell surface and extracellular matrix heparan sulfate. Biol. Chem. 272,15891–15897 (1997).
  • McCarthy KD, deVellis J. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell. Biol. 85,890–902 (1980).
  • Marchetti D, Li J, Shen R-J. Astrocytes contribute to the brain-metastatic specificity of melanoma cells by producing heparanase. Cancer Res. 60,4767–4770 (2000).
  • ••First description of heparanase geneexpression and functionality in astrocytes.
  • Nicolson GL, Menter DG, Herrmann JL, Yun Z, Cavanaugh PG, Marchetti D. Brain metastasis: role of trophic, autocrine and paracrine factors in tumor invasion and colonization of the central nervous system. In: Attempts to understand metastasis formation IL Gunthert U, Birchmeier W (Eds), Springer-Verlag, Berlin, Germany, 90–115 (1996).
  • Marchetti D, Nicolson GL. Human heparanase: a molecular determinant of brain metastasis. Adv. Enz. Reg. 41,343–359 (2001).
  • Dong J, Kukula AK, Toyoshima M, Nakajima M. Genomic organization and chromosome localization of the newly identified human heparanase gene. Gene 253,171–178 (2000).
  • Uno F, Fujiwara T, Takata Y et al. Antisense-mediated suppression of human heparanase gene expression inhibits pleural dissemination of human cancer cells. Cancer Res. 61,7855–7866 (2001).
  • Vlodavsky I, Mohsen M, Lider 0 etal. Inhibition of tumor metastasis by heparanase inhibiting species of heparin. Invasion Metastasis14,290–302 (1994).
  • Hulett MD, Homby JR, Ohms SJ etal Identification of active-site residues of the pro-metastatic endoglycosidase heparanase. Biochemistry39, 15659–15667 (2000).
  • •First description of heparanase active-site residues.

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