Management of epilepsy during pregnancy

References

• Adedinsewo D, Thurman D, Luo Y, et al. Valproate prescriptions for nonepilepsy disorders in reproductive-age women. Birth Defects Res A Clin Mol Teratol 2013;97(6):403-8
   PubMed Web of Science ®Google Scholar
• Tomson T, Battino D, Bonizzoni E, et al. Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurology 2011;10(7):609-17
   PubMed Web of Science ®Google Scholar
• Hernández-Díaz S, Smith CR, Shen A, et al. Comparative safety of antiepileptic drugs during pregnancy. Neurology 2012;78(21):1692-9
   PubMed Web of Science ®Google Scholar
• Harden CL, Hopp J, Ting TY, et al. Practice Parameter update: Management issues for women with epilepsy–Focus on pregnancy (an evidence-based review): Obstetrical complications and change in seizure frequency report of the quality standards subcommittee and therapeutics and technology assessment subcommittee of the american academy of neurology and american epilepsy society. Neurology 2009;73(2):126-32
   PubMed Web of Science ®Google Scholar
• Battino D, Tomson T, Bonizzoni E, et al. Seizure control and treatment changes in pregnancy: Observations from the EURAP epilepsy pregnancy registry. Epilepsia 2013;54(9):1621-7
   PubMed Web of Science ®Google Scholar
• Neve A, Boero G, Francavilla T, et al. Prospective, case–control study on the effect of pregnancy on seizure frequency in women with epilepsy. Neurol Sci 2014;36(1):7983
   Google Scholar
• Thomas S, Syam U, Devi S. Predictors of seizures during pregnancy in women with epilepsy. Epilepsia 2012;53(5):e85-8
   PubMed Web of Science ®Google Scholar
• Vajda FJ, O’Brien TJ, Graham J, et al. The outcomes of pregnancy in women with untreated epilepsy. Seizure 2015;24:7781
   Web of Science ®Google Scholar
• Pennell P. Pregnancy, epilepsy, and women’s issues. Continuum (Minneapolis, Minn) 2013;19(3 Epilepsy):697-714
   PubMedGoogle Scholar
• Tomson T, Landmark C, Battino D. Antiepileptic drug treatment in pregnancy: Changes in drug disposition and their clinical implications. Epilepsia 2013;54(3):405-14
   PubMed Web of Science ®Google Scholar
• McGrath A, Sharpe L, Lah S, Parratt K. Pregnancy-related knowledge and information needs of women with epilepsy: A systematic review. Epilepsy & Behavior 2014;31:246255
   Web of Science ®Google Scholar
• Harden CL, Meador KJ, Pennell PB, et al. Practice Parameter update: Management issues for women with epilepsy–Focus on pregnancy (an evidence-based review): Teratogenesis and perinatal outcomes report of the quality standards subcommittee and therapeutics and technology assessment subcommittee of the american academy of neurology and american epilepsy society. Neurology 2009;73(2):133-41
   PubMed Web of Science ®Google Scholar
• Teramo K, Hiilesmaa V, Bardy A, Saarikoski S. Fetal heart rate during a maternal grand mal epileptic seizure. J Perinat Med 1978;7(1):3-6
   Web of Science ®Google Scholar
• Adab N, Kini U, Vinten J, et al. The longer term outcome of children born to mothers with epilepsy. J Neurol Neurosurg Psychiatry 2004;75(11):1575-83
   PubMed Web of Science ®Google Scholar
• Edey S, Moran N, Nashef L. SUDEP and epilepsy-related mortality in pregnancy. Epilepsia 2014;55(7):e72-4
   PubMed Web of Science ®Google Scholar
• Baker G, Bromley R, Briggs M, et al. IQ at 6 years after in utero exposure to antiepileptic drugs: a controlled cohort study. Neurology 2015;84(4):382-90
   PubMed Web of Science ®Google Scholar
• Pennell PB, Klein AM, Browning N, et al. Differential effects of antiepileptic drugs on neonatal outcomes. Epilepsy & behavior: E&B 2012;24(4):449-56
   PubMed Web of Science ®Google Scholar
• Campbell E, Devenney E, Morrow J, et al. Recurrence risk of congenital malformations in infants exposed to antiepileptic drugs in utero. Epilepsia 2012;54(1):165-71
   PubMed Web of Science ®Google Scholar
• Vajda F, O’Brien T, Lander C, et al. Teratogenesis in repeated pregnancies in antiepileptic drug-treated women. Epilepsia 2012;54(1):181-6
   PubMed Web of Science ®Google Scholar
• Meador K, Baker G, Browning N, et al. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study. Lancet Neurology 2013;12(3):244-52
   PubMed Web of Science ®Google Scholar
• Meador K, Baker G, Browning N, et al. Cognitive Function at 3 Years of Age after Fetal Exposure to Antiepileptic Drugs. N Engl J Med 2009;360(16):1597-605
   PubMed Web of Science ®Google Scholar
• Meador KJ, Baker GA, Browning N, et al. Effects of fetal antiepileptic drug exposure: outcomes at age 4.5 years. Neurology 2012;78(16):1207-14
   PubMed Web of Science ®Google Scholar
• Bromley RL, Mawer GE, Briggs M, et al. The prevalence of neurodevelopmental disorders in children prenatally exposed to antiepileptic drugs. J Neurol Neurosurg Psychiatr 2013;84(6):637-43
   PubMed Web of Science ®Google Scholar
• Veiby G, Daltveit A, Schjølberg S, et al. Exposure to antiepileptic drugs in utero and child development: a prospective population-based study. Epilepsia 2013;54(8):1462-72
   PubMed Web of Science ®Google Scholar
• Shallcross R, Bromley RL, Irwin B, et al. Child development following in utero exposure: levetiracetam vs sodium valproate. Neurology 2011;76(4):383-9
   PubMed Web of Science ®Google Scholar
• Shallcross R, Bromley RL, Cheyne CP, et al. In utero exposure to levetiracetam vs valproate: development and language at 3 years of age. Neurology 2014;82(3):213-21
   PubMed Web of Science ®Google Scholar
• Nadebaum C, Anderson VA, Vajda F, et al. Language skills of school-aged children prenatally exposed to antiepileptic drugs. Neurology 2011;76(8):719-26
   PubMed Web of Science ®Google Scholar
• Reisinger TL, Newman M, Loring DW, et al. Antiepileptic drug clearance and seizure frequency during pregnancy in women with epilepsy. Epilepsy & behavior: E&B 2013;29(1):13-18
   PubMed Web of Science ®Google Scholar
• Tomson T, Battino D. Teratogenic effects of antiepileptic drugs. Lancet Neurol 2012;11(9):803-13
   PubMed Web of Science ®Google Scholar
• Reinisch JM, Sanders SA, Mortensen EL, Rubin DB. In utero exposure to phenobarbital and intelligence deficits in adult men. JAMA 1995;274(19):1518-25
   PubMed Web of Science ®Google Scholar
• Bromley R, Weston J, Adab N, et al. Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child. Cochrane Database Systemat Rev 2013;10:CD010236
   Google Scholar
• Vajda F, O’Brien T, Lander C, et al. The efficacy of the newer antiepileptic drugs in controlling seizures in pregnancy. Epilepsia 2014;55(8):1229-34
   PubMed Web of Science ®Google Scholar
• Vajda FJ, O’Brien TJ, Lander CM. The teratogenicity of the newer antiepileptic drugs - an update. Acta Neurol Scand 2014;130(4):234-8
   PubMed Web of Science ®Google Scholar
• Campbell E, Kennedy F, Russell A, et al. Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers. J Neurol Neurosurg Psychiatry 2014;85(9):1029-34
   PubMed Web of Science ®Google Scholar
• Veiby G, Daltveit A, Engelsen B, Gilhus N. Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy. J Neurol 2014;261(3):579-88
   PubMed Web of Science ®Google Scholar
• Artama M, Gissler M, Malm H, et al. Effects of maternal epilepsy and antiepileptic drug use during pregnancy on perinatal health in offspring: nationwide, retrospective cohort study in Finland. Drug Saf 2013;36(5):359369
   Web of Science ®Google Scholar
• Johnson E, Stowe Z, Ritchie J, et al. Carbamazepine clearance and seizure stability during pregnancy. Epilepsy & Behavior 2014;33:4953
   Web of Science ®Google Scholar
• Marson A, Al-Kharusi A, Alwaidh M, et al. The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial. Lancet 2007;369(9566):1016-26
   PubMed Web of Science ®Google Scholar
• U.S. Food and Drug Administration. FDA drug safety communication: valproate anti-seizure products contraindicated for migraine prevention in pregnant women due to decreased IQ scores in exposed children. 2013. [Epub ahead of print]
   Google Scholar
• Unknown. PRAC recommends restricting valproate. Reactions Weekly 2014;1524(1):4
   Google Scholar
• Jentink J, Loane M, Dolk H, et al. Valproic acid monotherapy in pregnancy and major congenital malformations. N Engl J Med 2010;362(23):2185-93
   PubMed Web of Science ®Google Scholar
• Kilic D, Pedersen H, Kjaersgaard M, et al. Birth outcomes after prenatal exposure to antiepileptic drugs—A population-based study. Epilepsia 2014;55(11):1714-21
   PubMed Web of Science ®Google Scholar
• Christensen J, Grønborg T, Sørensen M, et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA 2013;309(16):1696-703
   PubMed Web of Science ®Google Scholar
• Mølgaard-Nielsen D, Hviid A. Newer-generation antiepileptic drugs and the risk of major birth defects. JAMA 2011;305(19):1996-2002
   PubMed Web of Science ®Google Scholar
• Artama M, Auvinen A, Raudaskoski T, et al. Antiepileptic drug use of women with epilepsy and congenital malformations in offspring. Neurology 2005;64(11):1874-8
   PubMed Web of Science ®Google Scholar
• Reimers A, Brodtkorb E. Second-generation antiepileptic drugs and pregnancy: a guide for clinicians. Expert Rev Neurother 2012;12(6):707-17
   PubMed Web of Science ®Google Scholar
• Group E. Seizure control and treatment in pregnancy: observations from the EURAP epilepsy pregnancy registry. Neurology 2006;66(3):354-60
   PubMed Web of Science ®Google Scholar
• Polepally A, Pennell P, Brundage R, et al. Model-based lamotrigine clearance changes during pregnancy: clinical implication. Annals of Clinical and Translational Neurology 2014;1(2):99-106
   PubMed Web of Science ®Google Scholar
• Pennell PB, Peng L, Newport DJ, et al. Lamotrigine in pregnancy: Clearance, therapeutic drug monitoring, and seizure frequency. Neurology 2007;70(22 Pt 2):2130-6
   PubMed Web of Science ®Google Scholar
• Morrow J, Russell A, Guthrie E, et al. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatr 2006;77(2):193-8
   PubMed Web of Science ®Google Scholar
• Montouris G. Gabapentin exposure in human pregnancy: results from the Gabapentin Pregnancy Registry. Epilepsy & behavior: E&B 2003;4(3):310-17
   PubMed Web of Science ®Google Scholar
• Fujii H, Goel A, Bernard N, et al. Pregnancy outcomes following gabapentin use: results of a prospective comparative cohort study. Neurology 2013;80(17):1565-70
   PubMed Web of Science ®Google Scholar
• Öhman I, Vitols S, Tomson T. Pharmacokinetics of gabapentin during delivery, in the neonatal period, and lactation: does a fetal accumulation occur during pregnancy? Epilepsia 2005;46(10):1621-4
   PubMed Web of Science ®Google Scholar
• Mines D, Tennis P, Curkendall S, et al. Topiramate use in pregnancy and the birth prevalence of oral clefts. Pharmacoepidemiol Drug Saf 2014;23(10):1017-25
   PubMed Web of Science ®Google Scholar
• Margulis A, Mitchell A, Gilboa S, et al. Use of topiramate in pregnancy and risk of oral clefts. Am J Obstetr Gynecol 2012;207(5):405.e1-7
   PubMed Web of Science ®Google Scholar
• Hernández-Díaz S, Mittendorf R, Smith C, et al. Association between topiramate and zonisamide use during pregnancy and low birth weight. Obstetr Gynecol 2014;123(1):21
   PubMed Web of Science ®Google Scholar
• Rihtman T, Parush S, Ornoy A. Preliminary findings of the developmental effects of in utero exposure to topiramate. Reproduct Toxicol (Elmsford, NY) 2012;34(3):308-11
   PubMed Web of Science ®Google Scholar
• Holmes L, Hernández-Díaz S. Newer anticonvulsants: lamotrigine, topiramate and gabapentin. Birth Defects Res A Clin Mol Teratol 2012;94(8):599-606
   PubMed Web of Science ®Google Scholar
• Mawhinney E, Craig J, Morrow J, et al. Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers. Neurology 2013;80(4):400-5
   PubMed Web of Science ®Google Scholar
• Chaudhry S, Jong G, Koren G. The fetal safety of Levetiracetam: a systematic review. Reproductive toxicology (Elmsford, N.Y.) 2014;46:40-5
   PubMed Web of Science ®Google Scholar
• Rektor I, Krauss GL, Bar M, et al. Perampanel Study 207: long-term open-label evaluation in patients with epilepsy. Acta Neurol Scand 2012;126(4):263-9
   PubMed Web of Science ®Google Scholar
• Vajda F, Hitchcock A, Graham J, et al. The teratogenic risk of antiepileptic drug polytherapy. Epilepsia 2010;51(5):805-10
   PubMed Web of Science ®Google Scholar
• Holmes L, Mittendorf R, Shen A, et al. Fetal effects of anticonvulsant polytherapies: different risks from different drug combinations. Arch Neurol 2011;68(10):1275-81
   PubMed Web of Science ®Google Scholar
• Forsberg L, Wide K, Källén B. School performance at age 16 in children exposed to antiepileptic drugs in utero--a population-based study. Epilepsia 2011;52(2):364-9
   PubMed Web of Science ®Google Scholar