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Drug Profiles

The possible use of the L-type calcium channel antagonist verapamil in drug-resistant epilepsy

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References

• The authors provide a useful revision of the pharmacokinetic, pharmacodynamics and metabolism of verapamil

• First reported case of resolution of super refractory status epilepticus after verapamil administration

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•• The authors summarize the main studies on this field

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•• The authors give new insights in the role of Pgp in temporal lobe epilepsy.

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• The authors do not confirm the involvement of Pgp and multidrug transport proteins in drug resistance

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