The comorbidity of ADHD and autism spectrum disorder

References

• American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR(4th Edition). American Psychiatric Association, Washington, DC (2000).
   Google Scholar
• Barbaresi WJ, Katusic SK, Colligan RC et al. How common is attention-deficit/hyperactivity disorder? Incidence in a population-based birth cohort in Rochester, Minn. Arch. Pediatr. Adolesc. Med. 156(3), 217–224 (2002).
   PubMedGoogle Scholar
• Antshel KM, Barkley R. Developmental and behavioral disorders grown up: attention deficit hyperactivity disorder. J. Dev. Behav. Pediatr. 30(1), 81–90 (2009).
   PubMed Web of Science ®Google Scholar
• Kessler RC, Adler L, Barkley R et al. The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am. J. Psychiatry 163(4), 716–723 (2006).
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. In: Diagnostic and Statistical Manual of Mental Disorders (5th Edition). American Psychiatric Publishing, Washington, DC (2013).
   Google Scholar
• Mta Collaborative Group. A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD. Arch. Gen. Psychiatry 56(12), 1073–1086 (1999).
   PubMedGoogle Scholar
• Pliszka S. Practice parameter for the assessment and treatment of children and adolescents with attention-deficit/hyperactivity disorder. J. Am. Acad. Child Adolesc. Psychiatry 46(7), 894–921 (2007).
   PubMed Web of Science ®Google Scholar
• Van Lier PA, Van Der Ende J, Koot HM, Verhulst FC. Which better predicts conduct problems? The relationship of trajectories of conduct problems with ODD and ADHD symptoms from childhood into adolescence. J. Child Psychol. Psychiatry, and allied disciplines 48(6), 601–608 (2007).
   PubMed Web of Science ®Google Scholar
• Biederman J, Ball SW, Monuteaux MC et al. New insights into the comorbidity between ADHD and major depression in adolescent and young adult females. J. Am. Acad. Child Adolesc. Psychiatry 47(4), 426–434 (2008).
   PubMed Web of Science ®Google Scholar
• Carlson CL, Tamm L, Gaub M. Gender differences in children with ADHD, ODD, and co-occurring ADHD/ODD identified in a school population. J. Am. Acad. Child Adolesc. Psychiatry 36(12), 1706–1714 (1997).
   PubMed Web of Science ®Google Scholar
• Blanchard LT, Gurka MJ, Blackman JA. Emotional, developmental, and behavioral health of American children and their families: a report from the 2003 National Survey of Children’s Health. Pediatrics 117(6), e1202–e1212 (2006).
   PubMed Web of Science ®Google Scholar
• Dupaul G, Stoner G. ADHD In The Schools: Assessment And Intervention Strategies. Guilford Press, NY, USA (2003).
   Google Scholar
• Goldstein S, Schwebach AJ. The comorbidity of pervasive developmental disorder and attention deficit hyperactivity disorder: results of a retrospective chart review. J. Autism Dev. Disord. 34(3), 329–339 (2004).
   PubMed Web of Science ®Google Scholar
• Sturm H, Fernell E, Gillberg C. Autism spectrum disorders in children with normal intellectual levels: associated impairments and subgroups. Dev Med. Child Neurol. 46(7), 444–447 (2004).
   PubMed Web of Science ®Google Scholar
• Yoshida Y, Uchiyama T. The clinical necessity for assessing Attention Deficit/Hyperactivity Disorder (AD/HD) symptoms in children with high-functioning Pervasive Developmental Disorder (PDD). Eur Child Adolesc. Psychiatry 13(5), 307–314 (2004).
   PubMed Web of Science ®Google Scholar
• Ehlers S, Gillberg C. The epidemiology of Asperger syndrome. A total population study. J. Child Psychol. Psychiatry 34(8), 1327–1350 (1993).
   PubMed Web of Science ®Google Scholar
• Yoshida Y, Uchiyama T. The clinical necessity for assessing attention deficit/hyperactivity disorder (AD/HD) symptoms in children with high-functioning pervasive developmental disorder (PDD). Eur Child Adolesc. Psychiatry 13(5), 307–314 (2004).
   PubMed Web of Science ®Google Scholar
• Leyfer OT, Folstein SE, Bacalman S et al. Comorbid psychiatric disorders in children with autism: interview development and rates of disorders. J. Autism Dev. Disord. 36(7), 849–861 (2006).
   PubMed Web of Science ®Google Scholar
• Keen D, Ward S. Autistic spectrum disorder. Autism 8(1), 39–48 (2004).
   PubMed Web of Science ®Google Scholar
• Sturm H, Fernell E, Gillberg C. Autism spectrum disorders in children with normal intellectual levels: Associated impairments and subgroups. Dev. Med.Child Neurol. 46(7), 444–447 (2004).
   PubMed Web of Science ®Google Scholar
• Goldstein S, Schwebach AJ. The comorbidity of pervasive developmental disorder and attention deficit hyperactivity disorder: Results of a retrospective chart review. J. Autism Dev. Disord. 34(3), 329–339 (2004).
   PubMed Web of Science ®Google Scholar
• Frazier JA, Biederman J, Bellordre CA et al. Should the diagnosis of attention-deficit/hyperactivity disorder be considered in children with pervasive developmental disorder? J. Attention Disord. 4(4), 203–211 (2001).
   Google Scholar
• Ghaziuddin M, Tsai LY, Alessi N. ADHD and PDD. J. Am. Acad. Child Adolesc. Psychiatry 31(3) 567 (1992).
   PubMedGoogle Scholar
• Sinzig J, Walter D, Doepfner M. Attention deficit/hyperactivity disorder in children and adolescents with autism spectrum disorder: symptom or syndrome? J. Atten. Disord. 13(2), 117–126 (2009).
   PubMed Web of Science ®Google Scholar
• Gjevik E, Eldevik S, Fjaeran-Granum T, Sponheim E. Kiddie-SADS reveals high rates of DSM-IV disorders in children and adolescents with autism spectrum disorders. J. Autism Dev. Disord. 41(6), 761–769 (2011).
   PubMedGoogle Scholar
• Dupaul GJ, Ervin RA, Hook CL, Mcgoey KE. Peer tutoring for children with attention deficit hyperactivity disorder: Effects on classroom behavior and academic performance. J. Appl. Behav. Anal. 31(4), 579–592 (1998).
   PubMed Web of Science ®Google Scholar
• Biederman J, Mick E, Faraone SV. Age-dependent decline of symptoms of attention deficit hyperactivity disorder: Impact of remission definition and symptom type. Am. J. Psychiatry 157(5), 816–818 (2000).
   PubMed Web of Science ®Google Scholar
• Sinzig J, Walter D, Doepfner M. Attention deficit/hyperactivity disorder in children and adolescents with autism spectrum disorder: Symptom or syndrome? J. Atten. Disord. 13(2), 117–126 (2009).
   PubMed Web of Science ®Google Scholar
• Lee DO, Ousley OY. Attention-deficit hyperactivity disorder symptoms in a clinic sample of children and adolescents with pervasive developmental disorders. J. Child Adolesc. Psychopharmacol. 16(6), 737–746 (2006).
   PubMedGoogle Scholar
• Pearson DA, Aman MG, Arnold LE et al. High concordance of parent and teacher attention-deficit/hyperactivity disorder ratings in medicated and unmedicated children with autism spectrum disorders. J. Child Adolesc. Psychopharmacol. 22(4), 284–291 (2012).
   PubMedGoogle Scholar
• Dupaul G, Power T, Anastopoulos A. Adhd Rating Scale-IV: Checklists, Norms, and Clinical Interpretation. Guilford Press, New York (1998).
   Google Scholar
• Muhle R, Trentacoste SV, Rapin I. The genetics of autism. Pediatrics 113(5), e472–e486 (2004).
   PubMed Web of Science ®Google Scholar
• Faraone SV, Biederman J. Neurobiology of attention-deficit hyperactivity disorder. Biol. Psychiatry 44(10), 951–958 (1998).
   PubMed Web of Science ®Google Scholar
• Faraone SV, Mick E. Molecular genetics of attention deficit hyperactivity disorder. Psychiatric Clin. North Am. 33(1), 159–180 (2010).
   PubMed Web of Science ®Google Scholar
• Mick E, Faraone SV. Genetics of attention deficit hyperactivity disorder. Child Adolesc. Psychiatr. Clin. North Am. 17(2), 261–284, vii–viii (2008).
   PubMedGoogle Scholar
• Faraone SV, Perlis RH, Doyle AE et al. Molecular genetics of attention-deficit/hyperactivity disorder. Biol. Psychiatry 57(11), 1313–1323 (2005).
   PubMed Web of Science ®Google Scholar
• Bailey A, Le Couteur A, Gottesman I et al. Autism as a strongly genetic disorder: evidence from a British twin study. Psychol. Med. 25(1), 63–77. (1995).
   PubMed Web of Science ®Google Scholar
• Smalley SL, Kustanovich V, Minassian SL et al. Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism. Am. J. Hum. Gene. 71(4), 959–963 (2002).
   PubMedGoogle Scholar
• Bakker SC, Van Der Meulen EM, Buitelaar JK et al. A whole-genome scan in 164 Dutch sib pairs with attention-deficit/hyperactivity disorder: suggestive evidence for linkage on chromosomes 7p and 15q. Am. J. Hum. Genet. 72(5), 1251–1260 (2003).
   PubMedGoogle Scholar
• Fisher SE, Francks C, Mccracken JT et al. A genomewide scan for loci involved in attention-deficit/hyperactivity disorder. Am. J. Hum. Gene. 70(5), 1183–1196 (2002).
   PubMedGoogle Scholar
• Ogdie MN, Macphie IL, Minassian SL et al. A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11. Am. J. Hum. Genet. 72(5), 1268–1279 (2003).
   PubMedGoogle Scholar
• Nijmeijer JS, Arias-Vasquez A, Rommelse NN et al. Identifying loci for the overlap between attention-deficit/hyperactivity disorder and autism spectrum disorder using a genome-wide QTL linkage approach. J. Am. Acad. Child Adolesc. Psychiatry 49(7), 675–685 (2010).
   PubMed Web of Science ®Google Scholar
• Rommelse NN, Franke B, Geurts HM, Hartman CA, Buitelaar JK. Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder. Eur. Child Adolesc. Psychiatry 19(3), 281–295 (2010).
   PubMed Web of Science ®Google Scholar
• Vorstman JA, Ophoff RA. Genetic causes of developmental disorders. Curr. Opin. Neurol. 26(2), 128–136 (2013).
   PubMed Web of Science ®Google Scholar
• Farzin F, Perry H, Hessl D et al. Autism spectrum disorders and attention-deficit/hyperactivity disorder in boys with the fragile X premutation. J. Dev. Behav. Pediatr. 27(2 Suppl. 2), S137–S144 (2006).
   Google Scholar
• Niklasson L, Rasmussen P, Oskarsdottir S, Gillberg C. Autism, ADHD, mental retardation and behavior problems in 100 individuals with 22q11 deletion syndrome. Res. dev. Disabil. 30(4), 763–773 (2009).
   PubMedGoogle Scholar
• Miller DT, Shen Y, Weiss LA et al. Microdeletion/duplication at 15q13.2q13.3 among individuals with features of autism and other neuropsychiatric disorders. J. Med. Genet. 46(4), 242–248 (2009).
   PubMedGoogle Scholar
• Williams NM, Franke B, Mick E et al. Genome-wide analysis of copy number variants in attention deficit hyperactivity disorder: the role of rare variants and duplications at 15q13.3. Am. J. Psychiatry 169(2), 195–204 (2012).
   PubMed Web of Science ®Google Scholar
• Sebat J, Lakshmi B, Malhotra D et al. Strong association of de novo copy number mutations with autism. Science 316(5823), 445–449 (2007).
   PubMed Web of Science ®Google Scholar
• Williams NM, Zaharieva I, Martin A et al. Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: a genome-wide analysis. Lancet 376(9750), 1401–1408 (2010).
   PubMed Web of Science ®Google Scholar
• Gadow KD, Nolan EE, Sverd J, Sprafkin J, Schneider J. Methylphenidate in children with oppositional defiant disorder and both comorbid chronic multiple tic disorder and ADHD. J. Child Neurol. 23(9), 981–990 (2008).
   PubMedGoogle Scholar
• Gizer IR, Ficks C, Waldman ID. Candidate gene studies of ADHD: a meta-analytic review. Hum. Genet. 126(1), 51–90 (2009).
   PubMed Web of Science ®Google Scholar
• Sinzig J, Lehmkuhl G. What do we know about the serotonergic genetic heterogeneity in attention-deficit/hyperactivity and autistic disorders? Psychopathology 40(5), 329–337 (2007).
   PubMedGoogle Scholar
• Smoller JW, Craddock N, Kendler K et al. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 381(9875), 1371–1379 (2013).
   PubMed Web of Science ®Google Scholar
• Nieoullon A. Dopamine and the regulation of cognition and attention. Prog. Neurobiol. 67(1), 53–83 (2002).
   PubMed Web of Science ®Google Scholar
• Yang Y, Pan C. Role of metabotropic glutamate receptor 7 in autism spectrum disorders: a pilot study. Life Sci. 92(2), 149–153 (2013).
   PubMedGoogle Scholar
• Elia J, Glessner JT, Wang K et al. Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nat. Genet. 44(1), 78–84 (2011).
   PubMed Web of Science ®Google Scholar
• Wang GX, Ma YH, Wang SF, Ren GF, Guo H. Association of dopaminergic/GABAergic genes with attention deficit hyperactivity disorder in children. Mol. Med. Rep. 6(5), 1093–1098 (2012).
   PubMedGoogle Scholar
• Piton A, Jouan L, Rochefort D et al. Analysis of the effects of rare variants on splicing identifies alterations in GABA(A) receptor genes in autism spectrum disorder individuals. Eur. J. Hum. genet. (2012).
   Google Scholar
• Marshall CR, Noor A, Vincent JB et al. Structural variation of chromosomes in autism spectrum disorder. Am. J. Hum. Genet. 82(2), 477–488 (2008).
   PubMed Web of Science ®Google Scholar
• Glessner JT, Wang K, Cai G et al. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature 459(7246), 569–573 (2009).
   PubMed Web of Science ®Google Scholar
• Lesch KP, Timmesfeld N, Renner TJ et al. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. J. Neural Trans. 115, 1573–1585 (2008).
   PubMed Web of Science ®Google Scholar
• Banaschewski T, Becker K, Scherag S, Franke B, Coghill D. Molecular genetics of attention-deficit/hyperactivity disorder: an overview. Eur. Child Adolesc. Psychiatry 19(3), 237–257 (2010).
   PubMed Web of Science ®Google Scholar
• Conner AC, Kissling C, Hodges E et al. Neurotrophic factor-related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high-risk male population. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B(8), 1476–1480 (2008).
   PubMedGoogle Scholar
• Shinawi M, Sahoo T, Maranda B et al. 11p14.1 microdeletions associated with ADHD, autism, developmental delay, and obesity. Am. J. Med. Genet. A. 155A(6), 1272–1280 (2011).
   PubMedGoogle Scholar
• Konrad K, Eickhoff SB. Is the ADHD brain wired differently? A review on structural and functional connectivity in attention deficit hyperactivity disorder. Hum. Brain Mapp. 31(6), 904–916 (2010).
   PubMed Web of Science ®Google Scholar
• Plessen KJ, Bansal R, Zhu H et al. Hippocampus and amygdala morphology in attention-deficit/hyperactivity disorder. Arch. Gen. Psychiatry 63(7), 795–807 (2006).
   PubMed Web of Science ®Google Scholar
• Ecker C, Suckling J, Deoni SC et al. Brain anatomy and its relationship to behavior in adults with autism spectrum disorder: a multicenter magnetic resonance imaging study. Arch. Gen. Psychiatry 69(2), 195–209 (2012).
   PubMed Web of Science ®Google Scholar
• Jou RJ, Jackowski AP, Papademetris X, Rajeevan N, Staib LH, Volkmar FR. Diffusion tensor imaging in autism spectrum disorders: preliminary evidence of abnormal neural connectivity. Aust. NZ J. Psychiatry 45(2), 153–162 (2011).
   PubMed Web of Science ®Google Scholar
• Clegg J, Gillott A, Jones J. Conceptual issues in neurodevelopmental disorders: lives out of synch. Curr. opin. Psychiatry 26(3), 289–294 (2013).
   PubMedGoogle Scholar
• Garg S, Lehtonen A, Huson SM et al. Autism and other psychiatric comorbidity in neurofibromatosis type 1: evidence from a population-based study. Dev. Med. Child Neurol. 55(2), 139–145 (2013).
   PubMedGoogle Scholar
• Lo-Castro A, D’agati E, Curatolo P. ADHD and genetic syndromes. Brain Dev. 33(6), 456–461 (2010).
   PubMedGoogle Scholar
• Gutierrez GC, Smalley SL, Tanguay PE. Autism in tuberous sclerosis complex. J. Autism. Dev. Disord. 28(2), 97–103 (1998).
   PubMedGoogle Scholar
• Kehrer-Sawatzki H, Vogt J, Mussotter T, Kluwe L, Cooper DN, Mautner VF. Dissecting the clinical phenotype associated with mosaic type-2 NF1 microdeletions. Neurogenetics 13(3), 229–236 (2012).
   PubMedGoogle Scholar
• Buxbaum JD, Cai G, Chaste P et al. Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly. Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B(4), 484–491 (2007).
   PubMedGoogle Scholar
• Mcbride KL, Varga EA, Pastore MT et al. Confirmation study of PTEN mutations among individuals with autism or developmental delays/mental retardation and macrocephaly. Autism Res. 3(3), 137–141 (2010).
   PubMedGoogle Scholar
• Neves-Pereira M, Muller B, Massie D et al. Deregulation of EIF4E: a novel mechanism for autism. J. Med. Genet. 46(11), 759–765 (2009).
   PubMedGoogle Scholar
• Lai ZW, Hanczko R, Bonilla E et al. N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 64(9), 2937–2946 (2012).
   PubMed Web of Science ®Google Scholar
• Garcia RJ, Francis L, Dawood M, Lai ZW, Faraone SV, Perl A. Brief report: attention deficit and hyperactivity disorder scores are elevated and respond to N-acetylcysteine treatment in patients with systemic lupus erythematosus. Arthritis Rheum. 65(5), 1313–1318 (2013).
   PubMedGoogle Scholar
• Bradstreet JJ, Smith S, Baral M, Rossignol DA. Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder. Altern. Med. Rev. 15(1), 15–32 (2010).
   PubMedGoogle Scholar
• Marazziti D, Baroni S, Picchetti M et al. Psychiatric disorders and mitochondrial dysfunctions. Eur. Rev. Med. Pharmacol. Sci. 16(2), 270–275 (2012).
   PubMed Web of Science ®Google Scholar
• Hultman CM, Sparen P, Cnattingius S. Perinatal risk factors for infantile autism. Epidemiology 13(4), 417–423 (2002).
   PubMedGoogle Scholar
• Langley K, Rice F, Van Den Bree MB, Thapar A. Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour. A review. Minerva. Pediatr. 57(6), 359–371 (2005).
   PubMedGoogle Scholar
• Winneke G. Developmental aspects of environmental neurotoxicology: lessons from lead and polychlorinated biphenyls. J. Neurol. Sci. 308(1–2), 9–15 (2011).
   PubMedGoogle Scholar
• Williams JH, Ross L. Consequences of prenatal toxin exposure for mental health in children and adolescents: a systematic review. Eur. Child Adolesc. Psychiatry 16(4), 243–253 (2007).
   PubMed Web of Science ®Google Scholar
• Zhang X, Lv CC, Tian J et al. Prenatal and perinatal risk factors for autism in China. J. Autism Dev. Disord. 40(11), 1311–1321 (2010).
   PubMed Web of Science ®Google Scholar
• Messer A. Mini-review: polybrominated diphenyl ether (PBDE) flame retardants as potential autism risk factors. Physiol. Behav. 100(3), 245–249 (2010).
   PubMed Web of Science ®Google Scholar
• Gascon M, Vrijheid M, Martinez D et al. Effects of pre and postnatal exposure to low levels of polybromodiphenyl ethers on neurodevelopment and thyroid hormone levels at 4 years of age. Environ. Int. 37(3), 605–611 (2011).
   PubMedGoogle Scholar
• Roman GC. Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents. J. Neurol. Sci. 262(1–2), 15–26 (2007).
   PubMed Web of Science ®Google Scholar
• Williams GR. Neurodevelopmental and neurophysiological actions of thyroid hormone. J. Neuroendocrinol. 20(6), 784–794 (2008).
   PubMed Web of Science ®Google Scholar
• Lima FR, Trentin AG, Rosenthal D, Chagas C, Moura Neto V. Thyroid hormone induces protein secretion and morphological changes in astroglial cells with an increase in expression of glial fibrillary acidic protein. J. Endocrinol. 154(1), 167–175 (1997).
   PubMedGoogle Scholar
• Oppenheimer JH, Schwartz HL. Molecular basis of thyroid hormone-dependent brain development. Endocr. Rev. 18(4), 462–475 (1997).
   PubMed Web of Science ®Google Scholar
• Weiss RE, Stein MA, Trommer B, Refetoff S. Attention-deficit hyperactivity disorder and thyroid function. J. Pediatr. 123(4), 539–545 (1993).
   PubMed Web of Science ®Google Scholar
• De Cock M, Maas YG, Van De Bor M. Does perinatal exposure to endocrine disruptors induce autism spectrum and attention deficit hyperactivity disorders? Review. Acta Paediatr. 101(8), 811–818 (2012).
   PubMedGoogle Scholar
• Schendel D, Bhasin TK. Birth weight and gestational age characteristics of children with autism, including a comparison with other developmental disabilities. Pediatrics 121(6), 1155–1164 (2008).
   PubMed Web of Science ®Google Scholar
• Mick E, Biederman J, Prince J, Fischer MJ, Faraone SV. Impact of low birth weight on attention-deficit hyperactivity disorder. J. Dev. Behav. Pediatr. 23(1), 16–22 (2002).
   PubMedGoogle Scholar
• Botting N, Powls A, Cooke RW, Marlow N. Attention deficit hyperactivity disorders and other psychiatric outcomes in very low birthweight children at 12 years. J. Child Psychol. Psychiatry 38(8), 931–941 (1997).
   PubMed Web of Science ®Google Scholar
• Johnson S, Hollis C, Kochhar P, Hennessy E, Wolke D, Marlow N. Autism spectrum disorders in extremely preterm children. J. Pediatr. 156(4), 525–531 e522 (2010).
   PubMed Web of Science ®Google Scholar
• Indredavik MS. Extremely preterm children at increased risk of autism spectrum disorders. Evid. Based Ment. Health 13, 92 (2010).
   PubMedGoogle Scholar
• Bhutta AT, Cleves MA, Casey PH, Cradock MM, Anand KJ. Cognitive and behavioral outcomes of school-aged children who were born preterm: a meta-analysis. JAMA 288(6), 728–737 (2002).
   PubMed Web of Science ®Google Scholar
• Sullivan EL, Nousen L, Chamlou K. Maternal high fat diet consumption during the perinatal period programs offspring behavior. Physiol. Behav. doi:10.1016/j.physbeh.2012.07.014 (2012) ( Epub ahead of print).
   Google Scholar
• Ronald A, Pennell CE, Whitehouse AJ. Prenatal maternal stress associated with ADHD and autistic traits in early childhood. Front. Psychol. 1, 223 (2010).
   PubMedGoogle Scholar
• Dasbanerjee T, Middleton FA, Berger DF, Lombardo JP, Sagvolden T, Faraone SV. A comparison of molecular alterations in environmental and genetic rat models of ADHD: A pilot study. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B(8), 1554–1563 (2008).
   PubMedGoogle Scholar
• Carney RM, Wolpert CM, Ravan SA et al. Identification of MeCP2 mutations in a series of females with autistic disorder. Pediatr. Neurol. 28(3), 205–211 (2003).
   PubMed Web of Science ®Google Scholar
• Amir RE, Van Den Veyver IB, Wan M, Tran CQ, Francke U, Zoghbi HY. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat. Genet. 23(2), 185–188 (1999).
   PubMed Web of Science ®Google Scholar
• Latham KE, Sapienza C, Engel N. The epigenetic lorax: gene-environment interactions in human health. Epigenomics 4(4), 383–402 (2012).
   PubMed Web of Science ®Google Scholar
• Keverne EB. Significance of epigenetics for understanding brain development, brain evolution and behaviour. Neuroscience doi:10.1016/j.neuroscience.2012.11.030 (2012) ( Epub ahead of print).
   Google Scholar
• Roth TL, Lubin FD, Funk AJ, Sweatt JD. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol. Psychiatry 65(9), 760–769 (2009).
   PubMed Web of Science ®Google Scholar
• Gadow KD, Roohi J, Devincent CJ, Kirsch S, Hatchwell E. Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder. J. Autism Dev. Disord. 39(11), 1542–1551 (2009).
   PubMedGoogle Scholar
• Nigg JT. Future Directions in ADHD Etiology Research. J. Clin. Child Adolesc. 41(2), 524–533 (2012).
   PubMedGoogle Scholar
• Shaw P, Eckstrand K, Sharp W et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proc. Natl Acad. Sci.USA 104(49), 19649–19654 (2007).
   PubMed Web of Science ®Google Scholar
• Hazlett HC, Poe MD, Gerig G et al. Early brain overgrowth in autism associated with an increase in cortical surface area before age 2 years. Arch. Gen. Psychiatry 68(5), 467–476 (2011).
   PubMed Web of Science ®Google Scholar
• Hardan AY, Libove RA, Keshavan MS, Melhem NM, Minshew NJ. A preliminary longitudinal magnetic resonance imaging study of brain volume and cortical thickness in autism. Biol. Psychiatry 66(4), 320–326 (2009).
   PubMed Web of Science ®Google Scholar
• Nigg JT, Blaskey LG, Huang-Pollock CL, Rappley MD. Neuropsychological executive functions and DSM-IV ADHD subtypes. J. Am. Acad. Child Adolesc. Psychiatry 41(1), 59–66 (2002).
   PubMed Web of Science ®Google Scholar
• Barkley RA. Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol. Bull 121(1), 65–94 (1997).
   PubMed Web of Science ®Google Scholar
• Russell J. Autism as an executive disorder. Oxford University Press, New York (1997).
   Google Scholar
• Ozonoff S, Jensen J. Brief report: specific executive function profiles in three neurodevelopmental disorders. J. Autism Dev. Disord. 29(2), 171–177 (1999).
   PubMed Web of Science ®Google Scholar
• Hill EL. Executive dysfunction in autism. Trends Cogn. Sci. 8(1), 26–32 (2004).
   PubMed Web of Science ®Google Scholar
• Nyden A, Gillberg C, Hjelmquist E, Heimann M. Executive function/attention deficits in boys with Asperger syndrome, attention disorder and reading/writing disorder. Autism 3, 213–228 (1999).
   Google Scholar
• Geurts HM, Verte S, Oosterlaan J, Roeyers H, Sergeant JA. How specific are executive functioning deficits in attention deficit hyperactivity disorder and autism? J. Child Psychol. Psychiatry 45(4), 836–854 (2004).
   PubMed Web of Science ®Google Scholar
• Johnson KA, Robertson IH, Kelly SP et al. Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention. Neuropsychologia 45(10), 2234–2245 (2007).
   PubMed Web of Science ®Google Scholar
• Happe F, Booth R, Charlton R, Hughes C. Executive function deficits in autism spectrum disorders and attention-deficit/hyperactivity disorder: examining profiles across domains and ages. Brain Cogn. 61(1), 25–39 (2006).
   PubMed Web of Science ®Google Scholar
• Sinzig J, Morsch D, Bruning N, Schmidt MH, Lehmkuhl G. Inhibition, flexibility, working memory and planning in autism spectrum disorders with and without comorbid ADHD-symptoms. Child Adolesc. Psychiatry Ment. Health 2(1), 4 (2008).
   PubMedGoogle Scholar
• Anholt GE, Cath DC, Van Oppen P et al. Autism and ADHD symptoms in patients with OCD: are they associated with specific OC symptom dimensions or OC symptom severity? J. Autism Dev. Disord. 40(5), 580–589 (2010).
   PubMed Web of Science ®Google Scholar
• Nyden A, Niklasson L, Stahlberg O et al. Adults with autism spectrum disorders and ADHD neuropsychological aspects. Res. Dev. Disabilities 31(6), 1659–1668 (2010).
   PubMed Web of Science ®Google Scholar
• Buitelaar JK, Van Der Wees M, Swaab-Barneveld H, Van Der Gaag RJ. Theory of mind and emotion-recognition functioning in autistic spectrum disorders and in psychiatric control and normal children. Dev. Psychopathol. 11(1), 39–58 (1999).
   PubMed Web of Science ®Google Scholar
• Brune M, Brune-Cohrs U. Theory of mind--evolution, ontogeny, brain mechanisms and psychopathology. Neurosci. Biobehav. Rev. 30(4), 437–455 (2006).
   PubMed Web of Science ®Google Scholar
• Clark T, Feehan C, Tinline C, Vostanis P. Autistic symptoms in children with attention deficit-hyperactivity disorder. Eur Child Adolesc. Psychiatry 8(1), 50–55 (1999).
   PubMed Web of Science ®Google Scholar
• Santosh PJ, Baird G, Pityaratstian N, Tavare E, Gringras P. Impact of comorbid autism spectrum disorders on stimulant response in children with attention deficit hyperactivity disorder: a retrospective and prospective effectiveness study. Child Care Health Dev. 32(5), 575–583 (2006).
   PubMed Web of Science ®Google Scholar
• Gillberg CL. The Emanuel Miller Memorial Lecture 1991. Autism and autistic-like conditions: subclasses among disorders of empathy. J. Child Psychol. Psychiatry 33(5), 813–842 (1992).
   PubMed Web of Science ®Google Scholar
• Dyck MJ, Ferguson K, Shochet IM. Do autism spectrum disorders differ from each other and from non-spectrum disorders on emotion recognition tests? Eur Child Adolesc. Psychiatry 10(2), 105–116 (2001).
   PubMed Web of Science ®Google Scholar
• Demurie E, Roeyers H, Baeyens D, Sonuga-Barke E. Common alterations in sensitivity to type but not amount of reward in ADHD and autism spectrum disorders. J. Child Psychol. Psychiatry 52(11), 1164–1173 (2011).
   PubMed Web of Science ®Google Scholar
• Buhler E, Bachmann C, Goyert H, Heinzel-Gutenbrunner M, Kamp-Becker I. Differential diagnosis of autism spectrum disorder and attention deficit hyperactivity disorder by means of inhibitory control and ‘theory of mind’. J. Autism Dev. Disord. 41(12), 1718–1726 (2011).
   PubMed Web of Science ®Google Scholar
• Jensen VK, Larrieu JA, Mack KK. Differential diagnosis between attention-deficit/hyperactivity disorder and pervasive developmental disorder--not otherwise specified. Clinical pediatrics 36(10), 555–561 (1997).
   PubMed Web of Science ®Google Scholar
• Luteijn EF, Serra M, Jackson S et al. How unspecified are disorders of children with a pervasive developmental disorder not otherwise specified? A study of social problems in children with PDD-NOS and ADHD. Eur Child Adolesc. Psychiatry 9(3), 168–179 (2000).
   PubMed Web of Science ®Google Scholar
• Hattori J, Ogino T, Abiru K, Nakano K, Oka M, Ohtsuka Y. Are pervasive developmental disorders and attention-deficit/hyperactivity disorder distinct disorders? Brain Dev. 28(6), 371–374 (2006).
   PubMed Web of Science ®Google Scholar
• Antshel KM, Remer R. Social skills training in children with attention deficit hyperactivity disorder: a randomized-controlled clinical trial. J. Clin. Child Adolesc. Psychol. 53 32(1), 152–165 (2003).
   PubMedGoogle Scholar
• Mulligan A, Anney RJ, O’regan M et al. Autism symptoms in attention-deficit/hyperactivity disorder: a familial trait which correlates with conduct, oppositional defiant, language and motor disorders. J. Autism Dev. Disord. 39(2), 197–209 (2009).
   PubMed Web of Science ®Google Scholar
• Reiersen AM, Constantino JN, Volk HE, Todd RD. Autistic traits in a population-based ADHD twin sample. J. Child Psychol. Psychiatry 48(5), 464–472 (2007).
   PubMed Web of Science ®Google Scholar
• Bishop DV, Baird G. Parent and teacher report of pragmatic aspects of communication: use of the children’s communication checklist in a clinical setting. Dev. Med. Child Neurol. 43(12), 809–818 (2001).
   PubMed Web of Science ®Google Scholar
• Geurts HM, Luman M, Van Meel CS. What’s in a game: the effect of social motivation on interference control in boys with ADHD and autism spectrum disorders. J. Child Psychol. Psychiatry 49(8), 848–857 (2008).
   PubMedGoogle Scholar
• Ames CS, White SJ. Are ADHD traits dissociable from the autistic profile? Links between cognition and behaviour. J. Autism Dev. Disord. 41(3), 357–363 (2011).
   PubMed Web of Science ®Google Scholar
• Grzadzinski R, Di Martino A, Brady E et al. Examining autistic traits in children with ADHD: does the autism spectrum extend to ADHD? J. Autism Dev. Disord. 41(9), 1178–1191 (2011).
   PubMed Web of Science ®Google Scholar
• Mayes SD, Calhoun SL, Mayes RD, Molitoris S. Autism and ADHD: overlapping and discriminating symptoms. Res. Autism Spectrum Disord. 6(1), 277–285 (2012).
   Web of Science ®Google Scholar
• Anckarsater H, Stahlberg O, Larson T et al. The impact of ADHD and autism spectrum disorders on temperament, character, and personality development. Am. J. Psychiatry 163(7), 1239–1244 (2006).
   PubMed Web of Science ®Google Scholar
• van der Meer JM, Oerlemans AM, Van Steijn DJ et al. Are autism spectrum disorder and attention-deficit/hyperactivity disorder different manifestations of one overarching disorder? Cognitive and symptom evidence from a clinical and population-based sample. J. Am. Acad. Child Adolesc. Psychiatry 51(11), 1160–1172 e1163 (2012).
   PubMed Web of Science ®Google Scholar
• Frazier TW, Shattuck PT, Narendorf SC, Cooper BP, Wagner M, Spitznagel EL. Prevalence and correlates of psychotropic medication use in adolescents with an autism spectrum disorder with and without caregiver-reported attention-deficit/hyperactivity disorder. J. Child Adolesc. Psychopharmacol. 21(6), 571–579 (2011).
   PubMedGoogle Scholar
• Handen BL, Taylor J, Tumuluru R. Psychopharmacological treatment of ADHD symptoms in children with autism spectrum disorder. Int. J. Adolesc. Med. Health 23(3), 167–173 (2011).
   PubMedGoogle Scholar
• Mcpheeters ML, Warren Z, Sathe N et al. A systematic review of medical treatments for children with autism spectrum disorders. Pediatrics 127(5), e1312–e1321 (2011).
   PubMed Web of Science ®Google Scholar
• Ghuman JK, Aman MG, Lecavalier L et al. Randomized, placebo-controlled, crossover study of methylphenidate for attention-deficit/hyperactivity disorder symptoms in preschoolers with developmental disorders. J. Child Adolesc. Psychopharmacol. 19(4), 329–339 (2009).
   PubMed Web of Science ®Google Scholar
• Quintana H, Birmaher B, Stedge D et al. Use of methylphenidate in the treatment of children with autistic disorder. J. Autism Dev. Disord. 25(3), 283–294 (1995).
   PubMed Web of Science ®Google Scholar
• Handen BL, Johnson CR, Lubetsky M. Efficacy of methylphenidate among children with autism and symptoms of attention-deficit hyperactivity disorder. J. Autism Dev. Disord. 30(3), 245–255 (2000).
   PubMed Web of Science ®Google Scholar
• Network RUOPPA. Randomized, controlled, crossover trial of methylphenidate in pervasive developmental disorders with hyperactivity. Arch. Gen. Psychiatry 62(11), 1266–1274 (2005).
   PubMedGoogle Scholar
• Birmaher B, Quintana H, Greenhill LL. Methylphenidate treatment of hyperactive autistic children. J. Am. Acad. Child Adolesc. Psychiatry 27(2), 248–251 (1988).
   PubMed Web of Science ®Google Scholar
• Strayhorn JM Jr., Rapp N, Donina W, Strain PS. Randomized trial of methylphenidate for an autistic child. J. Am. Acad. Child Adolesc. Psychiatry 27(2), 244–247 (1988).
   PubMed Web of Science ®Google Scholar
• Aman MG, Langworthy KS. Pharmacotherapy for hyperactivity in children with autism and other pervasive developmental disorders. J. Autism Dev. Disord. 30(5), 451–459 (2000).
   PubMedGoogle Scholar
• Di Martino A, Melis G, Cianchetti C, Zuddas A. Methylphenidate for pervasive developmental disorders: safety and efficacy of acute single dose test and ongoing therapy: an open-pilot study. J. Child Adolesc. Psychopharmacol. 14(2), 207–218 (2004).
   PubMed Web of Science ®Google Scholar
• Stigler KA, Desmond LA, Posey DJ, Wiegand RE, Mcdougle CJ. A naturalistic retrospective analysis of psychostimulants in pervasive developmental disorders. J. Child Adolesc. Psychopharmacol. 14(1), 49–56 (2004).
   PubMed Web of Science ®Google Scholar
• Nickels K, Katusic SK, Colligan RC, Weaver AL, Voigt RG, Barbaresi WJ. Stimulant medication treatment of target behaviors in children with autism: a population-based study. J. Dev. Behav. Pediatr. 29(2), 75–81 (2008).
   PubMedGoogle Scholar
• Zeiner P, Gjevik E, Weidle B. Response to atomoxetine in boys with high-functioning autism spectrum disorders and attention deficit/hyperactivity disorder. Acta Paediatr. 100(9), 1258–1261 (2011).
   PubMed Web of Science ®Google Scholar
• Harfterkamp M, Van De Loo-Neus G, Minderaa RB et al. A randomized double-blind study of atomoxetine versus placebo for attention-deficit/hyperactivity disorder symptoms in children with autism spectrum disorder. J. Am. Acad. Child Adolesc. Psychiatry 51(7), 733–741 (2012).
   PubMed Web of Science ®Google Scholar
• Golubchik P, Sever J, Weizman A. Reboxetine treatment for autistic spectrum disorder of pediatric patients with depressive and inattentive/hyperactive symptoms: an open-label trial. Clin. Neuropharmacol. 36(2), 37–41 (2013).
   PubMed Web of Science ®Google Scholar
• Handen BL, Sahl R, Hardan AY. Guanfacine in children with autism and/or intellectual disabilities. J. Dev. Behav. Pediatr. 29(4), 303–308 (2008).
   PubMed Web of Science ®Google Scholar
• Ming X, Gordon E, Kang N, Wagner GC. Use of clonidine in children with autism spectrum disorders. Brain Dev. 30(7), 454–460 (2008).
   PubMed Web of Science ®Google Scholar
• Maher AR, Theodore G. Summary of the comparative effectiveness review on off-label use of atypical antipsychotics. J. Manag. Care Pharm. 18(5 Suppl. B), S1–S20 (2012).
   PubMedGoogle Scholar
• Loy JH, Merry SN, Hetrick SE, Stasiak K. Atypical antipsychotics for disruptive behaviour disorders in children and youths. Cochrane Database Syst. Rev. 9, CD008559 (2012).
   PubMed Web of Science ®Google Scholar
• Matone M, Localio R, Huang YS, Dosreis S, Feudtner C, Rubin D. The relationship between mental health diagnosis and treatment with second-generation antipsychotics over time: a national study of U.S. Medicaid-enrolled children. Health Services Res. 47(5), 1836–1860 (2012).
   PubMed Web of Science ®Google Scholar
• Antshel KM, Polacek C, Mcmahon M et al. Comorbid ADHD and anxiety affect social skills group intervention treatment efficacy in children with autism spectrum disorders. J. Dev. Behav. Pediatr. 32(6), 439–446 (2011).
   PubMed Web of Science ®Google Scholar
• Frazier TW, Shattuck PT, Narendorf SC, Cooper BP, Wagner M, Spitznagel EL. Prevalence and correlates of psychotropic medication use in adolescents with an autism spectrum disorder with and without caregiver-reported attention-deficit/hyperactivity disorder. J. Child Adolesc. Psychopharmacol. 21(6), 571–579
   PubMedGoogle Scholar
• Jopp DA, Keys CB. Diagnostic overshadowing reviewed and reconsidered. Am. J. Ment. Retard. 106(5), 416–433 (2001).
   PubMedGoogle Scholar
• Biederman J, Newcorn J, Sprich S. Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. Am. J. Psychiatry 148(5), 564–577 (1991).
   PubMed Web of Science ®Google Scholar
• Robins E, Guze SB. Establishment of diagnostic validity in psychiatric illness: its application to schizophrenia. Am. J. Psychiatry 126(7), 983–987 (1970).
   PubMed Web of Science ®Google Scholar