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Review

Immunotherapy for epilepsy

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Pages 809-814 | Published online: 10 Jan 2014

References

  • Rogers SW, Andrews PI, Gahring LC et al. 1994. Autoantibodies to glutamate receptor G1uR3 in Rasmussen's encephalitis. Science 265, 648-651 (1994).
  • ••First report that immunization of rabbitswith GiuR3 produced epileptic seizures and inflammatory histopathology mimicking human RE. Since then, however, no study in any species has reproduced the finding that GiuR3 immunization causes epilepsy.
  • Rasmussen T, Olszweski J, Lloyd-Smith DL. Focal seizures due to chronic localized encephalitis. Neurology 8, 435–445 (1958).
  • •Why Rasmussen's is an eponymous syndrome.
  • Meldrum BS. The role of glutamate in epilepsy and other CNS disorders. Neurology44\(Suppl. 8), S14-523 (1994).
  • Chapman AG. Glutamate receptors in epilepsy. Prog. Brain Res. 116, 371–383 (1998).
  • Bernasconi P, Baggi F, Antozzi C et al. Anti-glutamate receptor 3 (G1uR3) antibodies: frequency and association with epilepsy. j NeuroimmunoL 118, 140 (2001). Abstract.
  • Bernasconi P, Passerini L, Baggi, F eta]. Anti- glutamate receptor 3 antibodies seem to be associated with severe forms of epilepsy rather than with Rasmussen's encephalitis. AutoimmuniO, Rev 1, 70 (2002).
  • Watson R, Beeson D, Bermudez I et al. Autoantibodies in Rasmussen's encephalitis. Autoimmunity Rev. 1, 70 (2002).
  • Wiendl H, Bien CG, Bernasconi P et al. G1uR3 antibodies: Prevalence in focal epilepsy but no specificity for Rasmussen's encephalitis. Neurology 57, 1511–1514 (2001).
  • Gahring LC, Twyman RE, Greenlee JE, Rogers SW Autoantibodies to neuronal glutamate receptors in patients with paraneoplastic neurodegenerative syndrome enhance receptor activation. MoL Med. 1, 245–253 (1995).
  • Gahring LC, Rogers SW, Twyman RE. Autoantibodies to glutamate receptor subunit G1uR2 in nonfamilial olivopontocerebellar degeneration. Neurology 48, 494–500 (1997).
  • Sillevis Smitt P, Kinoshita A, De Leeuw B et al. Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. N Engl. j Med. 342, 21–27 (2000).
  • Dambinova SA, Izykenova GA, Burov SV eta]. The presence of autoantibodies to N-terminus domain of G1uR1 subunit of AMPA receptor in the blood serum of patients with epilepsy. j NeuroL Sci. 152, 93 (1997).
  • DeGiorgio LA, Konstantinov KN, Lee SC et al. A subset of lupus antiDNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat. Med. 7, 1189–1193 (2001).
  • Twyman RE, Gahring LC, Spiess J eta]. Glutamate receptor antibodies activate a subset of receptors and reveal an agonist binding site. Neuron 14, 755–762 (1995).
  • ••First demonstration that antiGluR3antibodies can act as glutamate agonists, activate GluR and evoke ion currents. Based on these observations, it was suggested that antiGluR3 antibodies can mimic the actions of excess glutamate and cause excitotoxic neuronal death.
  • Levite M, Fleidervish IA, Schwarz A eta]. Autoantibodies to the glutamate receptor kill neurons via activation of the receptor ion channel.' Autaimmun. 13, 61–72 (1999).
  • ••Only currently existing murine model forantiGluR3 immunity, which showed for the first time that purified antiGluR3 can kill neurons. Killing occurred via activation of GluR and was complement-independent. However, neuronal death did not lead to detectable epilepsy.
  • Koustova EY, Sei L, Fossom ML eta]. LP- BM5 virus-infected mice produce activating autoantibodies to the AMPA receptor. j Clin. Invest. 107, 737–744 (2001).
  • ••First solid evidence that a specific viralinfection led (by partial molecular mimicry) to the in vivo production of antiGluR antibodies that bound, activated and killed neurons.
  • Levite M, Hermelin A. Autoimmunity to the glutamate receptor in mice - a model for Rasmussen's encephalitis? j Autoimmun. 13, 73–82 (1999).
  • Whitney K, McNamara JO. G1uR3 autoantibodies destroy neural cells in a complement-dependent manner modulated by complement regulatory proteins. j Neurosci. 20(19), 7307–7316 (2000).
  • Gahring L, Carlson NG, Meyer EL eta]. Granzyme B proteolysis of a neuronal glutamate receptor generates an autoantigen and is modulated by glycosylation. j ImmunoL 166, 1433–1438 (2001).
  • ••Important and elegant study that showedfor the first time how the autoantigenic peptide, G1uR3B, can be cleaved from its parent GluR3 protein. This cleaved peptide may subsequently lead to the production of pathogenic antiGluR3B antibodies.
  • Li Y, Uccelli A, Laxer KD et al. Local-clonal expansion of infiltrating T lymphocytes in chronic encephalitis of Rasmussen. j ImmunoL 158, 1428–1437 (1997).
  • Prayson RA, Frater JL. Rasmussen encephalitis: a clinicopathologic and immunohistochemical study of seven patients. Am. J Clin. PathoL 117, 776–782 (2002).
  • Bien CG, Bauer J, Deckwerth TL eta]. Destruction of neurons by cytotoxic T cells: A new pathogenic mechanism in Rasmussen's encephalitis. Ann. NeuroL 311–318 (2002).
  • Neumann H, Medana IM, Bauer J et aL Cytotoxic T-lymphocytes in autoimmune and degenerative CNS diseases. Trends Neurosci. 25, 313–319 (2002).
  • •Important review of the current evidence supporting the involvement of cytotoxic T-cells in several neurological diseases, including RE.
  • Archelos JJ, Hartung HP Pathogenetic role of autoantibodies in neurological diseases. Trends Neurosci. 23,317–327 (2000).
  • Levite M. Autoimmune epilepsy. Nat. ImmunoL 3, 500 (2002).
  • Dulac 0, Robain 0, Chiron C eta]. High-dose steroid treatment of epilepsia partialis continua due to chronic focal encephalitis. In:Chronic encephalitis and epilepsy - Rasmusvni syndrome. Andermann F (Ed.), Butterworth-Heinemann, Boston, USA, 193–199 (1991).
  • Hart YM, Cortez M, Andermann F eta]. Medical treatment of Rasmussen's syndrome (chronic encephalitis and epilepsy): effect of high-dose steroids or immunoglobulins in 19 patients. Neurology 44, 1030–1036 (1994).
  • ••Treatment guidelines based on one of theearliest and largest open-label studies of immunotherapy in RE.
  • Krauss GL, Campbell ML, Roche KW eta]. Chronic steroid-responsive encephalitis without autoantibodies to glutamate receptor G1uR3. Neurology 46, 247–249 (1996).
  • Andrews PI, Dichter MD, Berkovic SF eta]. Plasmapheresis in Rasmussen's encephalitis. Neurology 46, 242–246 (1996).
  • Antozzi C, Granata T, Aurisano 0 eta]. Long-term selective IgG irnmuno-adsorption improves Rasmussen's encephalitis. Neurology 51, 302–305 (1998).
  • Antozzi C, Granata T, Bernasconi P eta]. Apheresis and irnmunomodulatory treatments in Rasmussen's encephalitis: the Italian experience. AutoimmuniO, Rev 1, 24 (2002).
  • Leach JP, Chadwick DW, Miles JB et al. Improvement in adult-onset Rasmussen's encephalitis with long-term immunomodulatory therapy. Neurology 52, 738–742 (1999).
  • Hart IK, Chadwick DVV, Smith D. Adult Rasmussen's syndrome improves with immune therapy. Neuroimmund 118, 144 (2001).
  • Van Engelen BG, Renier WO, Weemaes CM et al. High-dose intravenous immunoglobulin treatment in cryptogenic West and Lennox-Gestaut syndrome; an add-on study. Eur j Pediat. 153, 762–769 (1994).
  • Van Rijckevorsel-Harmant K, Delire M, Rucquoy-Ponsar M. Treatment of idiopathic West and Lennox-Gestaut syndromes by iv. administration of human polyvalent inmmunoglobulins. Eur. Arch. Psych. NeuroL Sci. 236, 119–122 (1985).
  • Ariizumi M, Baba K, Hibio S et al. Immunoglobulin therapy in the West syndrome. Brain & Development 9, 422–425 (1987).
  • Duse M, Notarangelo LD, Tiberti S eta]. Intravenous immune globulin therapy in the treatment of intractable childhood epilepsy. Clin. Exp. Immunol 104 (51), 71–76 (1996).
  • •Review of the 29 studies of immunotherapy in 373 children with severe epilepsy that suggests useful improvement in 30-50% of cases.
  • Echenne B, Dulac 0, Parayre-Chanez MJ et aL treatment of infantile spasms with iv. gamma-globulins. Brain & Development 13, 313–319 (1991).
  • Lagae LG, Silberstein J, Gillis PL et al. Successful use of iv. immunoglobulins in Landau-Kleffner syndrome. Pediatr. NeuroL 18, 165–168 (1998).
  • Mikati MA, Saab R. Successful use of iv. immunoglobulin as initial monotherapy in Landau-Kleffner syndrome. Epilepsia 41, 880–886 (2000).
  • Palace J, Lang B. Epilepsy: an autoimmune disease? J NeuroL Neurosurg. Psychiatry 69, 711–714 (2000).
  • Bartolomei F, Boucraut J, Barrie M eta]. Cryptogenic partial epilepsies with antiGM1 antibodies: a new form of immune-mediated epilepsy? Epilepsia 37, 922–926 (1996).
  • Giometto B, Nicolao P, Macucci M et al. Temporal-lobe epilepsy associated with glutamic-acid-decarboxylase autoantibodies. Lancet (letter) 352, 457 (1998).
  • Lousa M, Sanchez-Alonsos S, Rodriguez-Diaz C et al. Status epilepticus with neuron-reactive serum antibodies: response to plasma exchange. Neurology54, 2163–2165 (2000).
  • Villani F, Avanzini G. The use of immunoglobulins in the treatment of human epilepsy. Neurol Sci. 23 (51), 533—S37 (2002).

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