Cessation of epilepsy therapy in children

References

• Fisher RS, Acevedo C, Arzimanoglou A, et al. A practical clinical definition of epilepsy. Epilepsia. 2014;55:475–482.
   PubMed Web of Science ®Google Scholar
• Shinnar S, Amir N, Branski D. Childood seizures. Pediatr Adolesc Medicine. Basel, Karger. 1995;6:67–77.
   Google Scholar
• French JA, Pedley TA. Clinical practice. Initial management of epilepsy. N Engl J Med. 2008;359:166–176.
   PubMed Web of Science ®Google Scholar
• Camfield PR, Camfield CS, Gordon K, et al. If a first antiepileptic drug fails to control a child’s epilepsy, what are the chances of success with the next drug? J Pediatr. 1997;131:821–824.
   PubMed Web of Science ®Google Scholar
• Wirrell E, Camfield C, Camfield P, et al. Prognostic significance of failure of the initial antiepileptic drug in children with absence epilepsy. Epilepsia. 2001;42:760–763.
   PubMed Web of Science ®Google Scholar
• Arts WF, Brouwer OF, Peters AC, et al. Course and prognosis of childhood epilepsy: 5-year follow-up of the Dutch study of epilepsy in childhood. Brain. 2004;127:1774–1784.
   PubMed Web of Science ®Google Scholar
• Malphrus AD, Wilfong A. Use of the newer antiepileptic drugs in pediatric epilepsies. Curr Treat Options Neurol. 2007;9:256–267.
   PubMedGoogle Scholar
• Anderson M, Egunsola O, Cherrill J, et al. A prospective study of adverse drug reactions to antiepileptic drugs in children. BMJ Open. 2015;5:e008298. doi:10.1136/bmjopen-2015-008298.
   PubMed Web of Science ®Google Scholar
• Mitchell AA, Lacouture PG, Sheehan JE, et al. Adverse drug reactions in children leading to hospital admission. Pediatrics. 1988;82:24–29.
   PubMed Web of Science ®Google Scholar
• Alvestad S, Lydersen S, Brodtkorb E. Rash from antiepileptic drugs: influence by gender, age, and learning disability. Epilepsia. 2007;48:1360–1365.
   PubMed Web of Science ®Google Scholar
• Guerrini R, Zaccara G, La Marca G, et al. Safety and tolerability of antiepileptic drug treatment in children with epilepsy. Drug Saf. 2012;35:519–533.
   PubMed Web of Science ®Google Scholar
• Greenwood RS, Tennison MB. When to start and stop anticonvulsant therapy in children. Neurol Rev. 1999;56:1073–1077.
   Google Scholar
• Altunbasak S, Artar O, Burgut R, et al. Relapse risk analysis after drug withdrawal in epileptic children with uncomplicated seizures. Seizure. 1999;8:384–389.
   PubMed Web of Science ®Google Scholar
• Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med. 2000;342:314–319.
   PubMed Web of Science ®Google Scholar
• Schmidt D, Löscher W. Uncontrolled epilepsy following discontinuation of antiepileptic drugs in seizure-free patients: A review of current clinical experience. Acta Neurol Scand. 2005;111:291–300.
   PubMed Web of Science ®Google Scholar
• Specchio LM, Beghi E. Should antiepileptic drugs be withdrawn in seizure-free patients? CNS Drugs. 2004;18:201–212.
   PubMed Web of Science ®Google Scholar
• Practice parameters: a guidelines for discontinuing antiepileptic drugs in seizure-free patients- Summary statement. Report of the quality standard subcommittee of American Academy of Neurology. Neurology. 1996;47:600–602.
   PubMed Web of Science ®Google Scholar
• Camfield P, Camfield C. The frequency of intractable seizures after stopping AEDs in seizure-free children with epilepsy. Neurology. 2005;64:973–975.
   PubMed Web of Science ®Google Scholar
• Avani C, Rausch J, Glauser T. Early pediatric antiepileptic drug nonadherence is related to lower long-term seizure freedom. Neurology. 2014;82:671–673.
   PubMed Web of Science ®Google Scholar
• Medical research council antiepileptic drug withdrawal study group. Randomized study of antiepileptic drug withdrawal in patients in remission. Lancet. 1991;337:1175–1180.
   PubMed Web of Science ®Google Scholar
• Archana V, Surendra M. Risk of seizure recurrence after antiepileptic drug withdrawal, an Indian study. Neurol Asia. 2006;11:19–23.
   Google Scholar
• Hixson JD. Stopping antiepileptic drugs: when and why? Curr Treat Options Neurol. 2010;12:434–442.
   PubMed Web of Science ®Google Scholar
• Hindley D, Staniforth H. Seizure relapse following medication withdrawal in childhood epilepsy. Arch Dis Child. 2011;96:113.
   PubMed Web of Science ®Google Scholar
• Vurucu S, Saldir M, Unay B, et al. Determination of risk factors associated with seizure relapse after antiepileptic drug withdrawal. Cent Eur J Med. 2010;5:251–256.
   Web of Science ®Google Scholar
• Emerson R, D’Souza BJ, Vining EP, et al. Stopping medication in children with epilepsy: Predictors of outcome. N Engl J Med. 1981;304:1125–1129.
   PubMed Web of Science ®Google Scholar
• Bouma PA, Peters AC, Arts RJ, et al. Discontinuation of antiepileptic therapy: A prospective study in children. J Neurol Neurosurg Psychiatry. 1987;50:1579–1583.
   PubMed Web of Science ®Google Scholar
• Shinnar S, Berg AT, Moshé SL, et al. Discontinuing antiepileptic drugs in children with epilepsy: A prospective study. Ann Neurol. 1994;35:534–545.
   PubMed Web of Science ®Google Scholar
• Camfield C, Camfield P, Gordon K, et al. Outcome of childhood epilepsy: a population-based study with a simple predictive scoring system for those treated with medication. J Peds. 1993;122:861–868.
   PubMed Web of Science ®Google Scholar
• Casetta I, Granieri E, Monetti VC, et al. Early predictors of intractability in childhood epilepsy: a community-based casecontrol study in Copparo, Italy. Acta Neurol Scand. 1999;99:329–333.
   PubMed Web of Science ®Google Scholar
• Ko TS, Holmes GL. EEG and clinical predictors of medically intractable childhood epilepsy. Clin Neurophysiol. 1999;110:1245–1251.
   PubMed Web of Science ®Google Scholar
• Mohanraj R, Brodie MJ. Early predictors of outcome in newly diagnosed epilepsy. Seizure. 2013;22:333–344.
   PubMed Web of Science ®Google Scholar
• Ohta H, Ohtsuka Y, Tsuda T, et al. Prognosis after withdrawal of antiepileptic drugs in childhood-onset cryptogenic localization-related epilepsies. Brain Dev. 2004;26:19–25.
   PubMed Web of Science ®Google Scholar
• Berg AT, Levy SR, Novotny EJ, et al. Predictors of intractable epilepsy in childhood: a case–control study. Epilepsia. 1996;37:24–30.
   PubMed Web of Science ®Google Scholar
• Incecik F, Herguner OM, Altunbasak S, et al. Risk of recurrence after discontinuation of antiepileptic drug therapy in children with epilepsy. J Pediatr Neurosci. 2014;9:100–104.
   PubMedGoogle Scholar
• Olmez A, Arslan U, Turanli G, et al. Risk of recurrence after drug withdrawal in childhood epilepsy. Seizure. 2009;18:251–256.
   PubMed Web of Science ®Google Scholar
• Gherpelli JL, Kok F, Dal Forno S, et al. Discontinuing medication in epileptic children: A study of risk factors related to recurrence. Epilepsia. 1992;33:681–686.
   PubMed Web of Science ®Google Scholar
• Verrotti A, D’Egidio C, Agostinelli S, et al. Antiepileptic drug withdrawal in childhood epilepsy: what are the risk factors associated with seizure relapse? Eur J Paediatr Neurol. 2012;16:599–604.
   PubMed Web of Science ®Google Scholar
• Berg AT, Shinnar S. Relapse following discontinuation of antiepileptic drugs: A meta-analysis. Neurology. 1994;44:601–608.
   PubMed Web of Science ®Google Scholar
• Tennison M, Greenwood R, Lewis D, et al. Rate of taper of anti- epileptic drugs withdrawal and the risk of seizure recurrence in children. N Engl J Med. 1994;330:1407–1410.
   PubMed Web of Science ®Google Scholar
• Verrotti A, Trotta D, Salladini C, et al. Risk factors of epilepsy and withdrawal of antiepileptic therapy: a practical approach. Ann Med. 2003;35:207–215.
   PubMed Web of Science ®Google Scholar
• Strozzi I, Nolan SJ, Sperlin MR. et al. Early versus late antiepileptic drug withdrawal for people with epilepsy in remission. Cochrane Database Syst Rev. 2015;2:CD001902.
   Google Scholar
• Delgado-Escueta AV, Enrile-Bacsal F. Juvenile myoclonic epilepsy of Janz. Neurology. 1984;34:285–294.
   PubMed Web of Science ®Google Scholar
• Alsaadi T, Shakra M, Turkawi L. Discontinuation of AEDs: when and how? Health. 2013;5:21–27.
   Google Scholar
• Camfield P, Camfield C. When is it safe to discontinue AED treatment? Epilepsia. 2008;49:25–28.
   PubMed Web of Science ®Google Scholar
• Englot DJ, Breshears JD, Sun PP, et al. Seizure outcomes after resective surgery for extra-temporal lobe epilepsy in pediatric patients. J Neurosurg Pediatr. 2013;12:126–133.
   PubMed Web of Science ®Google Scholar
• Gross-Tsur V, Shinnar S. Withdrawal of antiepileptic drugs in children. Harefuah. 1992;123:189–192.
   PubMedGoogle Scholar
• Dooley J, Gordon K, Camfield P, et al. Discontinuation of anticonvulsant therapy in children free of seizures for 1 year: A prospective study. Neurology. 1996;46:969–974.
   PubMed Web of Science ®Google Scholar
• Su L, Di Q, Yu N, et al. Predictors for relapse after antiepileptic drug withdrawal in seizure-free patients with epilepsy. J Clin Neurosci. 2013;20:790–794.
   PubMed Web of Science ®Google Scholar
• Kimura M, Yoshino K, Suzuki N. Seizure recurrence after reduction of an antiepileptic drug in patients with unprovoked seizures and severe neurological abnormalities. Psychiatry Clin Neurosci. 2000;54:41–44.
   PubMed Web of Science ®Google Scholar
• Medical research council antiepileptic drug withdrawal study group. Prognostic index for recurrence of seizures after remission of epilepsy. Br Med J. 1993;306:1374–1378.
   PubMedGoogle Scholar
• Bouma PAD, Peters ACB, Brouwer OF. Long term course of childhood epilepsy following relapse after antiepileptic drug withdrawal. J Neurol Neurosurg Psychiatry. 2002;72:507–510.
   PubMed Web of Science ®Google Scholar
• Delgado MR, Riela AR, Mills J, et al. Discontinuation of antiepileptic drug treatment after two seizure-free years in children with cerebral palsy. Pediatrics. 1996;97:192–197.
   PubMed Web of Science ®Google Scholar
• Zafeiriou DI, Kontopoulos EE, Tsikoulas I. Characteristics and prognosis of epilepsy in children with cerebral palsy. J Child Neurol. 1999;14:289–294.
   PubMed Web of Science ®Google Scholar
• Marson AG, Kadir ZA, Hutton JL, et al. The new antiepileptic drugs: A systematic review of their efficacy and tolerability. Epilepsia. 1997;38:859–880.
   PubMed Web of Science ®Google Scholar
• Callenbach PMC, Bouma PAD, Geerts AT, et al. Long term outcome of benign childhood epilepsy with centrotemporal spikes: Dutch study of epilepsy in childhood. Seizure. 2010;19:501–506.
   PubMed Web of Science ®Google Scholar
• Pavlovic M, Jovic N, Pekmezovic T. Antiepileptic drugs withdrawal in patients with idiopathic generalized epilepsy. Seizure. 2011;20:520–525.
   PubMed Web of Science ®Google Scholar
• Camfield C, Camfield P. Management guidelines for children with idiopathic generalized epilepsy. Epilepsia. 2005;46:112–116.
   PubMed Web of Science ®Google Scholar
• Martinez-Juarez IE, Alonso ME, Medina MT, et al. Juvenile myoclonic epilepsy subsyndromes: family studies and long-term follow-up. Brain. 2006;129:1269–1280.
   PubMed Web of Science ®Google Scholar
• Murakami M, Konishi T, Naganuma Y, et al. Withdrawal of antiepileptic drug treatment in childhood epilepsy: factors related to age. J Neurol Neurosurg Psychiatry. 1995;59:477–481.
   PubMed Web of Science ®Google Scholar
• Canevini MP, Mai R, Di Marco C, et al. Juvenile myoclonic epilepsy of Janz: clinical observation in 60 patients. Seizure. 1992;1:291–297.
   PubMedGoogle Scholar
• Braathen G, Melander H. Early discontinuation of treatment in children with uncomplicated epilepsy: a prospective study with a model for prediction of outcome. Epilepsia. 1997;38:561–569.
   PubMed Web of Science ®Google Scholar
• Peters ACB, Brouwer OF, Geerts AT, et al. Randomized prospective study of early discontinuation of antiepileptic drugs in children with epilepsy. Neurology. 1998;50:724–730.
   PubMed Web of Science ®Google Scholar
• Todt H. The late prognosis of epilepsy in childhood: results of a prospective follow-up study. Epilepsia. 1984;25:137–144.
   PubMed Web of Science ®Google Scholar
• Matricardi M, Brinciotti M, Benedetti P. Outcome after discontinuation of antiepileptic drug therapy in children with epilepsy. Epilepsia. 1989;30:582–589.
   PubMed Web of Science ®Google Scholar
• Ramos-Lizana J, Aguirre-Rodríguez J, Aguilera-López P, et al. Recurrence risk after withdrawal of antiepileptic drugs in children with epilepsy: a prospective study. Eur J Paediatr Neurol. 2010;14:116–124.
   PubMed Web of Science ®Google Scholar
• Tinuper P, Provini F, Marini C. Partial epilepsy of long duration: changing semiology with age. Epilepsia. 1996;37:162–164.
   PubMed Web of Science ®Google Scholar
• Verrotti A, Morresi S, Cutarella R, et al. Predictive value of EEG monitoring during drug withdrawal in children with cryptogenic partial epilepsy. Neurophysiol Clin. 2000;30:240–245.
   PubMed Web of Science ®Google Scholar
• Hawash KY, Rosman NP. Do partial seizures predict an increased risk of seizure recurrence after antiepilepsy drugs are withdrawn? J Child Neurol. 2003;18:331–337.
   PubMed Web of Science ®Google Scholar
• Gebremariam A, Mengesha W, Enqusilassie F. Discontinuing anti-epileptic medication(s) in epileptic children: 18 versus 24 months. Ann Trop Paediatr. 1999;19:93–99.
   PubMed Web of Science ®Google Scholar
• Snead OC. Surgical treatment of medically refractory epilepsy in childhood. Brain Dev. 2001;23:199–207.
   PubMed Web of Science ®Google Scholar
• Guerreiro MM, Andermann F, Andermann E, et al. Surgical treatment of epilepsy in tuberous sclerosis: strategies and results in 18 patients. Neurology. 1998;51:1263–1269.
   PubMed Web of Science ®Google Scholar
• Curatolo P. Neurological manifestations of tuberous sclerosis complex. Childs Nerv Syst. 1996;12:515–521.
   PubMed Web of Science ®Google Scholar
• Chandra PS, Salamon N, Huang J, et al. FDG-PET/MRI coregistration and diffusion-tensor imaging distinguish epileptogenic tubers and cortex in patients with tuberous sclerosis complex: a preliminary report. Epilepsia. 2006;47:1543–1549.
   PubMed Web of Science ®Google Scholar
• Cardoso TA, Coan AC, Kobayashi E, et al. Hippocampal abnormalities and seizure recurrence after antiepileptic drug withdrawal. Neurology. 2006;67:134–136.
   PubMed Web of Science ®Google Scholar
• Specchio LM, Tramacere L, La Neve A, et al. Discontinuing antiepileptic drugs in patients who are seizure free on monotherapy. J Neurol Neurosurg Psychiatry. 2002;72:22–25.
   PubMed Web of Science ®Google Scholar
• Sillanpää M, Schmidt D. Prognosis of seizure recurrence after stopping antiepileptic drugs in seizure-free patients: A long-term population-based study of childhood-onset epilepsy. Epilepsy Behav. 2006;8:713.
   PubMed Web of Science ®Google Scholar
• Sirven JI, Sperling M, Wingerchuk DM. Early versus late antiepileptic drug withdrawal for people with epilepsy in remission. Cochrane Database Syst Rev. 2001;(3):CD001902.
   Google Scholar
• Ranganathan LN, Ramaratnam S. Rapid versus slow withdrawal of antiepileptic drugs. Cochrane Database Syst Rev. 2006;(2):CD005003.
   PubMed Web of Science ®Google Scholar
• Serra JG, Montenegro MA, Guerreiro MM. Antiepileptic drug withdrawal in childhood: Does the duration of tapering off matter for seizure recurrence? J Child Neurol. 2005;20:624–626.
   PubMed Web of Science ®Google Scholar
• Beghi E, Giussani G, Grosso S, et al. Withdrawal of antiepileptic drugs: guidelines of the Italian league against epilepsy. Epilepsia. 2013;54:2–12.
   PubMed Web of Science ®Google Scholar
• Lossius MI, Hessen E, Mowinckel P, et al. Consequences of antiepileptic drug withdrawal: a randomized, double-blind study (Akershus Study). Epilepsia. 2008;49:455–463.
   PubMed Web of Science ®Google Scholar
• Hessen E, Lossius M, Gjerstad L. Improvement in verbal memory after withdrawal of carbamazepine and valproate in patients with well-controlled epilepsy: a randomized, double-blind study. Acta Neurol Scand. 2011;123:385–389.
   PubMed Web of Science ®Google Scholar
• Chadwick D, Taylor J. Johnson T outcomes after seizure recurrence in people with well-controlled epilepsy and the factors that influence it. The MRC antiepileptic drug withdrawal group. Epilepsia. 1996;37:1043–1050.
   PubMed Web of Science ®Google Scholar
• Engel J, Pedley TA. Epilepsy: A comprehensive textbook. Philadelphia: Lippincott-Raven; 1997.
   Google Scholar
• Spencer S, Huh L. Outcomes of epilepsy surgery in adults and children. Lancet Neurol. 2008;7:525–537.
   PubMed Web of Science ®Google Scholar
• Ryvlin P, Cross JH, Rheims S. Epilepsy surgery in children and adults. Lancet Neurol. 2014;13:1114–1126.
   PubMed Web of Science ®Google Scholar
• Asadi-Pooya AA, Sharan A, Nei M, et al. Corpus callosotomy. Epilepsy Behav. 2008;13:271.
   PubMed Web of Science ®Google Scholar
• Cukiert A, Burattini JA, Mariani PP, et al. Outcome after extended callosal section in patients with primary idiopathic generalized epilepsy. Epilepsia. 2009;50:1377.
   PubMed Web of Science ®Google Scholar
• Pomata HB, González R, Bartuluchi M, et al. Extratemporal epilepsy in children: candidate selection and surgical treatment. Childs Nerv Syst. 2000;16:842–850.
   PubMed Web of Science ®Google Scholar
• Engel J. Jr. Surgical treatment for epilepsy: too little, too late? Jama. 2008;300:2548–2550.
   PubMed Web of Science ®Google Scholar
• Kwan P, Sperling MR. Refractory seizures: try additional antiepileptic drugs (after two have failed) or go directly to early surgery evaluation? Epilepsia. 2009;50:57–62.
   PubMed Web of Science ®Google Scholar
• Mikati MA, Rahi AC, Shamseddine A, et al. Marked benefits in physical activity and wellbeing, but not in functioning domains, 2 years after successful epilepsy surgery in children. Epilepsy Behav. 2008;12:145 149.
   PubMed Web of Science ®Google Scholar
• Ansari SF, Maher CO, Tubbs RS, et al. Surgery for extratemporal nonlesional epilepsy in children: a meta-analysis. Childs Nerv Syst. 2010;26:945–951.
   PubMed Web of Science ®Google Scholar
• Englot DJ, Rolston JD, Wang DD, et al. Seizure outcomes after temporal lobectomy in pediatric patients. A systematic review. J Neurosurg Pediatr. 2013;12:134–141.
   PubMed Web of Science ®Google Scholar
• Schmidt D, Baumgartner C, Loscher W. Seizure recurrence after planned discontinuation of antiepileptic drugs in seizure-free patients after epilepsy surgery: a review of current clinical experience. Epilepsia. 2004;45:179–186.
   PubMed Web of Science ®Google Scholar
• Lachhwani DK, Loddenkemper T, Holland KD, et al. Discontinuation of medications after successful epilepsy surgery in children. Pediatr Neurol. 2008;38:340–344.
   PubMed Web of Science ®Google Scholar
• Hoppe C, Poepel A, Sassen R, et al. Discontinuation of anticonvulsant medication after epilepsy surgery in children. Epilepsia. 2006;47:580–583.
   PubMed Web of Science ®Google Scholar
• Boshuisen K, Arzimanoglou A, Cross JH, et al. Timing of antiepileptic drug withdrawal and long-term seizure outcome after paediatric epilepsy surgery (TimeToStop): a retrospective observational study. Lancet Neurol. 2012;11:784.
   PubMed Web of Science ®Google Scholar