270
Views
36
CrossRef citations to date
0
Altmetric
Reviews

Corticolimbic connectivity as a possible biomarker for bipolar disorder

, &

References

  • APA. Diagnostic and statistical manual of mental disorders: DSM-IV. 4th edition. text revision American Psychiatric Association; Washington, DC, USA: 2000
  • Murray CJ, Lopez AD. Evidence-based health policy – lessons from the Global Burden of Disease Study. Science 1996;274(5288):740-3
  • Strakowski SM, Adler CM, Almeida J, et al. The functional neuroanatomy of bipolar disorder: a consensus model. Bipolar Disord 2012;14(4):313-25
  • Frey BN, Andreazza AC, Houenou J, et al. Biomarkers in bipolar disorder: a positional paper from the International Society for Bipolar Disorders Biomarkers Task Force. Aust N Z J Psychiatry 2013;47(4):321-32
  • Friston KJ. Functional and effective connectivity: a review. Brain Connect 2011;1(1):13-36
  • Koch MA, Norris DG, Hund-Georgiadis M. An investigation of functional and anatomical connectivity using magnetic resonance imaging. Neuroimage 2002;16(1):241-50
  • Fingelkurts AA, Kahkonen S. Functional connectivity in the brain – is it an elusive concept? Neurosci Biobehav Rev 2005;28(8):827-36
  • Strakowski SM, Delbello MP, Adler CM. The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings. Mol Psychiatry 2005;10(1):105-16
  • Savitz J, Drevets WC. Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide. Neurosci Biobehav Rev 2009;33(5):699-771
  • Phillips ML, Ladouceur CD, Drevets WC. A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder. Mol Psychiatry 2008;13(9):829, 833-857
  • Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: implications for major psychiatric disorders. Biol Psychiatry 2003;54(5):515-28
  • Keener MT, Phillips ML. Neuroimaging in bipolar disorder: a critical review of current findings. Curr Psychiatry Rep 2007;9(6):512-20
  • Amaral DG, Price JL. Amygdalo-cortical projections in the monkey (Macaca fascicularis). J Comp Neurol 1984;230(4):465-96
  • LeDoux JE. Emotion circuits in the brain. Annu Rev Neurosci 2000;23:155-84
  • Townsend J, Altshuler LL. Emotion processing and regulation in bipolar disorder: a review. Bipolar Disord 2012;14(4):326-39
  • Stein JL, Wiedholz LM, Bassett DS, et al. A validated network of effective amygdala connectivity. Neuroimage 2007;36(3):736-45
  • Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception I: the neural basis of normal emotion perception. Biol Psychiatry 2003;54(5):504-14
  • Judd LL, Akiskal HS, Schettler PJ, et al. The long-term natural history of the weekly symptomatic status of bipolar I disorder. Arch Gen Psychiatry 2002;59(6):530-7
  • Kupka RW, Altshuler LL, Nolen WA, et al. Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder. Bipolar Disord 2007;9(5):531-5
  • Jogia J, Haldane M, Cobb A, et al. Pilot investigation of the changes in cortical activation during facial affect recognition with lamotrigine monotherapy in bipolar disorder. Br J Psychiatry 2008;192(3):197-201
  • Cabeza R, Nyberg L. Imaging cognition II: an empirical review of 275 PET and fMRI studies. J Cogn Neurosci 2000;12(1):1-47
  • Fuster JM. The prefrontal cortex – an update: time is of the essence. Neuron 2001;30(2):319-33
  • Strakowski SM, Eliassen JC, Lamy M, et al. Functional magnetic resonance imaging brain activation in bipolar mania: evidence for disruption of the ventrolateral prefrontal-amygdala emotional pathway. Biol Psychiatry 2011;69(4):381-8
  • Lennox BR, Jacob R, Calder AJ, et al. Behavioural and neurocognitive responses to sad facial affect are attenuated in patients with mania. Psychol Med 2004;34(5):795-802
  • Killgore WD, Gruber SA, Yurgelun-Todd DA. Abnormal corticostriatal activity during fear perception in bipolar disorder. Neuroreport 2008;19(15):1523-7
  • Hassel S, Almeida JR, Frank E, et al. Prefrontal cortical and striatal activity to happy and fear faces in bipolar disorder is associated with comorbid substance abuse and eating disorder. J Affect Disord 2009;118(1-3):19-27
  • Hassel S, Almeida JR, Kerr N, et al. Elevated striatal and decreased dorsolateral prefrontal cortical activity in response to emotional stimuli in euthymic bipolar disorder: no associations with psychotropic medication load. Bipolar Disord 2008;10(8):916-27
  • Surguladze SA, Marshall N, Schulze K, et al. Exaggerated neural response to emotional faces in patients with bipolar disorder and their first-degree relatives. Neuroimage 2010;53(1):58-64
  • Lagopoulos J, Malhi G. Impairments in "top-down" processing in bipolar disorder: a simultaneous fMRI-GSR study. Psychiatry Res 2011;192(2):100-8
  • Wessa M, Houenou J, Paillere-Martinot ML, et al. Fronto-striatal overactivation in euthymic bipolar patients during an emotional go/nogo task. Am J Psychiatry 2007;164(4):638-46
  • Cerullo MA, Fleck DE, Eliassen JC, et al. A longitudinal functional connectivity analysis of the amygdala in bipolar I disorder across mood states. Bipolar Disord 2012;14(2):175-84
  • Foland LC, Altshuler LL, Bookheimer SY, et al. Evidence for deficient modulation of amygdala response by prefrontal cortex in bipolar mania. Psychiatry Res 2008;162(1):27-37
  • Wang F, Kalmar JH, He Y, et al. Functional and structural connectivity between the perigenual anterior cingulate and amygdala in bipolar disorder. Biol Psychiatry 2009;66(5):516-21
  • Townsend JD, Torrisi SJ, Lieberman MD, et al. Frontal-amygdala connectivity alterations during emotion downregulation in bipolar I disorder. Biol Psychiatry 2013;73(2):127-35
  • Versace A, Thompson WK, Zhou D, et al. Abnormal left and right amygdala-orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar disorder. Biol Psychiatry 2010;67(5):422-31
  • Vizueta N, Rudie JD, Townsend JD, et al. Regional fMRI hypoactivation and altered functional connectivity during emotion processing in nonmedicated depressed patients with bipolar II disorder. Am J Psychiatry 2012;169(8):831-40
  • Pompei F, Dima D, Rubia K, et al. Dissociable functional connectivity changes during the Stroop task relating to risk, resilience and disease expression in bipolar disorder. Neuroimage 2011;57(2):576-82
  • Proal E, Alvarez-Segura M, de la Iglesia-Vaya M, et al. [Functional cerebral activity in a state of rest: connectivity networks]. Rev Neurol 2011;52(Suppl 1):S3-10
  • Lee MH, Hacker CD, Snyder AZ, et al. Clustering of resting state networks. PLoS One 2012;7(7):e40370
  • Buckner RL. The serendipitous discovery of the brain’s default network. Neuroimage 2012;62(2):1137-45
  • Greicius MD, Krasnow B, Reiss AL, Menon V. Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci USA 2003;100(1):253-8
  • Vargas C, Lopez-Jaramillo C, Vieta E. A systematic literature review of resting state network – functional MRI in bipolar disorder. J Affect Disord 2013;150(3):727-35
  • Anand A, Li Y, Wang Y, et al. Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression. Psychiatry Res 2009;171(3):189-98
  • Chai XJ, Whitfield-Gabrieli S, Shinn AK, et al. Abnormal medial prefrontal cortex resting-state connectivity in bipolar disorder and schizophrenia. Neuropsychopharmacology 2011;36(10):2009-17
  • Chepenik LG, Raffo M, Hampson M, et al. Functional connectivity between ventral prefrontal cortex and amygdala at low frequency in the resting state in bipolar disorder. Psychiatry Res 2010;182(3):207-10
  • Anticevic A, Brumbaugh MS, Winkler AM, et al. Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history. Biol Psychiatry 2013;73(6):565-73
  • Ongur D, Lundy M, Greenhouse I, et al. Default mode network abnormalities in bipolar disorder and schizophrenia. Psychiatry Res 2010;183(1):59-68
  • Meda SA, Gill A, Stevens MC, et al. Differences in resting-state functional magnetic resonance imaging functional network connectivity between schizophrenia and psychotic bipolar probands and their unaffected first-degree relatives. Biol Psychiatry 2012;71(10):881-9
  • Liu CH, Ma X, Li F, et al. Regional homogeneity within the default mode network in bipolar depression: a resting-state functional magnetic resonance imaging study. PLoS One 2012;7(11):e48181
  • Liu CH, Li F, Li SF, et al. Abnormal baseline brain activity in bipolar depression: a resting state functional magnetic resonance imaging study. Psychiatry Res 2012;203(2-3):175-9
  • Liu CH, Ma X, Wu X, et al. Resting-state abnormal baseline brain activity in unipolar and bipolar depression. Neurosci Lett 2012;516(2):202-6
  • Friston KJ, Harrison L, Penny W. Dynamic causal modelling. Neuroimage 2003;19(4):1273-302
  • Ding M, Chen Y, Bressler S. Granger causality: Basic theory and application to neuroscience. In: Schelter B, Winterhalder M, Timmer J, editors. Handbook of Time Series Analysis. Wiley-VCH; Weinheim, Germany: 2006
  • Almeida JR, Versace A, Mechelli A, et al. Abnormal amygdala-prefrontal effective connectivity to happy faces differentiates bipolar from major depression. Biol Psychiatry 2009;66(5):451-9
  • Almeida JR, Mechelli A, Hassel S, et al. Abnormally increased effective connectivity between parahippocampal gyrus and ventromedial prefrontal regions during emotion labeling in bipolar disorder. Psychiatry Res 2009;174(3):195-201
  • Perlman SB, Almeida JR, Kronhaus DM, et al. Amygdala activity and prefrontal cortex-amygdala effective connectivity to emerging emotional faces distinguish remitted and depressed mood states in bipolar disorder. Bipolar Disord 2012;14(2):162-74
  • Mullin BC, Perlman SB, Versace A, et al. An fMRI study of attentional control in the context of emotional distracters in euthymic adults with bipolar disorder. Psychiatry Res 2012;201(3):196-205
  • Dima D, Jogia J, Collier D, et al. Independent modulation of engagement and connectivity of the facial network during affect processing by CACNA1C and ANK3 risk genes for bipolar disorder. JAMA Psychiatry 2013;70(12):1303-11
  • Radaelli D, Sferrazza Papa G, Vai B, et al. Fronto-limbic disconnection in bipolar disorder. European Psychiatry; 2014. In press
  • Elliott R, Ogilvie A, Rubinsztein JS, et al. Abnormal ventral frontal response during performance of an affective go/no go task in patients with mania. Biol Psychiatry 2004;55(12):1163-70
  • Altshuler LL, Bookheimer SY, Townsend J, et al. Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study. Biol Psychiatry 2005;58(10):763-9
  • Adler CM, DelBello MP, Strakowski SM. Brain network dysfunction in bipolar disorder. CNS Spectr 2006;11(4):312-20. quiz 323-314
  • Benedetti F, Yeh PH, Bellani M, et al. Disruption of white matter integrity in bipolar depression as a possible structural marker of illness. Biol Psychiatry 2011;69(4):309-17
  • Assaf Y, Pasternak O. Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review. J Mol Neurosci 2008;34(1):51-61
  • Xekardaki A, Giannakopoulos P, Haller S. White matter changes in bipolar disorder, alzheimer disease, and mild cognitive impairment: new insights from DTI. J Aging Res 2011;2011:286564
  • Song SK, Sun SW, Ju WK, et al. Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia. Neuroimage 2003;20(3):1714-22
  • Song SK, Yoshino J, Le TQ, et al. Demyelination increases radial diffusivity in corpus callosum of mouse brain. Neuroimage 2005;26(1):132-40
  • Sun SW, Liang HF, Trinkaus K, et al. Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum. Magn Reson Med 2006;55(2):302-8
  • Song SK, Sun SW, Ramsbottom MJ, et al. Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water. Neuroimage 2002;17(3):1429-36
  • Pierpaoli C, Jezzard P, Basser PJ, et al. Diffusion tensor MR imaging of the human brain. Radiology 1996;201(3):637-48
  • Sen PN, Basser PJ. A model for diffusion in white matter in the brain. Biophys J 2005;89(5):2927-38
  • Beaulieu C. The basis of anisotropic water diffusion in the nervous system - a technical review. NMR Biomed 2002;15(7-8):435-55
  • Concha L, Gross DW, Wheatley BM, Beaulieu C. Diffusion tensor imaging of time-dependent axonal and myelin degradation after corpus callosotomy in epilepsy patients. Neuroimage 2006;32(3):1090-9
  • Adler CM, Holland SK, Schmithorst V, et al. Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study. Bipolar Disord 2004;6(3):197-203
  • Beyer JL, Taylor WD, MacFall JR, et al. Cortical white matter microstructural abnormalities in bipolar disorder. Neuropsychopharmacology 2005;30(12):2225-9
  • Bruno S, Cercignani M, Ron MA. White matter abnormalities in bipolar disorder: a voxel-based diffusion tensor imaging study. Bipolar Disord 2008;10(4):460-8
  • Chaddock CA, Barker GJ, Marshall N, et al. White matter microstructural impairments and genetic liability to familial bipolar I disorder. Br J Psychiatry 2009;194(6):527-34
  • Chen Z, Cui L, Li M, et al. Voxel based morphometric and diffusion tensor imaging analysis in male bipolar patients with first-episode mania. Prog Neuropsychopharmacol Biol Psychiatry 2012;36(2):231-8
  • Ha TH, Her JY, Kim JH, et al. Similarities and differences of white matter connectivity and water diffusivity in bipolar I and II disorder. Neurosci Lett 2011;505(2):150-4
  • Lin F, Weng S, Xie B, et al. Abnormal frontal cortex white matter connections in bipolar disorder: a DTI tractography study. J Affect Disord 2011;131(1-3):299-306
  • Macritchie KA, Lloyd AJ, Bastin ME, et al. White matter microstructural abnormalities in euthymic bipolar disorder. Br J Psychiatry 2010;196(1):52-8
  • McIntosh AM, Munoz Maniega S, Lymer GK, et al. White matter tractography in bipolar disorder and schizophrenia. Biol Psychiatry 2008;64(12):1088-92
  • Sprooten E, Sussmann JE, Clugston A, et al. White matter integrity in individuals at high genetic risk of bipolar disorder. Biol Psychiatry 2011;70(4):350-6
  • Sussmann JE, Lymer GK, McKirdy J, et al. White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging. Bipolar Disord 2009;11(1):11-18
  • Zanetti MV, Jackowski MP, Versace A, et al. State-dependent microstructural white matter changes in bipolar I depression. Eur Arch Psychiatry Clin Neurosci 2009;259(6):316-28
  • Wang F, Kalmar JH, Edmiston E, et al. Abnormal corpus callosum integrity in bipolar disorder: a diffusion tensor imaging study. Biol Psychiatry 2008;64(8):730-3
  • Wang F, Jackowski M, Kalmar JH, et al. Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging. Br J Psychiatry 2008;193(2):126-9
  • Benedetti F, Absinta M, Rocca MA, et al. Tract-specific white matter structural disruption in patients with bipolar disorder. Bipolar Disord 2011;13(4):414-24
  • Mahon K, Wu J, Malhotra AK, et al. A voxel-based diffusion tensor imaging study of white matter in bipolar disorder. Neuropsychopharmacology 2009;34(6):1590-600
  • Versace A, Almeida JR, Quevedo K, et al. Right orbitofrontal corticolimbic and left corticocortical white matter connectivity differentiate bipolar and unipolar depression. Biol Psychiatry 2010;68(6):560-7
  • Houenou J, Wessa M, Douaud G, et al. Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex. Mol Psychiatry 2007;12(11):1001-10
  • Haznedar MM, Roversi F, Pallanti S, et al. Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses. Biol Psychiatry 2005;57(7):733-42
  • Yurgelun-Todd DA, Silveri MM, Gruber SA, et al. White matter abnormalities observed in bipolar disorder: a diffusion tensor imaging study. Bipolar Disord 2007;9(5):504-12
  • Wessa M, Houenou J, Leboyer M, et al. Microstructural white matter changes in euthymic bipolar patients: a whole-brain diffusion tensor imaging study. Bipolar Disord 2009;11(5):504-14
  • Barysheva M, Jahanshad N, Foland-Ross L, et al. White matter microstructural abnormalities in bipolar disorder: a whole brain diffusion tensor imaging study. Neuroimage Clin 2013;2:558-68
  • Versace A, Almeida JR, Hassel S, et al. Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics. Arch Gen Psychiatry 2008;65(9):1041-52
  • Barnea-Goraly N, Chang KD, Karchemskiy A, et al. Limbic and corpus callosum aberrations in adolescents with bipolar disorder: a tract-based spatial statistics analysis. Biol Psychiatry 2009;66(3):238-44
  • Hoeft F, Barnea-Goraly N, Haas BW, et al. More is not always better: increased fractional anisotropy of superior longitudinal fasciculus associated with poor visuospatial abilities in Williams syndrome. J Neurosci 2007;27(44):11960-5
  • Emsell L, Chaddock C, Forde N, et al. White matter microstructural abnormalities in families multiply affected with bipolar I disorder: a diffusion tensor tractography study. Psychol Med 2013;1-12
  • Mahon K, Burdick KE, Ikuta T, et al. Abnormal temporal lobe white matter as a biomarker for genetic risk of bipolar disorder. Biol Psychiatry 2013;73(2):177-82
  • Tighe SK, Reading SA, Rivkin P, et al. Total white matter hyperintensity volume in bipolar disorder patients and their healthy relatives. Bipolar Disord 2012;14(8):888-93
  • Sprooten E, Fleming KM, Thomson PA, et al. White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder. Psychiatry Res 2013;206(2-3):223-31
  • Whalley HC, Sprooten E, Hackett S, et al. Polygenic risk and white matter integrity in individuals at high risk of mood disorder. Biol Psychiatry 2013;74(4):280-6
  • Borgwardt S, Fusar-Poli P. White matter pathology – an endophenotype for bipolar disorder? BMC Psychiatry 2012;12:138
  • Peters A. The effects of normal aging on myelinated nerve fibers in monkey central nervous system. Front Neuroanat 2009;3:11
  • Brambilla P, Bellani M, Yeh PH, et al. White matter connectivity in bipolar disorder. Int Rev Psychiatry 2009;21(4):380-6
  • Drevets WC, Price JL, Furey ML. Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression. Brain Struct Funct 2008;213(1-2):93-118
  • Price JL, Drevets WC. Neurocircuitry of mood disorders. Neuropsychopharmacology 2010;35(1):192-216
  • Egeland JA, Hostetter AM, Pauls DL, Sussex JN. Prodromal symptoms before onset of manic-depressive disorder suggested by first hospital admission histories. J Am Acad Child Adolesc Psychiatry 2000;39(10):1245-52
  • McNamara RK, Nandagopal JJ, Strakowski SM, DelBello MP. Preventative strategies for early-onset bipolar disorder: towards a clinical staging model. CNS Drugs 2010;24(12):983-96
  • Birmaher B, Axelson D, Strober M, et al. Clinical course of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry 2006;63(2):175-83
  • Hillegers MH, Reichart CG, Wals M, et al. Five-year prospective outcome of psychopathology in the adolescent offspring of bipolar parents. Bipolar Disord 2005;7(4):344-50
  • Singh MK, DelBello MP, Stanford KE, et al. Psychopathology in children of bipolar parents. J Affect Disord 2007;102(1-3):131-6
  • Pavuluri MN, O’Connor MM, Harral E, Sweeney JA. Affective neural circuitry during facial emotion processing in pediatric bipolar disorder. Biol Psychiatry 2007;62(2):158-67
  • Thomas LA, Kim P, Bones BL, et al. Elevated amygdala responses to emotional faces in youths with chronic irritability or bipolar disorder. Neuroimage Clin 2013;2:637-45
  • Pavuluri MN, Passarotti AM, Harral EM, Sweeney JA. An fMRI study of the neural correlates of incidental versus directed emotion processing in pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry 2009;48(3):308-19
  • Wang F, Bobrow L, Liu J, et al. Corticolimbic functional connectivity in adolescents with bipolar disorder. PLoS One 2012;7(11):e50177
  • Ladouceur CD, Farchione T, Diwadkar V, et al. Differential patterns of abnormal activity and connectivity in the amygdala-prefrontal circuitry in bipolar-I and bipolar-NOS youth. J Am Acad Child Adolesc Psychiatry 2011;50(12):1275-89. e1272
  • Rich BA, Fromm SJ, Berghorst LH, et al. Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit. J Child Psychol Psychiatry 2008;49(1):88-96
  • Wegbreit E, Ellis JA, Nandam A, et al. Amygdala functional connectivity predicts pharmacotherapy outcome in pediatric bipolar disorder. Brain Connect 2011;1(5):411-22
  • Dickstein DP, Gorrostieta C, Ombao H, et al. Fronto-temporal spontaneous resting state functional connectivity in pediatric bipolar disorder. Biol Psychiatry 2010;68(9):839-46
  • Frazier JA, Breeze JL, Papadimitriou G, et al. White matter abnormalities in children with and at risk for bipolar disorder. Bipolar Disord 2007;9(8):799-809
  • Kafantaris V, Kingsley P, Ardekani B, et al. Lower orbital frontal white matter integrity in adolescents with bipolar I disorder. J Am Acad Child Adolesc Psychiatry 2009;48(1):79-86
  • Pavuluri MN, Yang S, Kamineni K, et al. Diffusion tensor imaging study of white matter fiber tracts in pediatric bipolar disorder and attention-deficit/hyperactivity disorder. Biol Psychiatry 2009;65(7):586-93
  • Adler CM, Adams J, DelBello MP, et al. Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: a diffusion tensor imaging study. Am J Psychiatry 2006;163(2):322-4
  • Saxena K, Tamm L, Walley A, et al. A preliminary investigation of corpus callosum and anterior commissure aberrations in aggressive youth with bipolar disorders. J Child Adolesc Psychopharmacol 2012;22(2):112-19
  • Versace A, Ladouceur CD, Romero S, et al. Altered development of white matter in youth at high familial risk for bipolar disorder: a diffusion tensor imaging study. J Am Acad Child Adolesc Psychiatry 2010;49(12):1249-59. 1259 e1241
  • Schneider MR, DelBello MP, McNamara RK, et al. Neuroprogression in bipolar disorder. Bipolar Disord 2012;14(4):356-74
  • Caetano SC, Silveira CM, Kaur S, et al. Abnormal corpus callosum myelination in pediatric bipolar patients. J Affect Disord 2008;108(3):297-301
  • Baethge C, Tondo L, Bratti IM, et al. Prophylaxis latency and outcome in bipolar disorders. Can J Psychiatry 2003;48(7):449-57
  • Baldessarini RJ, Tondo L, Baethge CJ, et al. Effects of treatment latency on response to maintenance treatment in manic-depressive disorders. Bipolar Disord 2007;9(4):386-93
  • Hirschfeld RM, Lewis L, Vornik LA. Perceptions and impact of bipolar disorder: how far have we really come? Results of the national depressive and manic-depressive association 2000 survey of individuals with bipolar disorder. J Clin Psychiatry 2003;64(2):161-74
  • Perlis RH, Ostacher MJ, Goldberg JF, et al. Transition to mania during treatment of bipolar depression. Neuropsychopharmacology 2010;35(13):2545-52
  • Valenti M, Pacchiarotti I, Bonnin CM, et al. Risk factors for antidepressant-related switch to mania. J Clin Psychiatry 2012;73(2):e271-6
  • Goodwin GM. Bipolar depression and treatment with antidepressants. Br J Psychiatry 2012;200(1):5-6
  • Baldessarini RJ, Salvatore P, Khalsa HM, et al. Morbidity in 303 first-episode bipolar I disorder patients. Bipolar Disord 2010;12(3):264-70
  • Rosa AR, Reinares M, Michalak EE, et al. Functional impairment and disability across mood states in bipolar disorder. Value Health 2010;13(8):984-8
  • Cardoso de Almeida JR, Phillips ML. Distinguishing between unipolar depression and bipolar depression: current and future clinical and neuroimaging perspectives. Biol Psychiatry 2013;73(2):111-18
  • Konarski JZ, McIntyre RS, Kennedy SH, et al. Volumetric neuroimaging investigations in mood disorders: bipolar disorder versus major depressive disorder. Bipolar Disord 2008;10(1):1-37
  • Delvecchio G, Fossati P, Boyer P, et al. Common and distinct neural correlates of emotional processing in Bipolar Disorder and Major Depressive Disorder: a voxel-based meta-analysis of functional magnetic resonance imaging studies. Eur Neuropsychopharmacol 2012;22(2):100-13
  • Houenou J, Frommberger J, Carde S, et al. Neuroimaging-based markers of bipolar disorder: evidence from two meta-analyses. J Affect Disord 2011;132(3):344-55
  • Kempton MJ, Salvador Z, Munafo MR, et al. Structural neuroimaging studies in major depressive disorder. Meta-analysis and comparison with bipolar disorder. Arch Gen Psychiatry 2011;68(7):675-90
  • Almeida JR, Versace A, Hassel S, et al. Elevated amygdala activity to sad facial expressions: a state marker of bipolar but not unipolar depression. Biol Psychiatry 2010;67(5):414-21
  • Silverstone T, McPherson H, Li Q, Doyle T. Deep white matter hyperintensities in patients with bipolar depression, unipolar depression and age-matched control subjects. Bipolar Disord 2003;5(1):53-7
  • Akiskal HS, Judd LL, Gillin JC, Lemmi H. Subthreshold depressions: clinical and polysomnographic validation of dysthymic, residual and masked forms. J Affect Disord 1997;45(1-2):53-63
  • Carrasco JL, Tajima-Pozo K, Diaz-Marsa M, et al. Microstructural white matter damage at orbitofrontal areas in borderline personality disorder. J Affect Disord 2012;139(2):149-53
  • Rusch N, Luders E, Lieb K, et al. Corpus callosum abnormalities in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder. J Psychiatry Neurosci 2007;32(6):417-22
  • Rusch N, Weber M, Il’yasov KA, et al. Inferior frontal white matter microstructure and patterns of psychopathology in women with borderline personality disorder and comorbid attention-deficit hyperactivity disorder. Neuroimage 2007;35(2):738-47
  • Grant JE, Correia S, Brennan-Krohn T, et al. Frontal white matter integrity in borderline personality disorder with self-injurious behavior. J Neuropsychiatry Clin Neurosci 2007;19(4):383-90
  • Cullen KR, Vizueta N, Thomas KM, et al. Amygdala functional connectivity in young women with borderline personality disorder. Brain Connect 2011;1(1):61-71
  • Kamphausen S, Schroder P, Maier S, et al. Medial prefrontal dysfunction and prolonged amygdala response during instructed fear processing in borderline personality disorder. World J Biol Psychiatry 2013;14(4):307-18. S301-304
  • Purcell SM, Wray NR, Stone JL, et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 2009;460(7256):748-52
  • Lichtenstein P, Yip BH, Bjork C, et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet 2009;373(9659):234-9
  • Tamminga CA, Ivleva EI, Keshavan MS, et al. Clinical phenotypes of psychosis in the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP). Am J Psychiatry 2013;170(11):1263-74
  • Peralta V, de Jalon EG, Campos MS, Cuesta MJ. Phenomenological differences between spontaneous and drug-related extrapyramidal syndromes in patients with schizophrenia-spectrum disorders. J Clin Psychopharmacol 2013;33(3):438-40
  • Russo M, Levine SZ, Demjaha A, et al. Association between symptom dimensions and categorical diagnoses of psychosis: a cross-sectional and longitudinal investigation. Schizophr Bull 2014;40(1):111-19
  • Frangou S. A systems neuroscience perspective of schizophrenia and bipolar disorder. Schizophr Bull 2014;40(3):523-31
  • Leitman DI, Loughead J, Wolf DH, et al. Abnormal superior temporal connectivity during fear perception in schizophrenia. Schizophr Bull 2008;34(4):673-8
  • Liu H, Tang Y, Womer F, et al. Differentiating patterns of amygdala-frontal functional connectivity in schizophrenia and bipolar disorder. Schizophr Bull 2014;40(2):469-77
  • Das P, Kemp AH, Flynn G, et al. Functional disconnections in the direct and indirect amygdala pathways for fear processing in schizophrenia. Schizophr Res 2007;90(1-3):284-94
  • Mukherjee P, Whalley HC, McKirdy JW, et al. Altered amygdala connectivity within the social brain in schizophrenia. Schizophr Bull 2014;40(1):152-60
  • Modinos G, Ormel J, Aleman A. Altered activation and functional connectivity of neural systems supporting cognitive control of emotion in psychosis proneness. Schizophr Res 2010;118(1-3):88-97
  • Fan FM, Tan SP, Yang FD, et al. Ventral medial prefrontal functional connectivity and emotion regulation in chronic schizophrenia: a pilot study. Neurosci Bull 2013;29(1):59-74
  • Fornito A, Zalesky A, Pantelis C, Bullmore ET. Schizophrenia, neuroimaging and connectomics. Neuroimage 2012;62(4):2296-314
  • van den Heuvel MP, Sporns O, Collin G, et al. Abnormal rich club organization and functional brain dynamics in schizophrenia. JAMA Psychiatry 2013;70(8):783-92
  • Mamah D, Barch DM, Repovs G. Resting state functional connectivity of five neural networks in bipolar disorder and schizophrenia. J Affect Disord 2013;150(2):601-9
  • Argyelan M, Ikuta T, DeRosse P, et al. Resting-state FMRI connectivity impairment in schizophrenia and bipolar disorder. Schizophr Bull 2014;40(1):100-10
  • Khadka S, Meda SA, Stevens MC, et al. Is aberrant functional connectivity a psychosis endophenotype? A resting state functional magnetic resonance imaging study. Biol Psychiatry 2013;74(6):458-66
  • White T, Nelson M, Lim KO. Diffusion tensor imaging in psychiatric disorders. Top Magn Reson Imaging 2008;19(2):97-109
  • Yamasue H, Iwanami A, Hirayasu Y, et al. Localized volume reduction in prefrontal, temporolimbic, and paralimbic regions in schizophrenia: an MRI parcellation study. Psychiatry Res 2004;131(3):195-207
  • Friedman JI, Tang C, Carpenter D, et al. Diffusion tensor imaging findings in first-episode and chronic schizophrenia patients. Am J Psychiatry 2008;165(8):1024-32
  • Moriya J, Kakeda S, Abe O, et al. Gray and white matter volumetric and diffusion tensor imaging (DTI) analyses in the early stage of first-episode schizophrenia. Schizophr Res 2010;116(2-3):196-203
  • Shizukuishi T, Abe O, Aoki S. Diffusion tensor imaging analysis for psychiatric disorders. Magn Reson Med Sci 2013;12(3):153-9
  • Ellison-Wright I, Bullmore E. Meta-analysis of diffusion tensor imaging studies in schizophrenia. Schizophr Res 2009;108(1-3):3-10
  • Krishnan KR. Psychiatric and medical comorbidities of bipolar disorder. Psychosom Med 2005;67(1):1-8
  • Amerio A, Odone A, Liapis CC, Ghaemi SN. Diagnostic validity of comorbid bipolar disorder and obsessive-compulsive disorder: a systematic review. Acta Psychiatr Scand 2014;129(5):343-58
  • Koch K, Reess TJ, Rus OG, et al. Diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD): a review. J Psychiatr Res 2014. [Epub ahead of print]
  • Admon R, Bleich-Cohen M, Weizmant R, et al. Functional and structural neural indices of risk aversion in obsessive-compulsive disorder (OCD). Psychiatry Res 2012;203(2-3):207-13
  • Benedetti F, Giacosa C, Radaelli D, et al. Widespread changes of white matter microstructure in obsessive-compulsive disorder: effect of drug status. Eur Neuropsychopharmacol 2013;23(7):581-93
  • Tinelli E, Francia A, Quartuccio EM, et al. Structural brain MR imaging changes associated with obsessive-compulsive disorder in patients with multiple sclerosis. AJNR Am J Neuroradiol 2013;34(2):305-9
  • Fan Q, Yan X, Wang J, et al. Abnormalities of white matter microstructure in unmedicated obsessive-compulsive disorder and changes after medication. PLoS One 2012;7(4):e35889
  • Bora E, Harrison BJ, Fornito A, et al. White matter microstructure in patients with obsessive-compulsive disorder. J Psychiatry Neurosci 2011;36(1):42-6
  • Nakamae T, Narumoto J, Sakai Y, et al. Diffusion tensor imaging and tract-based spatial statistics in obsessive-compulsive disorder. J Psychiatr Res 2011;45(5):687-90
  • Nakamae T, Narumoto J, Shibata K, et al. Alteration of fractional anisotropy and apparent diffusion coefficient in obsessive-compulsive disorder: a diffusion tensor imaging study. Prog Neuropsychopharmacol Biol Psychiatry 2008;32(5):1221-6
  • Yoo SY, Jang JH, Shin YW, et al. White matter abnormalities in drug-naive patients with obsessive-compulsive disorder: a diffusion tensor study before and after citalopram treatment. Acta Psychiatr Scand 2007;116(3):211-19
  • Szeszko PR, Ardekani BA, Ashtari M, et al. White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study. Arch Gen Psychiatry 2005;62(7):782-90
  • Menzies L, Williams GB, Chamberlain SR, et al. White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives. Am J Psychiatry 2008;165(10):1308-15
  • Li F, Huang X, Yang Y, et al. Microstructural brain abnormalities in patients with obsessive-compulsive disorder: diffusion-tensor MR imaging study at 3.0 T. Radiology 2011;260(1):216-23
  • Ha TH, Kang DH, Park JS, et al. White matter alterations in male patients with obsessive-compulsive disorder. Neuroreport 2009;20(7):735-9
  • Garibotto V, Scifo P, Gorini A, et al. Disorganization of anatomical connectivity in obsessive compulsive disorder: a multi-parameter diffusion tensor imaging study in a subpopulation of patients. Neurobiol Dis 2010;37(2):468-76
  • Fontenelle LF, Harrison BJ, Yucel M, et al. Is there evidence of brain white-matter abnormalities in obsessive-compulsive disorder?: a narrative review. Top Magn Reson Imaging 2009;20(5):291-8
  • Zarei M, Mataix-Cols D, Heyman I, et al. Changes in gray matter volume and white matter microstructure in adolescents with obsessive-compulsive disorder. Biol Psychiatry 2011;70(11):1083-90
  • Silk T, Chen J, Seal M, Vance A. White matter abnormalities in pediatric obsessive-compulsive disorder. Psychiatry Res 2013;213(2):154-60
  • Jayarajan RN, Venkatasubramanian G, Viswanath B, et al. White matter abnormalities in children and adolescents with obsessive-compulsive disorder: a diffusion tensor imaging study. Depress Anxiety 2012;29(9):780-8
  • Gruner P, Vo A, Ikuta T, et al. White matter abnormalities in pediatric obsessive-compulsive disorder. Neuropsychopharmacology 2012;37(12):2730-9
  • Veale DM, Sahakian BJ, Owen AM, Marks IM. Specific cognitive deficits in tests sensitive to frontal lobe dysfunction in obsessive-compulsive disorder. Psychol Med 1996;26(6):1261-9
  • Saxena S, Rauch SL. Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr Clin North Am 2000;23(3):563-86
  • Schlosser RG, Wagner G, Schachtzabel C, et al. Fronto-cingulate effective connectivity in obsessive compulsive disorder: a study with fMRI and dynamic causal modeling. Hum Brain Mapp 2010;31(12):1834-50
  • Hou J, Song L, Zhang W, et al. Morphologic and functional connectivity alterations of corticostriatal and default mode network in treatment-naive patients with obsessive-compulsive disorder. PLoS One 2013;8(12):e83931
  • Anticevic A, Hu S, Zhang S, et al. Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder. Biol Psychiatry 2014;75(8):595-605
  • Jung WH, Kang DH, Kim E, et al. Abnormal corticostriatal-limbic functional connectivity in obsessive-compulsive disorder during reward processing and resting-state. Neuroimage Clin 2013;3:27-38
  • Posner J, Marsh R, Maia TV, et al. Reduced functional connectivity within the limbic cortico-striato-thalamo-cortical loop in unmedicated adults with obsessive-compulsive disorder. Hum Brain Mapp 2013. [Epub ahead of print]
  • Peng ZW, Xu T, He QH, et al. Default network connectivity as a vulnerability marker for obsessive compulsive disorder. Psychol Med 2013;1-10
  • Cheng Y, Xu J, Nie B, et al. Abnormal resting-state activities and functional connectivities of the anterior and the posterior cortexes in medication-naive patients with obsessive-compulsive disorder. PLoS One 2013;8(6):e67478
  • Ping L, Su-Fang L, Hai-Ying H, et al. Abnormal Spontaneous Neural Activity in Obsessive-Compulsive Disorder: a Resting-State Functional Magnetic Resonance Imaging Study. PLoS One 2013;8(6):e67262
  • Beucke JC, Sepulcre J, Talukdar T, et al. Abnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder. JAMA Psychiatry 2013;70(6):619-29
  • Cardoner N, Harrison BJ, Pujol J, et al. Enhanced brain responsiveness during active emotional face processing in obsessive compulsive disorder. World J Biol Psychiatry 2011;12(5):349-63

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.