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Review

Selective serotonin reuptake inhibitors in the treatment of generalized anxiety disorder

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Pages 717-724 | Published online: 10 Jan 2014

References

  • Wittchen HU, Carter RM, Pfisster H. Epidemiology of generalised anxiety disorder in the community and in primary care. Neuropsychiatry (In press).
  • Carter RM, Wittchen H-U, Pfisster H et al One-year prevalence of subthreshold and threshold DSM-IV generalised anxiety disorder in a nationally representative sample. Depress. Anxien,13,78–88 (2001).
  • Wittchen HU, Carter RM, Pfisster H et al Disabilities and quality of life in pure and comorbid generalized anxiety disorder and major depression in a national survey. int. PTchopharmacol 15,319–328 (2000).
  • Yonkers 1KA, Dyck IR, Warshaw M et al. Factors predicting the clinical course of generalised anxiety disorder. BE j Psychiatry 176,544–549 (2000).
  • Beekman AT, Bremmer MA, Deeg DJ et al Anxiety disorders in later life: a report fromthe Longitudinal Aging Study Amsterdam. Int.j Geriatt: Bychiatry 13,717–726 (1998).
  • Weiner E, Bisserbe JC, Maier W et al. Prevalence and recognition of anxiety syndromes in five European primary care settings. A report from the WHO study on Psychological Problems in General Healthcare. BE j Psychiatry173\(Suppl. 34), 18–23 (1998).
  • •• Emphasises that anxiety disorders are common in primary care, but recognized only infrequently.
  • Kessler RC, DuPont RL, Berglund P et al. Impairment in pure and comorbid generalized anxiety disorder and major depression at 12 months in two national surveys. Am. J. Psychiatry 156,1915-1923 (1999).
  • Greenberg PE, Sisitsky T, Kessler RC et al The economic burden of anxiety disorders in the 1990s. J. Clin. fiychiatry60, 427–435 (1999).
  • Maier W Falkai P. The epidemiology of comorbidity between depression, anxiety disorders and somatic diseases. Int. Clin. PFchopharmacol 14(Suppl. 2), 51–56 (1999).
  • Connor KM, Davidson JRT. Generalized anxiety disorder: neurobiological and pharmacotherapeutic perspectives. Biol. PFchiatry 44, 1286–1294 (1998).
  • Chamey DS, Woods SW, Heninger GR. Noradrenergic function in generalized anxiety disorder: effects of yohimbine in healthy subjects and patients with generalized anxiety disorder. Psychiatry Res. 27,173–182 (1989).
  • Sevy S, Papadimitriou GN, Surmont DW et al Noradrenergic function in generalized anxiety disorder, major depressive disorder and healthy subjects. Biol. Psychiatry 25, 141–152 (1989).
  • Weizman R, Tanne Z, Granek M et al Peripheral benzodiazepine binding sites on platelet membranes are increased during diazepam treatment of anxious patients. Eur Pharmacol 138,289–292 (1987).
  • Rocca P, Ferrero P, Gualerzi A et al Peripheral-type benzodiazepine receptors in anxiety disorders. Acta PFchiatr Scaml 84, 537–544 (1991).
  • Rosenberg C, Damsbo N, Fuglum E et al 1994. Citalopram and imipramine in the treatment of depressive patients in general practice. A Nordic multicentre clinical study. Int. Gun. Psychopharmacol 9\(Suppl. 1), 41–48 (1994).
  • Jefferson J, Greist J. A double-blind comparison of citalopram and paroxetine in the treatment of patients with depression and anxiety. Presented at American College of Neuropsychopharmacology, San Juan, Puerto Rico, December 10–14, 2000.
  • Stahl S. Placebo-controlled comparison of the selective serotonin re-uptake inhibitors citalopram and sertraline. Bid Psychiatry 48,894–901 (2000).
  • Hyttel J, Bsego IQ, Perregard JA, Sanchez C. The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer. j Neural 7iansm. Gen. Sect. 88, 157–160 (1992).
  • Gorman JM, Korotzer A, Su G. Efficacy comparison of escitalopram and citalopram in the treatment of major depressive disorder: pooled analysis of placebo-controlled trials. CNS Spectrums 7\(Suppl. 1), S40—S44 (2002).
  • Davidson J, Bose A, Su G. Escitalopram in the treatment of generalized anxiety disorder. Int. .1. Neuropsychopharmacol 5\(Suppl. 1), S214 (2002).
  • Fairbanks JM, Pine DS, Tancer NK et al Open fluoxetine treatment of mixed anxiety disorders in children and adolescents. J. Child Adolesc fiychopharmacol7 (1), 17–29 (1997).
  • Hurst M, Lamb HM. Fluoxetine: a review of its use in anxiety disorders and mixed anxiety and depression. CNS Drug 14,51–80 (2000).
  • Sonawalla SB, Spillmann MK, Kolsky AR et al Efficacy of fluvoxamine in the treatment of major depression with comorbid anxiety disorders. J. Gun. Psychiatry60(9), 580–583 (1999).
  • Baldwin DS. SSRIs in the treatment of generalised anxiety disorder. In:SSRh in Depression andAnxiev Montgomery SA, den Boer JA (Eds). Wiley, Chichester, UK, 193–209 (2001).
  • •Review of evidence supporting use of SSRI in GAD treatment.
  • Rocca P, Fonzo V, Scotta M et al Paroxetine efficacy in the treatment of generalized anxiety disorder. Acta Psychiatr Scaml 95, 444–450 (1997).
  • Pollack MET, Zaninelli R, Goddard A et al Paroxetine in the treatment of generalized anxiety disorder: results of a placebo-controlled, flexible-dosage trial. j Clin. Psychiatry62, 350–357 (2001).
  • ••Key study showing that SSRI treatmentcan be effective in GAD.
  • Stocchi G, Nordera G, Jokinen RII et al Continued benefit of long-term paroxetine treatment for generalised anxiety disorder. Int. .1. Neuropsychopharmacol 5 (Suppl. 1), S213 (2002).
  • Allgulander C, Cloninger CR, Przybeck TR, Brandt L. Changes on the temperament and character inventory after paroxetine treatment in volunteers with generalized anxiety disorder. PFchopharmacol Bull 34(2), 165–166 (1998).
  • Baldwin DS, McCafferty J, Bellew K et al Improving the disability and impairment associated with generalised anxiety disorder with paroxetine treatment. int. J. Neuropsychopharmacol 5 (Suppl. 1), S213 (2002).
  • Fontaine R, Ontiveros A, Elie R et al. Double- blind comparison of nefazodone, imipramine and placebo in major depression. j Gun. Psychiatry55, 234–241 (1994).
  • Hedges DW, Reimherr FW, Strong RE et al An open trial of nefazodone in adult patients with generalised anxiety disorder. PFchopharmacol Bull 32,671–676 (1996).
  • Feighner JP, Entsuah AR, McPherson MK. Efficacy of once-daily venlafaxine extended release (XR) for symptoms of anxiety in depressed out-patients. J. Affect. Disord. 47, 55–62 (1998).
  • Davidson JR, DuPont RL, Hedges D et al Efficacy, safety and tolerability of venlafaxine extended release and buspirone in out-patients with generalised anxiety disorder. J. Gun. Psychiatry 60,528–530 (1999).
  • Rickels K, Pollack M, Sheehan D et al Efficacy of venlafaxine extended-release (XR) capsules in nondepressed out-patients with generalised anxiety disorder. Am. J. Psychiatry 157,968–974 (2000).
  • Salinas E. Placebo-controlled evidence for the use of antidepressants in generalised anxiety disorder. Eur. Neuropsychopharmacol 9\(Suppl. 5), S176 (1999).
  • Hackett D, Meoni P, White C et al. Efficacy of short and long-term venlafaxine ER treatment for somatic and psychic symptoms of GAD. Eur. Neuropsychopharmacol 10\(Suppl. 10), S337 (2000).
  • Gelenberg AJ, Lydiard RB, Rudolph RL et al Efficacy of venlafaxine extended-release capsules in nondepressed out-patients with generalised anxiety disorder. JÁ MA 283,3082–3088 (2000).
  • Allgulander C, Hackett D, Salinas E. Venlafaxine extended release (ER) in the treatment of generalised anxiety disorder: twenty-four-week placebo-controlled dose-ranging study. Br. J. fiychiatry179,15–22 (2001).
  • Sitsen JMA, Moors J. Mirtazapine, a novel antidepressant, in the treatment of anxiety symptoms: results from a placebo-controlled trial. Drug- Invest. 8,339–344 (1994).
  • Fawcett J, Barkin RL. Meta-analysis of eight randomised, double-blind, controlled trials of mirtazapine, a novel antidepressant drug.j Clin. Psychiatry 59,123–127 (1998).
  • Goa KL, Ward A. Buspirone: a preliminary review of its pharmacological properties and therapeutic efficacy as an anxiolytic. Drugs 32,114–129 (1986).
  • Goldberg HL, Finnerty RJ. The comparative efficacy of buspirone and diazepam in the treatment of anxiety. Am. J. fiychiatry 136,1184–1187 (1979).
  • Gammans RE, Stringfellow JC, Hvidzos AJ et al Use of buspirone in patients with generalised anxiety disorder and coexisting depressive symptoms: a meta-analysis of eight randomised controlled trials. Neuropsychobiol 25,193–201 (1992).
  • Sramek JJ, Tansman M, Sun i etal. Efficacy of buspirone in generalised anxiety disorder with coexisting mild depressive symptoms. J. Clin. Psychiatry 57,287–291 (1996).
  • Ansseau M, Papart P, Gerard MAA et al Controlled comparison of buspirone and oxazepam in generalised anxiety. Neuropsychobiol 24,74–78 (1990).
  • Rickets K, Schweizer E. The spectrum of generalised anxiety in clinical practice: the role of short-term, intermittent treatment. Br. Psychiatry173\(Suppl. 34), 49–54 (1998).
  • Bradford LD, Stevens G. Double-blind, placebo-controlled fixed dose study of flesinoxan in generalized anxiety disorder. Am. Coll Neumpsychopharmacol 167.
  • Gould RA, Otto MW, Pollack MH et al Cognitive behavioural and pharmacological treatment of generalised anxiety disorder: a preliminary meta-analysis. Behar/. Ther. 28, 285–305 (1997).
  • Lader MET. Limitations on the use of benzodiazepines in anxiety and insomnia: are they justified? Eur Neuropsychopharmacol 9(Suppl. 9), S399—S405 (1999).
  • •• Highlights the potential drawbacks of benzodiazepine treatment of anxiety
  • Argyropoulos SV, Nutt DJ. The use of benzodiazepines in anxiety and other disorders. Eur Neuropsychophatmacol 9\(Suppl. 9), S407—S412 (1999).
  • ••Argues that benzodiazepines should not bewithheld from chronically ill, substantially disabled patients.
  • Aufdembrinke B. Abercarnil, a new beta- carboline, in the treatment of anxiety disorders. Br. PTchiatry173,55–63 (1998).
  • Ballenger JC, McDonald S, Noyes R et al The first double-blind placebo-controlled trial of a partial BZD agonists abercamil (ZK-112-119) in generalised anxiety disorder. fiychophatmacol Bull. 27,171–179 (1991).
  • Lydiard RB, Ballenger JC, Rickels K. A double-blind evaluation of the safety and efficacy of abercarnil, alprazolam and placebo in out-patients with generalised anxiety disorder. J. Clin. Psychiatry 58\(Suppl. 11), 11–18 (1997).
  • Pollack MH, Worthington JH, Manfro GG et al. Abercarnil for the treatment of generalised anxiety disorder: a placebo-controlled comparison of two dose ranges of abercarnil and buspirone. j Clin. fiychMtry58\(Suppl. 11), 19–23 (1997).
  • Small GW, Bystritsky A. Double-blind, placebo-controlled trial of two doses of abercarnil for geriatric anxiety. j Clin. fiychMtry58\(Suppl. 11), 24–29 (1997).
  • Adams JB, Pyke RE, Costa J et al. A double-blind, placebo-controlled study of a CCK-B antagonist, CIO-988, in patients with generalised anxiety disorder. J. Clin. fiychophatmacol 15,428–434 (1995).
  • Field MJ, Oles RJ, Singh L. Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activity. BE J. Pharmacol 132,1–4 (2001).
  • •Description of the preclinical and pharmacological properties of a promising compound for the treatment of GAD.
  • Pande AC, Crockatt JG, Janney C etal. Pregabalin, a novel agent, in the treatment of generalized anxiety disorder. Presented at American Psychiatric Association, San Diego, USA, May 2000.
  • Rickets K, Pollack MET, Lydiard RB et al Comparison of the efficacy and safety of pregabalin and alprazolam in generalised anxiety disorder. Int. J. NeuropTchophalmacol 5 (Suppl. 1), S213 (2002).
  • Gould RA, Otto MW, Pollack MH, Yap L. Cognitive behavioural and pharmacological treatment of generalised anxiety disorder: a preliminary meta-analysis. Behar/. Ther. 28, 285–305 (1997).
  • Durham RC, Fisher PL, Trevling LR et al One year follow-up of cognitive therapy, analytic psychotherapy and anxiety management training for generalised anxiety disorder: symptom change, medication usage and attitudes to treatment. Behav. Consult. fiychother. 27, 19–35 (1999).
  • Lader MH, Bond AJ. Interaction of pharmacological and psychological treatments of anxiety. BE J. fiychiatry 173\(Suppl. 34), 42–48 (1998).
  • Durham RC, Turvey AA. Cognitive therapy versusbehaviour therapy in the treatment of chronic generalised anxiety. fkhav. Res. Ther. 25,229–234 (1987).
  • Wardle J. Behaviour therapy and benzodiazepines: allies or antagonists? BE J. Psychiatry 156,163–168 (1990).
  • Power KG, Simpson RJ, Swanson V et al A controlled comparison of cognitive-behaviour therapy, diazepam and placebo, alone and in combination, for the treatment of generalised anxiety disorder. J. Anx. Dis. 4,267–292 (1990).
  • Keller MB, McCullough JP, Klein DN et al. A comparison of nefazodone, the cognitive-behavioural analysis system of psychotherapy and their combination for the treatment of chronic depression. N Engl. Med. 342,1462–1470 (2000).
  • Barlow DH, Gorman JM, Shear MK, Woods SW Cognitive-behavioural therapy, imipramine, or their combination for panic disorder: a randomized controlled trial. JA/V/A 283,2529–2536 (2000).
  • ECNP Consensus meeting, March 2000. Guidelines for investigating efficacy in GAD. Eur Neuropsychophalmacol 12,81-87 (2002).
  • ••The most recent guidelines for evaluatingefficacy in GAD treatment.

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