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Understanding the pathology and treatment of traumatic brain injury and posttraumatic stress disorder: a therapeutic role for hyperbaric oxygen therapy

Vivian A GuedesDepartment of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA

Shuojing SongDepartment of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA

Martina ProvenzanoLaboratory of Molecular Genetics, DISPUTer, School of Medicine and Health Sciences, “G. d’Annunzio” University, Chieti-Pescara, Chieti, Italy

Cesario V BorlonganDepartment of Neurosurgery and Brain Repair, Center of Excellence for Aging and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USACorrespondence[email protected]

Pages 61-70 | Published online: 08 Jan 2016

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https://doi.org/10.1586/14737175.2016.1126180
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Understanding the pathology and treatment of traumatic brain injury and posttraumatic stress disorder: a therapeutic role for hyperbaric oxygen therapy

References

• This paper provides recommendations to enhance the utility of available or emerging tools in order to facilitate implementation of a pathoanatomical classification approach for clinical trials.

• This review summarizes the complex effects of TBI on network function, new approaches to modeling brain dynamics during network dysfunction and highlights the importance of network-level diagnostics in diagnosis, prognosis and treatment after TBI.

• This review provides a clear overview of issues and challenges in the use of animal models and design of clinical trials. The failure in the translation of results from preclinical studies into successful clinical trials is discussed.

•• Prepared by the VA and DOD concussion/mild TBI working group, this clinical practice guideline provides a comprehensive review of the current therapies available for mild TBI. Information on the natural course of the disease and return to work guidelines are included as well.

• This Cochrane systematic review focuses on the use of hyperbaric oxygen therapy to chronic wounds, but also discusses many other applications of HBOT. The authors stress that the majority of proposed uses of HBOT are unproven or have shown no benefit in high-quality studies.

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Understanding the pathology and treatment of traumatic brain injury and posttraumatic stress disorder: a therapeutic role for hyperbaric oxygen therapy

References

• This paper provides recommendations to enhance the utility of available or emerging tools in order to facilitate implementation of a pathoanatomical classification approach for clinical trials.

• This review summarizes the complex effects of TBI on network function, new approaches to modeling brain dynamics during network dysfunction and highlights the importance of network-level diagnostics in diagnosis, prognosis and treatment after TBI.

• This review provides a clear overview of issues and challenges in the use of animal models and design of clinical trials. The failure in the translation of results from preclinical studies into successful clinical trials is discussed.

•• Prepared by the VA and DOD concussion/mild TBI working group, this clinical practice guideline provides a comprehensive review of the current therapies available for mild TBI. Information on the natural course of the disease and return to work guidelines are included as well.

• This Cochrane systematic review focuses on the use of hyperbaric oxygen therapy to chronic wounds, but also discusses many other applications of HBOT. The authors stress that the majority of proposed uses of HBOT are unproven or have shown no benefit in high-quality studies.

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