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Expert Review of Neurotherapeutics Volume 16, 2016 - Issue 1
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Editorials

Barriers to the use of genetic information for the development of new epilepsy treatments

Thomas N. FerraroDepartment of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ08103, USACorrespondence[email protected]
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Pages 5-8 | Published online: 27 Nov 2015

References

  • Miziak B, Chrościńska-Krawczyk M, Błaszczyk B, et al. Novel approaches to anticonvulsant drug discovery. Expert Opin Drug Discov. 2013;8(11):1415–1427. doi:10.1517/17460441.2013.837047. Epub2013 Sep 19.
  • Frankel WN. Genetics of complex neurological disease: challenges and opportunities for modeling epilepsy in mice and rats. Trends Genet. 2009;25(8):361–367. doi:10.1016/j.tig.2009.07.001. Epub2009 Aug 6.
  • Olson H, Shen Y, Avallone J, et al. Copy number variation plays an important role in clinical epilepsy. Ann Neurol. 2014;75(6):943–958. doi:10.1002/ana.24178. Epub2014 Jun 13.
  • Mercimek-Mahmutoglu S, Patel J, Cordeiro D, et al. Diagnostic yield of genetic testing in epileptic encephalopathy in childhood. Epilepsia. 2015;56(5):707–716. doi:10.1111/epi.12954. Epub2015 Mar 25.
  • Moulard B, Picard F, Le Hellard S, et al. Ion channel variation causes epilepsies. Brain Res Brain Res Rev. 2001;36(2–3):275–284.
  • Liu JS. Molecular genetics of neuronal migration disorders. Curr Neurol Neurosci Rep. 2011;11(2):171–178. doi:10.1007/s11910-010-0176-5.
  • Otáhal J, Folbergrová J, Kovacs R, et al. Epileptic focus and alteration of metabolism. Int Rev Neurobiol. 2014;114:209–243. doi:10.1016/B978-0-12-418693-4.00009-1.
  • Curatolo P1, Moavero R. mTOR inhibitors as a new therapeutic option for epilepsy. Expert Rev Neurother. 2013;13(6):627–638. doi:10.1586/ern.13.49.
  • Kasperaviciūte D, Catarino CB, Heinzen EL, et al. Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. Brain. 2010;133(Pt 7):2136–2147. doi:10.1093/brain/awq130. Epub2010 Jun 3.
  • Guo Y, Baum LW, Sham PC, et al. Two-stage genome-wide association study identifies variants in CAMSAP1L1 as susceptibility loci for epilepsy in Chinese. Hum Mol Genet. 2012;21(5):1184–1189. doi:10.1093/hmg/ddr550. Epub2011 Nov 24.
  • EPICURE Consortium; EMINet Consortium, Steffens M, Leu C, Ruppert AK, et al. Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32. Hum Mol Genet. 2012;21(24):5359–5372. doi:10.1093/hmg/dds373. Epub2012 Sep 4.
  • International League Against Epilepsy Consortium on Complex Epilepsies. Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies. Lancet Neurol. 2014;13(9):893–903. doi:10.1016/S1474-4422(14)70171-1. Epub2014 Jul 30.
  • Ferraro TN. The relationship between genes affecting the development of epilepsy and approaches to epilepsy therapy. Expert Rev Neurother. 2014;14(3):329–352. doi:10.1586/14737175.2014.888651.
  • Lossin C, Rhodes TH, Desai RR, et al. Epilepsy-associated dysfunction in the voltage-gated neuronal sodium channel SCN1A. J Neurosci. 2003;23(36):11289–11295.
  • Freilich ER, Jones JM, Gaillard WD, et al. Novel SCN1A mutation in a proband with malignant migrating partial seizures of infancy. Arch Neurol. 2011;68(5):665–671. doi:10.1001/archneurol.2011.98.
  • Rogawski MA, Löscher W. The neurobiology of antiepileptic drugs. Nat Rev Neurosci. 2004;5(7):553–564.
  • Rhodes TH, Lossin C, Vanoye CG, et al. Noninactivating voltage-gated sodium channels in severe myoclonic epilepsy of infancy. Proc Natl Acad Sci USA. 2004;101(30):11147–11152. Epub 2004 Jul 19.
  • Yaffe RB, Borger P, Megevand P, et al. Physiology of functional and effective networks in epilepsy. Clin Neurophysiol. 2015;126(2):227–236. doi:10.1016/j.clinph.2014.09.009. Epub2014 Sep 22.
  • Yuen ES, Trocóniz IF. Can pentylenetetrazole and maximal electroshock rodent seizure models quantitatively predict antiepileptic efficacy in humans? Seizure. 2015;24:21–27. doi:10.1016/j.seizure.2014.
  • Sibille J, Dao Duc K, Holcman D, et al. The neuroglial potassium cycle during neurotransmission: role of Kir4.1 channels. PLoS Comput Biol. 2015;11(3):e1004137. eCollection 2015. doi:10.1371/journal.pcbi.1004137.
  • Swale DR, Kharade SV, Denton JS, Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics. Curr Opin Pharmacol. 2014;15:7–15. doi:10.1016/j.coph.2013.11.002. Epub2013 Nov 26.
  • Maguire CA, Ramirez SH, Merkel SF, et al. Gene therapy for the nervous system: challenges and new strategies. Neurotherapeutics. 2014;11(4):817–839. doi:10.1007/s13311-014-0299-5.

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